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Protein

Putative 3-phosphoinositide-dependent protein kinase 2

Gene

PDPK2P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841ATPBy similarity
Binding sitei139 – 1391ATPBy similarity
Active sitei178 – 1781Proton acceptorPROSITE-ProRule annotation
Binding sitei182 – 1821ATP; via carbonyl oxygenBy similarity
Binding sitei196 – 1961ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 673ATPBy similarity
Nucleotide bindingi133 – 1353ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ6A1A2.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 3-phosphoinositide-dependent protein kinase 2 (EC:2.7.11.1)
Alternative name(s):
3-phosphoinositide-dependent protein kinase 2 pseudogeneCurated
Gene namesi
Name:PDPK2PImported
Synonyms:PDPK21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:49897. PDPK2P.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74757401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Putative 3-phosphoinositide-dependent protein kinase 2PRO_0000341967Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine and serine/threonine.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6A1A2.
PRIDEiQ6A1A2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344220.

Structurei

3D structure databases

ProteinModelPortaliQ6A1A2.
SMRiQ6A1A2. Positions 44-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 315261Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni86 – 13045PIF-pocketBy similarityAdd
BLAST

Domaini

The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.By similarity

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233026.
HOVERGENiHBG098357.
InParanoidiQ6A1A2.
PhylomeDBiQ6A1A2.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR011993. PH-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6A1A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRTQTESST PPGIPGGSRQ GPAMDGTAAE PRPGAGSLQH AQPPPQPRKK
60 70 80 90 100
RPEDFKFGKI LGEGSFSTVV LARELATSRE YAIKILEKRH IIKENKVPYV
110 120 130 140 150
TRERDVMSRL DHPFFVKLYF TFQDDEKLYF GLSYAKNGEL LKYIRKIGSF
160 170 180 190 200
DETCTRFYTA EIVSALEYLH GKGIIHRDLK PENILLNEDM YIQITDFGTA
210 220 230 240 250
KVLSPESKQA RANSFVGTAQ YVSPELLTEK SACKSSDLWA LGCIIYQLVA
260 270 280 290 300
GLPPFRAGNE YLIFQKIIKL EYDFPEKFFP KARDLVEKLL VLDATKRLGC
310 320 330 340 350
EEMEGYGPLK AHPFFESVTW ENLHQQTPPK LTAYLPAMSE DDEDCYGNVS
360 370 380 390
WPGWRARQVA LGPPCTGLHA RAPDPRVICS RKGRVSVPLR QACWWL
Length:396
Mass (Da):44,765
Last modified:September 13, 2004 - v1
Checksum:iA0661913B473D8DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ785968 mRNA. Translation: CAH05056.1.
UniGeneiHs.459691.

Genome annotation databases

UCSCiuc002cqv.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ785968 mRNA. Translation: CAH05056.1.
UniGeneiHs.459691.

3D structure databases

ProteinModelPortaliQ6A1A2.
SMRiQ6A1A2. Positions 44-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344220.

Polymorphism and mutation databases

DMDMi74757401.

Proteomic databases

PaxDbiQ6A1A2.
PRIDEiQ6A1A2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc002cqv.1. human.

Organism-specific databases

HGNCiHGNC:49897. PDPK2P.
neXtProtiNX_Q6A1A2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233026.
HOVERGENiHBG098357.
InParanoidiQ6A1A2.
PhylomeDBiQ6A1A2.

Enzyme and pathway databases

SignaLinkiQ6A1A2.

Miscellaneous databases

PROiQ6A1A2.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR011993. PH-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel member of human 3-phosphoinositide dependent protein kinase-1 family, PDPK2."
    Pingzhang W., Xin W., Tianjing C., Jun W., Ying L.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPDPK2_HUMAN
AccessioniPrimary (citable) accession number: Q6A1A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: September 13, 2004
Last modified: July 22, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.