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Protein

Pre-mRNA-splicing factor ISY1 homolog

Gene

Isy1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in pre-mRNA splicing as component of the spliceosome.By similarity

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor ISY1 homolog
Gene namesi
Name:Isy1
Synonyms:Kiaa1160
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1923310 Isy1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002358141 – 285Pre-mRNA-splicing factor ISY1 homologAdd BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei127N6-acetyllysineBy similarity1
Modified residuei247PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ69ZQ2
MaxQBiQ69ZQ2
PaxDbiQ69ZQ2
PeptideAtlasiQ69ZQ2
PRIDEiQ69ZQ2

PTM databases

iPTMnetiQ69ZQ2
PhosphoSitePlusiQ69ZQ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000030056
CleanExiMM_ISY1
ExpressionAtlasiQ69ZQ2 baseline and differential
GenevisibleiQ69ZQ2 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE. Identified in a pentameric intron-binding (IB) complex composed of AQR, XAB2, ISY1, ZNF830 and PPIE that is incorporated into the spliceosome as a preassembled complex. The IB complex does not contain PRPF19.By similarity

Protein-protein interaction databases

BioGridi208359, 18 interactors
IntActiQ69ZQ2, 19 interactors
MINTiQ69ZQ2
STRINGi10090.ENSMUSP00000086923

Structurei

Secondary structure

1285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni33 – 35Combined sources3
Helixi39 – 62Combined sources24
Helixi67 – 94Combined sources28
Turni100 – 102Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4TNMR-A24-102[»]
ProteinModelPortaliQ69ZQ2
SMRiQ69ZQ2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ69ZQ2

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi201 – 211Poly-GluAdd BLAST11

Sequence similaritiesi

Belongs to the ISY1 family.Curated

Phylogenomic databases

eggNOGiKOG3068 Eukaryota
ENOG410XPPC LUCA
GeneTreeiENSGT00390000014109
HOGENOMiHOG000173970
HOVERGENiHBG061071
InParanoidiQ69ZQ2
KOiK12870
OMAiWEVQIRN
OrthoDBiEOG091G0JHQ
PhylomeDBiQ69ZQ2
TreeFamiTF105841

Family and domain databases

Gene3Di1.10.287.660, 1 hit
InterProiView protein in InterPro
IPR029012 Helix_hairpin_bin_sf
IPR009360 Isy1
IPR037200 Isy1_sf
PANTHERiPTHR13021 PTHR13021, 1 hit
PfamiView protein in Pfam
PF06246 Isy1, 1 hit
SUPFAMiSSF140102 SSF140102, 1 hit

Sequencei

Sequence statusi: Complete.

Q69ZQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNAEKAMT ALARFRQAQL EEGKVKERRP FLASECTELP KAEKWRRQII
60 70 80 90 100
GEISKKVAQI QNAGLGEFRI RDLNDEINKL LREKGHWEVR IKELGGPDYG
110 120 130 140 150
KVGPKMLDHE GKEVPGNRGY KYFGAAKDLP GVRELFEKEP LPPPRKTRAE
160 170 180 190 200
LMKAIDFEYY GYLDEDDGVI VPLEQEYEKK LRAELVEKWK AEREARLARG
210 220 230 240 250
EKEEEEEEEE EINIYAVTEE ESDEEGNQEK AGEDGQQKFI AHVPVPSQQE
260 270 280
IEEALVRRKK MELLQKYASE TLQAQSEEAK RLLGY
Length:285
Mass (Da):32,989
Last modified:May 16, 2006 - v2
Checksum:i4A456045660F29D6
GO

Sequence cautioni

The sequence BAD32394 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133R → K in BAB31028 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173116 mRNA Translation: BAD32394.1 Different initiation.
AK017996 mRNA Translation: BAB31028.1
BC020103 mRNA Translation: AAH20103.1
BC037695 mRNA Translation: AAH37695.1
CCDSiCCDS39548.1
RefSeqiNP_598695.1, NM_133934.4
UniGeneiMm.241546

Genome annotation databases

EnsembliENSMUST00000089497; ENSMUSP00000086923; ENSMUSG00000030056
GeneIDi57905
KEGGimmu:57905
UCSCiuc009cub.1 mouse

Similar proteinsi

Entry informationi

Entry nameiISY1_MOUSE
AccessioniPrimary (citable) accession number: Q69ZQ2
Secondary accession number(s): Q8VDX4, Q9D3E2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: March 28, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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