Reviewed, UniProtKB/Swiss-Prot Q69ZA1 (CD2L5_MOUSE)

Names and origin

Protein names

Recommended name:
    Cell division cycle 2-like protein kinase 5
    EC=2.7.11.22
Alternative name(s):
    CDC2-related protein kinase 5

Gene names

Name:	Cdc2l5
Synonyms:	Kiaa1791

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1511 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be a controller of the mitotic cell cycle. Involved in the blood cell development By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence BAC29077.1 differs from that shown. Reason: Frameshift at positions 633 and 666.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q69ZA1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q69ZA1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1079-1138: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1511	1511	Cell division cycle 2-like protein kinase 5		PRO_0000085712
Regions
	Domain	705 – 998	294	Protein kinase
	Nucleotide binding	711 – 719	9	ATP By similarity
Sites
	Active site	837	1	Proton acceptor By similarity
	Binding site	734	1	ATP By similarity
Amino acid modifications
	Modified residue	316	1	Phosphoserine By similarity
	Modified residue	318	1	Phosphoserine By similarity
	Modified residue	326	1	Phosphoserine Ref.5
	Modified residue	341	1	Phosphoserine By similarity
	Modified residue	343	1	Phosphoserine By similarity
	Modified residue	350	1	Phosphoserine By similarity
	Modified residue	359	1	Phosphoserine By similarity
	Modified residue	361	1	Phosphoserine By similarity
	Modified residue	368	1	Phosphoserine By similarity
	Modified residue	384	1	Phosphoserine Ref.4
	Modified residue	396	1	Phosphoserine Ref.5 Ref.4
	Modified residue	398	1	Phosphoserine Ref.5 Ref.4
	Modified residue	401	1	Phosphoserine Ref.5 Ref.4
	Modified residue	410	1	Phosphoserine Ref.5
	Modified residue	437	1	Phosphoserine Ref.4
	Modified residue	438	1	Phosphoserine Ref.5 Ref.4
	Modified residue	440	1	Phosphoserine By similarity
	Modified residue	442	1	Phosphoserine By similarity
	Modified residue	443	1	Phosphothreonine By similarity
	Modified residue	526	1	Phosphoserine By similarity
	Modified residue	557	1	N6-acetyllysine By similarity
	Modified residue	664	1	Phosphoserine By similarity
	Modified residue	871	1	Phosphothreonine Ref.5
	Modified residue	1054	1	Phosphoserine By similarity
	Modified residue	1056	1	Phosphothreonine By similarity
	Modified residue	1245	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	1079 – 1138	60	Missing in isoform 2.		VSP_013580
Experimental info
	Sequence conflict	637	1	E → K in BAC29077. Ref.2
	Sequence conflict	1009	1	P → L in BAD32543. Ref.1
	Sequence conflict	1079 – 1138	60	Missing in AAH51093. Ref.3
	Sequence conflict	1206	1	E → K in AAH32179. Ref.3
	Sequence conflict	1400	1	A → P in AAH51093. Ref.3
	Sequence conflict	1464	1	N → D in BAC29077. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 26, 2005. Version 2. Checksum: F945976C6CF54CB8	FASTA	1,511	164,609
	10 20 30 40 50 60 MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ PPPPPPPLLF 70 80 90 100 110 120 LAAPGAAAAA AAVAAASSSC FSPGPPLEVK RLARGKRRPG GRRKRRRGPR AGQEAEKRRV 130 140 150 160 170 180 FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA AGGTGGNGGS 190 200 210 220 230 240 PASSSGTQRR AEGSERRPRR DRRSSSGRSK ERHREHRRRD GTRSGSEASK ARSRHGHSGE 250 260 270 280 290 300 ERAEAAKSGS SSSSGGRRKS ASATSSSSSS RKDRDLKAHR SRTKSSKEPP SAYKEPPKAY 310 320 330 340 350 360 REDKSEPKAY RRRQRSLSPL GGRDESPVSH RASQSLRSRK SPSPAGGGSS PYSRRLPRSP 370 380 390 400 410 420 SPYSRRRSPS YSRHSSYERG GDVSPSPYSS SSWRRSRSPY SPVLRRSAKS RSRSPYSSRH 430 440 450 460 470 480 SRSRSRHRLS RSRSRHSSIS PSTLTLKSSL AAELNKNKKA RAAEAARAAE AAKAAEAAKA 490 500 510 520 530 540 AEAAAKAAKA SNASTPTKGN TETGASVSQT NHVKEVKKLK TEHAPSPSSG GTVKSDKAKT 550 560 570 580 590 600 KPPLQVTKVD NNLTVEKATK KTVVGKESKP AATKEEPVST KEKSKPLTPS TGAKEKEQHV 610 620 630 640 650 660 ALVTSTLPPL PLPPMLPEDK DADSLRGNIS VKAVKKEVEK KLRCLLADLP LPPELPGGDD 670 680 690 700 710 720 LSKSPEEKKT AAQLHSKRRP KICGPRYGEI KEKDIDWGKR CVDKFDIIGI IGEGTYGQVY 730 740 750 760 770 780 KARDKDTGEM VALKKVRLDN EKEGFPITAI REIKILRQLT HQSIINMKEI VTDKEDALDF 790 800 810 820 830 840 KKDKGAFYLV FEYMDHDLMG LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC 850 860 870 880 890 900 SNILLNNRGQ IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC 910 920 930 940 950 960 GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM KPKKQYRRKL 970 980 990 1000 1010 1020 REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD VEPSKMPPPD LPLWQDCHEL 1030 1040 1050 1060 1070 1080 WSKKRRRQKQ MGMTDDLSTI KAPRKDLSLG LDDSRTNTPQ GVLPPAQLKS QSNSNVAPVI 1090 1100 1110 1120 1130 1140 TGPGQPLNHS ELAILLNLLQ SKSSVNMADF VQVLNIKVNS ETQQQLNKIN LPAGILATGE 1150 1160 1170 1180 1190 1200 KQTDPSTPQQ ESSKSLGGVQ PSQTIQPKVE TDAAQAAVQS AFAVLLTQLI KAQQSKQKDA 1210 1220 1230 1240 1250 1260 MLEERENGSG HEAPLQLRPP LEPSTPGSGQ DDLIQHQDRR ILELTPEPDR PRILPPDQRP 1270 1280 1290 1300 1310 1320 PEPPEPPPVT EEDLDYRTEN QHVPTTSSSL TDPHAGVKAA LLQLLAQHQP QDDPKREGGI 1330 1340 1350 1360 1370 1380 DYPTGDTYVP SSDYKDNFGS SFSAAPYVSS DGLGSSSAAA PLEARSFIGN SDIQSLDNYS 1390 1400 1410 1420 1430 1440 TASSHTGGPP QTSAFTESFA SSVAGYGDIY LNAGPMLFSG DKDHRFEYSH GPITVLTNSN 1450 1460 1470 1480 1490 1500 DPSTGPESTH PLPAKMHNYN YGGNLQENPG GPSLMHGQTW TSPAQGPGYS QGYRGHISTS 1510 AGRGRGRGLP Y
	Isoform 2. Checksum: BCEAC9CDEB90D8AD	FASTA	1,451	158,190
	10 20 30 40 50 60 MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ PPPPPPPLLF 70 80 90 100 110 120 LAAPGAAAAA AAVAAASSSC FSPGPPLEVK RLARGKRRPG GRRKRRRGPR AGQEAEKRRV 130 140 150 160 170 180 FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA AGGTGGNGGS 190 200 210 220 230 240 PASSSGTQRR AEGSERRPRR DRRSSSGRSK ERHREHRRRD GTRSGSEASK ARSRHGHSGE 250 260 270 280 290 300 ERAEAAKSGS SSSSGGRRKS ASATSSSSSS RKDRDLKAHR SRTKSSKEPP SAYKEPPKAY 310 320 330 340 350 360 REDKSEPKAY RRRQRSLSPL GGRDESPVSH RASQSLRSRK SPSPAGGGSS PYSRRLPRSP 370 380 390 400 410 420 SPYSRRRSPS YSRHSSYERG GDVSPSPYSS SSWRRSRSPY SPVLRRSAKS RSRSPYSSRH 430 440 450 460 470 480 SRSRSRHRLS RSRSRHSSIS PSTLTLKSSL AAELNKNKKA RAAEAARAAE AAKAAEAAKA 490 500 510 520 530 540 AEAAAKAAKA SNASTPTKGN TETGASVSQT NHVKEVKKLK TEHAPSPSSG GTVKSDKAKT 550 560 570 580 590 600 KPPLQVTKVD NNLTVEKATK KTVVGKESKP AATKEEPVST KEKSKPLTPS TGAKEKEQHV 610 620 630 640 650 660 ALVTSTLPPL PLPPMLPEDK DADSLRGNIS VKAVKKEVEK KLRCLLADLP LPPELPGGDD 670 680 690 700 710 720 LSKSPEEKKT AAQLHSKRRP KICGPRYGEI KEKDIDWGKR CVDKFDIIGI IGEGTYGQVY 730 740 750 760 770 780 KARDKDTGEM VALKKVRLDN EKEGFPITAI REIKILRQLT HQSIINMKEI VTDKEDALDF 790 800 810 820 830 840 KKDKGAFYLV FEYMDHDLMG LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC 850 860 870 880 890 900 SNILLNNRGQ IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC 910 920 930 940 950 960 GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM KPKKQYRRKL 970 980 990 1000 1010 1020 REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD VEPSKMPPPD LPLWQDCHEL 1030 1040 1050 1060 1070 1080 WSKKRRRQKQ MGMTDDLSTI KAPRKDLSLG LDDSRTNTPQ GVLPPAQLKS QSNSNVAPGE 1090 1100 1110 1120 1130 1140 KQTDPSTPQQ ESSKSLGGVQ PSQTIQPKVE TDAAQAAVQS AFAVLLTQLI KAQQSKQKDA 1150 1160 1170 1180 1190 1200 MLEERENGSG HEAPLQLRPP LEPSTPGSGQ DDLIQHQDRR ILELTPEPDR PRILPPDQRP 1210 1220 1230 1240 1250 1260 PEPPEPPPVT EEDLDYRTEN QHVPTTSSSL TDPHAGVKAA LLQLLAQHQP QDDPKREGGI 1270 1280 1290 1300 1310 1320 DYPTGDTYVP SSDYKDNFGS SFSAAPYVSS DGLGSSSAAA PLEARSFIGN SDIQSLDNYS 1330 1340 1350 1360 1370 1380 TASSHTGGPP QTSAFTESFA SSVAGYGDIY LNAGPMLFSG DKDHRFEYSH GPITVLTNSN 1390 1400 1410 1420 1430 1440 DPSTGPESTH PLPAKMHNYN YGGNLQENPG GPSLMHGQTW TSPAQGPGYS QGYRGHISTS 1450 AGRGRGRGLP Y

References

[1]	"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H. DNA Res. 11:205-218(2004) [PubMed: 15368895] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Embryonic tail.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 295-1511 (ISOFORM 1). Strain: C57BL/6J. Tissue: Urinary bladder.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 891-1511 (ISOFORMS 1 AND 2). Strain: FVB/N. Tissue: Mammary tumor.
[4]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384; SER-396; SER-398; SER-401; SER-437 AND SER-438, MASS SPECTROMETRY. Tissue: Liver.
[5]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326; SER-396; SER-398; SER-401; SER-410; SER-438 AND THR-871, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK173265 mRNA. Translation: BAD32543.1. Different initiation. AK035493 mRNA. Translation: BAC29077.1. Sequence problems. BC032179 mRNA. Translation: AAH32179.1. Different initiation. BC051093 mRNA. Translation: AAH51093.1.
IPI	IPI00464128. IPI00556693.
UniGene	Mm.193924
3D structure databases
HSSP	HSSP built from PDB template 1P2A based on UniProtKB P24941.
ModBase	Search...
PTM databases
PhosphoSite	Q69ZA1.
Proteomic databases
PRIDE	Q69ZA1.
Genome annotation databases
Ensembl	ENSMUST00000042365; ENSMUSP00000036013; ENSMUSG00000041297; Mus musculus. [Genome view]
UCSC	uc007poc.1. mouse. uc007pod.1. mouse.
Organism-specific databases
MGI	MGI:1916812. Cdc2l5.
Rouge	Search...
Phylogenomic databases
HOGENOM	Q69ZA1.
HOVERGEN	Q69ZA1.
Enzyme and pathway databases
BRENDA	2.7.11.22. 244.
Gene expression databases
ArrayExpress	Q69ZA1.
Bgee	Q69ZA1.
Genevestigator	Q69ZA1.
GermOnline	ENSMUSG00000041297. Mus musculus.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

CD2L5_MOUSE

Accession

Primary (citable) accession number: Q69ZA1
Secondary accession number(s): Q80V11, Q8BZG1, Q8K0A4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	October 13, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)