ID   Q69ZQ8_MOUSE            Unreviewed;       512 AA.
AC   Q69ZQ8;
DT   13-SEP-2004, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2004, sequence version 1.
DT   24-JAN-2024, entry version 127.
DE   SubName: Full=MKIAA1144 protein {ECO:0000313|EMBL:BAD32388.1};
DE   Flags: Fragment;
GN   Name=Kcns2 {ECO:0000313|MGI:MGI:1197011};
GN   Synonyms=mKIAA1144 {ECO:0000313|EMBL:BAD32388.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:BAD32388.1};
RN   [1] {ECO:0000313|EMBL:BAD32388.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Fetal brain {ECO:0000313|EMBL:BAD32388.1};
RX   PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA   Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 11:205-218(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK173110; BAD32388.1; -; mRNA.
DR   RefSeq; NP_851834.1; NM_181317.4.
DR   AlphaFoldDB; Q69ZQ8; -.
DR   DNASU; 16539; -.
DR   GeneID; 16539; -.
DR   AGR; MGI:1197011; -.
DR   CTD; 3788; -.
DR   MGI; MGI:1197011; Kcns2.
DR   OrthoDB; 1478695at2759; -.
DR   BioGRID-ORCS; 16539; 1 hit in 77 CRISPR screens.
DR   ChiTaRS; Kcns2; mouse.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   CDD; cd18427; BTB_POZ_KCNS2; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR11537:SF60; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY S MEMBER 2; 1.
DR   PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01494; KV9CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   Genevisible; Q69ZQ8; MM.
PE   2: Evidence at transcript level;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|ARBA:ARBA00022958};
KW   Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW   Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   TRANSMEM        223..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        295..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        367..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        424..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          52..161
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|SMART:SM00225"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD32388.1"
SQ   SEQUENCE   512 AA;  57710 MW;  34B5298F4B02D0C8 CRC64;
     CLPAGRGSFP PASAAGSRAP RCSAPARRGR LGISSMTRQS LWDVSDTDVE DGEIRINVGG
     FKRRLRSHTL LRFPETRLGR LLLCHSREAI LELCDDYDDV QREFYFDRNP ELFPYVLHFY
     HTGKLHVMAE LCVFSFSQEI EYWGINEFFI DSCCSYSYHG RKVEPEQEKW DEQSDQESTT
     SSFDEILAFY NDASKFDGQP LGNFRRQLWL ALDNPGYSVL SRVFSVLSIL VVLGSIITMC
     LNSLPDFQIP DSQGNPGEDP RFEIVEHFGI AWFTFELVAR FAVAPDFLKF FKNALNLIDL
     MSIVPFYITL VVNLVVESSP TLANLGRVAQ VLRLMRIFRI LKLARHSTGL RSLGATLKYS
     YKEVGLLLLY LSVGISIFSV VAYTIEKEEN EGLATIPACW WWATVSMTTV GYGDVVPGTT
     AGKLTASACI LAGILVVVLP ITLIFNKFSH FYRRQKQLES AMRSCDFGDG MKEVPSVNLR
     DYYAHKVKSL MASLTNMSRS SPSELSLDDS LH
//