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Q69ZX7

- Q69ZX7_MOUSE

UniProt

Q69ZX7 - Q69ZX7_MOUSE

Protein
Submitted name:

MKIAA0846 protein

Gene

Rasgrp3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (13 Sep 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. kinase binding Source: MGI
    3. Rap GTPase activator activity Source: Ensembl
    4. Ras GTPase binding Source: MGI
    5. Ras guanyl-nucleotide exchange factor activity Source: MGI

    GO - Biological processi

    1. Ras protein signal transduction Source: MGI
    2. regulation of GTPase activity Source: MGI

    Keywords - Ligandi

    CalciumUniRule annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_199122. Activation of RAS in B cells.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MKIAA0846 proteinImported
    Gene namesi
    Name:Rasgrp3Imported
    Synonyms:mKIAA0846Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:3028579. Rasgrp3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. guanyl-nucleotide exchange factor complex Source: MGI
    3. perinuclear region of cytoplasm Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiQ69ZX7.
    BgeeiQ69ZX7.
    GenevestigatoriQ69ZX7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000092828.

    Structurei

    3D structure databases

    ProteinModelPortaliQ69ZX7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains Ras-GEF domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000293171.
    HOVERGENiHBG007513.
    InParanoidiQ69ZX7.
    PhylomeDBiQ69ZX7.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.840.10. 1 hit.
    InterProiIPR020454. DAG/PE-bd.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF13202. EF-hand_5. 1 hit.
    PF13405. EF-hand_6. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    PRINTSiPR00008. DAGPEDOMAIN.
    SMARTiSM00109. C1. 1 hit.
    SM00054. EFh. 2 hits.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q69ZX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    RTMGSNGLGK AATLDELLST CIEMFDDNGD LNDSYLPRIV LLMHRWYLSS    50
    TELAGKLLCM YRNASGESCD EFRLKICYFM RYWILKFPAE FNLDLGLIRM 100
    TEEFREVASQ LGHEKHISLM DISSVPSYDW MRRVTQRKKV SKRGKACLLF 150
    DHLEPIELAE HLTFLEHKSF RRISFTDYQS YVIHGCLENN PTLERSIALF 200
    NGISKWVQLM VLSKPSAQQR AEVITKFINV AQKLLQLKNF NTLMAVVGGL 250
    SHSSISRLKD THSHLSSEVT KNWNEMTELV SSNGNYCNYR KAFADCDGFK 300
    IPILGVHLKD LIAVHVIFPD WMEENKVNVV KMHQLSVTLS ELVSLQNASH 350
    HLEPNMDLIN LLTLSLDLYH TEDDIYKLSL VLEPRNSKSQ PTSPTTPNKP 400
    VVPLEWASEV VPKPDPTIIN KHIRKLVESV FRNYDHDHDG YISQEDFESI 450
    AANFPFLDSF CVLDKDQDGL ISKDEMMAYF LRAKSQLHCK MGPGFIHNFQ 500
    EMNYLKPTFC EHCAGFLWGI IKQGYKCKDC GANCHKQCKD LLVLACRRLA 550
    RAPSLSSNPG SLPGSPALPP VQDEVFEFPG VTAGHRDLDS RAITLVTGSS 600
    RKISVRLQRA TTSQATQTEP VWSEAVWGDS GSHTFPKMKS KFHDKAAKDK 650
    GFAKWENEKP TVQAGVDVVD RGTAFEPDQD DGQDEAKQGG EDG 693
    Length:693
    Mass (Da):78,407
    Last modified:September 13, 2004 - v1
    Checksum:i705C4824EF5A1AA8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK173041 mRNA. Translation: BAD32319.1.
    UniGeneiMm.329203.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK173041 mRNA. Translation: BAD32319.1 .
    UniGenei Mm.329203.

    3D structure databases

    ProteinModelPortali Q69ZX7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000092828.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:3028579. Rasgrp3.

    Phylogenomic databases

    HOGENOMi HOG000293171.
    HOVERGENi HBG007513.
    InParanoidi Q69ZX7.
    PhylomeDBi Q69ZX7.

    Enzyme and pathway databases

    Reactomei REACT_199122. Activation of RAS in B cells.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q69ZX7.
    Bgeei Q69ZX7.
    Genevestigatori Q69ZX7.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.840.10. 1 hit.
    InterProi IPR020454. DAG/PE-bd.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF13202. EF-hand_5. 1 hit.
    PF13405. EF-hand_6. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00008. DAGPEDOMAIN.
    SMARTi SM00109. C1. 1 hit.
    SM00054. EFh. 2 hits.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Fetal brainImported.

    Entry informationi

    Entry nameiQ69ZX7_MOUSE
    AccessioniPrimary (citable) accession number: Q69ZX7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 13, 2004
    Last sequence update: September 13, 2004
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)