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Protein

Synaptic vesicle glycoprotein 2C

Gene

Sv2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).By similarity
Receptor for the botulinium neurotoxin type A/BOTA.2 Publications

GO - Molecular functioni

GO - Biological processi

  • neurotransmitter transport Source: UniProtKB-KW
  • synaptic transmission Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Neurotransmitter transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2C
Short name:
Synaptic vesicle protein 2C
Gene namesi
Name:Sv2c
Synonyms:Kiaa1054
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1922459. Sv2c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 154154CytoplasmicSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 19116ExtracellularSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Topological domaini213 – 22614CytoplasmicSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST
Topological domaini248 – 2481ExtracellularSequence analysis
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Topological domaini270 – 28011CytoplasmicSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Topological domaini302 – 32019ExtracellularSequence analysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence analysisAdd
BLAST
Topological domaini342 – 43796CytoplasmicSequence analysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence analysisAdd
BLAST
Topological domaini459 – 578120ExtracellularSequence analysisAdd
BLAST
Transmembranei579 – 59921HelicalSequence analysisAdd
BLAST
Topological domaini600 – 60910CytoplasmicSequence analysis
Transmembranei610 – 63021HelicalSequence analysisAdd
BLAST
Topological domaini631 – 6366ExtracellularSequence analysis
Transmembranei637 – 65721HelicalSequence analysisAdd
BLAST
Topological domaini658 – 67013CytoplasmicSequence analysisAdd
BLAST
Transmembranei671 – 69323HelicalSequence analysisAdd
BLAST
Topological domaini694 – 6974ExtracellularSequence analysis
Transmembranei698 – 71619HelicalSequence analysisAdd
BLAST
Topological domaini717 – 72711CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • synaptic vesicle Source: MGI
  • synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Synaptic vesicle glycoprotein 2CPRO_0000239772Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence analysis
Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence analysis
Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence analysis
Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ69ZS6.
PaxDbiQ69ZS6.
PRIDEiQ69ZS6.

PTM databases

iPTMnetiQ69ZS6.
PhosphoSiteiQ69ZS6.

Expressioni

Tissue specificityi

Expressed in specific subsets of conventional synapses in the retina (at protein level).1 Publication

Developmental stagei

Expressed during synaptogenesis in the retina (at protein level).1 Publication

Inductioni

Up-regulated upon Sv2a depletion.1 Publication

Gene expression databases

BgeeiQ69ZS6.
CleanExiMM_SV2C.
ExpressionAtlasiQ69ZS6. baseline and differential.
GenevisibleiQ69ZS6. MM.

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-dependent manner.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124473.

Structurei

3D structure databases

ProteinModelPortaliQ69ZS6.
SMRiQ69ZS6. Positions 182-365, 473-565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5757Interaction with SYT1By similarityAdd
BLAST
Regioni529 – 56638BOTA-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ69ZS6.
KOiK06258.
OMAiDFEPYKF.
OrthoDBiEOG74TWZ1.
PhylomeDBiQ69ZS6.
TreeFamiTF324824.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q69ZS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSYKDRTS LMKGAKDIAK EVKKQTVKKV NQAVDRAQDE YTQRSYSRFQ
60 70 80 90 100
DEEDDDDYYP PGETYSGEVN DDEGSSEATE GHDEEDEIYE GEYQGIPSTN
110 120 130 140 150
QGKDSIVSVG QPKGDEYKDR RELESERRAD EEELAQQYEL IIQECGHGRF
160 170 180 190 200
QWALFFVLGM ALMADGVEVF VVGFVLPSAE TDLCIPNSGS GWLGSIVYLG
210 220 230 240 250
MMVGAFFWGG LADKVGRKQS LLICMSVNGF FAFLSSFVQG YGFFLVCRLL
260 270 280 290 300
SGFGIGGAIP TVFSYFAEVL AREKRGEHLS WLCMFWMIGG IYASAMAWAI
310 320 330 340 350
IPHYGWSFSM GSAYQFHSWR VFVIVCALPC VSSVVALTFM PESPRFLLEV
360 370 380 390 400
GKHDEAWMIL KLIHDTNMRA RGQPEKVFTV NKIKTPKQID ELIEIESDTG
410 420 430 440 450
TWYRRCFVRI RTELYGIWLT FMRCFNYPVR ENTIKLTIVW FTLSFGYYGL
460 470 480 490 500
SVWFPDVIKH LQSDEYALLT RNVQKDKYAN FSINFTMENQ IHTGMEYENG
510 520 530 540 550
RFLGVKFKSV TFKDSVFKSC TFDDVTSVNT YFKNCTFIDT LFDNTDFEPY
560 570 580 590 600
KFIDSEFQNC SFLHNKTGCQ ITFDDDYSAY WIYFVNFLGT LAVLPGNIVS
610 620 630 640 650
ALLMDRIGRL TMLGGSMVLS GISCFFLWFG TSESMMIGML CLYNGLTISA
660 670 680 690 700
WNSLDVVTVE LYPTDRRATG FGFLNALCKA AAVLGNLIFG SLVSITKAIP
710 720
ILLASTVLVC GGLVGLRLPD TRTQVLM
Length:727
Mass (Da):82,291
Last modified:June 13, 2006 - v2
Checksum:iE1D78203D4E3183A
GO

Sequence cautioni

The sequence BAD32370.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173092 mRNA. Translation: BAD32370.1. Different initiation.
CCDSiCCDS49333.1.
RefSeqiNP_083486.1. NM_029210.1.
UniGeneiMm.40436.

Genome annotation databases

EnsembliENSMUST00000161263; ENSMUSP00000124473; ENSMUSG00000051111.
GeneIDi75209.
KEGGimmu:75209.
UCSCiuc007rmt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173092 mRNA. Translation: BAD32370.1. Different initiation.
CCDSiCCDS49333.1.
RefSeqiNP_083486.1. NM_029210.1.
UniGeneiMm.40436.

3D structure databases

ProteinModelPortaliQ69ZS6.
SMRiQ69ZS6. Positions 182-365, 473-565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124473.

PTM databases

iPTMnetiQ69ZS6.
PhosphoSiteiQ69ZS6.

Proteomic databases

MaxQBiQ69ZS6.
PaxDbiQ69ZS6.
PRIDEiQ69ZS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161263; ENSMUSP00000124473; ENSMUSG00000051111.
GeneIDi75209.
KEGGimmu:75209.
UCSCiuc007rmt.2. mouse.

Organism-specific databases

CTDi22987.
MGIiMGI:1922459. Sv2c.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
ENOG410YQME. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ69ZS6.
KOiK06258.
OMAiDFEPYKF.
OrthoDBiEOG74TWZ1.
PhylomeDBiQ69ZS6.
TreeFamiTF324824.

Miscellaneous databases

ChiTaRSiSv2c. mouse.
NextBioi342458.
PROiQ69ZS6.
SOURCEiSearch...

Gene expression databases

BgeeiQ69ZS6.
CleanExiMM_SV2C.
ExpressionAtlasiQ69ZS6. baseline and differential.
GenevisibleiQ69ZS6. MM.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. "SV2 modulates the size of the readily releasable pool of secretory vesicles."
    Xu T., Bajjalieh S.M.
    Nat. Cell Biol. 3:691-698(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  3. "Differential distribution and developmental expression of synaptic vesicle protein 2 isoforms in the mouse retina."
    Wang M.M., Janz R., Belizaire R., Frishman L.J., Sherry D.M.
    J. Comp. Neurol. 460:106-122(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. "The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves."
    Mahrhold S., Rummel A., Bigalke H., Davletov B., Binz T.
    FEBS Lett. 580:2011-2014(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A BOTA RECEPTOR.
  5. "SV2 is the protein receptor for botulinum neurotoxin A."
    Dong M., Yeh F., Tepp W.H., Dean C., Johnson E.A., Janz R., Chapman E.R.
    Science 312:592-596(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A BOTA RECEPTOR.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiSV2C_MOUSE
AccessioniPrimary (citable) accession number: Q69ZS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: February 17, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.