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Protein

Transmembrane and coiled-coil domains protein 1

Gene

Tmcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domains protein 1
Gene namesi
Name:Tmcc1
Synonyms:Kiaa0779
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2442368. Tmcc1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 587CytoplasmicSequence analysisAdd BLAST587
Transmembranei588 – 608HelicalSequence analysisAdd BLAST21
Transmembranei621 – 641HelicalSequence analysisAdd BLAST21
Topological domaini642 – 649CytoplasmicSequence analysis8

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001845961 – 649Transmembrane and coiled-coil domains protein 1Add BLAST649

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei378PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ69ZZ6.
PRIDEiQ69ZZ6.

PTM databases

iPTMnetiQ69ZZ6.
PhosphoSitePlusiQ69ZZ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030126.
CleanExiMM_TMCC1.
ExpressionAtlasiQ69ZZ6. baseline and differential.
GenevisibleiQ69ZZ6. MM.

Interactioni

Subunit structurei

May form homo- or heterodimers with other TMCC proteins via the coiled-coil domains. Interacts with ribosomal proteins RPL4 and RPS6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086285.

Structurei

3D structure databases

ProteinModelPortaliQ69ZZ6.
SMRiQ69ZZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili224 – 310Sequence analysisAdd BLAST87
Coiled coili457 – 566Sequence analysisAdd BLAST110

Sequence similaritiesi

Belongs to the TEX28 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3850. Eukaryota.
ENOG410Y9KV. LUCA.
GeneTreeiENSGT00390000007639.
HOGENOMiHOG000294160.
HOVERGENiHBG057342.
InParanoidiQ69ZZ6.
PhylomeDBiQ69ZZ6.
TreeFamiTF316292.

Family and domain databases

InterProiView protein in InterPro
IPR019394. TEX28/TMCC.
PANTHERiPTHR17613. PTHR17613. 1 hit.
PfamiView protein in Pfam
PF10267. Tmemb_cc2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69ZZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPSGSEQLY EDPDPGGKSQ DAEARRQTES EQKLSKMTHN ALENINVIGQ
60 70 80 90 100
GLKHLFQHQR RRSSVSPHDV QQIQTDPEPE VDLDSQNACA EIDGVSTHPT
110 120 130 140 150
ALNRVLQQIR VPPKMKRGTS LHSRRGKSEA PKGSPQINRK SGQEVAAVIQ
160 170 180 190 200
SGRPRSSSTT DAPTSSSVME IACAAGVCVP GEEATAERIE RLEVSSLAQT
210 220 230 240 250
SSAVASSTDG SIHTESVDGI PDPQRTKAAI AHLQQKILKL TEQIKIAQTA
260 270 280 290 300
RDDNVAEYLK LANSADKQQA ARIKQVFEKK NQKSAQTILQ LQKKLEHYHR
310 320 330 340 350
KLREVEQNGI PRQPKDVFRD MHQGLKDVGA KVTGFSEGVV DSVKGGFSSF
360 370 380 390 400
SQATHSAAGA VVSKPREIAS LIRNKFGSAD NIPNLKDSLE EGQVDDGGKA
410 420 430 440 450
LGVISNFQSS PKYGSEEDCS SATSGSVGAN STTGGIAVGA SSSKTNTLDM
460 470 480 490 500
QSSGFDALLH EVQEIRETQA RLEDSFETLK EHYQRDYSLI MQTLQEERYR
510 520 530 540 550
CERLEEQLND LTELHQNEIL NLKQELASME EKIAYQSYER ARDIQEALEA
560 570 580 590 600
CQTRISKMEL QQQQQQVVQL EGLENATARN LLGKLINILL AVMAVLLVFV
610 620 630 640
STVANCVVPL MKTRNRTFST LFLVAFIAFL WKHWDALFSY VDRLFSPPR
Length:649
Mass (Da):71,642
Last modified:November 22, 2005 - v2
Checksum:i6A7E07076CD3BF08
GO
Isoform 2 (identifier: Q69ZZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.
     176-188: GVCVPGEEATAER → MVQRFSLRRQLSK

Note: No experimental confirmation available.
Show »
Length:474
Mass (Da):52,922
Checksum:iB9A6B4CF9CF85A92
GO
Isoform 3 (identifier: Q69ZZ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-320: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):36,413
Checksum:iD914BB2AE70819E2
GO

Sequence cautioni

Q69ZZ6: The sequence BAD32300 differs from that shown. Reason: Erroneous initiation.Curated
Q69ZZ6: The sequence BAE32665 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0195891 – 320Missing in isoform 3. 1 PublicationAdd BLAST320
Alternative sequenceiVSP_0195901 – 175Missing in isoform 2. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_019591176 – 188GVCVP…ATAER → MVQRFSLRRQLSK in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173022 mRNA. Translation: BAD32300.1. Different initiation.
AK028322 mRNA. Translation: BAC25880.1.
AK154540 mRNA. Translation: BAE32665.1. Different initiation.
CCDSiCCDS51881.1. [Q69ZZ6-1]
RefSeqiNP_803131.1. NM_177412.1. [Q69ZZ6-1]
XP_006506371.1. XM_006506308.2. [Q69ZZ6-1]
XP_006506373.1. XM_006506310.1. [Q69ZZ6-2]
XP_006506377.1. XM_006506314.3. [Q69ZZ6-3]
XP_017177146.1. XM_017321657.1. [Q69ZZ6-3]
UniGeneiMm.425352.
Mm.477923.

Genome annotation databases

EnsembliENSMUST00000088896; ENSMUSP00000086285; ENSMUSG00000030126. [Q69ZZ6-1]
ENSMUST00000172510; ENSMUSP00000133665; ENSMUSG00000030126. [Q69ZZ6-3]
ENSMUST00000173140; ENSMUSP00000134455; ENSMUSG00000030126. [Q69ZZ6-3]
ENSMUST00000204353; ENSMUSP00000144971; ENSMUSG00000030126. [Q69ZZ6-2]
GeneIDi330401.
KEGGimmu:330401.
UCSCiuc009djo.2. mouse. [Q69ZZ6-1]
uc009djp.2. mouse. [Q69ZZ6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTMCC1_MOUSE
AccessioniPrimary (citable) accession number: Q69ZZ6
Secondary accession number(s): Q8CEF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 27, 2017
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families