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Q69ZX7

- Q69ZX7_MOUSE

UniProt

Q69ZX7 - Q69ZX7_MOUSE

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Protein
Submitted name: MKIAA0846 protein
Gene
Rasgrp3, mKIAA0846
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Rap GTPase activator activity Source: Ensembl
  2. Ras GTPase binding Source: MGI
  3. Ras guanyl-nucleotide exchange factor activity Source: MGI
  4. calcium ion binding Source: InterPro
  5. kinase binding Source: MGI

GO - Biological processi

  1. Ras protein signal transduction Source: MGI
  2. regulation of GTPase activity Source: MGI
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingSAAS annotations, ZincSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_199122. Activation of RAS in B cells.

Names & Taxonomyi

Protein namesi
Submitted name:
MKIAA0846 proteinImported
Gene namesi
Name:Rasgrp3Imported
Synonyms:mKIAA0846Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:3028579. Rasgrp3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. guanyl-nucleotide exchange factor complex Source: MGI
  3. perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiQ69ZX7.
BgeeiQ69ZX7.
GenevestigatoriQ69ZX7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092828.

Structurei

3D structure databases

ProteinModelPortaliQ69ZX7.

Family & Domainsi

Sequence similaritiesi

Contains Ras-GEF domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000293171.
HOVERGENiHBG007513.
InParanoidiQ69ZX7.
PhylomeDBiQ69ZX7.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.840.10. 1 hit.
InterProiIPR020454. DAG/PE-bd.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13405. EF-hand_6. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00054. EFh. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q69ZX7-1 [UniParc]FASTAAdd to Basket

« Hide

RTMGSNGLGK AATLDELLST CIEMFDDNGD LNDSYLPRIV LLMHRWYLSS    50
TELAGKLLCM YRNASGESCD EFRLKICYFM RYWILKFPAE FNLDLGLIRM 100
TEEFREVASQ LGHEKHISLM DISSVPSYDW MRRVTQRKKV SKRGKACLLF 150
DHLEPIELAE HLTFLEHKSF RRISFTDYQS YVIHGCLENN PTLERSIALF 200
NGISKWVQLM VLSKPSAQQR AEVITKFINV AQKLLQLKNF NTLMAVVGGL 250
SHSSISRLKD THSHLSSEVT KNWNEMTELV SSNGNYCNYR KAFADCDGFK 300
IPILGVHLKD LIAVHVIFPD WMEENKVNVV KMHQLSVTLS ELVSLQNASH 350
HLEPNMDLIN LLTLSLDLYH TEDDIYKLSL VLEPRNSKSQ PTSPTTPNKP 400
VVPLEWASEV VPKPDPTIIN KHIRKLVESV FRNYDHDHDG YISQEDFESI 450
AANFPFLDSF CVLDKDQDGL ISKDEMMAYF LRAKSQLHCK MGPGFIHNFQ 500
EMNYLKPTFC EHCAGFLWGI IKQGYKCKDC GANCHKQCKD LLVLACRRLA 550
RAPSLSSNPG SLPGSPALPP VQDEVFEFPG VTAGHRDLDS RAITLVTGSS 600
RKISVRLQRA TTSQATQTEP VWSEAVWGDS GSHTFPKMKS KFHDKAAKDK 650
GFAKWENEKP TVQAGVDVVD RGTAFEPDQD DGQDEAKQGG EDG 693
Length:693
Mass (Da):78,407
Last modified:September 13, 2004 - v1
Checksum:i705C4824EF5A1AA8
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK173041 mRNA. Translation: BAD32319.1.
UniGeneiMm.329203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK173041 mRNA. Translation: BAD32319.1 .
UniGenei Mm.329203.

3D structure databases

ProteinModelPortali Q69ZX7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000092828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:3028579. Rasgrp3.

Phylogenomic databases

HOGENOMi HOG000293171.
HOVERGENi HBG007513.
InParanoidi Q69ZX7.
PhylomeDBi Q69ZX7.

Enzyme and pathway databases

Reactomei REACT_199122. Activation of RAS in B cells.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

ArrayExpressi Q69ZX7.
Bgeei Q69ZX7.
Genevestigatori Q69ZX7.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.840.10. 1 hit.
InterProi IPR020454. DAG/PE-bd.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13405. EF-hand_6. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view ]
PRINTSi PR00008. DAGPEDOMAIN.
SMARTi SM00109. C1. 1 hit.
SM00054. EFh. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Fetal brainImported.

Entry informationi

Entry nameiQ69ZX7_MOUSE
AccessioniPrimary (citable) accession number: Q69ZX7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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