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Protein

HBS1-like protein

Gene

Hbs1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi265 – 2728GTPBy similarity
Nucleotide bindingi342 – 3465GTPBy similarity
Nucleotide bindingi404 – 4074GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: MGI
  • translation elongation factor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HBS1-like protein
Gene namesi
Name:Hbs1l
Synonyms:Hbs1, Kiaa1038
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1891704. Hbs1l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 682682HBS1-like proteinPRO_0000091492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631PhosphoserineBy similarity
Modified residuei113 – 1131PhosphoserineBy similarity
Modified residuei148 – 1481PhosphoserineCombined sources
Modified residuei150 – 1501PhosphoserineCombined sources
Modified residuei229 – 2291PhosphothreonineBy similarity
Modified residuei620 – 6201N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ69ZS7.
MaxQBiQ69ZS7.
PaxDbiQ69ZS7.
PeptideAtlasiQ69ZS7.
PRIDEiQ69ZS7.

PTM databases

iPTMnetiQ69ZS7.
PhosphoSiteiQ69ZS7.

Expressioni

Tissue specificityi

Detected in embryos.1 Publication

Gene expression databases

BgeeiENSMUSG00000019977.
CleanExiMM_HBS1L.
ExpressionAtlasiQ69ZS7. baseline and differential.
GenevisibleiQ69ZS7. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-61684N.
STRINGi10090.ENSMUSP00000020153.

Structurei

Secondary structure

1
682
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi51 – 577Combined sources
Helixi63 – 686Combined sources
Helixi71 – 8717Combined sources
Turni88 – 914Combined sources
Helixi94 – 10310Combined sources
Helixi108 – 12013Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UFZNMR-A51-120[»]
ProteinModelPortaliQ69ZS7.
SMRiQ69ZS7. Positions 56-123, 256-680.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ69ZS7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini256 – 480225tr-type GPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 2728G1PROSITE-ProRule annotation
Regioni321 – 3255G2PROSITE-ProRule annotation
Regioni342 – 3454G3PROSITE-ProRule annotation
Regioni404 – 4074G4PROSITE-ProRule annotation
Regioni443 – 4453G5PROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.PROSITE-ProRule annotation
Contains 1 tr-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0458. Eukaryota.
COG5256. LUCA.
GeneTreeiENSGT00620000087924.
HOGENOMiHOG000229291.
HOVERGENiHBG000179.
InParanoidiQ69ZS7.
KOiK14416.
OMAiEPRRGFE.
OrthoDBiEOG091G0637.
PhylomeDBiQ69ZS7.
TreeFamiTF105833.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR015033. HBS1-like_N.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03143. GTP_EFTU_D3. 1 hit.
PF08938. HBS1_N. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
ProDomiPD278081. DUF1916. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69ZS7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARHRNVRGY NYDEDFEDDD LYGQSVEDDY CISPSTAAQF IYSRRDNPEE
60 70 80 90 100
EYGYEDLRES SNSLLNHQLS EIDQARLYSC LDHMREVLGD AVPDDILTEA
110 120 130 140 150
ILKHKFDVQK ALSVVLEQDG VQPWKEKSER AVCAGQPSKG KSVISRSSQS
160 170 180 190 200
ESEIVPKVAK MTVSGKKQTM GFEVPGLTSE ENGLSVRAPH KGPPGDDVSV
210 220 230 240 250
ASPNIPETGT PKSALPPPSL QTSEELGSTP TPVRKSGKLR QQIDVKAELE
260 270 280 290 300
KRQGGKQLLN LVVIGHVDAG KSTLMGHMLY LLGNVNKRTM HKYEQESKKA
310 320 330 340 350
GKASFAYAWV LDETGEERER GVTMDVGMTK FETTTKVITL MDAPGHKDFI
360 370 380 390 400
PNMITGAAQA DVAVLVVDAS RGEFEAGFET GGQTREHGLL VRSLGVTQLA
410 420 430 440 450
VAVNKMDQVN WQQERFQEIT GKLGHFLKQA GFKESDVAFI PTSGLSGENL
460 470 480 490 500
TARSQSSDLT TWYKGMCLLE QIDSFKPPQR SIDKPFRLCV SDVFKDQGSG
510 520 530 540 550
FCVTGKIEAG YIQTGDRLLA MPPNETCTAK GITLHDEPVD WAAAGDHVNL
560 570 580 590 600
TLVGMDIIKI NVGCIFCGPK EPIKACTRFR ARILVFNIEV PITKGFPVLL
610 620 630 640 650
HYQTVSEPAV IKRLISVLNK STGEVTKKKP KLLTKGQNAL VELQTQRPVA
660 670 680
LELYKDFKEL GRFMLRYGGS TVAAGVVTEI KE
Length:682
Mass (Da):75,100
Last modified:May 10, 2005 - v2
Checksum:i53ADD45EC0872968
GO
Isoform 2 (identifier: Q69ZS7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:599
Mass (Da):65,283
Checksum:i2EEF947861C1A394
GO
Isoform 3 (identifier: Q69ZS7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-167: KSVISRSSQSESEIVPKVAKMTVSGKK → VLFSSFGVSPQNVHHSYLQSENHLDSS
     168-682: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:167
Mass (Da):19,077
Checksum:i4AD3CC16A2C7E645
GO

Sequence cautioni

The sequence BAD32369 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011A → R in AAD23351 (PubMed:9872408).Curated
Sequence conflicti251 – 2522KR → NAV in AAD23351 (PubMed:9872408).Curated
Sequence conflicti568 – 5681G → A in AAH10251 (PubMed:16141072).Curated
Isoform 3 (identifier: Q69ZS7-3)
Sequence conflicti146 – 1461F → L in BAB24679 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8383Missing in isoform 2. 1 PublicationVSP_013626Add
BLAST
Alternative sequencei141 – 16727KSVIS…VSGKK → VLFSSFGVSPQNVHHSYLQS ENHLDSS in isoform 3. 1 PublicationVSP_013627Add
BLAST
Alternative sequencei168 – 682515Missing in isoform 3. 1 PublicationVSP_013628Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087672 mRNA. Translation: AAD23351.1.
AK173091 mRNA. Translation: BAD32369.1. Different initiation.
AK006626 mRNA. Translation: BAB24679.1.
AK012856 mRNA. Translation: BAB28515.1.
BC010251 mRNA. Translation: AAH10251.1.
CCDSiCCDS35862.1. [Q69ZS7-1]
RefSeqiNP_062676.2. NM_019702.2. [Q69ZS7-1]
UniGeneiMm.25527.

Genome annotation databases

EnsembliENSMUST00000020153; ENSMUSP00000020153; ENSMUSG00000019977. [Q69ZS7-1]
GeneIDi56422.
KEGGimmu:56422.
UCSCiuc007eom.1. mouse. [Q69ZS7-3]
uc007eoo.1. mouse. [Q69ZS7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087672 mRNA. Translation: AAD23351.1.
AK173091 mRNA. Translation: BAD32369.1. Different initiation.
AK006626 mRNA. Translation: BAB24679.1.
AK012856 mRNA. Translation: BAB28515.1.
BC010251 mRNA. Translation: AAH10251.1.
CCDSiCCDS35862.1. [Q69ZS7-1]
RefSeqiNP_062676.2. NM_019702.2. [Q69ZS7-1]
UniGeneiMm.25527.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UFZNMR-A51-120[»]
ProteinModelPortaliQ69ZS7.
SMRiQ69ZS7. Positions 56-123, 256-680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61684N.
STRINGi10090.ENSMUSP00000020153.

PTM databases

iPTMnetiQ69ZS7.
PhosphoSiteiQ69ZS7.

Proteomic databases

EPDiQ69ZS7.
MaxQBiQ69ZS7.
PaxDbiQ69ZS7.
PeptideAtlasiQ69ZS7.
PRIDEiQ69ZS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020153; ENSMUSP00000020153; ENSMUSG00000019977. [Q69ZS7-1]
GeneIDi56422.
KEGGimmu:56422.
UCSCiuc007eom.1. mouse. [Q69ZS7-3]
uc007eoo.1. mouse. [Q69ZS7-1]

Organism-specific databases

CTDi10767.
MGIiMGI:1891704. Hbs1l.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0458. Eukaryota.
COG5256. LUCA.
GeneTreeiENSGT00620000087924.
HOGENOMiHOG000229291.
HOVERGENiHBG000179.
InParanoidiQ69ZS7.
KOiK14416.
OMAiEPRRGFE.
OrthoDBiEOG091G0637.
PhylomeDBiQ69ZS7.
TreeFamiTF105833.

Miscellaneous databases

EvolutionaryTraceiQ69ZS7.
PROiQ69ZS7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019977.
CleanExiMM_HBS1L.
ExpressionAtlasiQ69ZS7. baseline and differential.
GenevisibleiQ69ZS7. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR015033. HBS1-like_N.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03143. GTP_EFTU_D3. 1 hit.
PF08938. HBS1_N. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
ProDomiPD278081. DUF1916. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBS1L_MOUSE
AccessioniPrimary (citable) accession number: Q69ZS7
Secondary accession number(s): Q91Z32
, Q9CVT2, Q9CZ95, Q9WTY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.