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Q69ZA1 (CDK13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 13

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
CDC2-related protein kinase 5
Cell division cycle 2-like protein kinase 5
Cell division protein kinase 13
Gene names
Name:Cdk13
Synonyms:Cdc2l5, Kiaa1791
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1511 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. Ref.5

Catalytic activity

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with C1QBP By similarity. Interacts with CCNL1 and CCNL2. Ref.5

Subcellular location

Nucleus speckle By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAH32179.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAC29077.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC29077.1 differs from that shown. Reason: Frameshift at positions 633 and 666.

The sequence BAD32543.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q69ZA1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q69ZA1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1079-1138: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15111511Cyclin-dependent kinase 13
PRO_0000085712

Regions

Domain705 – 998294Protein kinase
Nucleotide binding711 – 7199ATP By similarity

Sites

Active site8371Proton acceptor By similarity
Binding site7341ATP By similarity

Amino acid modifications

Modified residue3161Phosphoserine By similarity
Modified residue3181Phosphoserine By similarity
Modified residue3261Phosphoserine By similarity
Modified residue3411Phosphoserine By similarity
Modified residue3431Phosphoserine By similarity
Modified residue3841Phosphoserine By similarity
Modified residue3961Phosphoserine By similarity
Modified residue3981Phosphoserine By similarity
Modified residue4011Phosphoserine By similarity
Modified residue4381Phosphoserine Ref.6
Modified residue4401Phosphoserine By similarity
Modified residue5261Phosphoserine By similarity
Modified residue5571N6-acetyllysine By similarity
Modified residue8711Phosphothreonine By similarity
Modified residue10481Phosphoserine By similarity
Modified residue12451Phosphothreonine By similarity

Natural variations

Alternative sequence1079 – 113860Missing in isoform 2.
VSP_013580

Experimental info

Sequence conflict731A → V in BAD32543. Ref.1
Sequence conflict1031Q → R in BAD32543. Ref.1
Sequence conflict6371E → K in BAC29077. Ref.3
Sequence conflict10091P → L in BAD32543. Ref.1
Sequence conflict12061E → K in AAH32179. Ref.4
Sequence conflict14001A → P in AAH51093. Ref.4
Sequence conflict14641N → D in BAC29077. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: EAF4438ABB5063CE

FASTA1,511164,553
        10         20         30         40         50         60 
MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ PPPPPPPLLF 

        70         80         90        100        110        120 
LAAPGAAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRPG GRQKRRRGPR AGQEAEKRRV 

       130        140        150        160        170        180 
FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA AGGTGGNGGS 

       190        200        210        220        230        240 
PASSSGTQRR AEGSERRPRR DRRSSSGRSK ERHREHRRRD GTRSGSEASK ARSRHGHSGE 

       250        260        270        280        290        300 
ERAEAAKSGS SSSSGGRRKS ASATSSSSSS RKDRDLKAHR SRTKSSKEPP SAYKEPPKAY 

       310        320        330        340        350        360 
REDKSEPKAY RRRQRSLSPL GGRDESPVSH RASQSLRSRK SPSPAGGGSS PYSRRLPRSP 

       370        380        390        400        410        420 
SPYSRRRSPS YSRHSSYERG GDVSPSPYSS SSWRRSRSPY SPVLRRSAKS RSRSPYSSRH 

       430        440        450        460        470        480 
SRSRSRHRLS RSRSRHSSIS PSTLTLKSSL AAELNKNKKA RAAEAARAAE AAKAAEAAKA 

       490        500        510        520        530        540 
AEAAAKAAKA SNASTPTKGN TETGASVSQT NHVKEVKKLK TEHAPSPSSG GTVKSDKAKT 

       550        560        570        580        590        600 
KPPLQVTKVD NNLTVEKATK KTVVGKESKP AATKEEPVST KEKSKPLTPS TGAKEKEQHV 

       610        620        630        640        650        660 
ALVTSTLPPL PLPPMLPEDK DADSLRGNIS VKAVKKEVEK KLRCLLADLP LPPELPGGDD 

       670        680        690        700        710        720 
LSKSPEEKKT AAQLHSKRRP KICGPRYGEI KEKDIDWGKR CVDKFDIIGI IGEGTYGQVY 

       730        740        750        760        770        780 
KARDKDTGEM VALKKVRLDN EKEGFPITAI REIKILRQLT HQSIINMKEI VTDKEDALDF 

       790        800        810        820        830        840 
KKDKGAFYLV FEYMDHDLMG LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC 

       850        860        870        880        890        900 
SNILLNNRGQ IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC 

       910        920        930        940        950        960 
GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM KPKKQYRRKL 

       970        980        990       1000       1010       1020 
REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD VEPSKMPPPD LPLWQDCHEL 

      1030       1040       1050       1060       1070       1080 
WSKKRRRQKQ MGMTDDLSTI KAPRKDLSLG LDDSRTNTPQ GVLPPAQLKS QSNSNVAPVI 

      1090       1100       1110       1120       1130       1140 
TGPGQPLNHS ELAILLNLLQ SKSSVNMADF VQVLNIKVNS ETQQQLNKIN LPAGILATGE 

      1150       1160       1170       1180       1190       1200 
KQTDPSTPQQ ESSKSLGGVQ PSQTIQPKVE TDAAQAAVQS AFAVLLTQLI KAQQSKQKDA 

      1210       1220       1230       1240       1250       1260 
MLEERENGSG HEAPLQLRPP LEPSTPGSGQ DDLIQHQDRR ILELTPEPDR PRILPPDQRP 

      1270       1280       1290       1300       1310       1320 
PEPPEPPPVT EEDLDYRTEN QHVPTTSSSL TDPHAGVKAA LLQLLAQHQP QDDPKREGGI 

      1330       1340       1350       1360       1370       1380 
DYPTGDTYVP SSDYKDNFGS SFSAAPYVSS DGLGSSSAAA PLEARSFIGN SDIQSLDNYS 

      1390       1400       1410       1420       1430       1440 
TASSHTGGPP QTSAFTESFA SSVAGYGDIY LNAGPMLFSG DKDHRFEYSH GPITVLTNSN 

      1450       1460       1470       1480       1490       1500 
DPSTGPESTH PLPAKMHNYN YGGNLQENPG GPSLMHGQTW TSPAQGPGYS QGYRGHISTS 

      1510 
AGRGRGRGLP Y 

« Hide

Isoform 2 [UniParc].

Checksum: 83560368EE52A192
Show »

FASTA1,451158,133

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Embryonic tail.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 295-1511 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Urinary bladder.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 891-1511 (ISOFORMS 1 AND 2).
Strain: FVB/N.
Tissue: Mammary tumor.
[5]"CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing."
Chen H.H., Wong Y.H., Geneviere A.M., Fann M.J.
Biochem. Biophys. Res. Commun. 354:735-740(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CCNL1 AND CCNL2.
[6]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[7]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK173265 mRNA. Translation: BAD32543.1. Different initiation.
AC154219 Genomic DNA. No translation available.
AC154828 Genomic DNA. No translation available.
AK035493 mRNA. Translation: BAC29077.1. Sequence problems.
BC032179 mRNA. Translation: AAH32179.1. Different initiation.
BC051093 mRNA. Translation: AAH51093.1.
RefSeqNP_001074527.1. NM_001081058.2.
NP_081394.1. NM_027118.1.
UniGeneMm.193924.

3D structure databases

ProteinModelPortalQ69ZA1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ69ZA1. 1 interaction.
MINTMINT-4113604.
STRING10090.ENSMUSP00000036013.

PTM databases

PhosphoSiteQ69ZA1.

Proteomic databases

PaxDbQ69ZA1.
PRIDEQ69ZA1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042365; ENSMUSP00000036013; ENSMUSG00000041297. [Q69ZA1-1]
GeneID69562.
KEGGmmu:69562.
UCSCuc007poc.2. mouse. [Q69ZA1-1]
uc007pod.2. mouse. [Q69ZA1-2]

Organism-specific databases

CTD8621.
MGIMGI:1916812. Cdk13.
RougeSearch...

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00740000114964.
HOGENOMHOG000049118.
HOVERGENHBG050851.
InParanoidQ69ZA1.
KOK08819.
OMANVAPVKT.
OrthoDBEOG76DTSM.
TreeFamTF101060.

Gene expression databases

BgeeQ69ZA1.
GenevestigatorQ69ZA1.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio329780.
PROQ69ZA1.
SOURCESearch...

Entry information

Entry nameCDK13_MOUSE
AccessionPrimary (citable) accession number: Q69ZA1
Secondary accession number(s): E9QKZ6 expand/collapse secondary AC list , Q80V11, Q8BZG1, Q8K0A4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot