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Protein

Constitutive coactivator of PPAR-gamma-like protein 1

Gene

FAM120A

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II (By similarity). May participate in mRNA transport in the cytoplasm.By similarity1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive coactivator of PPAR-gamma-like protein 1
Alternative name(s):
Oxidative stress-associated Src activator
Protein FAM120A
Gene namesi
Name:FAM120A
Synonyms:Kiaa0183, Ossa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2446163. Fam120a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11121112Constitutive coactivator of PPAR-gamma-like protein 1PRO_0000363780Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei653 – 6531PhosphothreonineBy similarity
Modified residuei930 – 9301N6-acetyllysineCombined sources
Modified residuei958 – 9581PhosphoserineBy similarity
Modified residuei980 – 9801Omega-N-methylated arginineBy similarity
Modified residuei1021 – 10211PhosphoserineBy similarity
Modified residuei1042 – 10421PhosphoserineBy similarity

Post-translational modificationi

Arg-980 is dimethylated, probably to asymmetric dimethylarginine.By similarity
Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ6A0A9.
MaxQBiQ6A0A9.
PaxDbiQ6A0A9.
PeptideAtlasiQ6A0A9.
PRIDEiQ6A0A9.

PTM databases

iPTMnetiQ6A0A9.
PhosphoSiteiQ6A0A9.
SwissPalmiQ6A0A9.

Expressioni

Tissue specificityi

Present in Purkinje cells in the cerebellum, and in cortical neurons (at protein level).1 Publication

Developmental stagei

Expressed in the developing brain at E12. Expression increases postnatally and is maintained at an adult level beyond 4 weeks after birth.1 Publication

Gene expression databases

BgeeiQ6A0A9.
GenevisibleiQ6A0A9. MM.

Interactioni

Subunit structurei

Interacts with YES1, SRC, FYN. Upon tyrosine phosphorylation, interacts with PIK3R1 (By similarity). Interacts with PURA.By similarity1 Publication

Protein-protein interaction databases

IntActiQ6A0A9. 6 interactions.
MINTiMINT-1858841.
STRINGi10090.ENSMUSP00000053877.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni339 – 40365Interaction with YES1, SRC and FYNBy similarityAdd
BLAST
Regioni827 – 1112286RNA bindingBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE6R. Eukaryota.
ENOG410XPY7. LUCA.
GeneTreeiENSGT00530000063168.
HOGENOMiHOG000112430.
HOVERGENiHBG050957.
InParanoidiQ6A0A9.
OMAiHVLTKAK.
OrthoDBiEOG7G4QD9.
PhylomeDBiQ6A0A9.
TreeFamiTF328642.

Family and domain databases

InterProiIPR026784. Coact_PPARg.
IPR026783. Coact_PPARg-like_1.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976. PTHR15976. 2 hits.
PTHR15976:SF14. PTHR15976:SF14. 2 hits.
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6A0A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVQGFQDYI EKHCPSAVVP VELQKLARGS LVGGGRQRPP QTPLRLLVDA
60 70 80 90 100
DNCLHRLYGG FYTDWVSGGQ WNHMLGYLAA LAKACFGGNI ELFVFFNGAL
110 120 130 140 150
EKARLHEWVK RQGNERQTAQ QIVSHVQNKG TPPPKVWFLP PVCMAHCIRL
160 170 180 190 200
ALIRFHVKVA QSIEDHHQEV IGFCRENGFH GLVAYDSDYA LCNIPYYFSA
210 220 230 240 250
HALKLSRNGK SLTTSQYLMH EVAKQLDLNP NRFPIFAALL GNHILPDEDL
260 270 280 290 300
ASFHWSLLGP EHPLASLKVR AHQLVLPPCD VVIKAVADYV RNIHDTSDLD
310 320 330 340 350
AIAKDVFQHS QSRTDDKVIR FKRAVGYYSA TSKPMPFHPP HYLARPNPFG
360 370 380 390 400
MPGMVPPYVP PQMLNIPQTS LQAKPAVPQV PSPGGTPGQA PYPYSLSEPA
410 420 430 440 450
LTLDTSGKNL TEQNSYSNIP HEGKHTPLYE RSSPINLAQS GSPNHVDSAY
460 470 480 490 500
FPGSSTSSSS DNDEGGGGAT NHISGNKIGW EKTGSHAEPL ARGDPGDQVK
510 520 530 540 550
VEGSSTASSG SQLAEGKGSH MGTVQPIPCL LSMPTRNHMD ITTPPLPPVA
560 570 580 590 600
PEVLRVAEHR HKKGLMYPYI FHILTKGEIK IAVSIEDEAN KDLPPAALLY
610 620 630 640 650
RPVRQYVYGV LFSLAESRKK TERLAFRKNR LPPEFSPLII KEWAAYKGKS
660 670 680 690 700
PQTPELVEAL AFREWTCPNL KRLWLGKAVE DKNRRMRAFL ACMRSDTPAM
710 720 730 740 750
LNPANVPTHL MVLCCVLRYM VQWPGARILR RQELDAFLAQ ALSPKLYEPD
760 770 780 790 800
QLQELKIDNL DPRGIQLSAL FMSGVDMALF ANDACGQPIP WEHCCPWMYF
810 820 830 840 850
DGKLFQSKLL KASREKTPLI DLCDGQAEQA AKVEKMRQSI LEGLSFSRQN
860 870 880 890 900
HPLPFPPPPA LPFYPASVYP RHFGPVPPSQ GRGRGFAGVC GFGGHYGETV
910 920 930 940 950
ATGPYRAFRV TAASGHCGAF SGSDSSRTSK SQGGVQPIPS QGGKLEIAGT
960 970 980 990 1000
VVGHWAGSRR GRGGRGPFPL QVVSVGGPAR GRPRGVISTP VIRTFGRGGR
1010 1020 1030 1040 1050
YYGRGYKSQG AIQGRPPYAA SAEEVAKELK SKSGESKSSA VSLAENGVMA
1060 1070 1080 1090 1100
EEKPVPQLNG STGDPRVPSH SESALNNDSK PCNTNPHLNA LSTDSACRRE
1110
AALEAAVLNK EE
Length:1,112
Mass (Da):121,646
Last modified:February 10, 2009 - v2
Checksum:i5B9086869336B9D6
GO

Sequence cautioni

The sequence BAD32187.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172909 mRNA. Translation: BAD32187.1. Different initiation.
BC010304 mRNA. Translation: AAH10304.1.
BC042582 mRNA. Translation: AAH42582.1.
BC158134 mRNA. Translation: AAI58135.1.
CCDSiCCDS49259.1.
RefSeqiNP_001028440.2. NM_001033268.2.
UniGeneiMm.426571.

Genome annotation databases

EnsembliENSMUST00000060805; ENSMUSP00000053877; ENSMUSG00000038014.
GeneIDi218236.
KEGGimmu:218236.
UCSCiuc007qio.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172909 mRNA. Translation: BAD32187.1. Different initiation.
BC010304 mRNA. Translation: AAH10304.1.
BC042582 mRNA. Translation: AAH42582.1.
BC158134 mRNA. Translation: AAI58135.1.
CCDSiCCDS49259.1.
RefSeqiNP_001028440.2. NM_001033268.2.
UniGeneiMm.426571.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6A0A9. 6 interactions.
MINTiMINT-1858841.
STRINGi10090.ENSMUSP00000053877.

PTM databases

iPTMnetiQ6A0A9.
PhosphoSiteiQ6A0A9.
SwissPalmiQ6A0A9.

Proteomic databases

EPDiQ6A0A9.
MaxQBiQ6A0A9.
PaxDbiQ6A0A9.
PeptideAtlasiQ6A0A9.
PRIDEiQ6A0A9.

Protocols and materials databases

DNASUi218236.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060805; ENSMUSP00000053877; ENSMUSG00000038014.
GeneIDi218236.
KEGGimmu:218236.
UCSCiuc007qio.1. mouse.

Organism-specific databases

CTDi23196.
MGIiMGI:2446163. Fam120a.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IE6R. Eukaryota.
ENOG410XPY7. LUCA.
GeneTreeiENSGT00530000063168.
HOGENOMiHOG000112430.
HOVERGENiHBG050957.
InParanoidiQ6A0A9.
OMAiHVLTKAK.
OrthoDBiEOG7G4QD9.
PhylomeDBiQ6A0A9.
TreeFamiTF328642.

Miscellaneous databases

ChiTaRSiFam120a. mouse.
PROiQ6A0A9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6A0A9.
GenevisibleiQ6A0A9. MM.

Family and domain databases

InterProiIPR026784. Coact_PPARg.
IPR026783. Coact_PPARg-like_1.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976. PTHR15976. 2 hits.
PTHR15976:SF14. PTHR15976:SF14. 2 hits.
SUPFAMiSSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-1112.
    Strain: FVB/N.
    Tissue: Brain and Mammary tumor.
  3. "C9orf10 protein, a novel protein component of Puralpha-containing mRNA-protein particles (Puralpha-mRNPs): characterization of developmental and regional expressions in the mouse brain."
    Kobayashi Y., Suzuki K., Kobayashi H., Ohashi S., Koike K., Macchi P., Kiebler M., Anzai K.
    J. Histochem. Cytochem. 56:723-731(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH PURA, FUNCTION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-930, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiF120A_MOUSE
AccessioniPrimary (citable) accession number: Q6A0A9
Secondary accession number(s): A0PJK6, B3DFJ0, Q91Z16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: July 6, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.