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Protein

Ras-associating and dilute domain-containing protein

Gene

Radil

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-associating and dilute domain-containing protein
Gene namesi
Name:Radil
Synonyms:Kiaa1849
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2443088. Radil.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10991099Ras-associating and dilute domain-containing proteinPRO_0000050804Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei235 – 2351PhosphoserineCombined sources
Modified residuei245 – 2451PhosphoserineCombined sources
Modified residuei248 – 2481PhosphoserineCombined sources
Modified residuei250 – 2501PhosphoserineCombined sources
Modified residuei422 – 4221PhosphoserineBy similarity
Modified residuei432 – 4321PhosphoserineCombined sources
Modified residuei915 – 9151PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ69Z89.
PaxDbiQ69Z89.
PeptideAtlasiQ69Z89.
PRIDEiQ69Z89.

PTM databases

iPTMnetiQ69Z89.
PhosphoSiteiQ69Z89.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029576.
CleanExiMM_D930005D10RIK.
ExpressionAtlasiQ69Z89. baseline and differential.
GenevisibleiQ69Z89. MM.

Interactioni

Subunit structurei

Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family. Interacts (via PDZ domain) with KIF14; is recruited to the microtubule network restricting its interaction with activated RAP1A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064539.

Structurei

3D structure databases

ProteinModelPortaliQ69Z89.
SMRiQ69Z89. Positions 78-218, 997-1092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 193104Ras-associatingPROSITE-ProRule annotationAdd
BLAST
Domaini302 – 37776FHAAdd
BLAST
Domaini525 – 792268DilutePROSITE-ProRule annotationAdd
BLAST
Domaini1000 – 108586PDZPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RADIL family.Curated
Contains 1 dilute domain.PROSITE-ProRule annotation
Contains 1 FHA domain.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQUG. Eukaryota.
ENOG410ZVSZ. LUCA.
GeneTreeiENSGT00530000063674.
HOGENOMiHOG000154069.
HOVERGENiHBG079536.
InParanoidiQ69Z89.
OMAiQDCLVYL.
OrthoDBiEOG091G00X4.
PhylomeDBiQ69Z89.
TreeFamiTF350641.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000253. FHA_dom.
IPR001478. PDZ.
IPR000159. RA_dom.
IPR008984. SMAD_FHA_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 1 hit.
[Graphical view]
SMARTiSM01132. DIL. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51126. DILUTE. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69Z89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSSIFLGLQ PSPSHWLKSS VVIHEDAPTM FYGTQLIMSP PTKNKLKRQS
60 70 80 90 100
QLLSTMLSRT LSYKYRDLDS TFCSLGASDD PSELSTQLSA PGVLKVFGDS
110 120 130 140 150
VCTGTHYKSV LATGSSSAQE LVKEALERYA LDPECAGQYV LCDVVGQAGD
160 170 180 190 200
SGQRWQAQCF RVFGDNEKPL LIQELWKPRE GLSRRFELRK KSDVEELASR
210 220 230 240 250
DVDTTTAGIN AQARRLQRIR AKGTPALTSE AAQSSPPTRL RRTVSETSLS
260 270 280 290 300
PAPSLPEAAQ RPEEPVPEAM RYSLYQCPHL LLLQGYSQQH DSLVYVLSKE
310 320 330 340 350
RHTVGQRTPS SKPSISLSAP DILPLHCTIR RHQSPEGGPA GTRLVLEPIT
360 370 380 390 400
GASVSVNFSE VGRNPVVLQH GDLLSLGLYY LLLFKDPGQA QPLPACALAR
410 420 430 440 450
LGAAPQSCRM CGAVLRARGA PSLPAAVVRR RSLLLEFEPD VEDTLLQRIM
460 470 480 490 500
TLIEPGGDDH KLTPAFLLCL CIQHSAMHFQ PGTFRHLLLK ISKRVRDTVW
510 520 530 540 550
EKTKELAEKQ AQLQEPISWA SFPMADLVPD LQHILFWMSN SIELLYFIQQ
560 570 580 590 600
KSPLYVQSME EELDVTGSKE SLFSCTLTAS EEAMAALEEV VLYAFQQCVY
610 620 630 640 650
YLSKCLYVCL PALLECPPFQ TERRESWRSG PALPEELRRV VSVFQATLDL
660 670 680 690 700
LQQLQMHPEV ASQMLAYLFF FSGTLLLNQV LDKGPSLSCF HWPRGVQVCA
710 720 730 740 750
RLQQFLEWAR SAGLGAPAER FFRKLSCTLH LLATPRAQLI QMSWATLRVT
760 770 780 790 800
FPALNPAQLH RLLTQYQLAS AMGPVSAWEP GAPDGPEAFQ SEDILESYEN
810 820 830 840 850
PPPIVLPSQG FQVDLEADCV EDSIYQHLLY IRHFLWGLRG QASPDSGPAQ
860 870 880 890 900
PESIEGLYHT IPEGHLEGHG CPLANRDPGR VAVETAPPHS LPVTGAPRAQ
910 920 930 940 950
GPPGRQPTRG DRRGSQAGSL HTDSSCMLTP PSTPLGLEPA GPSWPEPSGL
960 970 980 990 1000
CGRAVLDGQR NGPGGLPGAV LEGDAIQDAE PPAEASSPSS SAEDFCYVFM
1010 1020 1030 1040 1050
VELERGPSGL GMGLIDGMHT PLGAQGLYIQ TLLPGSPAAS DGRLSLGDQI
1060 1070 1080 1090
LEVNGSSLRG VSYMRAVDLI RHGGKKMRFL VAKSDMETAK KIRFRNPPS
Length:1,099
Mass (Da):120,355
Last modified:November 8, 2005 - v2
Checksum:iCB1940EFFD10BC0D
GO
Isoform 2 (identifier: Q69Z89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     1019-1099: HTPLGAQGLY...KKIRFRNPPS → VRTLGPQPST...AFPWNIPGSG

Note: No experimental confirmation available.
Show »
Length:1,050
Mass (Da):114,933
Checksum:i7B70A682FF777253
GO
Isoform 3 (identifier: Q69Z89-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-269: Missing.

Note: No experimental confirmation available.
Show »
Length:830
Mass (Da):90,912
Checksum:iBCF3809A5A03323C
GO
Isoform 4 (identifier: Q69Z89-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     485-1079: Missing.

Note: No experimental confirmation available.
Show »
Length:475
Mass (Da):52,088
Checksum:i2943CB51E311CF77
GO
Isoform 5 (identifier: Q69Z89-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Show »
Length:1,070
Mass (Da):117,251
Checksum:iA411CD5FAB5290A4
GO

Sequence cautioni

The sequence BAC38904 differs from that shown. Reason: Frameshift at position 985. Curated
The sequence BAD32555 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti575 – 5751C → S in BAC37675 (PubMed:16141072).Curated
Sequence conflicti909 – 9091R → Q in BAC38904 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 269269Missing in isoform 3. 1 PublicationVSP_016100Add
BLAST
Alternative sequencei1 – 2929Missing in isoform 2, isoform 4 and isoform 5. 3 PublicationsVSP_016101Add
BLAST
Alternative sequencei485 – 1079595Missing in isoform 4. 1 PublicationVSP_016102Add
BLAST
Alternative sequencei1019 – 109981HTPLG…RNPPS → VRTLGPQPSTPPTPTPCFCR LILYSVSTVEASERCPDCLM GLPLGALMEPSAFPWNIPGS G in isoform 2. 1 PublicationVSP_016103Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173277 mRNA. Translation: BAD32555.1. Different initiation.
AK038570 mRNA. Translation: BAC30049.1.
AK052964 mRNA. Translation: BAC35223.1.
AK079539 mRNA. Translation: BAC37675.1.
AK083410 mRNA. Translation: BAC38904.1. Frameshift.
BC056483 mRNA. Translation: AAH56483.1.
CCDSiCCDS19827.1. [Q69Z89-5]
CCDS80453.1. [Q69Z89-1]
RefSeqiNP_001297681.1. NM_001310752.1. [Q69Z89-1]
NP_848817.2. NM_178702.4. [Q69Z89-5]
XP_006504749.1. XM_006504686.2. [Q69Z89-3]
UniGeneiMm.33766.

Genome annotation databases

EnsembliENSMUST00000063635; ENSMUSP00000064539; ENSMUSG00000029576. [Q69Z89-5]
ENSMUST00000085758; ENSMUSP00000082910; ENSMUSG00000029576. [Q69Z89-1]
ENSMUST00000110784; ENSMUSP00000106411; ENSMUSG00000029576. [Q69Z89-3]
GeneIDi231858.
KEGGimmu:231858.
UCSCiuc009ais.2. mouse. [Q69Z89-1]
uc009aiu.2. mouse. [Q69Z89-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173277 mRNA. Translation: BAD32555.1. Different initiation.
AK038570 mRNA. Translation: BAC30049.1.
AK052964 mRNA. Translation: BAC35223.1.
AK079539 mRNA. Translation: BAC37675.1.
AK083410 mRNA. Translation: BAC38904.1. Frameshift.
BC056483 mRNA. Translation: AAH56483.1.
CCDSiCCDS19827.1. [Q69Z89-5]
CCDS80453.1. [Q69Z89-1]
RefSeqiNP_001297681.1. NM_001310752.1. [Q69Z89-1]
NP_848817.2. NM_178702.4. [Q69Z89-5]
XP_006504749.1. XM_006504686.2. [Q69Z89-3]
UniGeneiMm.33766.

3D structure databases

ProteinModelPortaliQ69Z89.
SMRiQ69Z89. Positions 78-218, 997-1092.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064539.

PTM databases

iPTMnetiQ69Z89.
PhosphoSiteiQ69Z89.

Proteomic databases

MaxQBiQ69Z89.
PaxDbiQ69Z89.
PeptideAtlasiQ69Z89.
PRIDEiQ69Z89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063635; ENSMUSP00000064539; ENSMUSG00000029576. [Q69Z89-5]
ENSMUST00000085758; ENSMUSP00000082910; ENSMUSG00000029576. [Q69Z89-1]
ENSMUST00000110784; ENSMUSP00000106411; ENSMUSG00000029576. [Q69Z89-3]
GeneIDi231858.
KEGGimmu:231858.
UCSCiuc009ais.2. mouse. [Q69Z89-1]
uc009aiu.2. mouse. [Q69Z89-4]

Organism-specific databases

CTDi55698.
MGIiMGI:2443088. Radil.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IQUG. Eukaryota.
ENOG410ZVSZ. LUCA.
GeneTreeiENSGT00530000063674.
HOGENOMiHOG000154069.
HOVERGENiHBG079536.
InParanoidiQ69Z89.
OMAiQDCLVYL.
OrthoDBiEOG091G00X4.
PhylomeDBiQ69Z89.
TreeFamiTF350641.

Miscellaneous databases

PROiQ69Z89.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029576.
CleanExiMM_D930005D10RIK.
ExpressionAtlasiQ69Z89. baseline and differential.
GenevisibleiQ69Z89. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
2.60.200.20. 1 hit.
InterProiIPR002710. Dilute_dom.
IPR000253. FHA_dom.
IPR001478. PDZ.
IPR000159. RA_dom.
IPR008984. SMAD_FHA_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF01843. DIL. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 1 hit.
[Graphical view]
SMARTiSM01132. DIL. 1 hit.
SM00228. PDZ. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51126. DILUTE. 1 hit.
PS50106. PDZ. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRADIL_MOUSE
AccessioniPrimary (citable) accession number: Q69Z89
Secondary accession number(s): Q8BNL0
, Q8C549, Q8C6X2, Q8CAL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.