Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q69ZA1 (CD2L5_MOUSE)

Last modified October 13, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cell division cycle 2-like protein kinase 5
    EC=2.7.11.22
Alternative name(s):
    CDC2-related protein kinase 5
Gene names
Name: Cdc2l5
Synonyms: Kiaa1791
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length1511 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May be a controller of the mitotic cell cycle. Involved in the blood cell development By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAC29077.1 differs from that shown. Reason: Frameshift at positions 633 and 666.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q69ZA1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q69ZA1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1079-1138: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15111511Cell division cycle 2-like protein kinase 5
PRO_0000085712

Regions

Domain705 – 998294Protein kinase
Nucleotide binding711 – 7199ATP By similarity

Sites

Active site8371Proton acceptor By similarity
Binding site7341ATP By similarity

Amino acid modifications

Modified residue3161Phosphoserine By similarity
Modified residue3181Phosphoserine By similarity
Modified residue3261Phosphoserine Ref.5
Modified residue3411Phosphoserine By similarity
Modified residue3431Phosphoserine By similarity
Modified residue3501Phosphoserine By similarity
Modified residue3591Phosphoserine By similarity
Modified residue3611Phosphoserine By similarity
Modified residue3681Phosphoserine By similarity
Modified residue3841Phosphoserine Ref.4
Modified residue3961Phosphoserine Ref.5 Ref.4
Modified residue3981Phosphoserine Ref.5 Ref.4
Modified residue4011Phosphoserine Ref.5 Ref.4
Modified residue4101Phosphoserine Ref.5
Modified residue4371Phosphoserine Ref.4
Modified residue4381Phosphoserine Ref.5 Ref.4
Modified residue4401Phosphoserine By similarity
Modified residue4421Phosphoserine By similarity
Modified residue4431Phosphothreonine By similarity
Modified residue5261Phosphoserine By similarity
Modified residue5571N6-acetyllysine By similarity
Modified residue6641Phosphoserine By similarity
Modified residue8711Phosphothreonine Ref.5
Modified residue10541Phosphoserine By similarity
Modified residue10561Phosphothreonine By similarity
Modified residue12451Phosphothreonine By similarity

Natural variations

Alternative sequence1079 – 113860Missing in isoform 2.
VSP_013580

Experimental info

Sequence conflict6371E → K in BAC29077. Ref.2
Sequence conflict10091P → L in BAD32543. Ref.1
Sequence conflict1079 – 113860Missing in AAH51093. Ref.3
Sequence conflict12061E → K in AAH32179. Ref.3
Sequence conflict14001A → P in AAH51093. Ref.3
Sequence conflict14641N → D in BAC29077. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: F945976C6CF54CB8

FASTA1,511164,609
        10         20         30         40         50         60 
MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ PPPPPPPLLF 

        70         80         90        100        110        120 
LAAPGAAAAA AAVAAASSSC FSPGPPLEVK RLARGKRRPG GRRKRRRGPR AGQEAEKRRV 

       130        140        150        160        170        180 
FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA AGGTGGNGGS 

       190        200        210        220        230        240 
PASSSGTQRR AEGSERRPRR DRRSSSGRSK ERHREHRRRD GTRSGSEASK ARSRHGHSGE 

       250        260        270        280        290        300 
ERAEAAKSGS SSSSGGRRKS ASATSSSSSS RKDRDLKAHR SRTKSSKEPP SAYKEPPKAY 

       310        320        330        340        350        360 
REDKSEPKAY RRRQRSLSPL GGRDESPVSH RASQSLRSRK SPSPAGGGSS PYSRRLPRSP 

       370        380        390        400        410        420 
SPYSRRRSPS YSRHSSYERG GDVSPSPYSS SSWRRSRSPY SPVLRRSAKS RSRSPYSSRH 

       430        440        450        460        470        480 
SRSRSRHRLS RSRSRHSSIS PSTLTLKSSL AAELNKNKKA RAAEAARAAE AAKAAEAAKA 

       490        500        510        520        530        540 
AEAAAKAAKA SNASTPTKGN TETGASVSQT NHVKEVKKLK TEHAPSPSSG GTVKSDKAKT 

       550        560        570        580        590        600 
KPPLQVTKVD NNLTVEKATK KTVVGKESKP AATKEEPVST KEKSKPLTPS TGAKEKEQHV 

       610        620        630        640        650        660 
ALVTSTLPPL PLPPMLPEDK DADSLRGNIS VKAVKKEVEK KLRCLLADLP LPPELPGGDD 

       670        680        690        700        710        720 
LSKSPEEKKT AAQLHSKRRP KICGPRYGEI KEKDIDWGKR CVDKFDIIGI IGEGTYGQVY 

       730        740        750        760        770        780 
KARDKDTGEM VALKKVRLDN EKEGFPITAI REIKILRQLT HQSIINMKEI VTDKEDALDF 

       790        800        810        820        830        840 
KKDKGAFYLV FEYMDHDLMG LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC 

       850        860        870        880        890        900 
SNILLNNRGQ IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC 

       910        920        930        940        950        960 
GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM KPKKQYRRKL 

       970        980        990       1000       1010       1020 
REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD VEPSKMPPPD LPLWQDCHEL 

      1030       1040       1050       1060       1070       1080 
WSKKRRRQKQ MGMTDDLSTI KAPRKDLSLG LDDSRTNTPQ GVLPPAQLKS QSNSNVAPVI 

      1090       1100       1110       1120       1130       1140 
TGPGQPLNHS ELAILLNLLQ SKSSVNMADF VQVLNIKVNS ETQQQLNKIN LPAGILATGE 

      1150       1160       1170       1180       1190       1200 
KQTDPSTPQQ ESSKSLGGVQ PSQTIQPKVE TDAAQAAVQS AFAVLLTQLI KAQQSKQKDA 

      1210       1220       1230       1240       1250       1260 
MLEERENGSG HEAPLQLRPP LEPSTPGSGQ DDLIQHQDRR ILELTPEPDR PRILPPDQRP 

      1270       1280       1290       1300       1310       1320 
PEPPEPPPVT EEDLDYRTEN QHVPTTSSSL TDPHAGVKAA LLQLLAQHQP QDDPKREGGI 

      1330       1340       1350       1360       1370       1380 
DYPTGDTYVP SSDYKDNFGS SFSAAPYVSS DGLGSSSAAA PLEARSFIGN SDIQSLDNYS 

      1390       1400       1410       1420       1430       1440 
TASSHTGGPP QTSAFTESFA SSVAGYGDIY LNAGPMLFSG DKDHRFEYSH GPITVLTNSN 

      1450       1460       1470       1480       1490       1500 
DPSTGPESTH PLPAKMHNYN YGGNLQENPG GPSLMHGQTW TSPAQGPGYS QGYRGHISTS 

      1510 
AGRGRGRGLP Y 

« Hide

Isoform 2.

Checksum: BCEAC9CDEB90D8AD
Show »

FASTA1,451158,190

References

[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed: 15368895] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Embryonic tail.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 295-1511 (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Urinary bladder.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 891-1511 (ISOFORMS 1 AND 2).
Strain: FVB/N.
Tissue: Mammary tumor.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384; SER-396; SER-398; SER-401; SER-437 AND SER-438, MASS SPECTROMETRY.
Tissue: Liver.
[5]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326; SER-396; SER-398; SER-401; SER-410; SER-438 AND THR-871, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

AK173265 mRNA. Translation: BAD32543.1. Different initiation.
AK035493 mRNA. Translation: BAC29077.1. Sequence problems.
BC032179 mRNA. Translation: AAH32179.1. Different initiation.
BC051093 mRNA. Translation: AAH51093.1.
IPIIPI00464128.
IPI00556693.
UniGeneMm.193924

3D structure databases

HSSPHSSP built from PDB template 1P2A based on UniProtKB P24941.
ModBaseSearch...

PTM databases

PhosphoSiteQ69ZA1.

Proteomic databases

PRIDEQ69ZA1.

Genome annotation databases

EnsemblENSMUST00000042365; ENSMUSP00000036013; ENSMUSG00000041297; Mus musculus. [Genome view]
UCSCuc007poc.1. mouse.
uc007pod.1. mouse.

Organism-specific databases

MGIMGI:1916812. Cdc2l5.
RougeSearch...

Phylogenomic databases

HOGENOMQ69ZA1.
HOVERGENQ69ZA1.

Enzyme and pathway databases

BRENDA2.7.11.22. 244.

Gene expression databases

ArrayExpressQ69ZA1.
BgeeQ69ZA1.
GenevestigatorQ69ZA1.
GermOnlineENSMUSG00000041297. Mus musculus.

Family and domain databases

InterProIPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameCD2L5_MOUSE
AccessionPrimary (citable) accession number: Q69ZA1
Secondary accession number(s): Q80V11, Q8BZG1, Q8K0A4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 13, 2009
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents