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Protein
Submitted name:

MKIAA0846 protein

Gene

Rasgrp3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi435 – 446PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi464 – 475PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • GTPase activator activity Source: MGI
  • kinase binding Source: MGI
  • Ras GTPase binding Source: MGI
  • Ras guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  • Ras protein signal transduction Source: MGI
  • regulation of GTPase activity Source: MGI

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotation
LigandCalciumPROSITE-ProRule annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
MKIAA0846 proteinImported
Gene namesi
Name:Rasgrp3Imported
Synonyms:mKIAA0846Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:3028579 Rasgrp3

Subcellular locationi

Interactioni

GO - Molecular functioni

  • kinase binding Source: MGI
  • Ras GTPase binding Source: MGI
  • Ras guanyl-nucleotide exchange factor activity Source: MGI

Structurei

3D structure databases

ProteinModelPortaliQ69ZX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 127N-terminal Ras-GEFInterPro annotationAdd BLAST123
Domaini154 – 385Ras-GEFInterPro annotationAdd BLAST232
Domaini422 – 457EF-handInterPro annotationAdd BLAST36
Domaini460 – 486EF-handInterPro annotationAdd BLAST27
Domaini496 – 546Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51

Phylogenomic databases

eggNOGiENOG410KD39 Eukaryota
ENOG410XTGZ LUCA
HOGENOMiHOG000293171
HOVERGENiHBG007513
PhylomeDBiQ69ZX7

Family and domain databases

CDDicd00029 C1, 1 hit
cd00051 EFh, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029645 RASGRP1/RASGRP3
PANTHERiPTHR23113:SF178 PTHR23113:SF178, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF13202 EF-hand_5, 2 hits
PF00617 RasGEF, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00054 EFh, 2 hits
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q69ZX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RTMGSNGLGK AATLDELLST CIEMFDDNGD LNDSYLPRIV LLMHRWYLSS
60 70 80 90 100
TELAGKLLCM YRNASGESCD EFRLKICYFM RYWILKFPAE FNLDLGLIRM
110 120 130 140 150
TEEFREVASQ LGHEKHISLM DISSVPSYDW MRRVTQRKKV SKRGKACLLF
160 170 180 190 200
DHLEPIELAE HLTFLEHKSF RRISFTDYQS YVIHGCLENN PTLERSIALF
210 220 230 240 250
NGISKWVQLM VLSKPSAQQR AEVITKFINV AQKLLQLKNF NTLMAVVGGL
260 270 280 290 300
SHSSISRLKD THSHLSSEVT KNWNEMTELV SSNGNYCNYR KAFADCDGFK
310 320 330 340 350
IPILGVHLKD LIAVHVIFPD WMEENKVNVV KMHQLSVTLS ELVSLQNASH
360 370 380 390 400
HLEPNMDLIN LLTLSLDLYH TEDDIYKLSL VLEPRNSKSQ PTSPTTPNKP
410 420 430 440 450
VVPLEWASEV VPKPDPTIIN KHIRKLVESV FRNYDHDHDG YISQEDFESI
460 470 480 490 500
AANFPFLDSF CVLDKDQDGL ISKDEMMAYF LRAKSQLHCK MGPGFIHNFQ
510 520 530 540 550
EMNYLKPTFC EHCAGFLWGI IKQGYKCKDC GANCHKQCKD LLVLACRRLA
560 570 580 590 600
RAPSLSSNPG SLPGSPALPP VQDEVFEFPG VTAGHRDLDS RAITLVTGSS
610 620 630 640 650
RKISVRLQRA TTSQATQTEP VWSEAVWGDS GSHTFPKMKS KFHDKAAKDK
660 670 680 690
GFAKWENEKP TVQAGVDVVD RGTAFEPDQD DGQDEAKQGG EDG
Length:693
Mass (Da):78,407
Last modified:September 13, 2004 - v1
Checksum:i705C4824EF5A1AA8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173041 mRNA Translation: BAD32319.1
UniGeneiMm.329203

Similar proteinsi

Entry informationi

Entry nameiQ69ZX7_MOUSE
AccessioniPrimary (citable) accession number: Q69ZX7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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