Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Actin-binding LIM protein 3

Gene

Ablim3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-binding LIM protein 3
Short name:
abLIM-3
Alternative name(s):
Actin-binding LIM protein family member 3
Gene namesi
Name:Ablim3
Synonyms:Kiaa0843
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2442582. Ablim3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757031 – 682Actin-binding LIM protein 3Add BLAST682

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei277PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei282PhosphoserineCombined sources1
Modified residuei286PhosphoserineBy similarity1
Modified residuei290PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei376PhosphotyrosineBy similarity1
Modified residuei379PhosphoserineCombined sources1
Modified residuei388PhosphoserineBy similarity1
Modified residuei492PhosphoserineBy similarity1
Modified residuei502PhosphoserineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei542PhosphothreonineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei606PhosphoserineCombined sources1
Modified residuei630Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ69ZX8.
PaxDbiQ69ZX8.
PeptideAtlasiQ69ZX8.
PRIDEiQ69ZX8.

PTM databases

iPTMnetiQ69ZX8.
PhosphoSitePlusiQ69ZX8.

Expressioni

Tissue specificityi

Expressed in heart, brain, lung and liver. In the brain, highly expressed in the olfactory bulb. In the hippocampus, expressed selectively in the CA2 and CA3 fields. In the cerebellum, expressed in internal granular cells.1 Publication

Developmental stagei

At 15.5 dpc, expressed in skeletal muscle. Down-regulated in adult skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000032735.
CleanExiMM_ABLIM3.
GenevisibleiQ69ZX8. MM.

Interactioni

Subunit structurei

Directly interacts with F-actin and ABRA.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041243.

Structurei

3D structure databases

ProteinModelPortaliQ69ZX8.
SMRiQ69ZX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 80LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini80 – 140LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini149 – 208LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini208 – 268LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST61
Domaini614 – 682HPPROSITE-ProRule annotationAdd BLAST69

Sequence similaritiesi

Contains 1 HP (headpiece) domain.PROSITE-ProRule annotation
Contains 4 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1044. Eukaryota.
ENOG410XRPY. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000285997.
HOVERGENiHBG031499.
InParanoidiQ69ZX8.
KOiK07520.
OMAiDPYYASE.
OrthoDBiEOG091G025W.
PhylomeDBiQ69ZX8.
TreeFamiTF318042.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
2.10.110.10. 4 hits.
InterProiIPR028449. ABLIM3.
IPR032402. AbLIM_anchor.
IPR003128. Villin_headpiece.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24213:SF0. PTHR24213:SF0. 1 hit.
PfamiPF16182. AbLIM_anchor. 1 hit.
PF00412. LIM. 4 hits.
PF02209. VHP. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q69ZX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSIPYQQS PYSPRGGSNV IQCYRCGDTC KGEVVRVHNN HFHIRCFTCQ
60 70 80 90 100
VCGCGLAQSG FFFKNQEYIC TQDYQQLYGT RCDSCRDFIT GEVISALGRT
110 120 130 140 150
YHPKCFVCSL CRKPFPIGDK VTFSGKECVC QTCSQSMTSS KPIKIRGPSH
160 170 180 190 200
CAGCKEEIKH GQSLLALDKQ WHVSCFKCQT CSVILTGEYI SKDGVPYCES
210 220 230 240 250
DYHSQFGIKC ETCDRYISGR VLEAGGKHYH PTCARCVRCH QMFTEGEEMY
260 270 280 290 300
LTGSEVWHPI CKQAARAEKK LKHRRTSETS ISPPGSSIGS PNRVICAKVD
310 320 330 340 350
NEILNYKDLA ALPKVKSIYE VQRPDLISYE PHSRYTSDEM LERCGYGESL
360 370 380 390 400
GTLSPYSQDI YENLDLRQRR ASSPGYIDSP TYSRQGMSPT FSRSPHYYRS
410 420 430 440 450
GPESGRSSPY HSQLDVRSST PTSYQAPKHF HIPAGESNIY RKPPIYKRHG
460 470 480 490 500
DLSTATKSKT SEDISQASKY SPAYSPDPYY ASESEYWTYH GSPKVPRARR
510 520 530 540 550
FSSGGEEEDF DRSMHKLQSG IGRLILKEEM KARSSSYADP WTPPRSSTSS
560 570 580 590 600
REALHTTGYE MSFNGSPRSH YLADSDPLIS KSASLPAYRR NGLHRTPSAD
610 620 630 640 650
LFHYDSMNAV NWGMREYKIY PYELLLVTTR GRNRLPKDVD RTRLERHLSQ
660 670 680
EEFYQVFGMT ISEFERLALW KRNELKKQAR LF
Length:682
Mass (Da):77,630
Last modified:December 7, 2004 - v2
Checksum:i44E7E59BD850F9CE
GO

Sequence cautioni

The sequence BAD32318 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti381T → I in AAH60275 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173040 mRNA. Translation: BAD32318.1. Different initiation.
BC060275 mRNA. Translation: AAH60275.1.
BC094229 mRNA. Translation: AAH94229.1.
CCDSiCCDS37839.1.
RefSeqiNP_001157963.1. NM_001164491.1.
NP_941051.2. NM_198649.3.
UniGeneiMm.329478.

Genome annotation databases

EnsembliENSMUST00000049378; ENSMUSP00000041243; ENSMUSG00000032735.
ENSMUST00000166783; ENSMUSP00000125836; ENSMUSG00000032735.
GeneIDi319713.
KEGGimmu:319713.
UCSCiuc008fct.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173040 mRNA. Translation: BAD32318.1. Different initiation.
BC060275 mRNA. Translation: AAH60275.1.
BC094229 mRNA. Translation: AAH94229.1.
CCDSiCCDS37839.1.
RefSeqiNP_001157963.1. NM_001164491.1.
NP_941051.2. NM_198649.3.
UniGeneiMm.329478.

3D structure databases

ProteinModelPortaliQ69ZX8.
SMRiQ69ZX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041243.

PTM databases

iPTMnetiQ69ZX8.
PhosphoSitePlusiQ69ZX8.

Proteomic databases

MaxQBiQ69ZX8.
PaxDbiQ69ZX8.
PeptideAtlasiQ69ZX8.
PRIDEiQ69ZX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049378; ENSMUSP00000041243; ENSMUSG00000032735.
ENSMUST00000166783; ENSMUSP00000125836; ENSMUSG00000032735.
GeneIDi319713.
KEGGimmu:319713.
UCSCiuc008fct.2. mouse.

Organism-specific databases

CTDi22885.
MGIiMGI:2442582. Ablim3.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1044. Eukaryota.
ENOG410XRPY. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000285997.
HOVERGENiHBG031499.
InParanoidiQ69ZX8.
KOiK07520.
OMAiDPYYASE.
OrthoDBiEOG091G025W.
PhylomeDBiQ69ZX8.
TreeFamiTF318042.

Miscellaneous databases

PROiQ69ZX8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032735.
CleanExiMM_ABLIM3.
GenevisibleiQ69ZX8. MM.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
2.10.110.10. 4 hits.
InterProiIPR028449. ABLIM3.
IPR032402. AbLIM_anchor.
IPR003128. Villin_headpiece.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24213:SF0. PTHR24213:SF0. 1 hit.
PfamiPF16182. AbLIM_anchor. 1 hit.
PF00412. LIM. 4 hits.
PF02209. VHP. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABLM3_MOUSE
AccessioniPrimary (citable) accession number: Q69ZX8
Secondary accession number(s): Q52KR1, Q6PAI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.