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Q6A065

- CE170_MOUSE

UniProt

Q6A065 - CE170_MOUSE

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Protein

Centrosomal protein of 170 kDa

Gene

Cep170

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in microtubule organization.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 170 kDa
Short name:
Cep170
Gene namesi
Name:Cep170
Synonyms:Kiaa0470
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1918348. Cep170.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity. Cytoplasmcytoskeletonspindle By similarity
Note: Associated with the mature mother centriole. Associated with spindle microtubules during mitosis.By similarity

GO - Cellular componenti

  1. centriole Source: MGI
  2. microtubule Source: UniProtKB-KW
  3. nuclear membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15881588Centrosomal protein of 170 kDaPRO_0000282888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei355 – 3551PhosphoserineBy similarity
Modified residuei358 – 3581Phosphoserine1 Publication
Modified residuei363 – 3631PhosphotyrosineBy similarity
Modified residuei443 – 4431Phosphoserine1 Publication
Modified residuei494 – 4941PhosphoserineBy similarity
Modified residuei498 – 4981PhosphothreonineBy similarity
Modified residuei628 – 6281PhosphoserineBy similarity
Modified residuei631 – 6311PhosphoserineBy similarity
Modified residuei829 – 8291Phosphoserine1 Publication
Modified residuei922 – 9221PhosphoserineBy similarity
Modified residuei925 – 9251PhosphoserineBy similarity
Modified residuei950 – 9501PhosphoserineBy similarity
Modified residuei1102 – 11021Phosphoserine1 Publication
Modified residuei1104 – 11041PhosphoserineBy similarity
Modified residuei1150 – 11501PhosphoserineBy similarity
Modified residuei1155 – 11551PhosphoserineBy similarity
Modified residuei1241 – 12411PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated; probably by PLK1.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6A065.
PaxDbiQ6A065.
PRIDEiQ6A065.

PTM databases

PhosphoSiteiQ6A065.

Expressioni

Gene expression databases

BgeeiQ6A065.
CleanExiMM_CEP170.
ExpressionAtlasiQ6A065. baseline and differential.
GenevestigatoriQ6A065.

Interactioni

Subunit structurei

Interacts with PLK1.By similarity

Protein-protein interaction databases

IntActiQ6A065. 15 interactions.
MINTiMINT-4126922.
STRINGi10090.ENSMUSP00000059562.

Structurei

3D structure databases

ProteinModelPortaliQ6A065.
SMRiQ6A065. Positions 1-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 7351FHAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni844 – 1588745Targeting to microtubulesBy similarityAdd
BLAST
Regioni1103 – 1588486Targeting to centrosomesBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1467 – 149529Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CEP170 family.Curated
Contains 1 FHA domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG18196.
HOGENOMiHOG000111524.
HOVERGENiHBG058059.
InParanoidiQ6A065.
KOiK16463.
PhylomeDBiQ6A065.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR026644. CEP170.
IPR029300. CEP170_C.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR15715:SF17. PTHR15715:SF17. 1 hit.
PfamiPF15308. CEP170_C. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6A065-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLTSWFLVS SGGTRHRLPR EMIFVGRDDC ELMLQSRSVD KQHAVINYDA
60 70 80 90 100
SMDEHLVKDL GSLNGTFVND VRIPEQTYIT LKLEDKLRFG YDTNLFTVVR
110 120 130 140 150
GEMRVPEEAL KHEKFTIQLQ LSQKSSESEL PKSASAKGTD SKVEAAAEVQ
160 170 180 190 200
PRATEALKSE EKPMDVSAMP RGTPLYGQPS WWGDAEEDEQ RAFKANGKPE
210 220 230 240 250
GKSQEAGASG CSTEAKHVEG QSAAASEEAL FPFCREPSYF EIPTKEFQQP
260 270 280 290 300
SQIAESTIHE IPTKDTPSSH TAGAGHASFT IEFDDSTPGK VTIRDHVTKF
310 320 330 340 350
TSDQRHKSKK ASPGTQDLPG IQTGMMAPEN KVADWLAQNN PPQMVWERTE
360 370 380 390 400
EDSKSIKSDV PVYLKRLKGN KHDDGTQSDS ENAGAHRRCS KRATLEEHLR
410 420 430 440 450
RHHSEQKKKA QSTEKHQEQA ATSSTHHRGG HGVPHGKLLK QKSEEPSVSL
460 470 480 490 500
PFLQTALLRS SGSLGHRPSQ EMDVMLKNQA TSASSEKDND DDQSDKGTYT
510 520 530 540 550
IELENPNSEE VEARKMIDKV FGVDDNQDYN RPIINEKHKG LIKDWALNSA
560 570 580 590 600
AVVMEERKPL STPGFHNSEE AISSSGSKRW VSQWASLAAN HTRHDPEERL
610 620 630 640 650
MELSATVENE TDTGDAGVSL RSTSCTTSLA SQGERKRRTL PQLPNEEKLL
660 670 680 690 700
ESSRAKVVPQ RSEIGEKQDT ELQEKEAQVY QSEKHDADRG LSKMSRAVNG
710 720 730 740 750
ESPKTGGDGK ALLHSGSSSS KEKSETEKET SLVKQTLAKM QQQEQKEQAQ
760 770 780 790 800
WTPTKFPSKN ALGHIDKCRE ESSKQESQLL EKVSGHSTSK GDRVIQNESK
810 820 830 840 850
RRKAEEIPKC QASKGDKKES SKSLVRQGSF TIDKPSSNIP IELIPHINKQ
860 870 880 890 900
NSSVPTALAL TSASRLRERS DSLDTDSSMD TTLILKDTEA VMAFLEAKLR
910 920 930 940 950
EDNNKTDEGP DTPSYNRDNS ISPESDVDTA STISLVTGET ERKSTQKRKS
960 970 980 990 1000
FTSLYKDRCS TSSPSKDVTK SGSREKIEKK AKSRSADIGA RADGRKFVQS
1010 1020 1030 1040 1050
SGRIRQPSID LTDDDQTSSV PHSAISDIMS SDQETYSCKS HGRTPLTSAD
1060 1070 1080 1090 1100
EHNIHSKLEG GKATKSKTSP VASGSTSKST TLPRPRPTRT SLLRRARLGE
1110 1120 1130 1140 1150
ASDSELADAD KASVASEVST TSSTSKPPTG RRTISRIDLL AQPRRTRLGS
1160 1170 1180 1190 1200
LSARSDSEAT ISRSSASART AEAVIRSGAR LVPSDKLSPR TRANSISRLS
1210 1220 1230 1240 1250
DSKVKSMSST HGSPSVNSRW RRFPTDYAST SEDEFGSNRN SPKHTRLRTS
1260 1270 1280 1290 1300
PALKTTRMQS TGSAMPASSS FKHRIKEQED YIRDWTAHRE EIARISQDLA
1310 1320 1330 1340 1350
LIAREINDVA GEIDSVTSSG TAPSTTVSTA ATTPGSAIDT REEVGDLHGE
1360 1370 1380 1390 1400
MHKLVDRVFD ESLNFRKIPP LVHSKTPEGN NGRSVDSRPQ PAEHPDHLTI
1410 1420 1430 1440 1450
TRRRTWSRDE VMGDNLLLSS VFQFSRKIRQ SIDKTAGKIR ILFKDKDRNW
1460 1470 1480 1490 1500
DDIENKLRAE SEVPIVKTSS MEISSILQEL KRVEKQLQVI NAMIDPDGTL
1510 1520 1530 1540 1550
EALNNMGFPN AILPSPPKQK SSPVNNHSSP SQTPALCPPE TRALHPAAAG
1560 1570 1580
VAAAASTEFE NAESEADFSI HFNRFNPDGE EEDVTVHE
Length:1,588
Mass (Da):175,050
Last modified:April 3, 2007 - v2
Checksum:iB7140E6F82AF93A7
GO
Isoform 2 (identifier: Q6A065-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-236: CSTEAKHVEGQSAAASEEALFPFCRE → KNTSVAVASNSYWASIYSLNKSHSTL
     237-1588: Missing.

Note: No experimental confirmation available.

Show »
Length:236
Mass (Da):26,206
Checksum:i316C395EA550A7AA
GO
Isoform 3 (identifier: Q6A065-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1257: Missing.
     1344-1353: Missing.

Note: No experimental confirmation available.

Show »
Length:321
Mass (Da):35,531
Checksum:i92A5A8D7B504F9E6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 12571257Missing in isoform 3. 1 PublicationVSP_024243Add
BLAST
Alternative sequencei211 – 23626CSTEA…PFCRE → KNTSVAVASNSYWASIYSLN KSHSTL in isoform 2. 1 PublicationVSP_024244Add
BLAST
Alternative sequencei237 – 15881352Missing in isoform 2. 1 PublicationVSP_024245Add
BLAST
Alternative sequencei1344 – 135310Missing in isoform 3. 1 PublicationVSP_024246

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016937 mRNA. Translation: BAB30507.2.
AK078541 mRNA. Translation: BAC37328.1.
AC113311 Genomic DNA. No translation available.
BC054781 mRNA. Translation: AAH54781.1.
BC057019 mRNA. Translation: AAH57019.1.
AK172953 mRNA. Translation: BAD32231.1.
RefSeqiXP_006497000.1. XM_006496937.1. [Q6A065-1]
XP_006497001.1. XM_006496938.1. [Q6A065-1]
UniGeneiMm.269991.

Genome annotation databases

GeneIDi545389.
KEGGimmu:545389.
UCSCiuc007dub.1. mouse. [Q6A065-3]
uc007duc.1. mouse. [Q6A065-1]
uc007dug.1. mouse. [Q6A065-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016937 mRNA. Translation: BAB30507.2 .
AK078541 mRNA. Translation: BAC37328.1 .
AC113311 Genomic DNA. No translation available.
BC054781 mRNA. Translation: AAH54781.1 .
BC057019 mRNA. Translation: AAH57019.1 .
AK172953 mRNA. Translation: BAD32231.1 .
RefSeqi XP_006497000.1. XM_006496937.1. [Q6A065-1 ]
XP_006497001.1. XM_006496938.1. [Q6A065-1 ]
UniGenei Mm.269991.

3D structure databases

ProteinModelPortali Q6A065.
SMRi Q6A065. Positions 1-123.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6A065. 15 interactions.
MINTi MINT-4126922.
STRINGi 10090.ENSMUSP00000059562.

PTM databases

PhosphoSitei Q6A065.

Proteomic databases

MaxQBi Q6A065.
PaxDbi Q6A065.
PRIDEi Q6A065.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 545389.
KEGGi mmu:545389.
UCSCi uc007dub.1. mouse. [Q6A065-3 ]
uc007duc.1. mouse. [Q6A065-1 ]
uc007dug.1. mouse. [Q6A065-2 ]

Organism-specific databases

CTDi 9859.
MGIi MGI:1918348. Cep170.
Rougei Search...

Phylogenomic databases

eggNOGi NOG18196.
HOGENOMi HOG000111524.
HOVERGENi HBG058059.
InParanoidi Q6A065.
KOi K16463.
PhylomeDBi Q6A065.

Miscellaneous databases

ChiTaRSi Cep170. mouse.
PROi Q6A065.
SOURCEi Search...

Gene expression databases

Bgeei Q6A065.
CleanExi MM_CEP170.
ExpressionAtlasi Q6A065. baseline and differential.
Genevestigatori Q6A065.

Family and domain databases

Gene3Di 2.60.200.20. 1 hit.
InterProi IPR026644. CEP170.
IPR029300. CEP170_C.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view ]
PANTHERi PTHR15715:SF17. PTHR15715:SF17. 1 hit.
Pfami PF15308. CEP170_C. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view ]
SMARTi SM00240. FHA. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
PROSITEi PS50006. FHA_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1462-1588 (ISOFORMS 1/3).
    Strain: C57BL/6J.
    Tissue: Muellerian duct and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 786-1588 (ISOFORM 1).
  5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358 AND SER-1102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443 AND SER-829, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCE170_MOUSE
AccessioniPrimary (citable) accession number: Q6A065
Secondary accession number(s): Q7TQD9, Q8BJW2, Q9D3Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 26, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3