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Protein

Armadillo repeat-containing X-linked protein 2

Gene

Armcx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing X-linked protein 2
Gene namesi
Name:Armcx2
Synonyms:Kiaa0512
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1914666. Armcx2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 784784Armadillo repeat-containing X-linked protein 2PRO_0000191365Add
BLAST

Proteomic databases

EPDiQ6A058.
MaxQBiQ6A058.
PaxDbiQ6A058.
PRIDEiQ6A058.

PTM databases

iPTMnetiQ6A058.
PhosphoSiteiQ6A058.

Expressioni

Gene expression databases

BgeeiQ6A058.
CleanExiMM_ARMCX2.
GenevisibleiQ6A058. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049147.

Structurei

3D structure databases

ProteinModelPortaliQ6A058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati528 – 56841ARM 1Add
BLAST
Repeati570 – 60940ARM 2Add
BLAST
Repeati650 – 68940ARM 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi179 – 292114Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 ARM repeats.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ18. Eukaryota.
ENOG41116WA. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG057677.
InParanoidiQ6A058.
OMAiVIGASAW.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ6A058.
TreeFamiTF335652.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6A058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRARDAGCV AAGIVIGASA WYCVYKYTRG KDQKKKRLTK PKNRASVGTG
60 70 80 90 100
SRARAGLRAG FTIDLGPGFS PPNPVDIEIM NKAQGEASNL ATTVAEEVAP
110 120 130 140 150
AAPSPKVQNG AESKVQELNG AKTEANLESV VMPSATCTVT PPPKVAGGLT
160 170 180 190 200
AAEAPEIIGA PKVLEAPSTT EASGAVAAPG PTVSPMIAQT PGPVVPSPTI
210 220 230 240 250
VSTGPAAIPW AVAHPGAVQS PGPAVPPMAV QSLVPAAPSW AVVAPPGAVY
260 270 280 290 300
IPVAAHFAGP AAASRVTQSP GTVIPPLPPP SSVLPRGVPS VPGRTVQSPG
310 320 330 340 350
AAVHPVAAQS TGVVVPPRAV QYSGAAVTSG GAAVPSGGAA TPRAAASTQR
360 370 380 390 400
TASTEVMQVP RVAAATEATE TPRIGTPAMV AEASLPVHSG AAENPGTSGS
410 420 430 440 450
SKTAATGKKA APGAHTGAIP KAGSATGAVP KGGGGKGGNK NRSGGKGKNR
460 470 480 490 500
KNKVDVDELG MGFRPGDGAA AAAAASANGG QAFLAEIPES EEGESGWTDT
510 520 530 540 550
ESDSDSEPDV PQRGKGKRTI PMHKRPFPYE IDEILGVRDL RKVLALLQKS
560 570 580 590 600
DDPFIQQVAL LTLSNNANYS CNQETIRKLG GLPIIANMIN KTDPHIKEKA
610 620 630 640 650
LMAMNNLSEN YENQGRLQVY MNKVMDDIMA SNLNSAVQVV GLKFLTNMTI
660 670 680 690 700
TNDYQHLLVN SIANFFRLLS QGGGKIKVEI LKILSNFAEN PDMLKKLLGT
710 720 730 740 750
QVPSSFSSLY NSYVESEILI NALTLFEIIF DNLRAEVFNY REFNKGSLFY
760 770 780
LCTTSGVCVK KIRALANHHD LLVKVKVIKL VNKF
Length:784
Mass (Da):81,036
Last modified:December 20, 2005 - v2
Checksum:i3EEE7DB7EE6B0086
GO

Sequence cautioni

The sequence BAD32238.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172960 mRNA. Translation: BAD32238.1. Different initiation.
AK014329 mRNA. Translation: BAB29276.1.
AK034185 mRNA. Translation: BAC28622.1.
AK044926 mRNA. Translation: BAC32145.1.
AL772348 Genomic DNA. Translation: CAM20586.1.
BC054839 mRNA. Translation: AAH54839.1.
CCDSiCCDS30401.1.
RefSeqiNP_001159869.1. NM_001166397.1.
NP_001159870.1. NM_001166398.1.
NP_080415.3. NM_026139.4.
XP_006528663.1. XM_006528600.1.
XP_006528665.1. XM_006528602.1.
XP_006528666.1. XM_006528603.1.
UniGeneiMm.285969.

Genome annotation databases

EnsembliENSMUST00000035559; ENSMUSP00000049147; ENSMUSG00000033436.
ENSMUST00000113193; ENSMUSP00000108818; ENSMUSG00000033436.
ENSMUST00000119010; ENSMUSP00000112507; ENSMUSG00000033436.
ENSMUST00000168264; ENSMUSP00000127305; ENSMUSG00000033436.
GeneIDi67416.
KEGGimmu:67416.
UCSCiuc009ugq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172960 mRNA. Translation: BAD32238.1. Different initiation.
AK014329 mRNA. Translation: BAB29276.1.
AK034185 mRNA. Translation: BAC28622.1.
AK044926 mRNA. Translation: BAC32145.1.
AL772348 Genomic DNA. Translation: CAM20586.1.
BC054839 mRNA. Translation: AAH54839.1.
CCDSiCCDS30401.1.
RefSeqiNP_001159869.1. NM_001166397.1.
NP_001159870.1. NM_001166398.1.
NP_080415.3. NM_026139.4.
XP_006528663.1. XM_006528600.1.
XP_006528665.1. XM_006528602.1.
XP_006528666.1. XM_006528603.1.
UniGeneiMm.285969.

3D structure databases

ProteinModelPortaliQ6A058.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049147.

PTM databases

iPTMnetiQ6A058.
PhosphoSiteiQ6A058.

Proteomic databases

EPDiQ6A058.
MaxQBiQ6A058.
PaxDbiQ6A058.
PRIDEiQ6A058.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035559; ENSMUSP00000049147; ENSMUSG00000033436.
ENSMUST00000113193; ENSMUSP00000108818; ENSMUSG00000033436.
ENSMUST00000119010; ENSMUSP00000112507; ENSMUSG00000033436.
ENSMUST00000168264; ENSMUSP00000127305; ENSMUSG00000033436.
GeneIDi67416.
KEGGimmu:67416.
UCSCiuc009ugq.2. mouse.

Organism-specific databases

CTDi9823.
MGIiMGI:1914666. Armcx2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJ18. Eukaryota.
ENOG41116WA. LUCA.
GeneTreeiENSGT00550000074488.
HOGENOMiHOG000231611.
HOVERGENiHBG057677.
InParanoidiQ6A058.
OMAiVIGASAW.
OrthoDBiEOG70PBZ0.
PhylomeDBiQ6A058.
TreeFamiTF335652.

Miscellaneous databases

NextBioi324502.
PROiQ6A058.
SOURCEiSearch...

Gene expression databases

BgeeiQ6A058.
CleanExiMM_ARMCX2.
GenevisibleiQ6A058. MM.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR006911. ARM-rpt_dom.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF04826. Arm_2. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreatic islet.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon and Head.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiARMX2_MOUSE
AccessioniPrimary (citable) accession number: Q6A058
Secondary accession number(s): A2AKS5, Q9CXI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 11, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.