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Protein

HBS1-like protein

Gene

Hbs1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi265 – 272GTPBy similarity8
Nucleotide bindingi342 – 346GTPBy similarity5
Nucleotide bindingi404 – 407GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: MGI
  • translation elongation factor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-429958. mRNA decay by 3' to 5' exoribonuclease.

Names & Taxonomyi

Protein namesi
Recommended name:
HBS1-like protein
Gene namesi
Name:Hbs1l
Synonyms:Hbs1, Kiaa1038
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1891704. Hbs1l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000914921 – 682HBS1-like proteinAdd BLAST682

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei148PhosphoserineCombined sources1
Modified residuei150PhosphoserineCombined sources1
Modified residuei229PhosphothreonineBy similarity1
Modified residuei620N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ69ZS7.
PaxDbiQ69ZS7.
PeptideAtlasiQ69ZS7.
PRIDEiQ69ZS7.

PTM databases

iPTMnetiQ69ZS7.
PhosphoSitePlusiQ69ZS7.

Expressioni

Tissue specificityi

Detected in embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000019977.
CleanExiMM_HBS1L.
ExpressionAtlasiQ69ZS7. baseline and differential.
GenevisibleiQ69ZS7. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-61684N.
STRINGi10090.ENSMUSP00000020153.

Structurei

Secondary structure

1682
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi51 – 57Combined sources7
Helixi63 – 68Combined sources6
Helixi71 – 87Combined sources17
Turni88 – 91Combined sources4
Helixi94 – 103Combined sources10
Helixi108 – 120Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UFZNMR-A51-120[»]
ProteinModelPortaliQ69ZS7.
SMRiQ69ZS7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ69ZS7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini256 – 480tr-type GPROSITE-ProRule annotationAdd BLAST225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 272G1PROSITE-ProRule annotation8
Regioni321 – 325G2PROSITE-ProRule annotation5
Regioni342 – 345G3PROSITE-ProRule annotation4
Regioni404 – 407G4PROSITE-ProRule annotation4
Regioni443 – 445G5PROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0458. Eukaryota.
COG5256. LUCA.
GeneTreeiENSGT00620000087924.
HOGENOMiHOG000229291.
HOVERGENiHBG000179.
InParanoidiQ69ZS7.
KOiK14416.
OMAiEPRRGFE.
OrthoDBiEOG091G0637.
PhylomeDBiQ69ZS7.
TreeFamiTF105833.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR015033. HBS1-like_N.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03143. GTP_EFTU_D3. 1 hit.
PF08938. HBS1_N. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
ProDomiPD278081. DUF1916. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69ZS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARHRNVRGY NYDEDFEDDD LYGQSVEDDY CISPSTAAQF IYSRRDNPEE
60 70 80 90 100
EYGYEDLRES SNSLLNHQLS EIDQARLYSC LDHMREVLGD AVPDDILTEA
110 120 130 140 150
ILKHKFDVQK ALSVVLEQDG VQPWKEKSER AVCAGQPSKG KSVISRSSQS
160 170 180 190 200
ESEIVPKVAK MTVSGKKQTM GFEVPGLTSE ENGLSVRAPH KGPPGDDVSV
210 220 230 240 250
ASPNIPETGT PKSALPPPSL QTSEELGSTP TPVRKSGKLR QQIDVKAELE
260 270 280 290 300
KRQGGKQLLN LVVIGHVDAG KSTLMGHMLY LLGNVNKRTM HKYEQESKKA
310 320 330 340 350
GKASFAYAWV LDETGEERER GVTMDVGMTK FETTTKVITL MDAPGHKDFI
360 370 380 390 400
PNMITGAAQA DVAVLVVDAS RGEFEAGFET GGQTREHGLL VRSLGVTQLA
410 420 430 440 450
VAVNKMDQVN WQQERFQEIT GKLGHFLKQA GFKESDVAFI PTSGLSGENL
460 470 480 490 500
TARSQSSDLT TWYKGMCLLE QIDSFKPPQR SIDKPFRLCV SDVFKDQGSG
510 520 530 540 550
FCVTGKIEAG YIQTGDRLLA MPPNETCTAK GITLHDEPVD WAAAGDHVNL
560 570 580 590 600
TLVGMDIIKI NVGCIFCGPK EPIKACTRFR ARILVFNIEV PITKGFPVLL
610 620 630 640 650
HYQTVSEPAV IKRLISVLNK STGEVTKKKP KLLTKGQNAL VELQTQRPVA
660 670 680
LELYKDFKEL GRFMLRYGGS TVAAGVVTEI KE
Length:682
Mass (Da):75,100
Last modified:May 10, 2005 - v2
Checksum:i53ADD45EC0872968
GO
Isoform 2 (identifier: Q69ZS7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:599
Mass (Da):65,283
Checksum:i2EEF947861C1A394
GO
Isoform 3 (identifier: Q69ZS7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-167: KSVISRSSQSESEIVPKVAKMTVSGKK → VLFSSFGVSPQNVHHSYLQSENHLDSS
     168-682: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:167
Mass (Da):19,077
Checksum:i4AD3CC16A2C7E645
GO

Sequence cautioni

The sequence BAD32369 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201A → R in AAD23351 (PubMed:9872408).Curated1
Sequence conflicti251 – 252KR → NAV in AAD23351 (PubMed:9872408).Curated2
Sequence conflicti568G → A in AAH10251 (PubMed:16141072).Curated1
Isoform 3 (identifier: Q69ZS7-3)
Sequence conflicti146F → L in BAB24679 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0136261 – 83Missing in isoform 2. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_013627141 – 167KSVIS…VSGKK → VLFSSFGVSPQNVHHSYLQS ENHLDSS in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_013628168 – 682Missing in isoform 3. 1 PublicationAdd BLAST515

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087672 mRNA. Translation: AAD23351.1.
AK173091 mRNA. Translation: BAD32369.1. Different initiation.
AK006626 mRNA. Translation: BAB24679.1.
AK012856 mRNA. Translation: BAB28515.1.
BC010251 mRNA. Translation: AAH10251.1.
CCDSiCCDS35862.1. [Q69ZS7-1]
RefSeqiNP_062676.2. NM_019702.2. [Q69ZS7-1]
UniGeneiMm.25527.

Genome annotation databases

EnsembliENSMUST00000020153; ENSMUSP00000020153; ENSMUSG00000019977. [Q69ZS7-1]
GeneIDi56422.
KEGGimmu:56422.
UCSCiuc007eom.1. mouse. [Q69ZS7-3]
uc007eoo.1. mouse. [Q69ZS7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087672 mRNA. Translation: AAD23351.1.
AK173091 mRNA. Translation: BAD32369.1. Different initiation.
AK006626 mRNA. Translation: BAB24679.1.
AK012856 mRNA. Translation: BAB28515.1.
BC010251 mRNA. Translation: AAH10251.1.
CCDSiCCDS35862.1. [Q69ZS7-1]
RefSeqiNP_062676.2. NM_019702.2. [Q69ZS7-1]
UniGeneiMm.25527.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UFZNMR-A51-120[»]
ProteinModelPortaliQ69ZS7.
SMRiQ69ZS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61684N.
STRINGi10090.ENSMUSP00000020153.

PTM databases

iPTMnetiQ69ZS7.
PhosphoSitePlusiQ69ZS7.

Proteomic databases

EPDiQ69ZS7.
PaxDbiQ69ZS7.
PeptideAtlasiQ69ZS7.
PRIDEiQ69ZS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020153; ENSMUSP00000020153; ENSMUSG00000019977. [Q69ZS7-1]
GeneIDi56422.
KEGGimmu:56422.
UCSCiuc007eom.1. mouse. [Q69ZS7-3]
uc007eoo.1. mouse. [Q69ZS7-1]

Organism-specific databases

CTDi10767.
MGIiMGI:1891704. Hbs1l.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0458. Eukaryota.
COG5256. LUCA.
GeneTreeiENSGT00620000087924.
HOGENOMiHOG000229291.
HOVERGENiHBG000179.
InParanoidiQ69ZS7.
KOiK14416.
OMAiEPRRGFE.
OrthoDBiEOG091G0637.
PhylomeDBiQ69ZS7.
TreeFamiTF105833.

Enzyme and pathway databases

ReactomeiR-MMU-429958. mRNA decay by 3' to 5' exoribonuclease.

Miscellaneous databases

EvolutionaryTraceiQ69ZS7.
PROiQ69ZS7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019977.
CleanExiMM_HBS1L.
ExpressionAtlasiQ69ZS7. baseline and differential.
GenevisibleiQ69ZS7. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR015033. HBS1-like_N.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03143. GTP_EFTU_D3. 1 hit.
PF08938. HBS1_N. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
ProDomiPD278081. DUF1916. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBS1L_MOUSE
AccessioniPrimary (citable) accession number: Q69ZS7
Secondary accession number(s): Q91Z32
, Q9CVT2, Q9CZ95, Q9WTY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.