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Q6A026 (PDS5A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sister chromatid cohesion protein PDS5 homolog A
Gene names
Name:Pds5a
Synonyms:Kiaa0648
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1332 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair By similarity.

Subunit structure

Interacts with the cohesin complex. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63 By similarity.

Subcellular location

Nucleus By similarity. Note: Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase By similarity. UniProtKB Q29RF7

Sequence similarities

Belongs to the PDS5 family.

Contains 1 HEAT repeat.

Sequence caution

The sequence BAD32270.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Cellular componentNucleus
   DomainRepeat
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitosis

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of DNA replication

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13321332Sister chromatid cohesion protein PDS5 homolog A
PRO_0000296342

Regions

Repeat392 – 42837HEAT

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue11451N6-acetyllysine Ref.3
Modified residue11941Phosphoserine By similarity
Modified residue12071Phosphothreonine By similarity UniProtKB Q29RF7
Modified residue12101N6-acetyllysine Ref.3
Modified residue12881N6-acetyllysine By similarity
Modified residue13031Phosphoserine By similarity UniProtKB Q29RF7

Experimental info

Sequence conflict5571K → E in BAD32270. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q6A026 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 0D6473650AC9D89B

FASTA1,332150,327
        10         20         30         40         50         60 
MDFTQPKPAT ALCGVVSADG KIAYPPGVKE ITDKITTDEM IKRLKMVVKT FMDMDQDSED 

        70         80         90        100        110        120 
EKQQYLPLAL HLASEFFLRN PNKDVRLLVA CCLADIFRIY APEAPYTSHD KLKDIFLFIT 

       130        140        150        160        170        180 
RQLKGLEDTK SPQFNRYFYL LENLAWVKSY NICFELEDCN EIFIQLFRTL FSVINNSHNT 

       190        200        210        220        230        240 
KVQMHMLDLM SSIIMEGDGV TQELLDSILI NLIPAHKNLN KQSFDLAKVL LKRTVQTIEA 

       250        260        270        280        290        300 
CIANFFNQVL VLGRSSVSDL SEHVFDLIQE LFAIDPQLLL SVMPQLEFKL KSNDGEERLA 

       310        320        330        340        350        360 
VVRLLAKLFG SKDSDLATQN RPLWQCFLGR FNDIHVPVRL ESVKFASHCL MNHPDLAKDL 

       370        380        390        400        410        420 
TEYLKVRSHD PEEAIRHDVI VTIITAAKRD LALVNDQLLG FVRERTLDKR WRVRKEAMMG 

       430        440        450        460        470        480 
LAQLYKKYCL HGEAGKEAAE KVSWIKDKLL HIYYQNSIDD KLLVEKIFAQ YLVPHNLETE 

       490        500        510        520        530        540 
ERMKCLYYLY ASLDPNAVKA LNEMWKCQNM LRSHVRELLD LHKQPTSEAN CSAMFGKLMT 

       550        560        570        580        590        600 
IAKNLPDPGK AQDFVKKFNQ VLGDDEKLRS QLELLISPTC SCKQADVCVR EIARKLANPK 

       610        620        630        640        650        660 
QPTNPFLEMV KFLLERIAPV HIDSEAISAL VKLMNKSIEG TADDEEEGVS PDSAIRSGLE 

       670        680        690        700        710        720 
LLKVLSFTHP TSFHSAETYE SLLQCLRMED DKVAEAAIQI FRNTGHKIET DLPQIRSTLI 

       730        740        750        760        770        780 
PILHQKAKRG TPHQAKQAVH CIHAIFSNKE VQLAQIFEPL SRSLNADVPE QLITPLVSLG 

       790        800        810        820        830        840 
HISMLAPDQF ASPMKSVVAN FIVKDLLMND RSTGEKNGKL WSPDEEVSPE VLAKVYLLRL 

       850        860        870        880        890        900 
LVRWLLGMKN NQSKSANSTL RLLSAMLVSE GDLTEQKRIS KSDMSRLRLA AGSAIMKLAQ 

       910        920        930        940        950        960 
EPCYHEIITP EQFQLCALVI NDECYQVRQI FAQKLHKALV KLLLPLEYMA IFALCAKDPV 

       970        980        990       1000       1010       1020 
KERRAHARQC LLKNISIRRE YIKQNPMATE KLLSLLPEYV VPYMIHLLAH DPDFTRSQDV 

      1030       1040       1050       1060       1070       1080 
DQLRDIKECL WFMLEVLMTK NENNSHAFMK KMAENIKLTR DAQSPDESKT NEKLYTVCDV 

      1090       1100       1110       1120       1130       1140 
ALCVINSKSA LCNADSPKDP VLPMKFFTQP EKDFCNDKSY ISEETRVLLL TGKPKPTGVL 

      1150       1160       1170       1180       1190       1200 
GTVNKPLSAT GRKPYVRSAG TETGSNINAN SELSPSAGSR SREQSSEASE TGVSENEENP 

      1210       1220       1230       1240       1250       1260 
VRIISVTPVK NIDTVKNKEI NSDQSTQGNI SSDRGKKRIV TAAGAENIQK PDEKVDESGP 

      1270       1280       1290       1300       1310       1320 
PAPSKPRRGR RPKSESQGNA TKNDDLNKPV SKGRKRAAGS QESLEAGNAK APKLQDGAKK 

      1330 
AVPAERQIDL QR 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1112.
Tissue: Embryonic intestine.
[3]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1145 AND LYS-1210, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC112263 Genomic DNA. No translation available.
AK172992 Transcribed RNA. Translation: BAD32270.1. Different initiation.
UniGeneMm.278974.

3D structure databases

ProteinModelPortalQ6A026.
SMRQ6A026. Positions 77-104, 284-350, 885-971.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6A026. 12 interactions.
STRING10090.ENSMUSP00000031104.

PTM databases

PhosphoSiteQ6A026.

Proteomic databases

PaxDbQ6A026.
PRIDEQ6A026.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1918771. Pds5a.
RougeSearch...

Phylogenomic databases

eggNOGNOG268017.
HOGENOMHOG000230672.
HOVERGENHBG108241.
InParanoidQ6A026.

Gene expression databases

GenevestigatorQ6A026.

Family and domain databases

Gene3D1.25.10.10. 5 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMSSF48371. SSF48371. 4 hits.
ProtoNetSearch...

Other

PROQ6A026.
SOURCESearch...

Entry information

Entry namePDS5A_MOUSE
AccessionPrimary (citable) accession number: Q6A026
Secondary accession number(s): E9Q656
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 27, 2011
Last modified: March 19, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot