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Protein

Pre-mRNA-splicing factor ISY1 homolog

Gene

Isy1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in pre-mRNA splicing.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-6781823. Formation of TC-NER Pre-Incision Complex.
R-MMU-6782135. Dual incision in TC-NER.
R-MMU-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor ISY1 homolog
Gene namesi
Name:Isy1
Synonyms:Kiaa1160
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1923310. Isy1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Pre-mRNA-splicing factor ISY1 homologPRO_0000235814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei127 – 1271N6-acetyllysineBy similarity
Modified residuei247 – 2471PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ69ZQ2.
MaxQBiQ69ZQ2.
PaxDbiQ69ZQ2.
PeptideAtlasiQ69ZQ2.
PRIDEiQ69ZQ2.

PTM databases

iPTMnetiQ69ZQ2.
PhosphoSiteiQ69ZQ2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030056.
CleanExiMM_ISY1.
ExpressionAtlasiQ69ZQ2. baseline and differential.
GenevisibleiQ69ZQ2. MM.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.By similarity

Protein-protein interaction databases

BioGridi208359. 18 interactions.
IntActiQ69ZQ2. 19 interactions.
MINTiMINT-4126892.
STRINGi10090.ENSMUSP00000086923.

Structurei

Secondary structure

1
285
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni33 – 353Combined sources
Helixi39 – 6224Combined sources
Helixi67 – 9428Combined sources
Turni100 – 1023Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4TNMR-A24-102[»]
ProteinModelPortaliQ69ZQ2.
SMRiQ69ZQ2. Positions 23-102.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ69ZQ2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi201 – 21111Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the ISY1 family.Curated

Phylogenomic databases

eggNOGiKOG3068. Eukaryota.
ENOG410XPPC. LUCA.
GeneTreeiENSGT00390000014109.
HOGENOMiHOG000173970.
HOVERGENiHBG061071.
InParanoidiQ69ZQ2.
KOiK12870.
OMAiRDKMARD.
OrthoDBiEOG091G0JHQ.
PhylomeDBiQ69ZQ2.
TreeFamiTF105841.

Family and domain databases

InterProiIPR009360. Isy1.
[Graphical view]
PANTHERiPTHR13021. PTHR13021. 1 hit.
PfamiPF06246. Isy1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q69ZQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNAEKAMT ALARFRQAQL EEGKVKERRP FLASECTELP KAEKWRRQII
60 70 80 90 100
GEISKKVAQI QNAGLGEFRI RDLNDEINKL LREKGHWEVR IKELGGPDYG
110 120 130 140 150
KVGPKMLDHE GKEVPGNRGY KYFGAAKDLP GVRELFEKEP LPPPRKTRAE
160 170 180 190 200
LMKAIDFEYY GYLDEDDGVI VPLEQEYEKK LRAELVEKWK AEREARLARG
210 220 230 240 250
EKEEEEEEEE EINIYAVTEE ESDEEGNQEK AGEDGQQKFI AHVPVPSQQE
260 270 280
IEEALVRRKK MELLQKYASE TLQAQSEEAK RLLGY
Length:285
Mass (Da):32,989
Last modified:May 16, 2006 - v2
Checksum:i4A456045660F29D6
GO

Sequence cautioni

The sequence BAD32394 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331R → K in BAB31028 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173116 mRNA. Translation: BAD32394.1. Different initiation.
AK017996 mRNA. Translation: BAB31028.1.
BC020103 mRNA. Translation: AAH20103.1.
BC037695 mRNA. Translation: AAH37695.1.
CCDSiCCDS39548.1.
RefSeqiNP_598695.1. NM_133934.4.
UniGeneiMm.241546.

Genome annotation databases

EnsembliENSMUST00000089497; ENSMUSP00000086923; ENSMUSG00000030056.
GeneIDi57905.
KEGGimmu:57905.
UCSCiuc009cub.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173116 mRNA. Translation: BAD32394.1. Different initiation.
AK017996 mRNA. Translation: BAB31028.1.
BC020103 mRNA. Translation: AAH20103.1.
BC037695 mRNA. Translation: AAH37695.1.
CCDSiCCDS39548.1.
RefSeqiNP_598695.1. NM_133934.4.
UniGeneiMm.241546.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4TNMR-A24-102[»]
ProteinModelPortaliQ69ZQ2.
SMRiQ69ZQ2. Positions 23-102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208359. 18 interactions.
IntActiQ69ZQ2. 19 interactions.
MINTiMINT-4126892.
STRINGi10090.ENSMUSP00000086923.

PTM databases

iPTMnetiQ69ZQ2.
PhosphoSiteiQ69ZQ2.

Proteomic databases

EPDiQ69ZQ2.
MaxQBiQ69ZQ2.
PaxDbiQ69ZQ2.
PeptideAtlasiQ69ZQ2.
PRIDEiQ69ZQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089497; ENSMUSP00000086923; ENSMUSG00000030056.
GeneIDi57905.
KEGGimmu:57905.
UCSCiuc009cub.1. mouse.

Organism-specific databases

CTDi57461.
MGIiMGI:1923310. Isy1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3068. Eukaryota.
ENOG410XPPC. LUCA.
GeneTreeiENSGT00390000014109.
HOGENOMiHOG000173970.
HOVERGENiHBG061071.
InParanoidiQ69ZQ2.
KOiK12870.
OMAiRDKMARD.
OrthoDBiEOG091G0JHQ.
PhylomeDBiQ69ZQ2.
TreeFamiTF105841.

Enzyme and pathway databases

ReactomeiR-MMU-6781823. Formation of TC-NER Pre-Incision Complex.
R-MMU-6782135. Dual incision in TC-NER.
R-MMU-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Miscellaneous databases

EvolutionaryTraceiQ69ZQ2.
PROiQ69ZQ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030056.
CleanExiMM_ISY1.
ExpressionAtlasiQ69ZQ2. baseline and differential.
GenevisibleiQ69ZQ2. MM.

Family and domain databases

InterProiIPR009360. Isy1.
[Graphical view]
PANTHERiPTHR13021. PTHR13021. 1 hit.
PfamiPF06246. Isy1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISY1_MOUSE
AccessioniPrimary (citable) accession number: Q69ZQ2
Secondary accession number(s): Q8VDX4, Q9D3E2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.