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Protein

Keratin, type I cytoskeletal 39

Gene

KRT39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in late hair differentiation.

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei345Stutter1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 39
Alternative name(s):
Cytokeratin-39
Short name:
CK-39
Keratin-39
Short name:
K39
Type I hair keratin Ka35
Gene namesi
Name:KRT39
Synonyms:KA35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000196859.7
HGNCiHGNC:32971 KRT39
MIMi616678 gene
neXtProtiNX_Q6A163

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196859
PharmGKBiPA147357633

Polymorphism and mutation databases

BioMutaiKRT39
DMDMi166218816

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148531 – 491Keratin, type I cytoskeletal 39Add BLAST491

Proteomic databases

PaxDbiQ6A163
PeptideAtlasiQ6A163
PRIDEiQ6A163

PTM databases

iPTMnetiQ6A163
PhosphoSitePlusiQ6A163

Expressioni

Tissue specificityi

Expressed in skin and scalp. In the hair follicle, it is present in the upper hair cuticle and the upper cortex. Also present in the in the upper portion of beard hairs (at protein level).2 Publications

Developmental stagei

During differentiation of the hair, it is one of the last keratins expressed.1 Publication

Gene expression databases

BgeeiENSG00000196859
CleanExiHS_KRT39
ExpressionAtlasiQ6A163 baseline and differential

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ6A163, 35 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6A163
SMRiQ6A163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 407IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 96HeadAdd BLAST96
Regioni97 – 131Coil 1AAdd BLAST35
Regioni132 – 142Linker 1Add BLAST11
Regioni143 – 243Coil 1BAdd BLAST101
Regioni244 – 259Linker 12Add BLAST16
Regioni260 – 403Coil 2Add BLAST144
Regioni404 – 491TailAdd BLAST88

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIZN Eukaryota
ENOG4111DA1 LUCA
GeneTreeiENSGT00900000140814
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ6A163
KOiK07604
OMAiTKGCTTT
OrthoDBiEOG09370BAL
PhylomeDBiQ6A163
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6A163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTKGCTTTN SPSTPCQNCS RITNVSTISS NNGCHPGGLT VNNCQPAGHV
60 70 80 90 100
LRIPWDQGCQ PTPRFCRKPI YLMNNFNARF SLDDCSWYGE GINSNEKETM
110 120 130 140 150
QILNERLANY LQKVRMLERE NAELESKIQE ESNKELPVLC PDYLSYYTTI
160 170 180 190 200
EELQQKILCT KAENSRLVSQ IDNTKLTADD LRAKYEAEVS LRQLVESDAN
210 220 230 240 250
GLKQILNVLT LGKADLEAQV QSLKEELLCL KNNHKEEINS LQCQLGERLD
260 270 280 290 300
IEVTAAPSAD LNQVLQEMRC QYEPIMETNR KDVEQWFNTQ IEELNQQVVT
310 320 330 340 350
SSQQQQCCQK EIIELRRSVN TLEVELQAQH RMRDSQECIL TETEARYTAL
360 370 380 390 400
LTQIQSLIDN LEAQLAEIRC ALERQNQEYE ILLDVKSRLE CEITTYRSLL
410 420 430 440 450
ESSDGKRPCY PRATKCEPSP WTSCKSGAIE STAPACTSSS PCSLKEHCSA
460 470 480 490
CGPLSRILVK ICTITKEIKD GKVISSYEHV QPCFIIRPAK V
Length:491
Mass (Da):55,651
Last modified:January 15, 2008 - v2
Checksum:i4299E51361B30BAC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038075341T → M. Corresponds to variant dbSNP:rs17843021Ensembl.1
Natural variantiVAR_038076383L → M. Corresponds to variant dbSNP:rs17843023Ensembl.1
Natural variantiVAR_038077456R → Q2 PublicationsCorresponds to variant dbSNP:rs7213256Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ786657 mRNA Translation: CAH10352.1
AC004231 Genomic DNA No translation available.
AC007455 Genomic DNA No translation available.
BC157887 mRNA Translation: AAI57888.1
BK004054 mRNA Translation: DAA04487.1
CCDSiCCDS11382.1
RefSeqiNP_998821.3, NM_213656.3
UniGeneiHs.28467

Genome annotation databases

EnsembliENST00000355612; ENSP00000347823; ENSG00000196859
ENST00000575391; ENSP00000459016; ENSG00000262164
GeneIDi390792
KEGGihsa:390792
UCSCiuc002hvo.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiK1C39_HUMAN
AccessioniPrimary (citable) accession number: Q6A163
Secondary accession number(s): B2RXK6, Q6IFU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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