Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho GTPase-activating protein 23

Gene

Arhgap23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 23
Alternative name(s):
Rho-type GTPase-activating protein 23
Gene namesi
Name:Arhgap23
Synonyms:Kiaa1501
ORF Names:MNCb-1301
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3697726. Arhgap23.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14831483Rho GTPase-activating protein 23PRO_0000280472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei361 – 3611PhosphoserineCombined sources
Modified residuei372 – 3721PhosphoserineCombined sources
Modified residuei421 – 4211PhosphoserineBy similarity
Modified residuei515 – 5151PhosphoserineCombined sources
Modified residuei579 – 5791PhosphoserineCombined sources
Modified residuei607 – 6071PhosphoserineCombined sources
Modified residuei619 – 6191PhosphoserineCombined sources
Modified residuei652 – 6521PhosphothreonineCombined sources
Modified residuei655 – 6551PhosphoserineCombined sources
Modified residuei658 – 6581PhosphoserineCombined sources
Modified residuei673 – 6731PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ69ZH9.
PaxDbiQ69ZH9.
PRIDEiQ69ZH9.

PTM databases

PhosphoSiteiQ69ZH9.

Expressioni

Gene expression databases

BgeeiQ69ZH9.
ExpressionAtlasiQ69ZH9. baseline and differential.
GenevisibleiQ69ZH9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103227.

Structurei

3D structure databases

ProteinModelPortaliQ69ZH9.
SMRiQ69ZH9. Positions 41-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 15585PDZPROSITE-ProRule annotationAdd
BLAST
Domaini684 – 804121PHPROSITE-ProRule annotationAdd
BLAST
Domaini901 – 1093193Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi183 – 27391Pro-richAdd
BLAST
Compositional biasi1421 – 14244Poly-Gly

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQ9B. Eukaryota.
ENOG410YY7B. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000049125.
HOVERGENiHBG093896.
InParanoidiQ69ZH9.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69ZH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGVAFCLVG IPPRPEPRPP QLPLGPRDGC SSGRPLPWPG PRTLLLRKSL
60 70 80 90 100
QDGFGFTLRH FIVYPPESAV HCILKEEENG GRGGGPSPRH RLEPMDTIFV
110 120 130 140 150
KNVKDGGPAH RAGLRTGDRL VKVNGESIIG KTYSQVIGLI QNSDDTLELS
160 170 180 190 200
IMPKDEDILQ LAYSQDAYLK GNEPYSGEAR SIPEPPPLCY PRKTYAPPTR
210 220 230 240 250
APAWATMVPE PISALPPDPR SPAAWSDPGS RVPSATRAHL DNSSLGMSQP
260 270 280 290 300
RPSPGAFPHL PSESRTPRAF PEPGSRVLPS RLECQQALSH WLSNQIPRRA
310 320 330 340 350
GERRCPAMPP RARSASQDRL EDVTTHHPWP CSTSQDALSQ LGQEGWHRAR
360 370 380 390 400
SDDYLSRATR SAEALGPGAL VSPRLERCGW ASQRPSARTS ACPSRDLTQA
410 420 430 440 450
PPPSGLQGLD DIGYIGYRSY SPSFQRRTGL LHALSFRDSP FGGLPTFSLA
460 470 480 490 500
QSPASFPPEA SEPPRVVRPD PSTRALEPPA EDHRDEVVLR QKPPTGRKVQ
510 520 530 540 550
LTPARQMNLG FGDESPEPEA RGERLGRKVA PLATTEDSLA SIPFIDEPTS
560 570 580 590 600
PSIDLQAKHV PASAVVSSAM NSAPVLGTSP SSPTFTFALS RHYSQDCSSI
610 620 630 640 650
KAGRRSSYLL AITTERSKSC DDGLNTFRDE GRVLRRLPSR VPSLRVLRSF
660 670 680 690 700
FTDGSLDSWG TSEDADAPSK RHSTSDLSDA TFSDIRREGW LYYKQILTKK
710 720 730 740 750
GKKAGGGLRQ WKRVYAVLRA RSLSLSKERR EPGPAAAGAA AAGAGEDEAA
760 770 780 790 800
PVCIGSCLVD ISYSETKRRH VFRLTTADFC EYLFQAEDRD DMLGWIRAIR
810 820 830 840 850
ENSRAEGEDP GCANQALISK KLNDYRKVSH SSGPKADSSP KGSRGLGGLK
860 870 880 890 900
SEFLKQTAVR GLRTQEQPPG SKEDSVAAPK TPWGINIIKK NKKAAPRAFG
910 920 930 940 950
IRLEECQPAT ENQRVPLIVA ACCRIVEARG LESTGIYRVP GNNAVVSSLQ
960 970 980 990 1000
EQLNRGPSDI NLQDERWQDL NVISSLLKAF FRKLPEPLFT DDKYNDFIEA
1010 1020 1030 1040 1050
NRIEDSRERM KTLRKLIRDL PGHYYETLKF LVGHLKTIAD HSEKNKMEPR
1060 1070 1080 1090 1100
NLALVFGPTL VRTSEDNMTD MVTHMPDRYK IVETLIQHSD WFFSDDEDKG
1110 1120 1130 1140 1150
ERTPVDDKEP QSVPNIEYLL PNIGRTVPPS DPGSDSTTCS SAKSKGSWVP
1160 1170 1180 1190 1200
KKEPYAREML AISFISAVNR KRKKRREARG LGSSTDDDSE QEAHKAAVGT
1210 1220 1230 1240 1250
QEPPEGQLPG PAAEEAPGRL SPPTAPDERP AADTRSIVSG YSTLSTMDRS
1260 1270 1280 1290 1300
VCSGTGGRRA GAGDEADDER SELSHVETDT EGGAGPGGRL SRRPSFSSHH
1310 1320 1330 1340 1350
LMPCDTLARR RLSRSRAEAE GPGAGTARAC PRGPEPPGSA SSSSQESLRP
1360 1370 1380 1390 1400
PAAAPALGSR PSRVEALRLR LRGTADDMLA VRLRRPLSPE TRRRRSSWRR
1410 1420 1430 1440 1450
HTVVVQSPLT DLNFNEWKEL GGGGPQESVG VRPHSDNKDS GLSSLESTKA
1460 1470 1480
RASSAASLPS GDLGALQGLP QRRSAAARLH QCL
Note: No experimental confirmation available. Gene prediction based on EST data.
Length:1,483
Mass (Da):161,832
Last modified:March 20, 2007 - v2
Checksum:i652088C6725EC9BE
GO
Isoform 2 (identifier: Q69ZH9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1158: Missing.

Note: No experimental confirmation available.
Show »
Length:325
Mass (Da):34,361
Checksum:iA85DCB18697C48C9
GO

Sequence cautioni

The sequence BAC37556.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1462 – 14643DLG → EPR in BAC37556 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11581158Missing in isoform 2. 1 PublicationVSP_023710Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041572 mRNA. Translation: BAA95056.1.
AL596088 Genomic DNA. Translation: CAM15705.1.
AK173187 mRNA. Translation: BAD32465.1.
AK079135 mRNA. Translation: BAC37556.1. Different initiation.
RefSeqiNP_067468.2. NM_021493.2.
UniGeneiMm.394118.

Genome annotation databases

EnsembliENSMUST00000093940; ENSMUSP00000091472; ENSMUSG00000049807. [Q69ZH9-2]
GeneIDi58996.
KEGGimmu:58996.
UCSCiuc007lec.1. mouse. [Q69ZH9-1]
uc007led.1. mouse. [Q69ZH9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041572 mRNA. Translation: BAA95056.1.
AL596088 Genomic DNA. Translation: CAM15705.1.
AK173187 mRNA. Translation: BAD32465.1.
AK079135 mRNA. Translation: BAC37556.1. Different initiation.
RefSeqiNP_067468.2. NM_021493.2.
UniGeneiMm.394118.

3D structure databases

ProteinModelPortaliQ69ZH9.
SMRiQ69ZH9. Positions 41-155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103227.

PTM databases

PhosphoSiteiQ69ZH9.

Proteomic databases

MaxQBiQ69ZH9.
PaxDbiQ69ZH9.
PRIDEiQ69ZH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093940; ENSMUSP00000091472; ENSMUSG00000049807. [Q69ZH9-2]
GeneIDi58996.
KEGGimmu:58996.
UCSCiuc007lec.1. mouse. [Q69ZH9-1]
uc007led.1. mouse. [Q69ZH9-2]

Organism-specific databases

CTDi57636.
MGIiMGI:3697726. Arhgap23.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IQ9B. Eukaryota.
ENOG410YY7B. LUCA.
GeneTreeiENSGT00840000129684.
HOGENOMiHOG000049125.
HOVERGENiHBG093896.
InParanoidiQ69ZH9.

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiArhgap23. mouse.
NextBioi314502.
PROiQ69ZH9.
SOURCEiSearch...

Gene expression databases

BgeeiQ69ZH9.
ExpressionAtlasiQ69ZH9. baseline and differential.
GenevisibleiQ69ZH9. MM.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 1 hit.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 878-1483 (ISOFORM 1).
    Tissue: Natural killer cell.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1107-1483.
    Strain: C57BL/6J.
    Tissue: Embryo.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361; SER-372; SER-515; SER-579; SER-607; SER-619; THR-652; SER-655; SER-658 AND SER-673, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiRHG23_MOUSE
AccessioniPrimary (citable) accession number: Q69ZH9
Secondary accession number(s): Q8BNY7, Q9JJD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: May 11, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.