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Q6A065

- CE170_MOUSE

UniProt

Q6A065 - CE170_MOUSE

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Protein
Centrosomal protein of 170 kDa
Gene
Cep170, Kiaa0470
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in microtubule organization By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 170 kDa
Short name:
Cep170
Gene namesi
Name:Cep170
Synonyms:Kiaa0470
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1918348. Cep170.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity. Cytoplasmcytoskeletonspindle By similarity
Note: Associated with the mature mother centriole By similarity. Associated with spindle microtubules during mitosis By similarity.

GO - Cellular componenti

  1. centriole Source: MGI
  2. microtubule Source: UniProtKB-KW
  3. spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15881588Centrosomal protein of 170 kDa
PRO_0000282888Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei355 – 3551Phosphoserine By similarity
Modified residuei358 – 3581Phosphoserine1 Publication
Modified residuei363 – 3631Phosphotyrosine By similarity
Modified residuei443 – 4431Phosphoserine1 Publication
Modified residuei494 – 4941Phosphoserine By similarity
Modified residuei498 – 4981Phosphothreonine By similarity
Modified residuei628 – 6281Phosphoserine By similarity
Modified residuei631 – 6311Phosphoserine By similarity
Modified residuei829 – 8291Phosphoserine1 Publication
Modified residuei922 – 9221Phosphoserine By similarity
Modified residuei925 – 9251Phosphoserine By similarity
Modified residuei950 – 9501Phosphoserine By similarity
Modified residuei1102 – 11021Phosphoserine1 Publication
Modified residuei1104 – 11041Phosphoserine By similarity
Modified residuei1150 – 11501Phosphoserine By similarity
Modified residuei1155 – 11551Phosphoserine By similarity
Modified residuei1241 – 12411Phosphoserine By similarity

Post-translational modificationi

Phosphorylated; probably by PLK1.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6A065.
PaxDbiQ6A065.
PRIDEiQ6A065.

PTM databases

PhosphoSiteiQ6A065.

Expressioni

Gene expression databases

BgeeiQ6A065.
CleanExiMM_CEP170.
GenevestigatoriQ6A065.

Interactioni

Subunit structurei

Interacts with PLK1 By similarity.

Protein-protein interaction databases

IntActiQ6A065. 15 interactions.
MINTiMINT-4126922.
STRINGi10090.ENSMUSP00000059562.

Structurei

3D structure databases

ProteinModelPortaliQ6A065.
SMRiQ6A065. Positions 1-123.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 7351FHA
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni844 – 1588745Targeting to microtubules By similarity
Add
BLAST
Regioni1103 – 1588486Targeting to centrosomes By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1467 – 149529 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the CEP170 family.
Contains 1 FHA domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG18196.
HOGENOMiHOG000111524.
HOVERGENiHBG058059.
InParanoidiQ6A065.
KOiK16463.
PhylomeDBiQ6A065.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR026644. CEP170.
IPR029300. CEP170_C.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR15715:SF17. PTHR15715:SF17. 1 hit.
PfamiPF15308. CEP170_C. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6A065-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLTSWFLVS SGGTRHRLPR EMIFVGRDDC ELMLQSRSVD KQHAVINYDA     50
SMDEHLVKDL GSLNGTFVND VRIPEQTYIT LKLEDKLRFG YDTNLFTVVR 100
GEMRVPEEAL KHEKFTIQLQ LSQKSSESEL PKSASAKGTD SKVEAAAEVQ 150
PRATEALKSE EKPMDVSAMP RGTPLYGQPS WWGDAEEDEQ RAFKANGKPE 200
GKSQEAGASG CSTEAKHVEG QSAAASEEAL FPFCREPSYF EIPTKEFQQP 250
SQIAESTIHE IPTKDTPSSH TAGAGHASFT IEFDDSTPGK VTIRDHVTKF 300
TSDQRHKSKK ASPGTQDLPG IQTGMMAPEN KVADWLAQNN PPQMVWERTE 350
EDSKSIKSDV PVYLKRLKGN KHDDGTQSDS ENAGAHRRCS KRATLEEHLR 400
RHHSEQKKKA QSTEKHQEQA ATSSTHHRGG HGVPHGKLLK QKSEEPSVSL 450
PFLQTALLRS SGSLGHRPSQ EMDVMLKNQA TSASSEKDND DDQSDKGTYT 500
IELENPNSEE VEARKMIDKV FGVDDNQDYN RPIINEKHKG LIKDWALNSA 550
AVVMEERKPL STPGFHNSEE AISSSGSKRW VSQWASLAAN HTRHDPEERL 600
MELSATVENE TDTGDAGVSL RSTSCTTSLA SQGERKRRTL PQLPNEEKLL 650
ESSRAKVVPQ RSEIGEKQDT ELQEKEAQVY QSEKHDADRG LSKMSRAVNG 700
ESPKTGGDGK ALLHSGSSSS KEKSETEKET SLVKQTLAKM QQQEQKEQAQ 750
WTPTKFPSKN ALGHIDKCRE ESSKQESQLL EKVSGHSTSK GDRVIQNESK 800
RRKAEEIPKC QASKGDKKES SKSLVRQGSF TIDKPSSNIP IELIPHINKQ 850
NSSVPTALAL TSASRLRERS DSLDTDSSMD TTLILKDTEA VMAFLEAKLR 900
EDNNKTDEGP DTPSYNRDNS ISPESDVDTA STISLVTGET ERKSTQKRKS 950
FTSLYKDRCS TSSPSKDVTK SGSREKIEKK AKSRSADIGA RADGRKFVQS 1000
SGRIRQPSID LTDDDQTSSV PHSAISDIMS SDQETYSCKS HGRTPLTSAD 1050
EHNIHSKLEG GKATKSKTSP VASGSTSKST TLPRPRPTRT SLLRRARLGE 1100
ASDSELADAD KASVASEVST TSSTSKPPTG RRTISRIDLL AQPRRTRLGS 1150
LSARSDSEAT ISRSSASART AEAVIRSGAR LVPSDKLSPR TRANSISRLS 1200
DSKVKSMSST HGSPSVNSRW RRFPTDYAST SEDEFGSNRN SPKHTRLRTS 1250
PALKTTRMQS TGSAMPASSS FKHRIKEQED YIRDWTAHRE EIARISQDLA 1300
LIAREINDVA GEIDSVTSSG TAPSTTVSTA ATTPGSAIDT REEVGDLHGE 1350
MHKLVDRVFD ESLNFRKIPP LVHSKTPEGN NGRSVDSRPQ PAEHPDHLTI 1400
TRRRTWSRDE VMGDNLLLSS VFQFSRKIRQ SIDKTAGKIR ILFKDKDRNW 1450
DDIENKLRAE SEVPIVKTSS MEISSILQEL KRVEKQLQVI NAMIDPDGTL 1500
EALNNMGFPN AILPSPPKQK SSPVNNHSSP SQTPALCPPE TRALHPAAAG 1550
VAAAASTEFE NAESEADFSI HFNRFNPDGE EEDVTVHE 1588
Length:1,588
Mass (Da):175,050
Last modified:April 3, 2007 - v2
Checksum:iB7140E6F82AF93A7
GO
Isoform 2 (identifier: Q6A065-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-236: CSTEAKHVEGQSAAASEEALFPFCRE → KNTSVAVASNSYWASIYSLNKSHSTL
     237-1588: Missing.

Note: No experimental confirmation available.

Show »
Length:236
Mass (Da):26,206
Checksum:i316C395EA550A7AA
GO
Isoform 3 (identifier: Q6A065-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1257: Missing.
     1344-1353: Missing.

Note: No experimental confirmation available.

Show »
Length:321
Mass (Da):35,531
Checksum:i92A5A8D7B504F9E6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 12571257Missing in isoform 3.
VSP_024243Add
BLAST
Alternative sequencei211 – 23626CSTEA…PFCRE → KNTSVAVASNSYWASIYSLN KSHSTL in isoform 2.
VSP_024244Add
BLAST
Alternative sequencei237 – 15881352Missing in isoform 2.
VSP_024245Add
BLAST
Alternative sequencei1344 – 135310Missing in isoform 3.
VSP_024246

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK016937 mRNA. Translation: BAB30507.2.
AK078541 mRNA. Translation: BAC37328.1.
AC113311 Genomic DNA. No translation available.
BC054781 mRNA. Translation: AAH54781.1.
BC057019 mRNA. Translation: AAH57019.1.
AK172953 mRNA. Translation: BAD32231.1.
RefSeqiXP_006497000.1. XM_006496937.1. [Q6A065-1]
XP_006497001.1. XM_006496938.1. [Q6A065-1]
UniGeneiMm.269991.

Genome annotation databases

GeneIDi545389.
KEGGimmu:545389.
UCSCiuc007dub.1. mouse. [Q6A065-3]
uc007duc.1. mouse. [Q6A065-1]
uc007dug.1. mouse. [Q6A065-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK016937 mRNA. Translation: BAB30507.2 .
AK078541 mRNA. Translation: BAC37328.1 .
AC113311 Genomic DNA. No translation available.
BC054781 mRNA. Translation: AAH54781.1 .
BC057019 mRNA. Translation: AAH57019.1 .
AK172953 mRNA. Translation: BAD32231.1 .
RefSeqi XP_006497000.1. XM_006496937.1. [Q6A065-1 ]
XP_006497001.1. XM_006496938.1. [Q6A065-1 ]
UniGenei Mm.269991.

3D structure databases

ProteinModelPortali Q6A065.
SMRi Q6A065. Positions 1-123.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6A065. 15 interactions.
MINTi MINT-4126922.
STRINGi 10090.ENSMUSP00000059562.

PTM databases

PhosphoSitei Q6A065.

Proteomic databases

MaxQBi Q6A065.
PaxDbi Q6A065.
PRIDEi Q6A065.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 545389.
KEGGi mmu:545389.
UCSCi uc007dub.1. mouse. [Q6A065-3 ]
uc007duc.1. mouse. [Q6A065-1 ]
uc007dug.1. mouse. [Q6A065-2 ]

Organism-specific databases

CTDi 9859.
MGIi MGI:1918348. Cep170.
Rougei Search...

Phylogenomic databases

eggNOGi NOG18196.
HOGENOMi HOG000111524.
HOVERGENi HBG058059.
InParanoidi Q6A065.
KOi K16463.
PhylomeDBi Q6A065.

Miscellaneous databases

ChiTaRSi CEP170. mouse.
PROi Q6A065.
SOURCEi Search...

Gene expression databases

Bgeei Q6A065.
CleanExi MM_CEP170.
Genevestigatori Q6A065.

Family and domain databases

Gene3Di 2.60.200.20. 1 hit.
InterProi IPR026644. CEP170.
IPR029300. CEP170_C.
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view ]
PANTHERi PTHR15715:SF17. PTHR15715:SF17. 1 hit.
Pfami PF15308. CEP170_C. 1 hit.
PF00498. FHA. 1 hit.
[Graphical view ]
SMARTi SM00240. FHA. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
PROSITEi PS50006. FHA_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1462-1588 (ISOFORMS 1/3).
    Strain: C57BL/6J.
    Tissue: Muellerian duct and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 786-1588 (ISOFORM 1).
  5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358 AND SER-1102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-443 AND SER-829, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCE170_MOUSE
AccessioniPrimary (citable) accession number: Q6A065
Secondary accession number(s): Q7TQD9, Q8BJW2, Q9D3Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 3, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi