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Protein

Raftlin

Gene

Rftn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor-mediated signaling.

GO - Molecular functioni

GO - Biological processi

  • B cell receptor signaling pathway Source: MGI
  • dsRNA transport Source: MGI
  • growth Source: MGI
  • interleukin-17 production Source: UniProtKB
  • membrane raft assembly Source: MGI
  • protein localization to membrane raft Source: UniProtKB
  • protein transport into membrane raft Source: UniProtKB
  • response to exogenous dsRNA Source: MGI
  • T cell antigen processing and presentation Source: UniProtKB
  • T cell receptor signaling pathway Source: UniProtKB
  • toll-like receptor 3 signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Raftlin
Alternative name(s):
Raft-linking protein
Gene namesi
Name:Rftn1
Synonyms:Kiaa0084
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1923688. Rftn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 554553RaftlinPRO_0000251954Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Lipidationi3 – 31S-palmitoyl cysteineBy similarity
Modified residuei183 – 1831PhosphoserineCombined sources
Modified residuei199 – 1991PhosphoserineBy similarity
Modified residuei507 – 5071PhosphoserineCombined sources
Modified residuei530 – 5301PhosphoserineCombined sources

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ6A0D4.
MaxQBiQ6A0D4.
PaxDbiQ6A0D4.
PRIDEiQ6A0D4.

PTM databases

iPTMnetiQ6A0D4.
PhosphoSiteiQ6A0D4.
SwissPalmiQ6A0D4.

Expressioni

Tissue specificityi

Specifically expressed by lymphocytes.1 Publication

Gene expression databases

BgeeiQ6A0D4.
CleanExiMM_RFTN1.
ExpressionAtlasiQ6A0D4. baseline and differential.
GenevisibleiQ6A0D4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046524.

Structurei

3D structure databases

ProteinModelPortaliQ6A0D4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the raftlin family.Curated

Phylogenomic databases

eggNOGiENOG410IETJ. Eukaryota.
ENOG410ZCAE. LUCA.
GeneTreeiENSGT00530000063609.
HOGENOMiHOG000121785.
HOVERGENiHBG093894.
InParanoidiQ6A0D4.
OMAiTHEREKT.
OrthoDBiEOG7034GW.
PhylomeDBiQ6A0D4.
TreeFamiTF333285.

Family and domain databases

InterProiIPR028169. Raftlin.
[Graphical view]
PfamiPF15250. Raftlin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6A0D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCSLNKLEK REEKRPGNIY STLKRPQVET KVDVTYEYCF LEFTTLTAAE
60 70 80 90 100
LPRSSATRLA SLRDLPDQLL ELYQQGFSLA ALHPFVQPTR RQEKILLEHI
110 120 130 140 150
FRAILVKKTN RSQKAELHDE GYTLELDYCS SLEHLADQKL IPEFIKKVQE
160 170 180 190 200
AASQGLKFVS VVPQYQPSVS SAGSRRLKPV ANSVEDARDV KCTLGDRSSL
210 220 230 240 250
ENDTPKAAET DAATAGVNRR PETKPGSTGD VPSAQQPGIP SPSAENEAGE
260 270 280 290 300
FPLRGLQPAL DRSEGDPSNG PEELPSRKME IFAFFNRPKS QQKCRQYYPV
310 320 330 340 350
TIPLQVSKNG QTVSSLDASW LEHMSDHFRK GGVLVNAVFQ LGMANDSFYG
360 370 380 390 400
LTDGVFIFEA VSTEDNRTTQ GYDAIVVEQW TVLEGTEVQT DYMPLLNSLA
410 420 430 440 450
AYGWQLTCVL PTPILKTTRE GNVSTKQIVF LQRPCLPQKT KKRESKFQWR
460 470 480 490 500
FSRNEIHGRQ TRKSKGKLSA SNKQQAEENE KNLEDQFSKA GDVGNCVLGA
510 520 530 540 550
PQWGRASEVR EQRQGSAAVQ NGPAGHNRDS VALRHSNPRA EAELAAGPTP

TEAN
Length:554
Mass (Da):61,537
Last modified:January 23, 2007 - v4
Checksum:i34AFE53D91861A2C
GO

Sequence cautioni

The sequence BAD32162.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAE31871.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti236 – 2361Q → R in BAE30971 (PubMed:16141072).Curated
Sequence conflicti236 – 2361Q → R in BAE31871 (PubMed:16141072).Curated
Sequence conflicti472 – 4721N → D in BAD32162 (PubMed:15368895).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172884 mRNA. Translation: BAD32162.1. Different initiation.
AK152130 mRNA. Translation: BAE30971.1.
AK153288 mRNA. Translation: BAE31871.1. Different initiation.
AK155870 mRNA. Translation: BAE33473.1.
BC052074 mRNA. Translation: AAH52074.1.
CCDSiCCDS28873.1.
RefSeqiNP_852062.1. NM_181397.2.
UniGeneiMm.41854.

Genome annotation databases

EnsembliENSMUST00000044503; ENSMUSP00000046524; ENSMUSG00000039316.
GeneIDi76438.
KEGGimmu:76438.
UCSCiuc008cyr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172884 mRNA. Translation: BAD32162.1. Different initiation.
AK152130 mRNA. Translation: BAE30971.1.
AK153288 mRNA. Translation: BAE31871.1. Different initiation.
AK155870 mRNA. Translation: BAE33473.1.
BC052074 mRNA. Translation: AAH52074.1.
CCDSiCCDS28873.1.
RefSeqiNP_852062.1. NM_181397.2.
UniGeneiMm.41854.

3D structure databases

ProteinModelPortaliQ6A0D4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046524.

PTM databases

iPTMnetiQ6A0D4.
PhosphoSiteiQ6A0D4.
SwissPalmiQ6A0D4.

Proteomic databases

EPDiQ6A0D4.
MaxQBiQ6A0D4.
PaxDbiQ6A0D4.
PRIDEiQ6A0D4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044503; ENSMUSP00000046524; ENSMUSG00000039316.
GeneIDi76438.
KEGGimmu:76438.
UCSCiuc008cyr.1. mouse.

Organism-specific databases

CTDi23180.
MGIiMGI:1923688. Rftn1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IETJ. Eukaryota.
ENOG410ZCAE. LUCA.
GeneTreeiENSGT00530000063609.
HOGENOMiHOG000121785.
HOVERGENiHBG093894.
InParanoidiQ6A0D4.
OMAiTHEREKT.
OrthoDBiEOG7034GW.
PhylomeDBiQ6A0D4.
TreeFamiTF333285.

Miscellaneous databases

PROiQ6A0D4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6A0D4.
CleanExiMM_RFTN1.
ExpressionAtlasiQ6A0D4. baseline and differential.
GenevisibleiQ6A0D4. MM.

Family and domain databases

InterProiIPR028169. Raftlin.
[Graphical view]
PfamiPF15250. Raftlin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction."
    Saeki K., Miura Y., Aki D., Kurosaki T., Yoshimura A.
    EMBO J. 22:3015-3026(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183 AND SER-530, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Lung and Spleen.

Entry informationi

Entry nameiRFTN1_MOUSE
AccessioniPrimary (citable) accession number: Q6A0D4
Secondary accession number(s): Q3U654, Q3U8P6, Q80US1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 83 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.