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Protein
Submitted name:

MKIAA1973 protein

Gene

Grin3a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • calcium channel activity Source: MGI
  • extracellular-glutamate-gated ion channel activity Source: GO_Central
  • glycine binding Source: MGI
  • identical protein binding Source: MGI
  • N-methyl-D-aspartate selective glutamate receptor activity Source: MGI

GO - Biological processi

  • calcium ion transmembrane transport Source: GOC
  • calcium ion transport Source: MGI
  • dendrite development Source: MGI
  • ionotropic glutamate receptor signaling pathway Source: GOC
  • ion transmembrane transport Source: GOC
  • prepulse inhibition Source: MGI
  • response to ethanol Source: MGI
  • synaptic transmission, glutamatergic Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
MKIAA1973 proteinImported
Gene namesi
Name:Grin3aImported
Synonyms:mKIAA1973Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1933206. Grin3a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

PTM databases

PhosphoSiteiQ69Z52.

Expressioni

Gene expression databases

BgeeiQ69Z52.
ExpressionAtlasiQ69Z52. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075970.

Structurei

3D structure databases

ProteinModelPortaliQ69Z52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG052634.

Family and domain databases

InterProiIPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q69Z52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RGPPGSRKLG EGAGTETLWP RDALLFAVEN LNRVEGLLPY NLSLEVVMAI
60 70 80 90 100
EAGLGDLPLM PFSSPSSPWS SDPFSFLQSV CHTVVVQGVS ALLAFPQSQG
110 120 130 140 150
EMMELDLVSS VLHIPVLSIV RHEFPRESQN PLHLQLSLEN SLSSDADVTV
160 170 180 190 200
SILTMNNWYN FSLLLCQEDW NITDFLLLTE NNSKFHLESI INITANLSST
210 220 230 240 250
KDLLSFLQVQ LENIRNSTPT MVMFGCDMGS IRQIFEMSTQ FGLSPPDLHW
260 270 280 290 300
VLGDSQNVEE LRTEGLPLGL IAHGKTTQSV FEYYVQDAME LVARAVATAT
310 320 330 340 350
MIQPELALLP STMNCMDVKT TNLTSGQYLS RFLANTTFRG LSGSIKVKGS
360 370 380 390 400
TIVSSENNFF IWNLQYDPMG KPMWTRLGSW QGGRIVMDSG IWPEQAQRHK
410 420 430 440 450
THFHHPNKLH LRVVTLIEHP FVFTREVDDE GLCPAGQLCL DPMTNDSSIL
460 470 480 490 500
DSLFSSLHSS NDTVPIKFKK CCYGYCIDLL EQLAEDMNFD FDLYIVGDGK
510 520 530 540 550
YGAWKNGHWT GLVGDLLSGT ANMAVTSFSI NTARSQVIDF TSPFFSTSLG
560 570 580 590 600
ILVRTRDTAA PIGAFMWPLH WTMWLGIFVA LHITAIFLTL YEWKSPFGMT
610 620 630 640 650
PKGRNRNKVF SFSSALNVCY ALLFGRTAAI KPPKCWTGRF LMNLWAIFCM
660 670 680 690 700
FCLSTYTANL AAVMVGEKIY EELSGIHDPK LHHPSQGFRF GTVRESSAED
710 720 730 740 750
YVRQSFPEMH EYMRRYNVPA TPDGVQYLKN DPEKLDAFIM DKALLDYEVS
760 770 780 790 800
IDADCKLLTV GKPFAIEGYG IGLPPNSPLT SNISELISQY KSHGFMDVLH
810 820 830 840 850
DKWYKVVPCG KRSFAVTETL QMGIKHFSGL FVLLCIGFGL SILTTIGEHI
860 870 880 890 900
VYRLLLPRIK NKSKLQYWLH TSQRFHRALN TSFVEEKQPC SKTKRVEKSR
910 920 930 940 950
WRRWTCKTEG DSELSLFPRS NMGPQQLMVW NTSNLSHDNQ RKYIFNDEEG
960 970 980 990 1000
QNQLGTQTHQ DIPLPPRRRE LPASLTTNGK ADSLNVARNS VMQELSELEK
1010 1020 1030
QIQVIRQELQ LAVSRKTELE EYQRTNRTCE S
Length:1,031
Mass (Da):116,392
Last modified:September 13, 2004 - v1
Checksum:i81767ACCAAEDA79F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173314 mRNA. Translation: BAD32592.1.
UniGeneiMm.440095.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173314 mRNA. Translation: BAD32592.1.
UniGeneiMm.440095.

3D structure databases

ProteinModelPortaliQ69Z52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075970.

PTM databases

PhosphoSiteiQ69Z52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1933206. Grin3a.

Phylogenomic databases

HOVERGENiHBG052634.

Miscellaneous databases

ChiTaRSiGrin3a. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ69Z52.
ExpressionAtlasiQ69Z52. baseline and differential.

Family and domain databases

InterProiIPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00060. Lig_chan. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Fetal brainImported.

Entry informationi

Entry nameiQ69Z52_MOUSE
AccessioniPrimary (citable) accession number: Q69Z52
Entry historyi
Integrated into UniProtKB/TrEMBL: September 13, 2004
Last sequence update: September 13, 2004
Last modified: July 22, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.