Q6A026 (PDS5A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sister chromatid cohesion protein PDS5 homolog A

Gene names

Name:	Pds5a
Synonyms:	Kiaa0648

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair By similarity.
Subunit structure	Interacts with the cohesin complex. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63 By similarity.
Subcellular location	Nucleus By similarity. Note: Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase By similarity. UniProtKB Q29RF7
Sequence similarities	Belongs to the PDS5 family. Contains 1 HEAT repeat.
Sequence caution	The sequence BAD32270.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Nucleus
Domain	Repeat
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of DNA replication Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1332	1332	Sister chromatid cohesion protein PDS5 homolog A		PRO_0000296342
Regions
	Repeat	392 – 428	37	HEAT
Amino acid modifications
	Modified residue	1145	1	N6-acetyllysine By similarity
	Modified residue	1194	1	Phosphoserine By similarity
	Modified residue	1207	1	Phosphothreonine By similarity UniProtKB Q29RF7
	Modified residue	1210	1	N6-acetyllysine By similarity
	Modified residue	1288	1	N6-acetyllysine By similarity
	Modified residue	1303	1	Phosphoserine By similarity UniProtKB Q29RF7
Experimental info
	Sequence conflict	557	1	K → E in BAD32270. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q6A026 [UniParc]. Last modified July 27, 2011. Version 3. Checksum: 0D6473650AC9D89B	FASTA	1,332	150,327
	10 20 30 40 50 60 MDFTQPKPAT ALCGVVSADG KIAYPPGVKE ITDKITTDEM IKRLKMVVKT FMDMDQDSED 70 80 90 100 110 120 EKQQYLPLAL HLASEFFLRN PNKDVRLLVA CCLADIFRIY APEAPYTSHD KLKDIFLFIT 130 140 150 160 170 180 RQLKGLEDTK SPQFNRYFYL LENLAWVKSY NICFELEDCN EIFIQLFRTL FSVINNSHNT 190 200 210 220 230 240 KVQMHMLDLM SSIIMEGDGV TQELLDSILI NLIPAHKNLN KQSFDLAKVL LKRTVQTIEA 250 260 270 280 290 300 CIANFFNQVL VLGRSSVSDL SEHVFDLIQE LFAIDPQLLL SVMPQLEFKL KSNDGEERLA 310 320 330 340 350 360 VVRLLAKLFG SKDSDLATQN RPLWQCFLGR FNDIHVPVRL ESVKFASHCL MNHPDLAKDL 370 380 390 400 410 420 TEYLKVRSHD PEEAIRHDVI VTIITAAKRD LALVNDQLLG FVRERTLDKR WRVRKEAMMG 430 440 450 460 470 480 LAQLYKKYCL HGEAGKEAAE KVSWIKDKLL HIYYQNSIDD KLLVEKIFAQ YLVPHNLETE 490 500 510 520 530 540 ERMKCLYYLY ASLDPNAVKA LNEMWKCQNM LRSHVRELLD LHKQPTSEAN CSAMFGKLMT 550 560 570 580 590 600 IAKNLPDPGK AQDFVKKFNQ VLGDDEKLRS QLELLISPTC SCKQADVCVR EIARKLANPK 610 620 630 640 650 660 QPTNPFLEMV KFLLERIAPV HIDSEAISAL VKLMNKSIEG TADDEEEGVS PDSAIRSGLE 670 680 690 700 710 720 LLKVLSFTHP TSFHSAETYE SLLQCLRMED DKVAEAAIQI FRNTGHKIET DLPQIRSTLI 730 740 750 760 770 780 PILHQKAKRG TPHQAKQAVH CIHAIFSNKE VQLAQIFEPL SRSLNADVPE QLITPLVSLG 790 800 810 820 830 840 HISMLAPDQF ASPMKSVVAN FIVKDLLMND RSTGEKNGKL WSPDEEVSPE VLAKVYLLRL 850 860 870 880 890 900 LVRWLLGMKN NQSKSANSTL RLLSAMLVSE GDLTEQKRIS KSDMSRLRLA AGSAIMKLAQ 910 920 930 940 950 960 EPCYHEIITP EQFQLCALVI NDECYQVRQI FAQKLHKALV KLLLPLEYMA IFALCAKDPV 970 980 990 1000 1010 1020 KERRAHARQC LLKNISIRRE YIKQNPMATE KLLSLLPEYV VPYMIHLLAH DPDFTRSQDV 1030 1040 1050 1060 1070 1080 DQLRDIKECL WFMLEVLMTK NENNSHAFMK KMAENIKLTR DAQSPDESKT NEKLYTVCDV 1090 1100 1110 1120 1130 1140 ALCVINSKSA LCNADSPKDP VLPMKFFTQP EKDFCNDKSY ISEETRVLLL TGKPKPTGVL 1150 1160 1170 1180 1190 1200 GTVNKPLSAT GRKPYVRSAG TETGSNINAN SELSPSAGSR SREQSSEASE TGVSENEENP 1210 1220 1230 1240 1250 1260 VRIISVTPVK NIDTVKNKEI NSDQSTQGNI SSDRGKKRIV TAAGAENIQK PDEKVDESGP 1270 1280 1290 1300 1310 1320 PAPSKPRRGR RPKSESQGNA TKNDDLNKPV SKGRKRAAGS QESLEAGNAK APKLQDGAKK 1330 AVPAERQIDL QR

References

[1]

"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.

[2]

"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H. DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1112. Tissue: Embryonic intestine.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC112263 Genomic DNA. No translation available. AK172992 Transcribed RNA. Translation: BAD32270.1. Different initiation.
IPI	IPI00669709.
UniGene	Mm.278974.
3D structure databases
ProteinModelPortal	Q6A026.
SMR	Q6A026. Positions 283-309, 680-705.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6A026. 12 interactions.
STRING	10090.ENSMUSP00000031104.
PTM databases
PhosphoSite	Q6A026.
Proteomic databases
PaxDb	Q6A026.
PRIDE	Q6A026.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc008xnw.1. mouse.
Organism-specific databases
MGI	MGI:1918771. Pds5a.
Rouge	Search...
Phylogenomic databases
eggNOG	NOG268017.
HOGENOM	HOG000230672.
HOVERGEN	HBG108241.
InParanoid	Q6A026.
OrthoDB	EOG46T30N.
Gene expression databases
Genevestigator	Q6A026.
Family and domain databases
Gene3D	1.25.10.10. 5 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50077. HEAT_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

PDS5A_MOUSE

Accession

Primary (citable) accession number: Q6A026
Secondary accession number(s): E9Q656

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program