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Protein

Keratin, type I cytoskeletal 40

Gene

KRT40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in late hair differentiation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei338Stutter1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31900-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 40
Alternative name(s):
Cytokeratin-40
Short name:
CK-40
Keratin-40
Short name:
K40
Type I hair keratin Ka36
Gene namesi
Name:KRT40
Synonyms:KA36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26707. KRT40.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204889.
ENSG00000262845.
PharmGKBiPA147357651.

Polymorphism and mutation databases

BioMutaiKRT40.
DMDMi166218814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148571 – 431Keratin, type I cytoskeletal 40Add BLAST431

Proteomic databases

PaxDbiQ6A162.
PeptideAtlasiQ6A162.
PRIDEiQ6A162.

PTM databases

iPTMnetiQ6A162.
SwissPalmiQ6A162.

Expressioni

Tissue specificityi

Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level).2 Publications

Developmental stagei

During differentiation of the hair, it is one of the last keratins expressed.1 Publication

Gene expression databases

BgeeiENSG00000204889.
CleanExiHS_KRT40.
ExpressionAtlasiQ6A162. baseline and differential.
GenevisibleiQ6A162. HS.

Organism-specific databases

HPAiHPA030068.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Binary interactionsi

WithEntry#Exp.IntActNotes
A8KAD63EBI-10171697,EBI-10174974
Q53FW83EBI-10171697,EBI-10242473
Q5BKY63EBI-10171697,EBI-10243533
Q5W1503EBI-10171697,EBI-10248148
Q8N9J23EBI-10171697,EBI-10268244
Q96GB03EBI-10171697,EBI-10286297
Q9H6F03EBI-10171697,EBI-10307481
Q9NWL93EBI-10171697,EBI-10315054
ADAMTSL3P829873EBI-10171697,EBI-10221726
AENQ8WTP83EBI-10171697,EBI-8637627
AESQ081173EBI-10171697,EBI-717810
AKAP17AQ02040-33EBI-10171697,EBI-10222656
ALDH3B1P433533EBI-10171697,EBI-2558314
ALS2CR11Q53TS83EBI-10171697,EBI-739879
ANKRD36BP1Q96IX93EBI-10171697,EBI-744859
AP1M1Q9BXS55EBI-10171697,EBI-541426
AQP1P299723EBI-10171697,EBI-745213
AQP5P550643EBI-10171697,EBI-746103
ARID5AC9J1Q03EBI-10171697,EBI-10176351
ARMC7Q9H6L45EBI-10171697,EBI-742909
ARSIQ5FYB13EBI-10171697,EBI-10243706
ASMTLO956713EBI-10171697,EBI-743231
ATPAF2Q8N5M14EBI-10171697,EBI-1166928
AVPI1Q5T6863EBI-10171697,EBI-8640233
BAHD1Q8TBE03EBI-10171697,EBI-742750
BARD1Q997283EBI-10171697,EBI-473181
BCAS2O759343EBI-10171697,EBI-1050106
BEX2Q9BXY83EBI-10171697,EBI-745073
BYSLQ138957EBI-10171697,EBI-358049
C10orf62Q5T6813EBI-10171697,EBI-744052
C11orf87Q6NUJ23EBI-10171697,EBI-6660291
C14orf105Q17R993EBI-10171697,EBI-10238351
C18orf45B2RAB73EBI-10171697,EBI-743338
C19orf57Q0VDD73EBI-10171697,EBI-741210
C19orf73Q9NVV23EBI-10171697,EBI-2859285
C1orf109Q9NX043EBI-10171697,EBI-8643161
C1orf216Q8TAB53EBI-10171697,EBI-747505
C20orf195Q9BVV23EBI-10171697,EBI-744935
C5orf60A6NFR6-43EBI-10171697,EBI-10173955
C6orf165Q8IYR05EBI-10171697,EBI-749051
C6orf226Q5I0X43EBI-10171697,EBI-10244057
C8orf48Q96LL43EBI-10171697,EBI-751596
CA6Q8N4G43EBI-10171697,EBI-10265475
CARD9Q9H2573EBI-10171697,EBI-751319
CATIPQ7Z7H33EBI-10171697,EBI-10258233
CBX8Q9HC525EBI-10171697,EBI-712912
CCDC112Q8NEF33EBI-10171697,EBI-745040
CCDC120Q96HB5-43EBI-10171697,EBI-10185348
CCDC146Q8IYE0-23EBI-10171697,EBI-10247802
CCDC185Q8N7153EBI-10171697,EBI-740814
CCDC26Q8TAB73EBI-10171697,EBI-10271580
CCER1Q8TC903EBI-10171697,EBI-746041
CCHCR1Q8TD31-35EBI-10171697,EBI-10175300
CCNG1P519593EBI-10171697,EBI-3905829
CD33P201383EBI-10171697,EBI-3906571
CDC20BQ86Y333EBI-10171697,EBI-10260504
CDK18Q070023EBI-10171697,EBI-746238
CDK5R1Q8N6193EBI-10171697,EBI-10266998
CEP57Q86XR83EBI-10171697,EBI-308614
CEP57L1Q8IYX83EBI-10171697,EBI-1104570
CEP57L1Q8IYX8-23EBI-10171697,EBI-10181988
CHCHD2Q9Y6H13EBI-10171697,EBI-2321769
CHCHD3Q9NX633EBI-10171697,EBI-743375
CHIC2Q9UKJ53EBI-10171697,EBI-741528
CLEC18AA5D8T83EBI-10171697,EBI-10173491
CNTFP264413EBI-10171697,EBI-1050897
COL8A1P276583EBI-10171697,EBI-747133
COMTP21964-23EBI-10171697,EBI-10200977
COX5AP206743EBI-10171697,EBI-715032
CREB5Q02930-35EBI-10171697,EBI-10192698
CTSZQ9UBR23EBI-10171697,EBI-8636823
CYCSP999993EBI-10171697,EBI-446479
CYTH4Q8WWE83EBI-10171697,EBI-10277443
DAAM2Q6DCB03EBI-10171697,EBI-10249414
DCDC2BA2VCK23EBI-10171697,EBI-10173222
DCXO436023EBI-10171697,EBI-8646694
DDX6P261963EBI-10171697,EBI-351257
DLGAP2Q9P1A63EBI-10171697,EBI-1753397
DMRT3Q9NQL93EBI-10171697,EBI-9679045
DOCK2Q926085EBI-10171697,EBI-448771
DOCK8Q8NF503EBI-10171697,EBI-2548605
DTNBO609413EBI-10171697,EBI-740402
EIF4E2O605733EBI-10171697,EBI-398610
ELA2BQ6ISP93EBI-10171697,EBI-10250477
EXOC3-AS1Q8N2X63EBI-10171697,EBI-749333
FAM107AO95990-33EBI-10171697,EBI-10192902
FAM124BQ9H5Z63EBI-10171697,EBI-741626
FAM214AQ32MH53EBI-10171697,EBI-2866142
FAM27E3Q08E933EBI-10171697,EBI-2602739
FAM64AQ9BSJ63EBI-10171697,EBI-2568609
FAM71CQ8NEG03EBI-10171697,EBI-752049
FAM74A6Q5TZK33EBI-10171697,EBI-10247271
FAM90A1Q86YD73EBI-10171697,EBI-6658203
FARS2O953633EBI-10171697,EBI-2513774
FASLGP480233EBI-10171697,EBI-495538
FBF1Q8TES7-63EBI-10171697,EBI-10244131
FBXL18Q96D163EBI-10171697,EBI-744419
FBXO34Q9NWN33EBI-10171697,EBI-719816
FBXW5Q969U63EBI-10171697,EBI-741068
FKBP1BP681063EBI-10171697,EBI-6693977
FLJ23584Q9H5C53EBI-10171697,EBI-7226406
FOXB1Q998533EBI-10171697,EBI-3916225
FRG1Q143313EBI-10171697,EBI-2515248
GATA2P237693EBI-10171697,EBI-2806671
GATAD2AQ86YP4-33EBI-10171697,EBI-10261080
GEMP550403EBI-10171697,EBI-744104
GFOD1Q9NXC23EBI-10171697,EBI-8799578
GGNQ86UU53EBI-10171697,EBI-10259069
GNAI2P048993EBI-10171697,EBI-353997
GNG5P632183EBI-10171697,EBI-10220734
GOLGA6L2Q8N9W4-23EBI-10171697,EBI-10268729
GPATCH2LQ9NWQ43EBI-10171697,EBI-5666657
GTF3C5Q9Y5Q83EBI-10171697,EBI-1045409
GUCD1Q96NT33EBI-10171697,EBI-8293751
HAUS1Q96CS23EBI-10171697,EBI-2514791
HBA2P699053EBI-10171697,EBI-714680
HBZP020083EBI-10171697,EBI-719843
HCKP086313EBI-10171697,EBI-346340
HDAC4P565243EBI-10171697,EBI-308629
HEL-S-90nV9HWJ53EBI-10171697,EBI-10330335
HGSO149643EBI-10171697,EBI-740220
HOXA1P496393EBI-10171697,EBI-740785
HSPA12BQ96MM63EBI-10171697,EBI-10291310
HSPD1P108093EBI-10171697,EBI-352528
ING5Q8WYH83EBI-10171697,EBI-488533
INPP5DQ928353EBI-10171697,EBI-1380477
IQUBQ8NA543EBI-10171697,EBI-10220600
ISCUQ9H1K13EBI-10171697,EBI-1047335
ITGB5L7RT223EBI-10171697,EBI-10178729
JOSD1Q150405EBI-10171697,EBI-2510602
KAT5Q929933EBI-10171697,EBI-399080
KCTD9Q7L2733EBI-10171697,EBI-4397613
KIFC3Q9BVG83EBI-10171697,EBI-2125614
KLHL38Q2WGJ63EBI-10171697,EBI-6426443
KPNA2Q6NVW73EBI-10171697,EBI-9377406
KRT2P359086EBI-10171697,EBI-1247312
KRT20P359003EBI-10171697,EBI-742094
KRT4P190135EBI-10171697,EBI-2371606
KRT5P136475EBI-10171697,EBI-702187
KRT6AP025386EBI-10171697,EBI-702198
KRT6CP486683EBI-10171697,EBI-2564105
KRT71Q3SY845EBI-10171697,EBI-2952676
KRT72Q14CN43EBI-10171697,EBI-1221280
KRT8P057875EBI-10171697,EBI-297852
KRT81Q145337EBI-10171697,EBI-739648
LAGE3Q146573EBI-10171697,EBI-1052105
LCE3EQ5T5B03EBI-10171697,EBI-10245456
LENG1Q96BZ83EBI-10171697,EBI-726510
LIMS2Q7Z4I7-53EBI-10171697,EBI-10257651
LIN37Q96GY33EBI-10171697,EBI-748884
LINC01588A1A4T83EBI-10171697,EBI-10171684
LMF2Q9BU233EBI-10171697,EBI-10298556
LMO1P258003EBI-10171697,EBI-8639312
LMO2P257913EBI-10171697,EBI-739696
LMO4P619683EBI-10171697,EBI-2798728
LRCH4O754273EBI-10171697,EBI-718707
MAB21L2Q9Y5863EBI-10171697,EBI-6659161
MAGOHBQ96A723EBI-10171697,EBI-746778
MAPKBP1O603363EBI-10171697,EBI-947402
MARK4Q6IPE93EBI-10171697,EBI-10250211
MED8Q96G25-23EBI-10171697,EBI-10286267
METTL17Q9H7H03EBI-10171697,EBI-749353
MFAP1P550813EBI-10171697,EBI-1048159
MGC13033Q4ZG743EBI-10171697,EBI-10241963
MOB3CQ70IA83EBI-10171697,EBI-9679267
MOSP005403EBI-10171697,EBI-1757866
MRPL11Q9Y3B73EBI-10171697,EBI-5453723
MTA1Q133303EBI-10171697,EBI-714236
MXI1P50539-33EBI-10171697,EBI-10211940
NAPRTQ6XQN6-23EBI-10171697,EBI-10254820
NDEL1Q9GZM83EBI-10171697,EBI-928842
NEK6Q9HC983EBI-10171697,EBI-740364
NFKBIDQ8NI383EBI-10171697,EBI-10271199
NINJ1Q929823EBI-10171697,EBI-2802124
NPBWR2P481463EBI-10171697,EBI-10210114
NPPBP168603EBI-10171697,EBI-747044
NR1D2Q6NSM03EBI-10171697,EBI-10250949
NXF1Q9UBU93EBI-10171697,EBI-398874
OPCMLA8K0Y03EBI-10171697,EBI-10174172
OTUB2Q9BWI93EBI-10171697,EBI-10300896
PDLIM5Q96HC43EBI-10171697,EBI-751267
PHF21AQ96BD53EBI-10171697,EBI-745085
PIGSQ96S523EBI-10171697,EBI-2908273
PIN1Q135263EBI-10171697,EBI-714158
PKD2Q135633EBI-10171697,EBI-7813714
POLDIP3Q8WUT13EBI-10171697,EBI-10276663
POLLQ9UGP5-23EBI-10171697,EBI-10320765
POP5Q969H63EBI-10171697,EBI-366525
PPP1R18Q6NYC83EBI-10171697,EBI-2557469
PRAM1Q96QH23EBI-10171697,EBI-2860740
PRKAA1Q131313EBI-10171697,EBI-1181405
PRKAB2O437415EBI-10171697,EBI-1053424
PRPF31F1T0A53EBI-10171697,EBI-10177194
PSMA1P257863EBI-10171697,EBI-359352
PSMC5P621953EBI-10171697,EBI-357745
PTGER3Q147X83EBI-10171697,EBI-10234038
PTPMT1Q8WUK03EBI-10171697,EBI-7199479
RAB3IL1Q8TBN03EBI-10171697,EBI-743796
RAB3IPQ96QF03EBI-10171697,EBI-747844
RAC1P630003EBI-10171697,EBI-413628
RASSF5Q8WWW03EBI-10171697,EBI-367390
RBM41Q96IZ53EBI-10171697,EBI-740773
RCOR3Q9P2K33EBI-10171697,EBI-743428
RECKQ6P9E23EBI-10171697,EBI-10253121
RNF213Q63HN8-63EBI-10171697,EBI-10248548
RPL11P629133EBI-10171697,EBI-354380
RSPH14Q9UHP63EBI-10171697,EBI-748350
RTP5Q14D333EBI-10171697,EBI-10217913
RWDD2BP570605EBI-10171697,EBI-724442
RYDENQ9NUL53EBI-10171697,EBI-10313866
SCOCQ9UIL13EBI-10171697,EBI-2686537
SEMA4CQ9C0C43EBI-10171697,EBI-10303490
SETD5Q9C0A6-23EBI-10171697,EBI-10303449
SFRS2Q6NXQ03EBI-10171697,EBI-10251550
SH2D4AQ9H7885EBI-10171697,EBI-747035
SHC3Q925293EBI-10171697,EBI-79084
SLC25A10Q9UBX33EBI-10171697,EBI-750394
SLIRPQ9GZT33EBI-10171697,EBI-1050793
SLU7O953913EBI-10171697,EBI-750559
SMARCE1Q969G35EBI-10171697,EBI-455078
SMCO4Q9NRQ53EBI-10171697,EBI-8640191
SNAI1O958633EBI-10171697,EBI-1045459
SNRPBP14678-23EBI-10171697,EBI-372475
SNW1Q135733EBI-10171697,EBI-632715
SPEF1Q9Y4P93EBI-10171697,EBI-740053
SPG7Q9UQ903EBI-10171697,EBI-717201
SSX2BQ163853EBI-10171697,EBI-2210673
SSX2IPQ9Y2D83EBI-10171697,EBI-2212028
SYT6Q5T7P8-23EBI-10171697,EBI-10246152
TBC1D22BQ9NU193EBI-10171697,EBI-8787464
TCEA2Q155603EBI-10171697,EBI-710310
TCEB3Q142413EBI-10171697,EBI-742350
TCHPQ9BT923EBI-10171697,EBI-740781
THAP7Q9BT493EBI-10171697,EBI-741350
TIE1P355903EBI-10171697,EBI-2256865
TMEM231Q9H6L23EBI-10171697,EBI-10307654
TMSB4XQ0P5Q03EBI-10171697,EBI-10226570
TNIP3Q96KP64EBI-10171697,EBI-2509913
TNNT1P138053EBI-10171697,EBI-726527
TRAF4Q9BUZ43EBI-10171697,EBI-3650647
TRIM42A1L4B63EBI-10171697,EBI-10172216
TROAPQ128153EBI-10171697,EBI-2349743
TRPV6Q9Y2603EBI-10171697,EBI-750052
TSC22D4Q8IV543EBI-10171697,EBI-10261521
TSGA10IPQ3SY003EBI-10171697,EBI-10241197
TSHZ3A1L0U73EBI-10171697,EBI-10171826
TTC23Q5W5X93EBI-10171697,EBI-6447954
TTC25Q96NG33EBI-10171697,EBI-1046387
TTLL10Q6ZVT03EBI-10171697,EBI-7844656
TXLNAP402223EBI-10171697,EBI-359793
TXN2Q997573EBI-10171697,EBI-2932492
TXNDC5Q86UY05EBI-10171697,EBI-2825190
TYK2P295973EBI-10171697,EBI-1383454
TYRO3Q064183EBI-10171697,EBI-3951628
UACAQ9BZF93EBI-10171697,EBI-350510
UBASH3AP570753EBI-10171697,EBI-2105393
USHBP1Q8N6Y03EBI-10171697,EBI-739895
USP2O756043EBI-10171697,EBI-743272
USP21Q9UK803EBI-10171697,EBI-373242
UTP14CQ08E773EBI-10171697,EBI-10225961
UTP23Q9BRU93EBI-10171697,EBI-5457544
UXTQ9UBK93EBI-10171697,EBI-357355
WDR25Q64LD23EBI-10171697,EBI-744560
WT1P195443EBI-10171697,EBI-2320534
WT1-ASQ062503EBI-10171697,EBI-10223946
ZBTB16Q055165EBI-10171697,EBI-711925
ZBTB24O431673EBI-10171697,EBI-744471
ZC2HC1CQ53FD03EBI-10171697,EBI-740767
ZFHX3Q15911-23EBI-10171697,EBI-10237226
ZFP2Q6ZN573EBI-10171697,EBI-7236323
ZFP69BQ9UJL93EBI-10171697,EBI-10322364
ZFYVE21Q9BQ243EBI-10171697,EBI-2849569
ZFYVE26Q96H433EBI-10171697,EBI-10286915
ZGPATQ8N5A53EBI-10171697,EBI-3439227
ZGPATQ8N5A5-23EBI-10171697,EBI-10183064
ZMAT2Q96NC03EBI-10171697,EBI-2682299
ZNF101Q8IZC73EBI-10171697,EBI-5278328
ZNF124Q159733EBI-10171697,EBI-2555767
ZNF138P52744-23EBI-10171697,EBI-10213071
ZNF165Q53Z403EBI-10171697,EBI-10186058
ZNF20P170243EBI-10171697,EBI-717634
ZNF202O951253EBI-10171697,EBI-751960
ZNF230Q9UIE03EBI-10171697,EBI-1105361
ZNF250P15622-35EBI-10171697,EBI-10177272
ZNF26P170313EBI-10171697,EBI-2841331
ZNF266Q145845EBI-10171697,EBI-7115319
ZNF286AQ9HBT8-23EBI-10171697,EBI-10310244
ZNF317Q96PQ6-43EBI-10171697,EBI-10292528
ZNF329Q86UD43EBI-10171697,EBI-7233259
ZNF337Q9Y3M93EBI-10171697,EBI-714987
ZNF417Q8TAU35EBI-10171697,EBI-740727
ZNF439Q8NDP45EBI-10171697,EBI-747580
ZNF446Q96AF53EBI-10171697,EBI-740232
ZNF488Q96MN93EBI-10171697,EBI-948288
ZNF564Q8TBZ83EBI-10171697,EBI-10273713
ZNF569Q5MCW43EBI-10171697,EBI-4395687
ZNF581Q9P0T43EBI-10171697,EBI-745520
ZNF587Q96SQ55EBI-10171697,EBI-6427977
ZNF625Q96I273EBI-10171697,EBI-4395587
ZNF655Q8N7203EBI-10171697,EBI-625509
ZNF697Q8N5083EBI-10171697,EBI-10265733
ZNF702PQ9H9633EBI-10171697,EBI-10309738
ZNF792Q3KQV33EBI-10171697,EBI-10240849
ZNF844Q08AG53EBI-10171697,EBI-10225757
ZSCAN21Q9Y5A63EBI-10171697,EBI-10281938

Protein-protein interaction databases

BioGridi125917. 313 interactors.
IntActiQ6A162. 350 interactors.
STRINGi9606.ENSP00000366984.

Structurei

3D structure databases

ProteinModelPortaliQ6A162.
SMRiQ6A162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 89HeadAdd BLAST89
Regioni90 – 396RodAdd BLAST307
Regioni90 – 124Coil 1AAdd BLAST35
Regioni125 – 135Linker 1Add BLAST11
Regioni136 – 236Coil 1BAdd BLAST101
Regioni237 – 252Linker 12Add BLAST16
Regioni253 – 396Coil 2Add BLAST144
Regioni397 – 431TailAdd BLAST35

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTS. Eukaryota.
ENOG41119VC. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6A162.
KOiK07604.
OMAiIDNVENQ.
OrthoDBiEOG091G087I.
PhylomeDBiQ6A162.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6A162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSDCSSTHC SPESCGTASG CAPASSCSVE TACLPGTCAT SRCQTPSFLS
60 70 80 90 100
RSRGLTGCLL PCYFTGSCNS PCLVGNCAWC EDGVFTSNEK ETMQFLNDRL
110 120 130 140 150
ASYLEKVRSL EETNAELESR IQEQCEQDIP MVCPDYQRYF NTIEDLQQKI
160 170 180 190 200
LCTKAENSRL AVQLDNCKLA TDDFKSKYES ELSLRQLLEA DISSLHGILE
210 220 230 240 250
ELTLCKSDLE AHVESLKEDL LCLKKNHEEE VNLLREQLGD RLSVELDTAP
260 270 280 290 300
TLDLNRVLDE MRCQCETVLA NNRREAEEWL AVQTEELNQQ QLSSAEQLQG
310 320 330 340 350
CQMEILELKR TASALEIELQ AQQSLTESLE CTVAETEAQY SSQLAQIQCL
360 370 380 390 400
IDNLENQLAE IRCDLERQNQ EYQVLLDVKA RLEGEINTYW GLLDSEDSRL
410 420 430
SCSPCSTTCT SSNTCEPCSA YVICTVENCC L
Length:431
Mass (Da):48,139
Last modified:January 15, 2008 - v2
Checksum:iD57C5153D50E7D41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241R → C in CAH10353 (PubMed:15617563).Curated1
Sequence conflicti349C → R in CAH10353 (PubMed:15617563).Curated1
Sequence conflicti408T → I in CAH10353 (PubMed:15617563).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03807837T → A.Corresponds to variant rs1510069dbSNPEnsembl.1
Natural variantiVAR_03807985F → S.1 PublicationCorresponds to variant rs17843015dbSNPEnsembl.1
Natural variantiVAR_038080102S → N.Corresponds to variant rs1510068dbSNPEnsembl.1
Natural variantiVAR_038081153T → M.Corresponds to variant rs9908304dbSNPEnsembl.1
Natural variantiVAR_049787235R → H.Corresponds to variant rs2010027dbSNPEnsembl.1
Natural variantiVAR_049788265C → Y.1 PublicationCorresponds to variant rs721957dbSNPEnsembl.1
Natural variantiVAR_049789286E → D.Corresponds to variant rs721958dbSNPEnsembl.1
Natural variantiVAR_049790303M → T.Corresponds to variant rs9908389dbSNPEnsembl.1
Natural variantiVAR_049791406S → L.Corresponds to variant rs16968862dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ786658 mRNA. Translation: CAH10353.1.
BC130396 mRNA. Translation: AAI30397.1.
BC150174 mRNA. Translation: AAI50175.1.
BC150191 mRNA. Translation: AAI50192.1.
BK004055 mRNA. Translation: DAA04488.1.
CCDSiCCDS42320.1.
RefSeqiNP_872303.2. NM_182497.3.
UniGeneiHs.534929.

Genome annotation databases

EnsembliENST00000377755; ENSP00000366984; ENSG00000204889.
ENST00000398486; ENSP00000381500; ENSG00000204889.
ENST00000576967; ENSP00000459621; ENSG00000262845.
ENST00000610983; ENSP00000479080; ENSG00000262845.
GeneIDi125115.
KEGGihsa:125115.
UCSCiuc010cxh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ786658 mRNA. Translation: CAH10353.1.
BC130396 mRNA. Translation: AAI30397.1.
BC150174 mRNA. Translation: AAI50175.1.
BC150191 mRNA. Translation: AAI50192.1.
BK004055 mRNA. Translation: DAA04488.1.
CCDSiCCDS42320.1.
RefSeqiNP_872303.2. NM_182497.3.
UniGeneiHs.534929.

3D structure databases

ProteinModelPortaliQ6A162.
SMRiQ6A162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125917. 313 interactors.
IntActiQ6A162. 350 interactors.
STRINGi9606.ENSP00000366984.

PTM databases

iPTMnetiQ6A162.
SwissPalmiQ6A162.

Polymorphism and mutation databases

BioMutaiKRT40.
DMDMi166218814.

Proteomic databases

PaxDbiQ6A162.
PeptideAtlasiQ6A162.
PRIDEiQ6A162.

Protocols and materials databases

DNASUi125115.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377755; ENSP00000366984; ENSG00000204889.
ENST00000398486; ENSP00000381500; ENSG00000204889.
ENST00000576967; ENSP00000459621; ENSG00000262845.
ENST00000610983; ENSP00000479080; ENSG00000262845.
GeneIDi125115.
KEGGihsa:125115.
UCSCiuc010cxh.2. human.

Organism-specific databases

CTDi125115.
GeneCardsiKRT40.
HGNCiHGNC:26707. KRT40.
HPAiHPA030068.
MIMi616679. gene.
neXtProtiNX_Q6A162.
OpenTargetsiENSG00000204889.
ENSG00000262845.
PharmGKBiPA147357651.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTS. Eukaryota.
ENOG41119VC. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ6A162.
KOiK07604.
OMAiIDNVENQ.
OrthoDBiEOG091G087I.
PhylomeDBiQ6A162.
TreeFamiTF332742.

Enzyme and pathway databases

BioCyciZFISH:G66-31900-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GenomeRNAii125115.
PROiQ6A162.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204889.
CleanExiHS_KRT40.
ExpressionAtlasiQ6A162. baseline and differential.
GenevisibleiQ6A162. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C40_HUMAN
AccessioniPrimary (citable) accession number: Q6A162
Secondary accession number(s): Q6IFU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.