Reviewed, UniProtKB/Swiss-Prot Q6A198 (FUT10_BOVIN)

Names and origin

Protein names

Recommended name:
    Alpha-(1,3)-fucosyltransferase 10
    EC=2.4.1.-
Alternative name(s):
    Galactoside 3-L-fucosyltransferase 10
      Short name=Fucosyltransferase 10
    Fucosyltransferase X
      Short name=FucT-X
      Short name=Fuc-TX

Gene names

Name:

FUT10

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable fucosyltransferase By similarity.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 10 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein amino acid glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alpha(1,3)-fucosyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Alpha-(1,3)-fucosyltransferase 10		PRO_0000299000
Regions
	Topological domain	1 – 9	9	Cytoplasmic Potential
	Transmembrane	10 – 30	21	Signal-anchor for type II membrane protein Potential
	Topological domain	31 – 478	448	Lumenal Potential
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
	Glycosylation	168	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6A198-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: 73A98FB7FFECBBB7	FASTA	478	55,717
	10 20 30 40 50 60 MVRIQRGKLL AFCLCVMATV FLLITLQVVV ELGKFEGKKF KNSHLKDGHA QMEAEPLHLH 70 80 90 100 110 120 PFFNREGLTL NRKKTLAADS FPIMLWWSPL TGETGRLGQC GADACFFTIN RTYLHHHRTK 130 140 150 160 170 180 AFLFYGTDFS IDSLPLPRKA HHDWALFHEE SPKNNYKLFH QPVITLFNYT ATFSRHSHLP 190 200 210 220 230 240 LTTQYLEGTE VLTSLRHLVP LRSKNHLRKS LAPLVYVQSD CDPPSDRDSY VRELMTYIEV 250 260 270 280 290 300 DSYGECLRNK PLPPQLSNPA SMDADGFFRI LAQYKFILAF ENAVCDDYIT EKLWRPLKLG 310 320 330 340 350 360 VVPVYYGSPS IADWLPSNRS AILVSEFSHP RELASYIRAL DRDDRRYQAY IEWKLKGEIS 370 380 390 400 410 420 NQRLLTALRE RKWGVQDVKQ DNYIDAFECM VCTKVWDNIR LQEKGLPPKR WQADVTHLSC 430 440 450 460 470 PEPTVFAFSP LVPRRRSLRE MWIPSFQQSK KEARALRWLV DRNQNFSTQE FWALVFKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Phylogeny of fucosyltransferases." Martinez-Duncker I., Oriol R., Mollicone R. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of 954 bovine full-CDS cDNA sequences." Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L. BMC Genomics 6:166-166(2005) [PubMed: 16305752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.
[4]	"Genomic organization and expression profile of putative alpha 1,3-fucosyltransferase genes, fut10 and fut11, in Bos taurus." Germot A., Dupuy F., Loriol C., Julien R., Maftah A. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-478.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ786259 mRNA. Translation: CAH05071.1. BT020712 mRNA. Translation: AAX08729.1. BC147891 mRNA. Translation: AAI47892.1. AY344579 mRNA. Translation: AAQ02331.1.
IPI	IPI00706031.
RefSeq	NP_892032.1.
UniGene	Bt.23151
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT10. Glycosyltransferase Family 10.
Genome annotation databases
Ensembl	ENSBTAG00000005454. Bos taurus. [Contig view]
GeneID	360195.
KEGG	bta:360195.
Phylogenomic databases
HOVERGEN	Q6A198.
Family and domain databases
InterPro	IPR017176. Alpha-1_3-FUT_met. IPR001503. Glyco_trans_10. [Graphical view]
PANTHER	PTHR11929. Glyco_trans_10. 1 hit.
Pfam	PF00852. Glyco_transf_10. 1 hit. [Graphical view]
PIRSF	PIRSF037332. Alpha1_3FUT_met. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUT10_BOVIN

Accession

Primary (citable) accession number: Q6A198
Secondary accession number(s): Q7YRE8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 13, 2004
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)