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Q6A065

- CE170_MOUSE

UniProt

Q6A065 - CE170_MOUSE

Protein

Centrosomal protein of 170 kDa

Gene

Cep170

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Plays a role in microtubule organization.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centrosomal protein of 170 kDa
    Short name:
    Cep170
    Gene namesi
    Name:Cep170
    Synonyms:Kiaa0470
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1918348. Cep170.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity. Cytoplasmcytoskeletonspindle By similarity
    Note: Associated with the mature mother centriole. Associated with spindle microtubules during mitosis.By similarity

    GO - Cellular componenti

    1. centriole Source: MGI
    2. microtubule Source: UniProtKB-KW
    3. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15881588Centrosomal protein of 170 kDaPRO_0000282888Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei355 – 3551PhosphoserineBy similarity
    Modified residuei358 – 3581Phosphoserine1 Publication
    Modified residuei363 – 3631PhosphotyrosineBy similarity
    Modified residuei443 – 4431Phosphoserine1 Publication
    Modified residuei494 – 4941PhosphoserineBy similarity
    Modified residuei498 – 4981PhosphothreonineBy similarity
    Modified residuei628 – 6281PhosphoserineBy similarity
    Modified residuei631 – 6311PhosphoserineBy similarity
    Modified residuei829 – 8291Phosphoserine1 Publication
    Modified residuei922 – 9221PhosphoserineBy similarity
    Modified residuei925 – 9251PhosphoserineBy similarity
    Modified residuei950 – 9501PhosphoserineBy similarity
    Modified residuei1102 – 11021Phosphoserine1 Publication
    Modified residuei1104 – 11041PhosphoserineBy similarity
    Modified residuei1150 – 11501PhosphoserineBy similarity
    Modified residuei1155 – 11551PhosphoserineBy similarity
    Modified residuei1241 – 12411PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated; probably by PLK1.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6A065.
    PaxDbiQ6A065.
    PRIDEiQ6A065.

    PTM databases

    PhosphoSiteiQ6A065.

    Expressioni

    Gene expression databases

    BgeeiQ6A065.
    CleanExiMM_CEP170.
    GenevestigatoriQ6A065.

    Interactioni

    Subunit structurei

    Interacts with PLK1.By similarity

    Protein-protein interaction databases

    IntActiQ6A065. 15 interactions.
    MINTiMINT-4126922.
    STRINGi10090.ENSMUSP00000059562.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6A065.
    SMRiQ6A065. Positions 1-123.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 7351FHAPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni844 – 1588745Targeting to microtubulesBy similarityAdd
    BLAST
    Regioni1103 – 1588486Targeting to centrosomesBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1467 – 149529Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CEP170 family.Curated
    Contains 1 FHA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG18196.
    HOGENOMiHOG000111524.
    HOVERGENiHBG058059.
    InParanoidiQ6A065.
    KOiK16463.
    PhylomeDBiQ6A065.

    Family and domain databases

    Gene3Di2.60.200.20. 1 hit.
    InterProiIPR026644. CEP170.
    IPR029300. CEP170_C.
    IPR000253. FHA_dom.
    IPR008984. SMAD_FHA_domain.
    [Graphical view]
    PANTHERiPTHR15715:SF17. PTHR15715:SF17. 1 hit.
    PfamiPF15308. CEP170_C. 1 hit.
    PF00498. FHA. 1 hit.
    [Graphical view]
    SMARTiSM00240. FHA. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    PROSITEiPS50006. FHA_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6A065-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLTSWFLVS SGGTRHRLPR EMIFVGRDDC ELMLQSRSVD KQHAVINYDA     50
    SMDEHLVKDL GSLNGTFVND VRIPEQTYIT LKLEDKLRFG YDTNLFTVVR 100
    GEMRVPEEAL KHEKFTIQLQ LSQKSSESEL PKSASAKGTD SKVEAAAEVQ 150
    PRATEALKSE EKPMDVSAMP RGTPLYGQPS WWGDAEEDEQ RAFKANGKPE 200
    GKSQEAGASG CSTEAKHVEG QSAAASEEAL FPFCREPSYF EIPTKEFQQP 250
    SQIAESTIHE IPTKDTPSSH TAGAGHASFT IEFDDSTPGK VTIRDHVTKF 300
    TSDQRHKSKK ASPGTQDLPG IQTGMMAPEN KVADWLAQNN PPQMVWERTE 350
    EDSKSIKSDV PVYLKRLKGN KHDDGTQSDS ENAGAHRRCS KRATLEEHLR 400
    RHHSEQKKKA QSTEKHQEQA ATSSTHHRGG HGVPHGKLLK QKSEEPSVSL 450
    PFLQTALLRS SGSLGHRPSQ EMDVMLKNQA TSASSEKDND DDQSDKGTYT 500
    IELENPNSEE VEARKMIDKV FGVDDNQDYN RPIINEKHKG LIKDWALNSA 550
    AVVMEERKPL STPGFHNSEE AISSSGSKRW VSQWASLAAN HTRHDPEERL 600
    MELSATVENE TDTGDAGVSL RSTSCTTSLA SQGERKRRTL PQLPNEEKLL 650
    ESSRAKVVPQ RSEIGEKQDT ELQEKEAQVY QSEKHDADRG LSKMSRAVNG 700
    ESPKTGGDGK ALLHSGSSSS KEKSETEKET SLVKQTLAKM QQQEQKEQAQ 750
    WTPTKFPSKN ALGHIDKCRE ESSKQESQLL EKVSGHSTSK GDRVIQNESK 800
    RRKAEEIPKC QASKGDKKES SKSLVRQGSF TIDKPSSNIP IELIPHINKQ 850
    NSSVPTALAL TSASRLRERS DSLDTDSSMD TTLILKDTEA VMAFLEAKLR 900
    EDNNKTDEGP DTPSYNRDNS ISPESDVDTA STISLVTGET ERKSTQKRKS 950
    FTSLYKDRCS TSSPSKDVTK SGSREKIEKK AKSRSADIGA RADGRKFVQS 1000
    SGRIRQPSID LTDDDQTSSV PHSAISDIMS SDQETYSCKS HGRTPLTSAD 1050
    EHNIHSKLEG GKATKSKTSP VASGSTSKST TLPRPRPTRT SLLRRARLGE 1100
    ASDSELADAD KASVASEVST TSSTSKPPTG RRTISRIDLL AQPRRTRLGS 1150
    LSARSDSEAT ISRSSASART AEAVIRSGAR LVPSDKLSPR TRANSISRLS 1200
    DSKVKSMSST HGSPSVNSRW RRFPTDYAST SEDEFGSNRN SPKHTRLRTS 1250
    PALKTTRMQS TGSAMPASSS FKHRIKEQED YIRDWTAHRE EIARISQDLA 1300
    LIAREINDVA GEIDSVTSSG TAPSTTVSTA ATTPGSAIDT REEVGDLHGE 1350
    MHKLVDRVFD ESLNFRKIPP LVHSKTPEGN NGRSVDSRPQ PAEHPDHLTI 1400
    TRRRTWSRDE VMGDNLLLSS VFQFSRKIRQ SIDKTAGKIR ILFKDKDRNW 1450
    DDIENKLRAE SEVPIVKTSS MEISSILQEL KRVEKQLQVI NAMIDPDGTL 1500
    EALNNMGFPN AILPSPPKQK SSPVNNHSSP SQTPALCPPE TRALHPAAAG 1550
    VAAAASTEFE NAESEADFSI HFNRFNPDGE EEDVTVHE 1588
    Length:1,588
    Mass (Da):175,050
    Last modified:April 3, 2007 - v2
    Checksum:iB7140E6F82AF93A7
    GO
    Isoform 2 (identifier: Q6A065-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         211-236: CSTEAKHVEGQSAAASEEALFPFCRE → KNTSVAVASNSYWASIYSLNKSHSTL
         237-1588: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:236
    Mass (Da):26,206
    Checksum:i316C395EA550A7AA
    GO
    Isoform 3 (identifier: Q6A065-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1257: Missing.
         1344-1353: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:321
    Mass (Da):35,531
    Checksum:i92A5A8D7B504F9E6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 12571257Missing in isoform 3. 1 PublicationVSP_024243Add
    BLAST
    Alternative sequencei211 – 23626CSTEA…PFCRE → KNTSVAVASNSYWASIYSLN KSHSTL in isoform 2. 1 PublicationVSP_024244Add
    BLAST
    Alternative sequencei237 – 15881352Missing in isoform 2. 1 PublicationVSP_024245Add
    BLAST
    Alternative sequencei1344 – 135310Missing in isoform 3. 1 PublicationVSP_024246

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016937 mRNA. Translation: BAB30507.2.
    AK078541 mRNA. Translation: BAC37328.1.
    AC113311 Genomic DNA. No translation available.
    BC054781 mRNA. Translation: AAH54781.1.
    BC057019 mRNA. Translation: AAH57019.1.
    AK172953 mRNA. Translation: BAD32231.1.
    RefSeqiXP_006497000.1. XM_006496937.1. [Q6A065-1]
    XP_006497001.1. XM_006496938.1. [Q6A065-1]
    UniGeneiMm.269991.

    Genome annotation databases

    GeneIDi545389.
    KEGGimmu:545389.
    UCSCiuc007dub.1. mouse. [Q6A065-3]
    uc007duc.1. mouse. [Q6A065-1]
    uc007dug.1. mouse. [Q6A065-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016937 mRNA. Translation: BAB30507.2 .
    AK078541 mRNA. Translation: BAC37328.1 .
    AC113311 Genomic DNA. No translation available.
    BC054781 mRNA. Translation: AAH54781.1 .
    BC057019 mRNA. Translation: AAH57019.1 .
    AK172953 mRNA. Translation: BAD32231.1 .
    RefSeqi XP_006497000.1. XM_006496937.1. [Q6A065-1 ]
    XP_006497001.1. XM_006496938.1. [Q6A065-1 ]
    UniGenei Mm.269991.

    3D structure databases

    ProteinModelPortali Q6A065.
    SMRi Q6A065. Positions 1-123.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6A065. 15 interactions.
    MINTi MINT-4126922.
    STRINGi 10090.ENSMUSP00000059562.

    PTM databases

    PhosphoSitei Q6A065.

    Proteomic databases

    MaxQBi Q6A065.
    PaxDbi Q6A065.
    PRIDEi Q6A065.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 545389.
    KEGGi mmu:545389.
    UCSCi uc007dub.1. mouse. [Q6A065-3 ]
    uc007duc.1. mouse. [Q6A065-1 ]
    uc007dug.1. mouse. [Q6A065-2 ]

    Organism-specific databases

    CTDi 9859.
    MGIi MGI:1918348. Cep170.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG18196.
    HOGENOMi HOG000111524.
    HOVERGENi HBG058059.
    InParanoidi Q6A065.
    KOi K16463.
    PhylomeDBi Q6A065.

    Miscellaneous databases

    ChiTaRSi CEP170. mouse.
    PROi Q6A065.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6A065.
    CleanExi MM_CEP170.
    Genevestigatori Q6A065.

    Family and domain databases

    Gene3Di 2.60.200.20. 1 hit.
    InterProi IPR026644. CEP170.
    IPR029300. CEP170_C.
    IPR000253. FHA_dom.
    IPR008984. SMAD_FHA_domain.
    [Graphical view ]
    PANTHERi PTHR15715:SF17. PTHR15715:SF17. 1 hit.
    Pfami PF15308. CEP170_C. 1 hit.
    PF00498. FHA. 1 hit.
    [Graphical view ]
    SMARTi SM00240. FHA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    PROSITEi PS50006. FHA_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1462-1588 (ISOFORMS 1/3).
      Strain: C57BL/6J.
      Tissue: Muellerian duct and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 786-1588 (ISOFORM 1).
    5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358 AND SER-1102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443 AND SER-829, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiCE170_MOUSE
    AccessioniPrimary (citable) accession number: Q6A065
    Secondary accession number(s): Q7TQD9, Q8BJW2, Q9D3Z0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3