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Protein

Succinate-semialdehyde dehydrogenase, mitochondrial

Gene

ALDH5A1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).By similarity

Catalytic activityi

Succinate semialdehyde + NAD+ + H2O = succinate + NADH.

Enzyme regulationi

Redox-regulated. Inhibited under oxydizing conditions (By similarity).By similarity

Pathwayi: 4-aminobutanoate degradation

This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei205 – 2051Transition state stabilizerBy similarity
Binding sitei213 – 2131NADBy similarity
Binding sitei213 – 2131SubstrateBy similarity
Active sitei306 – 3061Proton acceptorPROSITE-ProRule annotation
Binding sitei334 – 3341SubstrateBy similarity
Active sitei340 – 3401NucleophilePROSITE-ProRule annotation
Binding sitei498 – 4981SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi228 – 2314NADBy similarity
Nucleotide bindingi284 – 2896NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.24. 4497.
UniPathwayiUPA00733.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate-semialdehyde dehydrogenase, mitochondrial (EC:1.2.1.24)
Alternative name(s):
Aldehyde dehydrogenase family 5 member A1
NAD(+)-dependent succinic semialdehyde dehydrogenase
Gene namesi
Name:ALDH5A1
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4747MitochondrionSequence analysisAdd
BLAST
Chaini48 – 535488Succinate-semialdehyde dehydrogenase, mitochondrialPRO_0000007186Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei126 – 1261N6-acetyllysine; alternateBy similarity
Modified residuei126 – 1261N6-succinyllysine; alternateBy similarity
Modified residuei135 – 1351N6-succinyllysineBy similarity
Modified residuei184 – 1841N6-succinyllysineBy similarity
Modified residuei265 – 2651N6-acetyllysine; alternateBy similarity
Modified residuei265 – 2651N6-succinyllysine; alternateBy similarity
Disulfide bondi340 ↔ 342In inhibited formBy similarity
Modified residuei365 – 3651N6-acetyllysineBy similarity
Modified residuei402 – 4021N6-succinyllysineBy similarity
Modified residuei411 – 4111N6-acetyllysineBy similarity
Modified residuei499 – 4991PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ6A2H0.
PRIDEiQ6A2H0.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000054687.

Structurei

3D structure databases

ProteinModelPortaliQ6A2H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2451. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000271509.
HOVERGENiHBG108515.
InParanoidiQ6A2H0.
KOiK00139.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01780. SSADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6A2H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCIWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGG
60 70 80 90 100
LAGLSAALLR TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA
110 120 130 140 150
AVRAAYEAFC RWREVSAKER SSLLRKWYNL MIQNKDDLAR IITAESGKPL
160 170 180 190 200
KEAHGEILYS AFFLEWFSEE ARRVYGDIIY TPAKDRRALV LKQPXGVAAV
210 220 230 240 250
ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL AELASQAGIP
260 270 280 290 300
SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV
310 320 330 340 350
KRVSMELGGL APFIVFDSAN VDQAVAGAMA SKFRNTGQTC VCSNQFLVQR
360 370 380 390 400
GIHDAFVKAF AEAMKKNLRV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV
410 420 430 440 450
SKGATVVTGG KRHQLGKNFF EPTLLCNVTQ DMLCTHEETF GPLAPVIKFD
460 470 480 490 500
TEEEAIAIAN AADVGLAGYF YSQDPAQIWR VAEQLEVGMV GVNEGLISSV
510 520 530
ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL
Length:535
Mass (Da):57,140
Last modified:September 13, 2004 - v1
Checksum:i0FBDB50025DE25D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621752 mRNA. Translation: CAF21869.1.
RefSeqiNP_001008991.1. NM_001008991.1.
UniGeneiPtr.6190.

Genome annotation databases

GeneIDi449515.
KEGGiptr:449515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621752 mRNA. Translation: CAF21869.1.
RefSeqiNP_001008991.1. NM_001008991.1.
UniGeneiPtr.6190.

3D structure databases

ProteinModelPortaliQ6A2H0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000054687.

Proteomic databases

PaxDbiQ6A2H0.
PRIDEiQ6A2H0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi449515.
KEGGiptr:449515.

Organism-specific databases

CTDi7915.

Phylogenomic databases

eggNOGiKOG2451. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000271509.
HOVERGENiHBG108515.
InParanoidiQ6A2H0.
KOiK00139.

Enzyme and pathway databases

UniPathwayiUPA00733.
BRENDAi1.2.1.24. 4497.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01780. SSADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSDH_PANTR
AccessioniPrimary (citable) accession number: Q6A2H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 13, 2004
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.