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Q6A026

- PDS5A_MOUSE

UniProt

Q6A026 - PDS5A_MOUSE

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Protein

Sister chromatid cohesion protein PDS5 homolog A

Gene

Pds5a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair By similarity.By similarity

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. negative regulation of DNA replication Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog A
Gene namesi
Name:Pds5a
Synonyms:Kiaa0648Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1918771. Pds5a.

Subcellular locationi

Nucleus By similarity
Note: Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase By similarity.By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13321332Sister chromatid cohesion protein PDS5 homolog APRO_0000296342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei1145 – 11451N6-acetyllysine1 Publication
Modified residuei1194 – 11941PhosphoserineBy similarity
Modified residuei1207 – 12071PhosphothreonineBy similarity
Modified residuei1210 – 12101N6-acetyllysine1 Publication
Modified residuei1288 – 12881N6-acetyllysineBy similarity
Modified residuei1303 – 13031PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6A026.
PaxDbiQ6A026.
PRIDEiQ6A026.

PTM databases

PhosphoSiteiQ6A026.

Expressioni

Gene expression databases

GenevestigatoriQ6A026.

Interactioni

Subunit structurei

Interacts with the cohesin complex. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63 By similarity.By similarity

Protein-protein interaction databases

IntActiQ6A026. 12 interactions.
STRINGi10090.ENSMUSP00000031104.

Structurei

3D structure databases

ProteinModelPortaliQ6A026.
SMRiQ6A026. Positions 77-104, 284-350, 885-971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati392 – 42837HEATSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the PDS5 family.Curated
Contains 1 HEAT repeat.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG268017.
HOGENOMiHOG000230672.
HOVERGENiHBG108241.
InParanoidiQ6A026.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

Q6A026-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFTQPKPAT ALCGVVSADG KIAYPPGVKE ITDKITTDEM IKRLKMVVKT
60 70 80 90 100
FMDMDQDSED EKQQYLPLAL HLASEFFLRN PNKDVRLLVA CCLADIFRIY
110 120 130 140 150
APEAPYTSHD KLKDIFLFIT RQLKGLEDTK SPQFNRYFYL LENLAWVKSY
160 170 180 190 200
NICFELEDCN EIFIQLFRTL FSVINNSHNT KVQMHMLDLM SSIIMEGDGV
210 220 230 240 250
TQELLDSILI NLIPAHKNLN KQSFDLAKVL LKRTVQTIEA CIANFFNQVL
260 270 280 290 300
VLGRSSVSDL SEHVFDLIQE LFAIDPQLLL SVMPQLEFKL KSNDGEERLA
310 320 330 340 350
VVRLLAKLFG SKDSDLATQN RPLWQCFLGR FNDIHVPVRL ESVKFASHCL
360 370 380 390 400
MNHPDLAKDL TEYLKVRSHD PEEAIRHDVI VTIITAAKRD LALVNDQLLG
410 420 430 440 450
FVRERTLDKR WRVRKEAMMG LAQLYKKYCL HGEAGKEAAE KVSWIKDKLL
460 470 480 490 500
HIYYQNSIDD KLLVEKIFAQ YLVPHNLETE ERMKCLYYLY ASLDPNAVKA
510 520 530 540 550
LNEMWKCQNM LRSHVRELLD LHKQPTSEAN CSAMFGKLMT IAKNLPDPGK
560 570 580 590 600
AQDFVKKFNQ VLGDDEKLRS QLELLISPTC SCKQADVCVR EIARKLANPK
610 620 630 640 650
QPTNPFLEMV KFLLERIAPV HIDSEAISAL VKLMNKSIEG TADDEEEGVS
660 670 680 690 700
PDSAIRSGLE LLKVLSFTHP TSFHSAETYE SLLQCLRMED DKVAEAAIQI
710 720 730 740 750
FRNTGHKIET DLPQIRSTLI PILHQKAKRG TPHQAKQAVH CIHAIFSNKE
760 770 780 790 800
VQLAQIFEPL SRSLNADVPE QLITPLVSLG HISMLAPDQF ASPMKSVVAN
810 820 830 840 850
FIVKDLLMND RSTGEKNGKL WSPDEEVSPE VLAKVYLLRL LVRWLLGMKN
860 870 880 890 900
NQSKSANSTL RLLSAMLVSE GDLTEQKRIS KSDMSRLRLA AGSAIMKLAQ
910 920 930 940 950
EPCYHEIITP EQFQLCALVI NDECYQVRQI FAQKLHKALV KLLLPLEYMA
960 970 980 990 1000
IFALCAKDPV KERRAHARQC LLKNISIRRE YIKQNPMATE KLLSLLPEYV
1010 1020 1030 1040 1050
VPYMIHLLAH DPDFTRSQDV DQLRDIKECL WFMLEVLMTK NENNSHAFMK
1060 1070 1080 1090 1100
KMAENIKLTR DAQSPDESKT NEKLYTVCDV ALCVINSKSA LCNADSPKDP
1110 1120 1130 1140 1150
VLPMKFFTQP EKDFCNDKSY ISEETRVLLL TGKPKPTGVL GTVNKPLSAT
1160 1170 1180 1190 1200
GRKPYVRSAG TETGSNINAN SELSPSAGSR SREQSSEASE TGVSENEENP
1210 1220 1230 1240 1250
VRIISVTPVK NIDTVKNKEI NSDQSTQGNI SSDRGKKRIV TAAGAENIQK
1260 1270 1280 1290 1300
PDEKVDESGP PAPSKPRRGR RPKSESQGNA TKNDDLNKPV SKGRKRAAGS
1310 1320 1330
QESLEAGNAK APKLQDGAKK AVPAERQIDL QR
Length:1,332
Mass (Da):150,327
Last modified:July 27, 2011 - v3
Checksum:i0D6473650AC9D89B
GO

Sequence cautioni

The sequence BAD32270.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti557 – 5571K → E in BAD32270. (PubMed:15368895)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC112263 Genomic DNA. No translation available.
AK172992 Transcribed RNA. Translation: BAD32270.1. Different initiation.
CCDSiCCDS39099.1.
UniGeneiMm.278974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC112263 Genomic DNA. No translation available.
AK172992 Transcribed RNA. Translation: BAD32270.1 . Different initiation.
CCDSi CCDS39099.1.
UniGenei Mm.278974.

3D structure databases

ProteinModelPortali Q6A026.
SMRi Q6A026. Positions 77-104, 284-350, 885-971.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6A026. 12 interactions.
STRINGi 10090.ENSMUSP00000031104.

PTM databases

PhosphoSitei Q6A026.

Proteomic databases

MaxQBi Q6A026.
PaxDbi Q6A026.
PRIDEi Q6A026.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1918771. Pds5a.
Rougei Search...

Phylogenomic databases

eggNOGi NOG268017.
HOGENOMi HOG000230672.
HOVERGENi HBG108241.
InParanoidi Q6A026.

Miscellaneous databases

PROi Q6A026.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6A026.

Family and domain databases

Gene3Di 1.25.10.10. 5 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1112.
    Tissue: Embryonic intestineImported.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1145 AND LYS-1210, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiPDS5A_MOUSE
AccessioniPrimary (citable) accession number: Q6A026
Secondary accession number(s): E9Q656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3