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Protein

FYVE, RhoGEF and PH domain-containing protein 6

Gene

Fgd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1191 – 125060FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE, RhoGEF and PH domain-containing protein 6
Gene namesi
Name:Fgd6
Synonyms:Kiaa1362
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1261419. Fgd6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13991399FYVE, RhoGEF and PH domain-containing protein 6PRO_0000080953Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei494 – 4941PhosphoserineBy similarity
Modified residuei583 – 5831PhosphoserineCombined sources
Modified residuei670 – 6701PhosphoserineBy similarity
Modified residuei697 – 6971PhosphoserineBy similarity
Modified residuei1167 – 11671PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ69ZL1.
PaxDbiQ69ZL1.
PRIDEiQ69ZL1.

PTM databases

iPTMnetiQ69ZL1.
PhosphoSiteiQ69ZL1.

Expressioni

Gene expression databases

BgeeiQ69ZL1.
CleanExiMM_FGD6.
GenevisibleiQ69ZL1. MM.

Interactioni

Protein-protein interaction databases

BioGridi199529. 1 interaction.
STRINGi10090.ENSMUSP00000020208.

Structurei

Secondary structure

1
1399
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1306 – 13149Combined sources
Beta strandi1320 – 13278Combined sources
Beta strandi1330 – 13356Combined sources
Beta strandi1343 – 13475Combined sources
Beta strandi1349 – 13557Combined sources
Beta strandi1362 – 13709Combined sources
Beta strandi1373 – 13797Combined sources
Helixi1383 – 139715Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGQNMR-A1303-1398[»]
ProteinModelPortaliQ69ZL1.
SMRiQ69ZL1. Positions 1308-1398.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ69ZL1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini841 – 1030190DHPROSITE-ProRule annotationAdd
BLAST
Domaini1059 – 115395PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini1302 – 139897PH 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 7566Lys/Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1191 – 125060FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IUBB. Eukaryota.
ENOG410XRXV. LUCA.
GeneTreeiENSGT00750000117280.
HOGENOMiHOG000112571.
HOVERGENiHBG051610.
InParanoidiQ69ZL1.
KOiK05724.
OMAiKRITFCP.
OrthoDBiEOG7N63N3.
PhylomeDBiQ69ZL1.
TreeFamiTF343077.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69ZL1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSAAELKKP PLAPKPKLVG TNNKPPPPPI APKPDIGSAS VPRLTKKTKP
60 70 80 90 100
AIAPKPKVPT NSVVQDIKHP PSKKPTLNLE EREPELPEST GKSNCKDVRD
110 120 130 140 150
PHSDYILPTC SCSSGCIHEP RTRETQCVEQ LVLEPLGMKE NLENSKNGES
160 170 180 190 200
SKRGSSWDSS SEKCRGQSGV VLKASILEEK LKEVLTQQRS PCGSPGRHRA
210 220 230 240 250
PKKPEMNGDH SCTRQIRIEF ADVSSSLTGF EKVPAHHNCH PQLPRDESQT
260 270 280 290 300
LKTCQDGSAE SRGHTDSCEP ENKRVASDGI SQKTEVKGLG PLEIHLLPYT
310 320 330 340 350
SKFPTPKPRK THAAARLRRQ KHVDTPGEST EEPGNSNNGS SCLLEDYCLK
360 370 380 390 400
NNKVSVLRQN ALYNQGPVDE VRPANQRALT GDSNSGGQDS VGSQKAVQQQ
410 420 430 440 450
TPSLDTDSSL TSDSSGSGVS PAVDKETTYT QCSTQPLSLP KQVTSACTDQ
460 470 480 490 500
PPATCNPEVS APPIQKESSS SRIIPKKPQR HSLPAAGVLK KAASEELVEK
510 520 530 540 550
SSSGKETNVE KGLHRNYLHH PGPPNHGASA SPFDMPNPTS EKPVWKLPHP
560 570 580 590 600
ILPFSGSPEA LKRVTLSLNN EPSVSLTKPR AKSLSAVDAD RCNKPCKDPP
610 620 630 640 650
KKTSFKKLIN VKLSIGFIKS DFQKIRSKSC QHGDVSAGHP LAREPKGLES
660 670 680 690 700
DWQGLATGEE KRSKPTKAHS AENCSLESQK VKSWGQSSAV NGQRAESLDD
710 720 730 740 750
RILSRHTSCT GDFGPEYENV RHYEEIPEYE NLPFVMAGRN TPDLGWQNSS
760 770 780 790 800
SVEDTDASLY EVEEPYNAPD GQLQLDPRHQ PCSSGTSQEG KDALHLGLSD
810 820 830 840 850
LPSDEEVINS SDEDDVSSES SKGEPDPLED KQDEDAGMKS KVHHIAKEIM
860 870 880 890 900
SSEKVFVDVL KLLHIDFRGA VAHASRQLGK PVIEDRILNQ ILYYLPQLYE
910 920 930 940 950
LNRDLLKELE ERMLTWTEQQ RIADIFVKKG PYLKMYSTYI KEFDKNVALL
960 970 980 990 1000
DEQCKKNPGF AAVVREFEMS PRCANLALKH YLLKPVQRIP QYRLLLTDYL
1010 1020 1030 1040 1050
KNLLEDSVDH RDTQDALAVV IEVANHANDT MKQGDNFQKL MQIQYSLSGH
1060 1070 1080 1090 1100
HEIVQPGRVF LKEGTLMKLS RKVMQPRMFF LFNDALLYTT PMQSGMYKLN
1110 1120 1130 1140 1150
NMLSLAGMKV RKPTQEAYQN ELKIESVERS FILSASSAAE RDDWLEAISS
1160 1170 1180 1190 1200
SIEEYAKKRI TFCPSRSLDE DSERKEEVSP LGAKAPIWIP DTRATMCMIC
1210 1220 1230 1240 1250
TSEFTLTWRR HHCRACGKIV CQACSSNKYG LDYLKGQLAR VCEHCFQELQ
1260 1270 1280 1290 1300
KLDHQLSPRV GSPGNHKSPS SALSSVLHSI PSGRKQKKIP AALKEVSANT
1310 1320 1330 1340 1350
EDSTMSGYLY RSKGSKKPWK HLWFVIKNKV LYTYAASEDV AALESQPLLG
1360 1370 1380 1390
FTVTLVKDEN SESKVFQLLH KGMVFYVFKA DDAHSTQRWI DAFQEGTVL
Length:1,399
Mass (Da):155,169
Last modified:March 15, 2005 - v2
Checksum:iCB91142F176E5A2F
GO
Isoform 2 (identifier: Q69ZL1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-934: Missing.

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):52,949
Checksum:i44C12E99C084EA54
GO

Sequence cautioni

The sequence BAD32435.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261Q → L in BAC31876 (PubMed:16141072).Curated
Sequence conflicti262 – 2621R → H in BAC31876 (PubMed:16141072).Curated
Sequence conflicti286 – 2861V → D in BAC31876 (PubMed:16141072).Curated
Sequence conflicti347 – 3482YC → S in BAC31876 (PubMed:16141072).Curated
Sequence conflicti368 – 3681V → A in BAC31876 (PubMed:16141072).Curated
Sequence conflicti517 – 5171Y → H in BAC31876 (PubMed:16141072).Curated
Sequence conflicti517 – 5171Y → H in AAH26860 (PubMed:15489334).Curated
Sequence conflicti637 – 6371A → T in BAC31876 (PubMed:16141072).Curated
Sequence conflicti637 – 6371A → T in AAH26860 (PubMed:15489334).Curated
Sequence conflicti791 – 7911K → Q in BAC31876 (PubMed:16141072).Curated
Sequence conflicti791 – 7911K → Q in AAH26860 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 934934Missing in isoform 2. 1 PublicationVSP_013093Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173157 mRNA. Translation: BAD32435.1. Different initiation.
AK016940 mRNA. Translation: BAB30510.2.
AK044341 mRNA. Translation: BAC31876.1.
BC026860 mRNA. Translation: AAH26860.2.
CCDSiCCDS48674.1. [Q69ZL1-1]
RefSeqiNP_444302.4. NM_053072.3. [Q69ZL1-1]
UniGeneiMm.269596.

Genome annotation databases

EnsembliENSMUST00000020208; ENSMUSP00000020208; ENSMUSG00000020021. [Q69ZL1-1]
GeneIDi13998.
KEGGimmu:13998.
UCSCiuc011xlz.1. mouse. [Q69ZL1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173157 mRNA. Translation: BAD32435.1. Different initiation.
AK016940 mRNA. Translation: BAB30510.2.
AK044341 mRNA. Translation: BAC31876.1.
BC026860 mRNA. Translation: AAH26860.2.
CCDSiCCDS48674.1. [Q69ZL1-1]
RefSeqiNP_444302.4. NM_053072.3. [Q69ZL1-1]
UniGeneiMm.269596.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WGQNMR-A1303-1398[»]
ProteinModelPortaliQ69ZL1.
SMRiQ69ZL1. Positions 1308-1398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199529. 1 interaction.
STRINGi10090.ENSMUSP00000020208.

PTM databases

iPTMnetiQ69ZL1.
PhosphoSiteiQ69ZL1.

Proteomic databases

MaxQBiQ69ZL1.
PaxDbiQ69ZL1.
PRIDEiQ69ZL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020208; ENSMUSP00000020208; ENSMUSG00000020021. [Q69ZL1-1]
GeneIDi13998.
KEGGimmu:13998.
UCSCiuc011xlz.1. mouse. [Q69ZL1-1]

Organism-specific databases

CTDi55785.
MGIiMGI:1261419. Fgd6.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IUBB. Eukaryota.
ENOG410XRXV. LUCA.
GeneTreeiENSGT00750000117280.
HOGENOMiHOG000112571.
HOVERGENiHBG051610.
InParanoidiQ69ZL1.
KOiK05724.
OMAiKRITFCP.
OrthoDBiEOG7N63N3.
PhylomeDBiQ69ZL1.
TreeFamiTF343077.

Miscellaneous databases

EvolutionaryTraceiQ69ZL1.
NextBioi284882.
PROiQ69ZL1.
SOURCEiSearch...

Gene expression databases

BgeeiQ69ZL1.
CleanExiMM_FGD6.
GenevisibleiQ69ZL1. MM.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF00169. PH. 2 hits.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 2 hits.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreatic islet.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1156 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Retina and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 457-1399 (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-583, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-583, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.
  6. "Solution structure of the pleckstrin homology domain of mouse ethanol decreased 4 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1303-1398.

Entry informationi

Entry nameiFGD6_MOUSE
AccessioniPrimary (citable) accession number: Q69ZL1
Secondary accession number(s): Q8C8W5, Q8K3B0, Q9D3Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 20, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.