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Protein

Keratin, type I cytoskeletal 39

Gene

KRT39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in late hair differentiation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei345 – 3451Stutter

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 39
Alternative name(s):
Cytokeratin-39
Short name:
CK-39
Keratin-39
Short name:
K39
Type I hair keratin Ka35
Gene namesi
Name:KRT39
Synonyms:KA35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:32971. KRT39.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147357633.

Polymorphism and mutation databases

BioMutaiKRT39.
DMDMi166218816.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Keratin, type I cytoskeletal 39PRO_0000314853Add
BLAST

Proteomic databases

PaxDbiQ6A163.
PeptideAtlasiQ6A163.
PRIDEiQ6A163.

PTM databases

iPTMnetiQ6A163.
PhosphoSiteiQ6A163.

Expressioni

Tissue specificityi

Expressed in skin and scalp. In the hair follicle, it is present in the upper hair cuticle and the upper cortex. Also present in the in the upper portion of beard hairs (at protein level).2 Publications

Developmental stagei

During differentiation of the hair, it is one of the last keratins expressed.1 Publication

Gene expression databases

CleanExiHS_KRT39.
ExpressionAtlasiQ6A163. baseline and differential.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Structurei

3D structure databases

ProteinModelPortaliQ6A163.
SMRiQ6A163. Positions 314-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9696HeadAdd
BLAST
Regioni97 – 403307RodAdd
BLAST
Regioni97 – 13135Coil 1AAdd
BLAST
Regioni132 – 14211Linker 1Add
BLAST
Regioni143 – 243101Coil 1BAdd
BLAST
Regioni244 – 25916Linker 12Add
BLAST
Regioni260 – 403144Coil 2Add
BLAST
Regioni404 – 49188TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIZN. Eukaryota.
ENOG4111DA1. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6A163.
KOiK07604.
OMAiTKGCTTT.
OrthoDBiEOG091G087I.
PhylomeDBiQ6A163.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6A163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTKGCTTTN SPSTPCQNCS RITNVSTISS NNGCHPGGLT VNNCQPAGHV
60 70 80 90 100
LRIPWDQGCQ PTPRFCRKPI YLMNNFNARF SLDDCSWYGE GINSNEKETM
110 120 130 140 150
QILNERLANY LQKVRMLERE NAELESKIQE ESNKELPVLC PDYLSYYTTI
160 170 180 190 200
EELQQKILCT KAENSRLVSQ IDNTKLTADD LRAKYEAEVS LRQLVESDAN
210 220 230 240 250
GLKQILNVLT LGKADLEAQV QSLKEELLCL KNNHKEEINS LQCQLGERLD
260 270 280 290 300
IEVTAAPSAD LNQVLQEMRC QYEPIMETNR KDVEQWFNTQ IEELNQQVVT
310 320 330 340 350
SSQQQQCCQK EIIELRRSVN TLEVELQAQH RMRDSQECIL TETEARYTAL
360 370 380 390 400
LTQIQSLIDN LEAQLAEIRC ALERQNQEYE ILLDVKSRLE CEITTYRSLL
410 420 430 440 450
ESSDGKRPCY PRATKCEPSP WTSCKSGAIE STAPACTSSS PCSLKEHCSA
460 470 480 490
CGPLSRILVK ICTITKEIKD GKVISSYEHV QPCFIIRPAK V
Length:491
Mass (Da):55,651
Last modified:January 15, 2008 - v2
Checksum:i4299E51361B30BAC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti341 – 3411T → M.
Corresponds to variant rs17843021 [ dbSNP | Ensembl ].
VAR_038075
Natural varianti383 – 3831L → M.
Corresponds to variant rs17843023 [ dbSNP | Ensembl ].
VAR_038076
Natural varianti456 – 4561R → Q.2 Publications
Corresponds to variant rs7213256 [ dbSNP | Ensembl ].
VAR_038077

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ786657 mRNA. Translation: CAH10352.1.
AC004231 Genomic DNA. No translation available.
AC007455 Genomic DNA. No translation available.
BC157887 mRNA. Translation: AAI57888.1.
BK004054 mRNA. Translation: DAA04487.1.
CCDSiCCDS11382.1.
RefSeqiNP_998821.3. NM_213656.3.
UniGeneiHs.28467.

Genome annotation databases

EnsembliENST00000355612; ENSP00000347823; ENSG00000196859.
ENST00000575391; ENSP00000459016; ENSG00000262164.
GeneIDi390792.
KEGGihsa:390792.
UCSCiuc002hvo.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ786657 mRNA. Translation: CAH10352.1.
AC004231 Genomic DNA. No translation available.
AC007455 Genomic DNA. No translation available.
BC157887 mRNA. Translation: AAI57888.1.
BK004054 mRNA. Translation: DAA04487.1.
CCDSiCCDS11382.1.
RefSeqiNP_998821.3. NM_213656.3.
UniGeneiHs.28467.

3D structure databases

ProteinModelPortaliQ6A163.
SMRiQ6A163. Positions 314-401.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6A163.
PhosphoSiteiQ6A163.

Polymorphism and mutation databases

BioMutaiKRT39.
DMDMi166218816.

Proteomic databases

PaxDbiQ6A163.
PeptideAtlasiQ6A163.
PRIDEiQ6A163.

Protocols and materials databases

DNASUi390792.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355612; ENSP00000347823; ENSG00000196859.
ENST00000575391; ENSP00000459016; ENSG00000262164.
GeneIDi390792.
KEGGihsa:390792.
UCSCiuc002hvo.1. human.

Organism-specific databases

CTDi390792.
GeneCardsiKRT39.
H-InvDBHIX0173547.
HGNCiHGNC:32971. KRT39.
MIMi616678. gene.
neXtProtiNX_Q6A163.
PharmGKBiPA147357633.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIZN. Eukaryota.
ENOG4111DA1. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6A163.
KOiK07604.
OMAiTKGCTTT.
OrthoDBiEOG091G087I.
PhylomeDBiQ6A163.
TreeFamiTF332742.

Miscellaneous databases

GenomeRNAii390792.
PROiQ6A163.
SOURCEiSearch...

Gene expression databases

CleanExiHS_KRT39.
ExpressionAtlasiQ6A163. baseline and differential.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 2 hits.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C39_HUMAN
AccessioniPrimary (citable) accession number: Q6A163
Secondary accession number(s): B2RXK6, Q6IFU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.