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Protein

Zinc finger CCHC domain-containing protein 2

Gene

Zcchc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1119 – 113618CCHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 2
Gene namesi
Name:Zcchc2
Synonyms:Kiaa1744
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2444114. Zcchc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11661166Zinc finger CCHC domain-containing protein 2PRO_0000150950Add
BLAST

Proteomic databases

EPDiQ69ZB8.
MaxQBiQ69ZB8.
PaxDbiQ69ZB8.
PRIDEiQ69ZB8.

PTM databases

iPTMnetiQ69ZB8.
PhosphoSiteiQ69ZB8.

Expressioni

Gene expression databases

BgeeiQ69ZB8.
CleanExiMM_ZCCHC2.
ExpressionAtlasiQ69ZB8. baseline and differential.
GenevisibleiQ69ZB8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113974.

Structurei

3D structure databases

ProteinModelPortaliQ69ZB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 7266Pro-richAdd
BLAST
Compositional biasi783 – 964182Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1119 – 113618CCHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IZZC. Eukaryota.
ENOG4111U3M. LUCA.
GeneTreeiENSGT00520000055637.
HOGENOMiHOG000155766.
HOVERGENiHBG108762.
InParanoidiQ69ZB8.
OMAiLNSYYYP.
OrthoDBiEOG7966GG.
PhylomeDBiQ69ZB8.
TreeFamiTF335574.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR001683. Phox.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69ZB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRMKLPPKS THPSEPPPDA EEPEADARPG AKAPLRRRRD CRPPPPPTGL
60 70 80 90 100
PRGPPPPPSP PRGLEPPVAS GPTAGAGMPG GGGHAAALRE QERVYEWFGL
110 120 130 140 150
VLGSAQRLEF MCGLLDLCNP LELRFLGSCL EDLARKDYHY LRDSEAKANG
160 170 180 190 200
LSDPGSLADF REPAVRSRLI VYLALLGSEN REAAGRLHRL LPQVDAVLRS
210 220 230 240 250
LRATRAEGSR GSVEDEPSGD GEQDAEKDGP GPEGSGCAKL GTGGGLGFRA
260 270 280 290 300
QEELLLLFTM ASLHPAFSFH QRVTLREHLE RLRSALRVEP EDAEVEPSNF
310 320 330 340 350
AGSRAQNDSA CGDYIQSNET GLVEQAQIPP DGLTVAPHRA QREAVHIEKI
360 370 380 390 400
MLKGVQRKRA DKYWEYTFKV NWSDLSVTTV TKTHQELQEF LLKLPKEFSS
410 420 430 440 450
ESFDKTILKA LNQGSLRREE RRHPDLEPIL RQLFSTSPQA FLQSHKVRSF
460 470 480 490 500
FRSISSESQH NFNNLQSSLK TSKILEHLKE DSSEASSQEE DVLQHTIIHK
510 520 530 540 550
KHAGKSPALN VATSCSPLDG LTMQYAEQNG IVDWRNQGCA AIQHSEHCVS
560 570 580 590 600
SADQHSAEKR SLSSGNKKKG KPQVEKEKVK KTEDRLNSRI NGIRLSAPQH
610 620 630 640 650
VHGSTVKDMN LDIGSGHDTC GETSSESYSS PSSPRHDGRE SLESEEEKDR
660 670 680 690 700
DSDSNSEDSV NPSSARFSGY GSVAQTIAVK PPAETVSLGT EDGNLLEAAL
710 720 730 740 750
TSHKYPHIPF MPTLHCVTHN GAQKSQVVIP SPKSADGKTL GMLVPNAVAI
760 770 780 790 800
SAVMESSNSA PVGILGPAAS GESEKHLELL ASPLPLPSTF LPHSSAPALQ
810 820 830 840 850
LTLQSLKLQP PQGSSDSCPV SIPPQPTGSL SIGSPNTAFI PVHNPGSFPG
860 870 880 890 900
SPVATTDPIT KSAPQVVGLN QMVPQIEGNT GTVPQPSNVK VVLPAAGLSA
910 920 930 940 950
AQPPASFPFP GSPQAASALP TQNSSALNAA TSAQPASTGI SPSQSTVPPA
960 970 980 990 1000
VPTHTPGPAP SPSPALTHST AQSDSTSYIS AVGNTNANGT IVPPQQMGPC
1010 1020 1030 1040 1050
GSCGRRCSCG TNGNLQLNSY YYPNPMPGPM YRLPSFFTLP SICNGSYLNQ
1060 1070 1080 1090 1100
AHQSNGNQLP FFLPQTPYAN GLVHDPVMGS QASYGMQQMA GFGRLYPVYP
1110 1120 1130 1140 1150
APNVVANTSG SGPKKNGNVS CYNCGVSGHY AQDCKQSSME ANQQGTYRLR
1160
YAPPLPPSND TLDSAD
Length:1,166
Mass (Da):124,517
Last modified:April 8, 2008 - v3
Checksum:iBBE1E89BC7EED4E6
GO
Isoform 2 (identifier: Q69ZB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1146-1166: TYRLRYAPPLPPSNDTLDSAD → NPTNSQRTCF

Show »
Length:1,155
Mass (Da):123,322
Checksum:i23220B79AF4B214D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1146 – 116621TYRLR…LDSAD → NPTNSQRTCF in isoform 2. 2 PublicationsVSP_013721Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173248 mRNA. Translation: BAD32526.1.
AK037100 mRNA. Translation: BAC29703.1.
BC055760 mRNA. Translation: AAH55760.1.
CCDSiCCDS48335.1. [Q69ZB8-1]
CCDS48336.1. [Q69ZB8-2]
RefSeqiNP_001116147.1. NM_001122675.1. [Q69ZB8-2]
NP_001116148.1. NM_001122676.1. [Q69ZB8-1]
UniGeneiMm.210188.

Genome annotation databases

EnsembliENSMUST00000118196; ENSMUSP00000113974; ENSMUSG00000038866. [Q69ZB8-1]
ENSMUST00000119166; ENSMUSP00000113128; ENSMUSG00000038866. [Q69ZB8-2]
GeneIDi227449.
KEGGimmu:227449.
UCSCiuc007cgq.3. mouse. [Q69ZB8-2]
uc007cgt.3. mouse. [Q69ZB8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173248 mRNA. Translation: BAD32526.1.
AK037100 mRNA. Translation: BAC29703.1.
BC055760 mRNA. Translation: AAH55760.1.
CCDSiCCDS48335.1. [Q69ZB8-1]
CCDS48336.1. [Q69ZB8-2]
RefSeqiNP_001116147.1. NM_001122675.1. [Q69ZB8-2]
NP_001116148.1. NM_001122676.1. [Q69ZB8-1]
UniGeneiMm.210188.

3D structure databases

ProteinModelPortaliQ69ZB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113974.

PTM databases

iPTMnetiQ69ZB8.
PhosphoSiteiQ69ZB8.

Proteomic databases

EPDiQ69ZB8.
MaxQBiQ69ZB8.
PaxDbiQ69ZB8.
PRIDEiQ69ZB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118196; ENSMUSP00000113974; ENSMUSG00000038866. [Q69ZB8-1]
ENSMUST00000119166; ENSMUSP00000113128; ENSMUSG00000038866. [Q69ZB8-2]
GeneIDi227449.
KEGGimmu:227449.
UCSCiuc007cgq.3. mouse. [Q69ZB8-2]
uc007cgt.3. mouse. [Q69ZB8-1]

Organism-specific databases

CTDi54877.
MGIiMGI:2444114. Zcchc2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IZZC. Eukaryota.
ENOG4111U3M. LUCA.
GeneTreeiENSGT00520000055637.
HOGENOMiHOG000155766.
HOVERGENiHBG108762.
InParanoidiQ69ZB8.
OMAiLNSYYYP.
OrthoDBiEOG7966GG.
PhylomeDBiQ69ZB8.
TreeFamiTF335574.

Miscellaneous databases

ChiTaRSiZcchc2. mouse.
PROiQ69ZB8.
SOURCEiSearch...

Gene expression databases

BgeeiQ69ZB8.
CleanExiMM_ZCCHC2.
ExpressionAtlasiQ69ZB8. baseline and differential.
GenevisibleiQ69ZB8. MM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR001683. Phox.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Thymus.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 482-1166 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Vagina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 867-1166 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiZCHC2_MOUSE
AccessioniPrimary (citable) accession number: Q69ZB8
Secondary accession number(s): Q7TNF1, Q8CB08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: April 8, 2008
Last modified: June 8, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.