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Q6A026

- PDS5A_MOUSE

UniProt

Q6A026 - PDS5A_MOUSE

Protein

Sister chromatid cohesion protein PDS5 homolog A

Gene

Pds5a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair By similarity.By similarity

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. negative regulation of DNA replication Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sister chromatid cohesion protein PDS5 homolog A
    Gene namesi
    Name:Pds5a
    Synonyms:Kiaa0648Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1918771. Pds5a.

    Subcellular locationi

    Nucleus By similarity
    Note: Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase By similarity.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13321332Sister chromatid cohesion protein PDS5 homolog APRO_0000296342Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei1145 – 11451N6-acetyllysine1 Publication
    Modified residuei1194 – 11941PhosphoserineBy similarity
    Modified residuei1207 – 12071PhosphothreonineBy similarity
    Modified residuei1210 – 12101N6-acetyllysine1 Publication
    Modified residuei1288 – 12881N6-acetyllysineBy similarity
    Modified residuei1303 – 13031PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ6A026.
    PaxDbiQ6A026.
    PRIDEiQ6A026.

    PTM databases

    PhosphoSiteiQ6A026.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6A026.

    Interactioni

    Subunit structurei

    Interacts with the cohesin complex. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ6A026. 12 interactions.
    STRINGi10090.ENSMUSP00000031104.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6A026.
    SMRiQ6A026. Positions 77-104, 284-350, 885-971.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati392 – 42837HEATSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PDS5 family.Curated
    Contains 1 HEAT repeat.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG268017.
    HOGENOMiHOG000230672.
    HOVERGENiHBG108241.
    InParanoidiQ6A026.

    Family and domain databases

    Gene3Di1.25.10.10. 5 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 4 hits.

    Sequencei

    Sequence statusi: Complete.

    Q6A026-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFTQPKPAT ALCGVVSADG KIAYPPGVKE ITDKITTDEM IKRLKMVVKT     50
    FMDMDQDSED EKQQYLPLAL HLASEFFLRN PNKDVRLLVA CCLADIFRIY 100
    APEAPYTSHD KLKDIFLFIT RQLKGLEDTK SPQFNRYFYL LENLAWVKSY 150
    NICFELEDCN EIFIQLFRTL FSVINNSHNT KVQMHMLDLM SSIIMEGDGV 200
    TQELLDSILI NLIPAHKNLN KQSFDLAKVL LKRTVQTIEA CIANFFNQVL 250
    VLGRSSVSDL SEHVFDLIQE LFAIDPQLLL SVMPQLEFKL KSNDGEERLA 300
    VVRLLAKLFG SKDSDLATQN RPLWQCFLGR FNDIHVPVRL ESVKFASHCL 350
    MNHPDLAKDL TEYLKVRSHD PEEAIRHDVI VTIITAAKRD LALVNDQLLG 400
    FVRERTLDKR WRVRKEAMMG LAQLYKKYCL HGEAGKEAAE KVSWIKDKLL 450
    HIYYQNSIDD KLLVEKIFAQ YLVPHNLETE ERMKCLYYLY ASLDPNAVKA 500
    LNEMWKCQNM LRSHVRELLD LHKQPTSEAN CSAMFGKLMT IAKNLPDPGK 550
    AQDFVKKFNQ VLGDDEKLRS QLELLISPTC SCKQADVCVR EIARKLANPK 600
    QPTNPFLEMV KFLLERIAPV HIDSEAISAL VKLMNKSIEG TADDEEEGVS 650
    PDSAIRSGLE LLKVLSFTHP TSFHSAETYE SLLQCLRMED DKVAEAAIQI 700
    FRNTGHKIET DLPQIRSTLI PILHQKAKRG TPHQAKQAVH CIHAIFSNKE 750
    VQLAQIFEPL SRSLNADVPE QLITPLVSLG HISMLAPDQF ASPMKSVVAN 800
    FIVKDLLMND RSTGEKNGKL WSPDEEVSPE VLAKVYLLRL LVRWLLGMKN 850
    NQSKSANSTL RLLSAMLVSE GDLTEQKRIS KSDMSRLRLA AGSAIMKLAQ 900
    EPCYHEIITP EQFQLCALVI NDECYQVRQI FAQKLHKALV KLLLPLEYMA 950
    IFALCAKDPV KERRAHARQC LLKNISIRRE YIKQNPMATE KLLSLLPEYV 1000
    VPYMIHLLAH DPDFTRSQDV DQLRDIKECL WFMLEVLMTK NENNSHAFMK 1050
    KMAENIKLTR DAQSPDESKT NEKLYTVCDV ALCVINSKSA LCNADSPKDP 1100
    VLPMKFFTQP EKDFCNDKSY ISEETRVLLL TGKPKPTGVL GTVNKPLSAT 1150
    GRKPYVRSAG TETGSNINAN SELSPSAGSR SREQSSEASE TGVSENEENP 1200
    VRIISVTPVK NIDTVKNKEI NSDQSTQGNI SSDRGKKRIV TAAGAENIQK 1250
    PDEKVDESGP PAPSKPRRGR RPKSESQGNA TKNDDLNKPV SKGRKRAAGS 1300
    QESLEAGNAK APKLQDGAKK AVPAERQIDL QR 1332
    Length:1,332
    Mass (Da):150,327
    Last modified:July 27, 2011 - v3
    Checksum:i0D6473650AC9D89B
    GO

    Sequence cautioni

    The sequence BAD32270.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti557 – 5571K → E in BAD32270. (PubMed:15368895)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC112263 Genomic DNA. No translation available.
    AK172992 Transcribed RNA. Translation: BAD32270.1. Different initiation.
    CCDSiCCDS39099.1.
    UniGeneiMm.278974.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC112263 Genomic DNA. No translation available.
    AK172992 Transcribed RNA. Translation: BAD32270.1 . Different initiation.
    CCDSi CCDS39099.1.
    UniGenei Mm.278974.

    3D structure databases

    ProteinModelPortali Q6A026.
    SMRi Q6A026. Positions 77-104, 284-350, 885-971.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6A026. 12 interactions.
    STRINGi 10090.ENSMUSP00000031104.

    PTM databases

    PhosphoSitei Q6A026.

    Proteomic databases

    MaxQBi Q6A026.
    PaxDbi Q6A026.
    PRIDEi Q6A026.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1918771. Pds5a.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG268017.
    HOGENOMi HOG000230672.
    HOVERGENi HBG108241.
    InParanoidi Q6A026.

    Miscellaneous databases

    PROi Q6A026.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q6A026.

    Family and domain databases

    Gene3Di 1.25.10.10. 5 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 4 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1112.
      Tissue: Embryonic intestineImported.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1145 AND LYS-1210, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiPDS5A_MOUSE
    AccessioniPrimary (citable) accession number: Q6A026
    Secondary accession number(s): E9Q656
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 80 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3