Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6A1A2 (PDPK2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative 3-phosphoinositide-dependent protein kinase 2

EC=2.7.11.1
Gene names
Name:PDPK2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity.

Post-translational modification

Phosphorylated on tyrosine and serine/threonine By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

Contains 1 protein kinase domain.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Putative 3-phosphoinositide-dependent protein kinase 2
PRO_0000341967

Regions

Domain55 – 315261Protein kinase
Nucleotide binding61 – 699ATP By similarity

Sites

Active site1781Proton acceptor By similarity
Binding site841ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6A1A2 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: A0661913B473D8DF

FASTA39644,765
        10         20         30         40         50         60 
MVRTQTESST PPGIPGGSRQ GPAMDGTAAE PRPGAGSLQH AQPPPQPRKK RPEDFKFGKI 

        70         80         90        100        110        120 
LGEGSFSTVV LARELATSRE YAIKILEKRH IIKENKVPYV TRERDVMSRL DHPFFVKLYF 

       130        140        150        160        170        180 
TFQDDEKLYF GLSYAKNGEL LKYIRKIGSF DETCTRFYTA EIVSALEYLH GKGIIHRDLK 

       190        200        210        220        230        240 
PENILLNEDM YIQITDFGTA KVLSPESKQA RANSFVGTAQ YVSPELLTEK SACKSSDLWA 

       250        260        270        280        290        300 
LGCIIYQLVA GLPPFRAGNE YLIFQKIIKL EYDFPEKFFP KARDLVEKLL VLDATKRLGC 

       310        320        330        340        350        360 
EEMEGYGPLK AHPFFESVTW ENLHQQTPPK LTAYLPAMSE DDEDCYGNVS WPGWRARQVA 

       370        380        390 
LGPPCTGLHA RAPDPRVICS RKGRVSVPLR QACWWL 

« Hide

References

[1]"A novel member of human 3-phosphoinositide dependent protein kinase-1 family, PDPK2."
Pingzhang W., Xin W., Tianjing C., Jun W., Ying L.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ785968 mRNA. Translation: CAH05056.1.
UniGeneHs.459691.

3D structure databases

ProteinModelPortalQ6A1A2.
SMRQ6A1A2. Positions 48-332.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM74757401.

Proteomic databases

PaxDbQ6A1A2.
PRIDEQ6A1A2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc002cqv.1. human.

Organism-specific databases

neXtProtNX_Q6A1A2.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233026.
HOVERGENHBG098357.
InParanoidQ6A1A2.
PhylomeDBQ6A1A2.

Enzyme and pathway databases

SignaLinkQ6A1A2.

Gene expression databases

GenevestigatorQ6A1A2.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ6A1A2.

Entry information

Entry namePDPK2_HUMAN
AccessionPrimary (citable) accession number: Q6A1A2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM