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UniProtKB - Q69Z98 (BRSK2_MOUSE)

UniProt

Q69Z98 - BRSK2_MOUSE

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Protein

Serine/threonine-protein kinase BRSK2

Gene

Brsk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-261 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.5 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication
ATP + [tau protein] = ADP + [tau protein] phosphate.1 Publication

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by phosphorylation on Thr-175 by STK11/LKB1.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei142 – 1421Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATPase binding Source: MGI
  • ATP binding Source: MGI
  • magnesium ion binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • tau-protein kinase activity Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton reorganization Source: MGI
  • axonogenesis Source: UniProtKB
  • cell division Source: UniProtKB-KW
  • ERAD pathway Source: MGI
  • establishment of cell polarity Source: UniProtKB
  • exocytosis Source: UniProtKB-KW
  • G2/M transition of mitotic cell cycle Source: MGI
  • intracellular signal transduction Source: GO_Central
  • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
  • mitotic nuclear division Source: UniProtKB-KW
  • neuron differentiation Source: UniProtKB
  • neuron projection morphogenesis Source: MGI
  • peptidyl-serine phosphorylation Source: MGI
  • protein phosphorylation Source: UniProtKB
  • regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Exocytosis, Mitosis, Neurogenesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase BRSK2 (EC:2.7.11.1, EC:2.7.11.26)
Alternative name(s):
Brain-specific serine/threonine-protein kinase 2
Short name:
BR serine/threonine-protein kinase 2
Serine/threonine-protein kinase SAD-A
Gene namesi
Name:Brsk2
Synonyms:Kiaa4256, Sada
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1923020. Brsk2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice are fertile and healthy. In contrast, mice lacking both Brsk1 and Brsk2 show little spontaneous movement and are only weakly responsive to tactile stimulation: they die within 2 hours of birth. Defects are due to impaired neuronal differentiation and polarity.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi49 – 491K → A: Loss of kinase activity. 1 Publication
Mutagenesisi175 – 1751T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Serine/threonine-protein kinase BRSK2PRO_0000274036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751Phosphothreonine; by LKB11 Publication
Modified residuei261 – 2611Phosphothreonine; by PKABy similarity
Modified residuei295 – 2951PhosphoserineBy similarity
Modified residuei368 – 3681PhosphoserineBy similarity
Modified residuei383 – 3831PhosphoserineCombined sources
Modified residuei394 – 3941PhosphoserineCombined sources
Modified residuei413 – 4131PhosphoserineCombined sources
Modified residuei423 – 4231PhosphothreonineBy similarity
Modified residuei424 – 4241PhosphoserineCombined sources
Modified residuei428 – 4281PhosphoserineCombined sources
Modified residuei456 – 4561PhosphoserineCombined sources
Modified residuei460 – 4601PhosphothreonineCombined sources
Modified residuei464 – 4641PhosphothreonineCombined sources
Modified residuei510 – 5101PhosphothreonineCombined sources
Modified residuei513 – 5131PhosphoserineCombined sources
Modified residuei514 – 5141PhosphoserineCombined sources
Modified residuei521 – 5211PhosphoserineCombined sources

Post-translational modificationi

May be phosphorylated at Thr-261 by PKA (By similarity). Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-175 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-175 by PP2C.By similarity1 Publication
Polyubiquitinated by the APC complex in conjunction with FZR1, leading to its proteasomal degradation. Targeted for proteasomal degradation by interaction with COPS5. BRSK2 levels change during the cell cycle. BRSK2 levels are low at the G1/S boundary and gradually increase as cells progress into G2 phase. BRSK2 levels decrease rapidly at the end of mitosis (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ69Z98.
PaxDbiQ69Z98.
PeptideAtlasiQ69Z98.
PRIDEiQ69Z98.

PTM databases

iPTMnetiQ69Z98.
PhosphoSiteiQ69Z98.

Expressioni

Tissue specificityi

Detected in pancreas islets and in brain (at protein level). Detected in brain and pancreas.1 Publication

Gene expression databases

BgeeiENSMUSG00000053046.
CleanExiMM_BRSK2.
ExpressionAtlasiQ69Z98. baseline and differential.
GenevisibleiQ69Z98. MM.

Interactioni

Subunit structurei

Interacts with FZR1, a regulatory subunit of the APC ubiquitin ligase complex. Interacts with COPS5. Interacts with PAK1 (By similarity).By similarity

GO - Molecular functioni

  • ATPase binding Source: MGI
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi217728. 1 interaction.
STRINGi10090.ENSMUSP00000074969.

Structurei

Secondary structure

1
735
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi15 – 173Combined sources
Beta strandi20 – 2910Combined sources
Beta strandi32 – 398Combined sources
Turni40 – 423Combined sources
Beta strandi45 – 539Combined sources
Helixi58 – 7114Combined sources
Beta strandi82 – 876Combined sources
Beta strandi89 – 968Combined sources
Helixi104 – 1118Combined sources
Helixi116 – 13520Combined sources
Helixi145 – 1473Combined sources
Beta strandi148 – 1503Combined sources
Beta strandi156 – 1583Combined sources
Helixi164 – 1663Combined sources
Beta strandi172 – 1743Combined sources
Helixi180 – 1823Combined sources
Helixi185 – 1884Combined sources
Helixi195 – 21218Combined sources
Helixi222 – 23110Combined sources
Helixi242 – 25110Combined sources
Turni256 – 2583Combined sources
Helixi262 – 2665Combined sources
Helixi269 – 2724Combined sources
Turni274 – 2763Combined sources
Helixi296 – 2983Combined sources
Helixi301 – 3088Combined sources
Helixi311 – 3133Combined sources
Helixi316 – 3249Combined sources
Beta strandi325 – 3273Combined sources
Helixi330 – 34213Combined sources
Beta strandi520 – 5234Combined sources
Turni524 – 5263Combined sources
Beta strandi530 – 5323Combined sources
Beta strandi534 – 5396Combined sources
Helixi544 – 55613Combined sources
Beta strandi561 – 5677Combined sources
Beta strandi570 – 5756Combined sources
Beta strandi588 – 5969Combined sources
Beta strandi609 – 61810Combined sources
Helixi620 – 63516Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YNZX-ray2.00A/B15-342[»]
4YOMX-ray2.49A519-662[»]
B1-342[»]
ProteinModelPortaliQ69Z98.
SMRiQ69Z98. Positions 16-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 271252Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini298 – 34043UBAAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi604 – 6063KEN boxBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi425 – 46945Pro-richAdd
BLAST

Domaini

The KEN box motif is required for interaction with FZR1/CDH1 and essential for APC(CDH1)-mediated ubiquitination.By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 UBA domain.Curated

Phylogenomic databases

eggNOGiKOG0588. Eukaryota.
ENOG410XNQ0. LUCA.
GeneTreeiENSGT00840000129789.
HOGENOMiHOG000246447.
HOVERGENiHBG007240.
InParanoidiQ69Z98.
KOiK08796.
OMAiNCMELMT.
OrthoDBiEOG091G02CG.
PhylomeDBiQ69Z98.
TreeFamiTF313967.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69Z98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSTGKDGGG AQHAQYVGPY RLEKTLGKGQ TGLVKLGIHC VTCQKVAIKI 
        60         70         80         90        100
VNREKLSESV LMKVEREIAI LKLIEHPHVL KLHDVYENKK YLYLVLEHVS 
       110        120        130        140        150
GGELFDYLVK KGRLTPKEAR KFFRQIISAL DFCHSHSICH RDLKPENLLL 
       160        170        180        190        200
DERNNIRIAD FGMASLQVGD SLLETSCGSP HYACPEVIRG EKYDGRKADV 
       210        220        230        240        250
WSCGVILFAL LVGALPFDDD NLRQLLEKVK RGVFHMPHFI PPDCQSLLRG 
       260        270        280        290        300
MIEVDAARRL TLEHIQKHIW YIGGKNEPEP EQPIPRKVQI RSLPSLEDID 
       310        320        330        340        350
PDVLDSMHSL GCFRDRNKLL QDLLSEEENQ EKMIYFLLLD RKERYPSHED 
       360        370        380        390        400
EDLPPRNEID PPRKRVDSPM LNRHGKRRPE RKSMEVLSVT DGGSPVPARR 
       410        420        430        440        450
AIEMAQHGQR SRSISGASSG LSTSPLSSPR VTPHPSPRGS PLPTPKGTPV 
       460        470        480        490        500
HTPKESPAGT PNPTPPSSPS VGGVPWRTRL NSIKNSFLGS PRFHRRKLQV 
       510        520        530        540        550
PTPEEMSNLT PESSPELAKK SWFGNFINLE KEEQIFVVIK DKPLSSIKAD 
       560        570        580        590        600
IVHAFLSIPS LSHSVISQTS FRAEYKATGG PAVFQKPVKF QVDITYTEGG 
       610        620        630        640        650
EAQKENGIYS VTFTLLSGPS RRFKRVVETI QAQLLSTHDQ PSAQHLSDTT 
       660        670        680        690        700
NCMEVMTGRL SKCGTPLSNF FDVIKQLFSD EKNGQAAQAP STPAKRSAHG 
       710        720        730 
PLGDSAAAGP GGDTEYPMGK DMAKMGPPAA RREQP
Length:735
Mass (Da):81,733
Last modified:January 23, 2007 - v2
Checksum:iA37FCC6CC7253F11
GO
Isoform 2 (identifier: Q69Z98-2) [UniParc]FASTAAdd to basket
Also known as: SADA-beta

The sequence of this isoform differs from the canonical sequence as follows:
     648-735: DTTNCMEVMT...GPPAARREQP → EPPPPAPGLSWGAGLKGQKVATSYESSL

Note: No experimental confirmation available.
Show »
Length:675
Mass (Da):75,361
Checksum:iB01D8D8F9C24C71F
GO
Isoform 3 (identifier: Q69Z98-3) [UniParc]FASTAAdd to basket
Also known as: SADA-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     664-679: Missing.

Note: No experimental confirmation available.
Show »
Length:719
Mass (Da):79,938
Checksum:i4C2ABA57205974AB
GO
Isoform 4 (identifier: Q69Z98-4) [UniParc]FASTAAdd to basket
Also known as: SADA-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     648-653: DTTNCM → GIIPKS
     654-735: Missing.

Show »
Length:653
Mass (Da):73,150
Checksum:i8A23B94D71850E9A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 4313TGLVK…HCVTC → VDGDLLASDTVDS in BAD32546 (PubMed:15368895).CuratedAdd
BLAST

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei648 – 73588DTTNC…RREQP → EPPPPAPGLSWGAGLKGQKV ATSYESSL in isoform 2. 1 PublicationVSP_022605Add
BLAST
Alternative sequencei648 – 6536DTTNCM → GIIPKS in isoform 4. 3 PublicationsVSP_022607
Alternative sequencei654 – 73582Missing in isoform 4. 3 PublicationsVSP_022608Add
BLAST
Alternative sequencei664 – 67916Missing in isoform 3. 1 PublicationVSP_022606Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY533672 mRNA. Translation: AAT08447.1.
AY533673 mRNA. Translation: AAT08448.1.
AY533674 mRNA. Translation: AAT08449.1.
AY660739 mRNA. Translation: AAT74618.1.
AL603836 Genomic DNA. No translation available.
AL772165 Genomic DNA. No translation available.
AK173268 mRNA. Translation: BAD32546.1.
BC056498 mRNA. Translation: AAH56498.1.
CCDSiCCDS22021.1. [Q69Z98-4]
CCDS22022.1. [Q69Z98-3]
CCDS22023.1. [Q69Z98-2]
RefSeqiNP_001009929.1. NM_001009929.3. [Q69Z98-2]
NP_001009930.1. NM_001009930.3. [Q69Z98-3]
NP_083702.1. NM_029426.2. [Q69Z98-4]
UniGeneiMm.274868.
Mm.482784.

Genome annotation databases

EnsembliENSMUST00000018971; ENSMUSP00000018971; ENSMUSG00000053046. [Q69Z98-4]
ENSMUST00000075528; ENSMUSP00000074969; ENSMUSG00000053046. [Q69Z98-3]
ENSMUST00000078200; ENSMUSP00000077330; ENSMUSG00000053046. [Q69Z98-2]
ENSMUST00000105989; ENSMUSP00000101610; ENSMUSG00000053046. [Q69Z98-2]
ENSMUST00000174499; ENSMUSP00000134201; ENSMUSG00000053046. [Q69Z98-1]
GeneIDi75770.
KEGGimmu:75770.
UCSCiuc009kme.2. mouse. [Q69Z98-2]
uc009kmf.2. mouse. [Q69Z98-3]
uc009kmg.1. mouse. [Q69Z98-4]
uc009kmi.1. mouse. [Q69Z98-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY533672 mRNA. Translation: AAT08447.1.
AY533673 mRNA. Translation: AAT08448.1.
AY533674 mRNA. Translation: AAT08449.1.
AY660739 mRNA. Translation: AAT74618.1.
AL603836 Genomic DNA. No translation available.
AL772165 Genomic DNA. No translation available.
AK173268 mRNA. Translation: BAD32546.1.
BC056498 mRNA. Translation: AAH56498.1.
CCDSiCCDS22021.1. [Q69Z98-4]
CCDS22022.1. [Q69Z98-3]
CCDS22023.1. [Q69Z98-2]
RefSeqiNP_001009929.1. NM_001009929.3. [Q69Z98-2]
NP_001009930.1. NM_001009930.3. [Q69Z98-3]
NP_083702.1. NM_029426.2. [Q69Z98-4]
UniGeneiMm.274868.
Mm.482784.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YNZX-ray2.00A/B15-342[»]
4YOMX-ray2.49A519-662[»]
B1-342[»]
ProteinModelPortaliQ69Z98.
SMRiQ69Z98. Positions 16-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217728. 1 interaction.
STRINGi10090.ENSMUSP00000074969.

PTM databases

iPTMnetiQ69Z98.
PhosphoSiteiQ69Z98.

Proteomic databases

MaxQBiQ69Z98.
PaxDbiQ69Z98.
PeptideAtlasiQ69Z98.
PRIDEiQ69Z98.

Protocols and materials databases

DNASUi75770.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018971; ENSMUSP00000018971; ENSMUSG00000053046. [Q69Z98-4]
ENSMUST00000075528; ENSMUSP00000074969; ENSMUSG00000053046. [Q69Z98-3]
ENSMUST00000078200; ENSMUSP00000077330; ENSMUSG00000053046. [Q69Z98-2]
ENSMUST00000105989; ENSMUSP00000101610; ENSMUSG00000053046. [Q69Z98-2]
ENSMUST00000174499; ENSMUSP00000134201; ENSMUSG00000053046. [Q69Z98-1]
GeneIDi75770.
KEGGimmu:75770.
UCSCiuc009kme.2. mouse. [Q69Z98-2]
uc009kmf.2. mouse. [Q69Z98-3]
uc009kmg.1. mouse. [Q69Z98-4]
uc009kmi.1. mouse. [Q69Z98-1]

Organism-specific databases

CTDi9024.
MGIiMGI:1923020. Brsk2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0588. Eukaryota.
ENOG410XNQ0. LUCA.
GeneTreeiENSGT00840000129789.
HOGENOMiHOG000246447.
HOVERGENiHBG007240.
InParanoidiQ69Z98.
KOiK08796.
OMAiNCMELMT.
OrthoDBiEOG091G02CG.
PhylomeDBiQ69Z98.
TreeFamiTF313967.

Miscellaneous databases

PROiQ69Z98.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053046.
CleanExiMM_BRSK2.
ExpressionAtlasiQ69Z98. baseline and differential.
GenevisibleiQ69Z98. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRSK2_MOUSE
AccessioniPrimary (citable) accession number: Q69Z98
Secondary accession number(s): Q699J3
, Q699J4, Q6DMN7, Q6PHM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.