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Q6A026

- PDS5A_MOUSE

UniProt

Q6A026 - PDS5A_MOUSE

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Protein

Sister chromatid cohesion protein PDS5 homolog A

Gene
Pds5a, Kiaa0648
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair By similarity.

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. negative regulation of DNA replication Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog A
Gene namesi
Name:Pds5a
Synonyms:Kiaa0648
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1918771. Pds5a.

Subcellular locationi

Nucleus By similarity
Note: Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase By similarity.By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13321332Sister chromatid cohesion protein PDS5 homolog APRO_0000296342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei1145 – 11451N6-acetyllysine1 Publication
Modified residuei1194 – 11941Phosphoserine By similarity
Modified residuei1207 – 12071Phosphothreonine By similarityBy similarity
Modified residuei1210 – 12101N6-acetyllysine1 Publication
Modified residuei1288 – 12881N6-acetyllysine By similarity
Modified residuei1303 – 13031Phosphoserine By similarityBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6A026.
PaxDbiQ6A026.
PRIDEiQ6A026.

PTM databases

PhosphoSiteiQ6A026.

Expressioni

Gene expression databases

GenevestigatoriQ6A026.

Interactioni

Subunit structurei

Interacts with the cohesin complex. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63 By similarity.

Protein-protein interaction databases

IntActiQ6A026. 12 interactions.
STRINGi10090.ENSMUSP00000031104.

Structurei

3D structure databases

ProteinModelPortaliQ6A026.
SMRiQ6A026. Positions 77-104, 284-350, 885-971.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati392 – 42837HEATAdd
BLAST

Sequence similaritiesi

Belongs to the PDS5 family.
Contains 1 HEAT repeat.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG268017.
HOGENOMiHOG000230672.
HOVERGENiHBG108241.
InParanoidiQ6A026.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

Q6A026-1 [UniParc]FASTAAdd to Basket

« Hide

MDFTQPKPAT ALCGVVSADG KIAYPPGVKE ITDKITTDEM IKRLKMVVKT     50
FMDMDQDSED EKQQYLPLAL HLASEFFLRN PNKDVRLLVA CCLADIFRIY 100
APEAPYTSHD KLKDIFLFIT RQLKGLEDTK SPQFNRYFYL LENLAWVKSY 150
NICFELEDCN EIFIQLFRTL FSVINNSHNT KVQMHMLDLM SSIIMEGDGV 200
TQELLDSILI NLIPAHKNLN KQSFDLAKVL LKRTVQTIEA CIANFFNQVL 250
VLGRSSVSDL SEHVFDLIQE LFAIDPQLLL SVMPQLEFKL KSNDGEERLA 300
VVRLLAKLFG SKDSDLATQN RPLWQCFLGR FNDIHVPVRL ESVKFASHCL 350
MNHPDLAKDL TEYLKVRSHD PEEAIRHDVI VTIITAAKRD LALVNDQLLG 400
FVRERTLDKR WRVRKEAMMG LAQLYKKYCL HGEAGKEAAE KVSWIKDKLL 450
HIYYQNSIDD KLLVEKIFAQ YLVPHNLETE ERMKCLYYLY ASLDPNAVKA 500
LNEMWKCQNM LRSHVRELLD LHKQPTSEAN CSAMFGKLMT IAKNLPDPGK 550
AQDFVKKFNQ VLGDDEKLRS QLELLISPTC SCKQADVCVR EIARKLANPK 600
QPTNPFLEMV KFLLERIAPV HIDSEAISAL VKLMNKSIEG TADDEEEGVS 650
PDSAIRSGLE LLKVLSFTHP TSFHSAETYE SLLQCLRMED DKVAEAAIQI 700
FRNTGHKIET DLPQIRSTLI PILHQKAKRG TPHQAKQAVH CIHAIFSNKE 750
VQLAQIFEPL SRSLNADVPE QLITPLVSLG HISMLAPDQF ASPMKSVVAN 800
FIVKDLLMND RSTGEKNGKL WSPDEEVSPE VLAKVYLLRL LVRWLLGMKN 850
NQSKSANSTL RLLSAMLVSE GDLTEQKRIS KSDMSRLRLA AGSAIMKLAQ 900
EPCYHEIITP EQFQLCALVI NDECYQVRQI FAQKLHKALV KLLLPLEYMA 950
IFALCAKDPV KERRAHARQC LLKNISIRRE YIKQNPMATE KLLSLLPEYV 1000
VPYMIHLLAH DPDFTRSQDV DQLRDIKECL WFMLEVLMTK NENNSHAFMK 1050
KMAENIKLTR DAQSPDESKT NEKLYTVCDV ALCVINSKSA LCNADSPKDP 1100
VLPMKFFTQP EKDFCNDKSY ISEETRVLLL TGKPKPTGVL GTVNKPLSAT 1150
GRKPYVRSAG TETGSNINAN SELSPSAGSR SREQSSEASE TGVSENEENP 1200
VRIISVTPVK NIDTVKNKEI NSDQSTQGNI SSDRGKKRIV TAAGAENIQK 1250
PDEKVDESGP PAPSKPRRGR RPKSESQGNA TKNDDLNKPV SKGRKRAAGS 1300
QESLEAGNAK APKLQDGAKK AVPAERQIDL QR 1332
Length:1,332
Mass (Da):150,327
Last modified:July 27, 2011 - v3
Checksum:i0D6473650AC9D89B
GO

Sequence cautioni

The sequence BAD32270.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti557 – 5571K → E in BAD32270. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC112263 Genomic DNA. No translation available.
AK172992 Transcribed RNA. Translation: BAD32270.1. Different initiation.
CCDSiCCDS39099.1.
UniGeneiMm.278974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC112263 Genomic DNA. No translation available.
AK172992 Transcribed RNA. Translation: BAD32270.1 . Different initiation.
CCDSi CCDS39099.1.
UniGenei Mm.278974.

3D structure databases

ProteinModelPortali Q6A026.
SMRi Q6A026. Positions 77-104, 284-350, 885-971.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6A026. 12 interactions.
STRINGi 10090.ENSMUSP00000031104.

PTM databases

PhosphoSitei Q6A026.

Proteomic databases

MaxQBi Q6A026.
PaxDbi Q6A026.
PRIDEi Q6A026.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1918771. Pds5a.
Rougei Search...

Phylogenomic databases

eggNOGi NOG268017.
HOGENOMi HOG000230672.
HOVERGENi HBG108241.
InParanoidi Q6A026.

Miscellaneous databases

PROi Q6A026.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6A026.

Family and domain databases

Gene3Di 1.25.10.10. 5 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1112.
    Tissue: Embryonic intestine.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1145 AND LYS-1210, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiPDS5A_MOUSE
AccessioniPrimary (citable) accession number: Q6A026
Secondary accession number(s): E9Q656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi