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Protein

FYVE, RhoGEF and PH domain-containing protein 6

Gene

Fgd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1191 – 1250FYVE-typePROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 6
Gene namesi
Name:Fgd6
Synonyms:Kiaa1362
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1261419. Fgd6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809531 – 1399FYVE, RhoGEF and PH domain-containing protein 6Add BLAST1399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei494PhosphoserineBy similarity1
Modified residuei531PhosphoserineBy similarity1
Modified residuei583PhosphoserineCombined sources1
Modified residuei670PhosphoserineBy similarity1
Modified residuei697PhosphoserineBy similarity1
Modified residuei1167PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ69ZL1.
PeptideAtlasiQ69ZL1.
PRIDEiQ69ZL1.

PTM databases

iPTMnetiQ69ZL1.
PhosphoSitePlusiQ69ZL1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020021.
CleanExiMM_FGD6.
GenevisibleiQ69ZL1. MM.

Interactioni

Protein-protein interaction databases

BioGridi199529. 1 interactor.
STRINGi10090.ENSMUSP00000020208.

Structurei

Secondary structure

11399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1306 – 1314Combined sources9
Beta strandi1320 – 1327Combined sources8
Beta strandi1330 – 1335Combined sources6
Beta strandi1343 – 1347Combined sources5
Beta strandi1349 – 1355Combined sources7
Beta strandi1362 – 1370Combined sources9
Beta strandi1373 – 1379Combined sources7
Helixi1383 – 1397Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGQNMR-A1303-1398[»]
ProteinModelPortaliQ69ZL1.
SMRiQ69ZL1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ69ZL1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini841 – 1030DHPROSITE-ProRule annotationAdd BLAST190
Domaini1059 – 1153PH 1PROSITE-ProRule annotationAdd BLAST95
Domaini1302 – 1398PH 2PROSITE-ProRule annotationAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 75Lys/Pro-richAdd BLAST66

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1191 – 1250FYVE-typePROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IUBB. Eukaryota.
ENOG410XRXV. LUCA.
GeneTreeiENSGT00750000117280.
HOGENOMiHOG000112571.
HOVERGENiHBG051610.
InParanoidiQ69ZL1.
KOiK05724.
OMAiKRITFCP.
OrthoDBiEOG091G00IK.
PhylomeDBiQ69ZL1.
TreeFamiTF343077.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69ZL1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSAAELKKP PLAPKPKLVG TNNKPPPPPI APKPDIGSAS VPRLTKKTKP
60 70 80 90 100
AIAPKPKVPT NSVVQDIKHP PSKKPTLNLE EREPELPEST GKSNCKDVRD
110 120 130 140 150
PHSDYILPTC SCSSGCIHEP RTRETQCVEQ LVLEPLGMKE NLENSKNGES
160 170 180 190 200
SKRGSSWDSS SEKCRGQSGV VLKASILEEK LKEVLTQQRS PCGSPGRHRA
210 220 230 240 250
PKKPEMNGDH SCTRQIRIEF ADVSSSLTGF EKVPAHHNCH PQLPRDESQT
260 270 280 290 300
LKTCQDGSAE SRGHTDSCEP ENKRVASDGI SQKTEVKGLG PLEIHLLPYT
310 320 330 340 350
SKFPTPKPRK THAAARLRRQ KHVDTPGEST EEPGNSNNGS SCLLEDYCLK
360 370 380 390 400
NNKVSVLRQN ALYNQGPVDE VRPANQRALT GDSNSGGQDS VGSQKAVQQQ
410 420 430 440 450
TPSLDTDSSL TSDSSGSGVS PAVDKETTYT QCSTQPLSLP KQVTSACTDQ
460 470 480 490 500
PPATCNPEVS APPIQKESSS SRIIPKKPQR HSLPAAGVLK KAASEELVEK
510 520 530 540 550
SSSGKETNVE KGLHRNYLHH PGPPNHGASA SPFDMPNPTS EKPVWKLPHP
560 570 580 590 600
ILPFSGSPEA LKRVTLSLNN EPSVSLTKPR AKSLSAVDAD RCNKPCKDPP
610 620 630 640 650
KKTSFKKLIN VKLSIGFIKS DFQKIRSKSC QHGDVSAGHP LAREPKGLES
660 670 680 690 700
DWQGLATGEE KRSKPTKAHS AENCSLESQK VKSWGQSSAV NGQRAESLDD
710 720 730 740 750
RILSRHTSCT GDFGPEYENV RHYEEIPEYE NLPFVMAGRN TPDLGWQNSS
760 770 780 790 800
SVEDTDASLY EVEEPYNAPD GQLQLDPRHQ PCSSGTSQEG KDALHLGLSD
810 820 830 840 850
LPSDEEVINS SDEDDVSSES SKGEPDPLED KQDEDAGMKS KVHHIAKEIM
860 870 880 890 900
SSEKVFVDVL KLLHIDFRGA VAHASRQLGK PVIEDRILNQ ILYYLPQLYE
910 920 930 940 950
LNRDLLKELE ERMLTWTEQQ RIADIFVKKG PYLKMYSTYI KEFDKNVALL
960 970 980 990 1000
DEQCKKNPGF AAVVREFEMS PRCANLALKH YLLKPVQRIP QYRLLLTDYL
1010 1020 1030 1040 1050
KNLLEDSVDH RDTQDALAVV IEVANHANDT MKQGDNFQKL MQIQYSLSGH
1060 1070 1080 1090 1100
HEIVQPGRVF LKEGTLMKLS RKVMQPRMFF LFNDALLYTT PMQSGMYKLN
1110 1120 1130 1140 1150
NMLSLAGMKV RKPTQEAYQN ELKIESVERS FILSASSAAE RDDWLEAISS
1160 1170 1180 1190 1200
SIEEYAKKRI TFCPSRSLDE DSERKEEVSP LGAKAPIWIP DTRATMCMIC
1210 1220 1230 1240 1250
TSEFTLTWRR HHCRACGKIV CQACSSNKYG LDYLKGQLAR VCEHCFQELQ
1260 1270 1280 1290 1300
KLDHQLSPRV GSPGNHKSPS SALSSVLHSI PSGRKQKKIP AALKEVSANT
1310 1320 1330 1340 1350
EDSTMSGYLY RSKGSKKPWK HLWFVIKNKV LYTYAASEDV AALESQPLLG
1360 1370 1380 1390
FTVTLVKDEN SESKVFQLLH KGMVFYVFKA DDAHSTQRWI DAFQEGTVL
Length:1,399
Mass (Da):155,169
Last modified:March 15, 2005 - v2
Checksum:iCB91142F176E5A2F
GO
Isoform 2 (identifier: Q69ZL1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-934: Missing.

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):52,949
Checksum:i44C12E99C084EA54
GO

Sequence cautioni

The sequence BAD32435 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126Q → L in BAC31876 (PubMed:16141072).Curated1
Sequence conflicti262R → H in BAC31876 (PubMed:16141072).Curated1
Sequence conflicti286V → D in BAC31876 (PubMed:16141072).Curated1
Sequence conflicti347 – 348YC → S in BAC31876 (PubMed:16141072).Curated2
Sequence conflicti368V → A in BAC31876 (PubMed:16141072).Curated1
Sequence conflicti517Y → H in BAC31876 (PubMed:16141072).Curated1
Sequence conflicti517Y → H in AAH26860 (PubMed:15489334).Curated1
Sequence conflicti637A → T in BAC31876 (PubMed:16141072).Curated1
Sequence conflicti637A → T in AAH26860 (PubMed:15489334).Curated1
Sequence conflicti791K → Q in BAC31876 (PubMed:16141072).Curated1
Sequence conflicti791K → Q in AAH26860 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0130931 – 934Missing in isoform 2. 1 PublicationAdd BLAST934

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173157 mRNA. Translation: BAD32435.1. Different initiation.
AK016940 mRNA. Translation: BAB30510.2.
AK044341 mRNA. Translation: BAC31876.1.
BC026860 mRNA. Translation: AAH26860.2.
CCDSiCCDS48674.1. [Q69ZL1-1]
RefSeqiNP_444302.4. NM_053072.3. [Q69ZL1-1]
UniGeneiMm.269596.

Genome annotation databases

EnsembliENSMUST00000020208; ENSMUSP00000020208; ENSMUSG00000020021. [Q69ZL1-1]
GeneIDi13998.
KEGGimmu:13998.
UCSCiuc011xlz.1. mouse. [Q69ZL1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173157 mRNA. Translation: BAD32435.1. Different initiation.
AK016940 mRNA. Translation: BAB30510.2.
AK044341 mRNA. Translation: BAC31876.1.
BC026860 mRNA. Translation: AAH26860.2.
CCDSiCCDS48674.1. [Q69ZL1-1]
RefSeqiNP_444302.4. NM_053072.3. [Q69ZL1-1]
UniGeneiMm.269596.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGQNMR-A1303-1398[»]
ProteinModelPortaliQ69ZL1.
SMRiQ69ZL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199529. 1 interactor.
STRINGi10090.ENSMUSP00000020208.

PTM databases

iPTMnetiQ69ZL1.
PhosphoSitePlusiQ69ZL1.

Proteomic databases

PaxDbiQ69ZL1.
PeptideAtlasiQ69ZL1.
PRIDEiQ69ZL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020208; ENSMUSP00000020208; ENSMUSG00000020021. [Q69ZL1-1]
GeneIDi13998.
KEGGimmu:13998.
UCSCiuc011xlz.1. mouse. [Q69ZL1-1]

Organism-specific databases

CTDi55785.
MGIiMGI:1261419. Fgd6.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IUBB. Eukaryota.
ENOG410XRXV. LUCA.
GeneTreeiENSGT00750000117280.
HOGENOMiHOG000112571.
HOVERGENiHBG051610.
InParanoidiQ69ZL1.
KOiK05724.
OMAiKRITFCP.
OrthoDBiEOG091G00IK.
PhylomeDBiQ69ZL1.
TreeFamiTF343077.

Miscellaneous databases

EvolutionaryTraceiQ69ZL1.
PROiQ69ZL1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020021.
CleanExiMM_FGD6.
GenevisibleiQ69ZL1. MM.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGD6_MOUSE
AccessioniPrimary (citable) accession number: Q69ZL1
Secondary accession number(s): Q8C8W5, Q8K3B0, Q9D3Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.