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Protein
Submitted name:

MKIAA0846 protein

Gene

Rasgrp3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. kinase binding Source: MGI
  3. Rap GTPase activator activity Source: MGI
  4. Ras GTPase binding Source: MGI
  5. Ras guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  1. positive regulation of Rap GTPase activity Source: MGI
  2. Ras protein signal transduction Source: MGI
  3. regulation of GTPase activity Source: MGI
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_199122. Activation of RAS in B cells.

Names & Taxonomyi

Protein namesi
Submitted name:
MKIAA0846 proteinImported
Gene namesi
Name:Rasgrp3Imported
Synonyms:mKIAA0846Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:3028579. Rasgrp3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. guanyl-nucleotide exchange factor complex Source: MGI
  3. perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ69ZX7.
ExpressionAtlasiQ69ZX7. baseline and differential.
GenevestigatoriQ69ZX7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092828.

Structurei

3D structure databases

ProteinModelPortaliQ69ZX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains Ras-GEF domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000293171.
HOVERGENiHBG007513.
PhylomeDBiQ69ZX7.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.840.10. 1 hit.
InterProiIPR020454. DAG/PE-bd.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029645. RASGRP3.
[Graphical view]
PANTHERiPTHR23113:SF178. PTHR23113:SF178. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13405. EF-hand_6. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00054. EFh. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q69ZX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RTMGSNGLGK AATLDELLST CIEMFDDNGD LNDSYLPRIV LLMHRWYLSS
60 70 80 90 100
TELAGKLLCM YRNASGESCD EFRLKICYFM RYWILKFPAE FNLDLGLIRM
110 120 130 140 150
TEEFREVASQ LGHEKHISLM DISSVPSYDW MRRVTQRKKV SKRGKACLLF
160 170 180 190 200
DHLEPIELAE HLTFLEHKSF RRISFTDYQS YVIHGCLENN PTLERSIALF
210 220 230 240 250
NGISKWVQLM VLSKPSAQQR AEVITKFINV AQKLLQLKNF NTLMAVVGGL
260 270 280 290 300
SHSSISRLKD THSHLSSEVT KNWNEMTELV SSNGNYCNYR KAFADCDGFK
310 320 330 340 350
IPILGVHLKD LIAVHVIFPD WMEENKVNVV KMHQLSVTLS ELVSLQNASH
360 370 380 390 400
HLEPNMDLIN LLTLSLDLYH TEDDIYKLSL VLEPRNSKSQ PTSPTTPNKP
410 420 430 440 450
VVPLEWASEV VPKPDPTIIN KHIRKLVESV FRNYDHDHDG YISQEDFESI
460 470 480 490 500
AANFPFLDSF CVLDKDQDGL ISKDEMMAYF LRAKSQLHCK MGPGFIHNFQ
510 520 530 540 550
EMNYLKPTFC EHCAGFLWGI IKQGYKCKDC GANCHKQCKD LLVLACRRLA
560 570 580 590 600
RAPSLSSNPG SLPGSPALPP VQDEVFEFPG VTAGHRDLDS RAITLVTGSS
610 620 630 640 650
RKISVRLQRA TTSQATQTEP VWSEAVWGDS GSHTFPKMKS KFHDKAAKDK
660 670 680 690
GFAKWENEKP TVQAGVDVVD RGTAFEPDQD DGQDEAKQGG EDG
Length:693
Mass (Da):78,407
Last modified:September 13, 2004 - v1
Checksum:i705C4824EF5A1AA8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173041 mRNA. Translation: BAD32319.1.
UniGeneiMm.329203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173041 mRNA. Translation: BAD32319.1.
UniGeneiMm.329203.

3D structure databases

ProteinModelPortaliQ69ZX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:3028579. Rasgrp3.

Phylogenomic databases

HOGENOMiHOG000293171.
HOVERGENiHBG007513.
PhylomeDBiQ69ZX7.

Enzyme and pathway databases

ReactomeiREACT_199122. Activation of RAS in B cells.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ69ZX7.
ExpressionAtlasiQ69ZX7. baseline and differential.
GenevestigatoriQ69ZX7.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.840.10. 1 hit.
InterProiIPR020454. DAG/PE-bd.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029645. RASGRP3.
[Graphical view]
PANTHERiPTHR23113:SF178. PTHR23113:SF178. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13405. EF-hand_6. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00054. EFh. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Fetal brainImported.

Entry informationi

Entry nameiQ69ZX7_MOUSE
AccessioniPrimary (citable) accession number: Q69ZX7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: February 4, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.