Reviewed, UniProtKB/Swiss-Prot Q6A2H0 (SSDH_PANTR)

Names and origin

Protein names

Recommended name:
    Succinate-semialdehyde dehydrogenase, mitochondrial
    EC=1.2.1.24
Alternative name(s):
    NAD(+)-dependent succinic semialdehyde dehydrogenase
    Aldehyde dehydrogenase family 5 member A1

Gene names

Name:

ALDH5A1

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	535 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) By similarity.
Catalytic activity	Succinate semialdehyde + NAD+ + H2O = succinate + NADH.
Enzyme regulation	Redox-regulated. Inhibited under oxydizing conditions By similarity.
Pathway	Amino-acid degradation; 4-aminobutanoate degradation.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Acetylation Disulfide bond
Gene Ontology (GO)
Biological process	central nervous system development Inferred from sequence or structural similarity. Source: UniProtKB gamma-aminobutyric acid catabolic process Inferred from sequence or structural similarity. Source: UniProtKB oxidation reduction Inferred from sequence or structural similarity. Source: UniProtKB protein homotetramerization Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fraction Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	succinate-semialdehyde dehydrogenase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 47	47	Mitochondrion Potential
	Chain	48 – 535	488	Succinate-semialdehyde dehydrogenase, mitochondrial		PRO_0000007186
Regions
	Nucleotide binding	228 – 231	4	NAD By similarity
	Nucleotide binding	284 – 289	6	NAD By similarity
Sites
	Active site	306	1	Proton acceptor By similarity
	Active site	340	1	Nucleophile By similarity
	Binding site	213	1	NAD By similarity
	Binding site	213	1	Substrate By similarity
	Binding site	334	1	Substrate By similarity
	Binding site	498	1	Substrate By similarity
	Site	205	1	Transition state stabilizer By similarity
Amino acid modifications
	Modified residue	126	1	N6-acetyllysine By similarity
	Modified residue	358	1	N6-acetyllysine By similarity
	Disulfide bond	340 ↔ 342		In inhibited form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6A2H0-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 0FBDB50025DE25D2	FASTA	535	57,140
	10 20 30 40 50 60 MATCIWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGG LAGLSAALLR 70 80 90 100 110 120 TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA AVRAAYEAFC RWREVSAKER 130 140 150 160 170 180 SSLLRKWYNL MIQNKDDLAR IITAESGKPL KEAHGEILYS AFFLEWFSEE ARRVYGDIIY 190 200 210 220 230 240 TPAKDRRALV LKQPXGVAAV ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL 250 260 270 280 290 300 AELASQAGIP SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV 310 320 330 340 350 360 KRVSMELGGL APFIVFDSAN VDQAVAGAMA SKFRNTGQTC VCSNQFLVQR GIHDAFVKAF 370 380 390 400 410 420 AEAMKKNLRV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV SKGATVVTGG KRHQLGKNFF 430 440 450 460 470 480 EPTLLCNVTQ DMLCTHEETF GPLAPVIKFD TEEEAIAIAN AADVGLAGYF YSQDPAQIWR 490 500 510 520 530 VAEQLEVGMV GVNEGLISSV ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL

References

[1]	"Comparative analysis of succinic semialdehyde dehydrogenase in non three ape species." Blasi P., Malaspina P. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ621752 mRNA. Translation: CAF21869.1.
RefSeq	NP_001008991.1.
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000062134; ENSPTRP00000054687; ENSPTRG00000017776; Pan troglodytes. [Genome view]
GeneID	449515.
KEGG	ptr:449515.
Organism-specific databases
CTD	449515.
Phylogenomic databases
eggNOG	prNOG06436.
HOVERGEN	Q6A2H0.
Enzyme and pathway databases
BRENDA	1.2.1.24. 264977.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR010102. Succ_semiAld_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01780. SSADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SSDH_PANTR

Accession

Primary (citable) accession number: Q6A2H0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	September 13, 2004
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)