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Q6A1A2

- PDPK2_HUMAN

UniProt

Q6A1A2 - PDPK2_HUMAN

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Protein

Putative 3-phosphoinositide-dependent protein kinase 2

Gene
PDPK2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Protein uncertaini

Functioni

Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841ATP By similarity
Active sitei178 – 1781Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 699ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ6A1A2.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 3-phosphoinositide-dependent protein kinase 2 (EC:2.7.11.1)
Gene namesi
Name:PDPK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Putative 3-phosphoinositide-dependent protein kinase 2PRO_0000341967Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine and serine/threonine By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6A1A2.
PRIDEiQ6A1A2.

Expressioni

Gene expression databases

GenevestigatoriQ6A1A2.

Structurei

3D structure databases

ProteinModelPortaliQ6A1A2.
SMRiQ6A1A2. Positions 48-332.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 315261Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233026.
HOVERGENiHBG098357.
InParanoidiQ6A1A2.
PhylomeDBiQ6A1A2.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6A1A2-1 [UniParc]FASTAAdd to Basket

« Hide

MVRTQTESST PPGIPGGSRQ GPAMDGTAAE PRPGAGSLQH AQPPPQPRKK    50
RPEDFKFGKI LGEGSFSTVV LARELATSRE YAIKILEKRH IIKENKVPYV 100
TRERDVMSRL DHPFFVKLYF TFQDDEKLYF GLSYAKNGEL LKYIRKIGSF 150
DETCTRFYTA EIVSALEYLH GKGIIHRDLK PENILLNEDM YIQITDFGTA 200
KVLSPESKQA RANSFVGTAQ YVSPELLTEK SACKSSDLWA LGCIIYQLVA 250
GLPPFRAGNE YLIFQKIIKL EYDFPEKFFP KARDLVEKLL VLDATKRLGC 300
EEMEGYGPLK AHPFFESVTW ENLHQQTPPK LTAYLPAMSE DDEDCYGNVS 350
WPGWRARQVA LGPPCTGLHA RAPDPRVICS RKGRVSVPLR QACWWL 396
Length:396
Mass (Da):44,765
Last modified:September 13, 2004 - v1
Checksum:iA0661913B473D8DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ785968 mRNA. Translation: CAH05056.1.
UniGeneiHs.459691.

Genome annotation databases

UCSCiuc002cqv.1. human.

Polymorphism databases

DMDMi74757401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ785968 mRNA. Translation: CAH05056.1 .
UniGenei Hs.459691.

3D structure databases

ProteinModelPortali Q6A1A2.
SMRi Q6A1A2. Positions 48-332.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 74757401.

Proteomic databases

PaxDbi Q6A1A2.
PRIDEi Q6A1A2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc002cqv.1. human.

Organism-specific databases

neXtProti NX_Q6A1A2.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233026.
HOVERGENi HBG098357.
InParanoidi Q6A1A2.
PhylomeDBi Q6A1A2.

Enzyme and pathway databases

SignaLinki Q6A1A2.

Miscellaneous databases

PROi Q6A1A2.

Gene expression databases

Genevestigatori Q6A1A2.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel member of human 3-phosphoinositide dependent protein kinase-1 family, PDPK2."
    Pingzhang W., Xin W., Tianjing C., Jun W., Ying L.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPDPK2_HUMAN
AccessioniPrimary (citable) accession number: Q6A1A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: September 13, 2004
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3