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Protein

Attractin-like protein 1

Gene

Atrnl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in melanocortin signaling pathways that regulate energy homeostasis.By similarity

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Attractin-like protein 1
Gene namesi
Name:Atrnl1
Synonyms:Alp, Atrnl, Kiaa0534
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2147749. Atrnl1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini52 – 1229ExtracellularSequence analysisAdd BLAST1178
Transmembranei1230 – 1250HelicalSequence analysisAdd BLAST21
Topological domaini1251 – 1378CytoplasmicSequence analysisAdd BLAST128

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are grossly normal with no alterations of pigmentation, central nervous system pathology or body weight. In contrast, constitutive expression of Atrnl1 in mice lacking Atrn display normal, agouti-banded hairs and significantly delayed onset of spongiform neurodegeneration, indicating that overexpression of Atrnl1 compensates for loss of Atrn.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 51Sequence analysisAdd BLAST51
ChainiPRO_000033465152 – 1378Attractin-like protein 1Add BLAST1327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 78By similarity
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi80 ↔ 89By similarity
Disulfide bondi92 ↔ 118By similarity
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi210 ↔ 220By similarity
Disulfide bondi214 ↔ 232By similarity
Disulfide bondi234 ↔ 243By similarity
Glycosylationi379N-linked (GlcNAc...)Sequence analysis1
Glycosylationi703N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi775 ↔ 871By similarity
Glycosylationi777N-linked (GlcNAc...)Sequence analysis1
Glycosylationi897N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1013 ↔ 1021By similarity
Disulfide bondi1015 ↔ 1027By similarity
Disulfide bondi1030 ↔ 1039By similarity
Disulfide bondi1042 ↔ 1056By similarity
Disulfide bondi1059 ↔ 1068By similarity
Disulfide bondi1061 ↔ 1075By similarity
Disulfide bondi1077 ↔ 1087By similarity
Disulfide bondi1090 ↔ 1105By similarity
Glycosylationi1156N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6A051.
PeptideAtlasiQ6A051.
PRIDEiQ6A051.

PTM databases

PhosphoSitePlusiQ6A051.

Expressioni

Tissue specificityi

Highly expressed in brain, heart, lung, kidney and liver. In the central nervous system, it is highly expressed in the dentate gyrus, CA1-3 regions of the hippocampus, and the ventral taenia tecta.1 Publication

Gene expression databases

BgeeiENSMUSG00000054843.
GenevisibleiQ6A051. MM.

Interactioni

Subunit structurei

Interacts with MC4R.1 Publication

Protein-protein interaction databases

BioGridi230494. 1 interactor.
STRINGi10090.ENSMUSP00000076514.

Structurei

3D structure databases

ProteinModelPortaliQ6A051.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 90EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini92 – 208CUBPROSITE-ProRule annotationAdd BLAST117
Domaini206 – 244EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Repeati315 – 364Kelch 1Add BLAST50
Repeati366 – 414Kelch 2Add BLAST49
Repeati426 – 474Kelch 3Add BLAST49
Repeati479 – 530Kelch 4Add BLAST52
Repeati532 – 590Kelch 5Add BLAST59
Repeati591 – 637Kelch 6Add BLAST47
Domaini613 – 656PSI 1Add BLAST44
Domaini665 – 708PSI 2Add BLAST44
Domaini714 – 759PSI 3Add BLAST46
Domaini754 – 872C-type lectinPROSITE-ProRule annotationAdd BLAST119
Domaini888 – 938PSI 4Add BLAST51
Domaini941 – 1011PSI 5Add BLAST71
Domaini1013 – 1058Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST46
Domaini1059 – 1107Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1287 – 1324Interaction with MC4R1 PublicationAdd BLAST38

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated
Contains 2 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 5 PSI domains.Curated

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1388. Eukaryota.
ENOG410XRW4. LUCA.
GeneTreeiENSGT00390000001118.
HOGENOMiHOG000231727.
HOVERGENiHBG004312.
InParanoidiQ6A051.
OMAiLRTSCSN.
OrthoDBiEOG091G03A0.
PhylomeDBiQ6A051.
TreeFamiTF321873.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.120.10.80. 1 hit.
2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000859. CUB_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR002049. Laminin_EGF.
IPR002165. Plexin_repeat.
IPR016201. PSI.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF07974. EGF_2. 1 hit.
PF01344. Kelch_1. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF01437. PSI. 2 hits.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00042. CUB. 1 hit.
SM00181. EGF. 3 hits.
SM00180. EGF_Lam. 1 hit.
SM00423. PSI. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01180. CUB. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6A051-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPGVRARSG APQPASPVLW RARPAGGGGA SSWLLLDGNS WLLCYGFLYL
60 70 80 90 100
ALYAQVSQSK PCERTGSCFS GRCVNSTCLC DPGWVGDQCQ HCQGRFKLTE
110 120 130 140 150
PSGYLTDGPI NYKYKTKCTW LIEGYPNAVL RLRFNHFATE CSWDHMYVYD
160 170 180 190 200
GDSIYAPLVA VLSGLIVPEV RGNETVPEVV TTSGYALLHF FSDAAYNLTG
210 220 230 240 250
FNIFYSINSC PNNCSGHGKC TTSVSVASQV YCECDKYWKG EACDIPYCKA
260 270 280 290 300
NCGSPDHGYC DLTGEKLCVC NDSWQGPDCS LNVPSTESYW ILPNVKPFSP
310 320 330 340 350
SVGRASHKAV LHGKFMWVIG GYTFNYSSFQ MVLNYNLESS IWNVGAVSRG
360 370 380 390 400
PLQRYGHSLA LYQENIFMYG GRMETSDGNV TDELWVFNVR SQSWSTKTPT
410 420 430 440 450
VLGHSQQYAV EGHSAHIMEL DSRDVVMIVI FGYSAIYGYT SSIQEYHISS
460 470 480 490 500
NTWLVPETKG AIVQGGYGHT SVYDEVTKSI YVHGGYKALP GNKYGLVDDL
510 520 530 540 550
YKYEVNTRTW TILKESGFAR YLHSAVLING AMLIFGGNTH NDTSLSNGAK
560 570 580 590 600
CFSADFLAYD IACDEWKTLP KPNLHRDVNR FGHSAVVING SMYIFGGFSS
610 620 630 640 650
VLLNDILVYK PPNCKAFRDE ELCRNAGPGI KCVWNKNHCE SWESGNTNNI
660 670 680 690 700
LRAKCPPKTA ATDDRCYRYA DCASCTANTN GCQWCDDKKC ISASSNCSTS
710 720 730 740 750
VRNYTKCHIR NEQICNKLTS CKSCSLNLNC QWDQRQQECQ ALPAHLCGEG
760 770 780 790 800
WNHVGDACLR INSSRESYDN AKLYCYNLSG NLASLTTSKE VEFVLDEIQK
810 820 830 840 850
FTQQKVSPWV GLRKINISYW GWEDMSPFTN TSLQWLPGEP NDSGFCAYLE
860 870 880 890 900
RAAVAGLKAN PCTSMADGLV CEKPVVSPNQ NARPCKKPCS LRTSCANCTS
910 920 930 940 950
SGMECMWCSS TKRCVDSNAY IISFPYGQCL EWQTATCSPQ NCSGLRTCGQ
960 970 980 990 1000
CLEQPGCGWC NDPSNTGRGY CIEGSSRGPM KLAGVHNSDV VLDTSLCPKE
1010 1020 1030 1040 1050
KNYEWSFIQC PACQCNGHST CINNNVCEQC KNLTTGRQCQ ECMPGYYGDP
1060 1070 1080 1090 1100
TNGGQCTACT CGGHANVCHL HTGKCFCTTK GIKGDQCQLC DSENRYVGNP
1110 1120 1130 1140 1150
LRGTCYYSLL IDYQFTFSLL QEDDRHHTAI NFIANPEQSN KNLDISINAS
1160 1170 1180 1190 1200
NNFNLNITWS VGSTGGTISG EETPIVSKTN IKEYRDSFSY EKFNFRSNPN
1210 1220 1230 1240 1250
ITFYVYVSNF SWPIKIQIAF SQHNTIMDLV QFFVTFFSCF LSLLLVAAVV
1260 1270 1280 1290 1300
WKIKQTCWAS RRREQLLRER QQMASRPFAS VDVALEVGAE QTDFLRGPLE
1310 1320 1330 1340 1350
GAPKPIAIEP CAGNRAAVLT VFLCLPRGSS GAPPPGQSGL AIASALIDIS
1360 1370
QQKPSDNKDK TSGVRNRKHL STRQGTCV
Length:1,378
Mass (Da):152,467
Last modified:May 20, 2008 - v2
Checksum:i28E9AE30440E32A7
GO
Isoform 2 (identifier: Q6A051-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1090-1094: CDSEN → YCQFF
     1095-1378: Missing.

Note: No experimental confirmation available.
Show »
Length:1,094
Mass (Da):120,880
Checksum:iB434DCA9C4887A50
GO
Isoform 3 (identifier: Q6A051-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-561: MEPGVRARSG...FSADFLAYDI → MGWWTTSISTKSTPGL
     1012-1057: Missing.

Note: No experimental confirmation available.
Show »
Length:787
Mass (Da):87,278
Checksum:iC09A4BBA53620B9F
GO

Sequence cautioni

The sequence BAD32245 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47F → S in AAT99560 (Ref. 1) Curated1
Sequence conflicti851R → K in AAH50020 (PubMed:15489334).Curated1
Sequence conflicti983A → V in BAD32245 (PubMed:15368895).Curated1
Sequence conflicti1191E → D in AAH50020 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0337201 – 561MEPGV…LAYDI → MGWWTTSISTKSTPGL in isoform 3. 1 PublicationAdd BLAST561
Alternative sequenceiVSP_0337211012 – 1057Missing in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_0337221090 – 1094CDSEN → YCQFF in isoform 2. 1 Publication5
Alternative sequenceiVSP_0337231095 – 1378Missing in isoform 2. 1 PublicationAdd BLAST284

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY688677 mRNA. Translation: AAT99560.1.
AK172967 mRNA. Translation: BAD32245.1. Different initiation.
AK050882 mRNA. Translation: BAC34442.1.
AK147492 mRNA. Translation: BAE27947.1.
BC030872 mRNA. Translation: AAH30872.1.
BC050020 mRNA. Translation: AAH50020.1.
CCDSiCCDS29928.1. [Q6A051-1]
RefSeqiNP_852080.3. NM_181415.4. [Q6A051-1]
UniGeneiMm.245340.

Genome annotation databases

EnsembliENSMUST00000077282; ENSMUSP00000076514; ENSMUSG00000054843. [Q6A051-1]
GeneIDi226255.
KEGGimmu:226255.
UCSCiuc008iai.2. mouse. [Q6A051-1]
uc008iaj.1. mouse. [Q6A051-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY688677 mRNA. Translation: AAT99560.1.
AK172967 mRNA. Translation: BAD32245.1. Different initiation.
AK050882 mRNA. Translation: BAC34442.1.
AK147492 mRNA. Translation: BAE27947.1.
BC030872 mRNA. Translation: AAH30872.1.
BC050020 mRNA. Translation: AAH50020.1.
CCDSiCCDS29928.1. [Q6A051-1]
RefSeqiNP_852080.3. NM_181415.4. [Q6A051-1]
UniGeneiMm.245340.

3D structure databases

ProteinModelPortaliQ6A051.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230494. 1 interactor.
STRINGi10090.ENSMUSP00000076514.

PTM databases

PhosphoSitePlusiQ6A051.

Proteomic databases

PaxDbiQ6A051.
PeptideAtlasiQ6A051.
PRIDEiQ6A051.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077282; ENSMUSP00000076514; ENSMUSG00000054843. [Q6A051-1]
GeneIDi226255.
KEGGimmu:226255.
UCSCiuc008iai.2. mouse. [Q6A051-1]
uc008iaj.1. mouse. [Q6A051-3]

Organism-specific databases

CTDi26033.
MGIiMGI:2147749. Atrnl1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1388. Eukaryota.
ENOG410XRW4. LUCA.
GeneTreeiENSGT00390000001118.
HOGENOMiHOG000231727.
HOVERGENiHBG004312.
InParanoidiQ6A051.
OMAiLRTSCSN.
OrthoDBiEOG091G03A0.
PhylomeDBiQ6A051.
TreeFamiTF321873.

Miscellaneous databases

ChiTaRSiAtrnl1. mouse.
PROiQ6A051.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054843.
GenevisibleiQ6A051. MM.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.120.10.80. 1 hit.
2.60.120.290. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000859. CUB_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR002049. Laminin_EGF.
IPR002165. Plexin_repeat.
IPR016201. PSI.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF07974. EGF_2. 1 hit.
PF01344. Kelch_1. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF01437. PSI. 2 hits.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00042. CUB. 1 hit.
SM00181. EGF. 3 hits.
SM00180. EGF_Lam. 1 hit.
SM00423. PSI. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS01180. CUB. 1 hit.
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATRN1_MOUSE
AccessioniPrimary (citable) accession number: Q6A051
Secondary accession number(s): Q3UHB0
, Q68HV2, Q80VI3, Q8BKS4, Q8K0P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.