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Protein

Dynein heavy chain 17, axonemal

Gene

Dnah17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1831 – 18388ATPSequence analysis
Nucleotide bindingi2112 – 21198ATPSequence analysis
Nucleotide bindingi2439 – 24468ATPSequence analysis
Nucleotide bindingi2785 – 27928ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain 17, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 17
Ciliary dynein heavy chain 17
Gene namesi
Name:Dnah17
Synonyms:Dnahc17, Kiaa3028
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1917176. Dnah17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 44814481Dynein heavy chain 17, axonemalPRO_0000323750Add
BLAST

Proteomic databases

MaxQBiQ69Z23.
PaxDbiQ69Z23.
PRIDEiQ69Z23.

PTM databases

iPTMnetiQ69Z23.
PhosphoSiteiQ69Z23.

Expressioni

Gene expression databases

CleanExiMM_DNAHC17.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081864.

Structurei

3D structure databases

ProteinModelPortaliQ69Z23.
SMRiQ69Z23. Positions 1403-1605, 3039-4176, 4278-4364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati521 – 56949Kelch 1Add
BLAST
Repeati1533 – 156634TPR 1Add
BLAST
Repeati1688 – 172235TPR 2Add
BLAST
Repeati2229 – 227547Kelch 2Add
BLAST
Repeati2782 – 283453Kelch 3Add
BLAST
Repeati4138 – 417336TPR 3Add
BLAST
Repeati4272 – 432150Kelch 4Add
BLAST
Repeati4339 – 438547Kelch 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 17921792StemBy similarityAdd
BLAST
Regioni1793 – 2014222AAA 1By similarityAdd
BLAST
Regioni2074 – 2295222AAA 2By similarityAdd
BLAST
Regioni2401 – 2649249AAA 3By similarityAdd
BLAST
Regioni2747 – 2996250AAA 4By similarityAdd
BLAST
Regioni3011 – 3297287StalkBy similarityAdd
BLAST
Regioni3389 – 3616228AAA 5By similarityAdd
BLAST
Regioni3826 – 4059234AAA 6By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili759 – 82668Sequence analysisAdd
BLAST
Coiled coili3011 – 307161Sequence analysisAdd
BLAST
Coiled coili3241 – 329353Sequence analysisAdd
BLAST

Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated
Contains 5 Kelch repeats.Curated
Contains 3 TPR repeats.Curated

Keywords - Domaini

Coiled coil, Kelch repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
COG5245. LUCA.
HOGENOMiHOG000237309.
HOVERGENiHBG107831.
InParanoidiQ69Z23.
PhylomeDBiQ69Z23.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 3 hits.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69Z23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPDLRIDYLE TVSSVLLKFK ADKWGKLIGA EENMALLTEF FDKIDNPVLV
60 70 80 90 100
LTLNAAGMII PCLGFPESLK SKGVYFIKMK PENITKDNYK THLIYGDISP
110 120 130 140 150
TTVDQLIAVV EEVLYSLLNQ SENMDGWPRV VSEDIVKQVH RLKNEMFVMG
160 170 180 190 200
GKIKGKTLLP IPEHLGSLDG TLDSMERIPS SMDNSLLHSI ETIIIDWSHQ
210 220 230 240 250
IRDVLSKDSA QALLDGLHPL PRVEFEFWDA RLMNLQCIHE QLNRPKVNKI
260 270 280 290 300
VEILEKAKSC YWPALQNVYM NVTQGLKEAN GIVLYLKPLR ILLEEMEQAD
310 320 330 340 350
FTMLPSFIVK VLSTICFIWA TSEHYNTPSR VIVILREFCN QIIEMTRTYL
360 370 380 390 400
SPDEVLKGLQ GEIEEVLGNI SLSVSVLKGL FQAYDFCCAN MKLFFKDRPP
410 420 430 440 450
VPWEFPSSLA FSRMNSFFHR VQTIEDLYKT AIEFLKLEKI ELGGVWGNIL
460 470 480 490 500
GNLVTQIYDE VFELVKVFAE CKYDPLDPGD SSFDDDYSDF ETKIQDLDRR
510 520 530 540 550
LATIFCQAFD DCNCMESSAK LLYMCGGLLE RPLILVEVVP RYSVMLEMFN
560 570 580 590 600
TELDNAKLMY DAQMAASADG QIPPIHKNMS PVSGQLKWSL ELQERLEVSM
610 620 630 640 650
KYLKHIEHPV MSSMEAKLIY DKYDEMMGLL QSCRMKKYQQ WVEGVDQDCH
660 670 680 690 700
FNLGQPLIQR DPFTSLIQVN FSKALVAVLR EVKYLNFQQQ KEIPESAEKL
710 720 730 740 750
FSENETFRKF VGNLELIVGW YNEIKTTVKD VEFPLIKSEL EAIDVKLLSA
760 770 780 790 800
ETTLFWNGEN VMEYIQEMRE MLYNLQNRIQ KAKQNVEGIT QAMQEWSANP
810 820 830 840 850
LFERKDNKKE ALLDLDGRVA NLNKRYAAVK EAGVRIQAMV VENAELFRAD
860 870 880 890 900
TTSQSWKDYV NYIDTVVLDE FDRFIRKSLN YLMDNMTMDE SIAPLFEIRM
910 920 930 940 950
ELDKDGLTYN PSLEMGDEAG FLSLIEGLIN DLYNVARLIP RLAKGRLNYK
960 970 980 990 1000
SDLEDITDLI EMREEVSSLV IGAMKVAEEY QDSFERYSYL WVDDLQEFMK
1010 1020 1030 1040 1050
NFLIFGHAPT PEELDTKTDD TIPKTPPTLA QFQQQIDSYE KLYEEVSSCE
1060 1070 1080 1090 1100
NTKVFHGWLQ CDCRPFKQTL LNTIKRWSFL FKRYLNNHVI NSLADLESFM
1110 1120 1130 1140 1150
NITRTALKKP LKEGDYDGLV EVMGHLMKVK ERQVATDSMF EPLKQTIELL
1160 1170 1180 1190 1200
KSYGEEMPEE IYLKLQELPE QWTNTKKLAI QVKQNVAPLQ ANEVNILRRK
1210 1220 1230 1240 1250
CQQFELKQHE FREKFRRDAP FSFSDPEPYK SLNKIYLLYG VMEALCKSAS
1260 1270 1280 1290 1300
LFEVTVPDYK QLKACHREVR LLKELWDMIV MVNTSIDDWK TTKWKDINVE
1310 1320 1330 1340 1350
QMDIDCKKFA KDVRSLDKEM KPWDAFVGLD NTVKNMITSL RAVSELQNPA
1360 1370 1380 1390 1400
IRDRHWQQLM QATQVKFEMS EETTLADLLQ LNLHKYEDEV RNIVDKAVKE
1410 1420 1430 1440 1450
SGMEKVLKTL DITWTTMEFE HELHPRTGTM MLKSDEVLVE TLEDNQVQLQ
1460 1470 1480 1490 1500
NLMMSKYLSH FLKEVTSWQQ KLSTADSVIS IWFEVQRTWS HLESIFIGSE
1510 1520 1530 1540 1550
DIRAQLPEDS KRFDAIDQEF KALMEDAVKT PNVVEATNKP DLYNKLENLK
1560 1570 1580 1590 1600
MSLAVCEKAL AEYLETKRLA FPRFYFVSSA DLLDILSNGN DPVEVSRHLS
1610 1620 1630 1640 1650
KLFDSLCKLK FRLDASGKPL KFGLGMYSKE DEFVDFDKEC DLSGQVEVWL
1660 1670 1680 1690 1700
NRVLDRMRAT LRHEIPEAVV TYEEKPREQW IFDYPAQIWW TTEVGLAFAR
1710 1720 1730 1740 1750
LEEGYENAIK DYNKKQISQL NALITLLIGN LTAGDRMKIM TICTIDVHAR
1760 1770 1780 1790 1800
DVVAKMITVE SSQAFTWQSQ LRHRWDEEKK HCFANICDAQ IKYSYEYLGN
1810 1820 1830 1840 1850
TPRLVITPLT DRCYITLTQS LHLIMGGAPA GPAGTGKTET TKDLGRALGT
1860 1870 1880 1890 1900
MVYVFNCSEQ MDYKSCGNIY KGLAQTGAWG CFDEFNRISV EVLSVIAVQV
1910 1920 1930 1940 1950
KCVQDAIRAK KKKFNFLGEI ISLVPTVGIF ITMNPGYAGR TELPENLKAL
1960 1970 1980 1990 2000
FRPCAMVVPD FELICEIMLV AEGFLDARLL ARKFITLYTL CKELLSKQDH
2010 2020 2030 2040 2050
YDWGLRAIKS VLVVAGSLKR GDPTRAEDQV LMRALRDFNI PKIVTDDLPV
2060 2070 2080 2090 2100
FMGLIGDLFP ALDVPRKRDL NFEKIIKQSI VELKLQAEDS FVLKVVQLEE
2110 2120 2130 2140 2150
LLQVRHSVFV IGNAGSGKSQ VLKSLNKTYQ NLKRKPVAVD LDPKAVTCDE
2160 2170 2180 2190 2200
LFGIINPATR EWKDGLFSTI MRDLANLTHE GPKWIVLDGD IDPMWIESLN
2210 2220 2230 2240 2250
TVMDDNKVLT LASNERIPLN RTMRLVFEIS HLRTATPATV SRAGILYINP
2260 2270 2280 2290 2300
ADLGWNPVVS SWIERRKVQS EKANLIILFD KYLPTCLDKL RIGFKRITPV
2310 2320 2330 2340 2350
PEITVIQTIL YLLECLLTEK NAPPDSPKEL YELYFVFACF WAFGGAMFQD
2360 2370 2380 2390 2400
QLIDYRVEFS KWWINEFKTI KLPSQGTIFD YYIDPETKKF LPWTDKVPNF
2410 2420 2430 2440 2450
ELDPDIPLQA SLVHTTETIR IRYFIDLLME KAWPVMLVGN AGTGKSVLMG
2460 2470 2480 2490 2500
DKLENLSTDD YLVQAVPFNF YTTSAMLQGV LEKPLEKKSG RNYGPPGTKK
2510 2520 2530 2540 2550
LIYFIDDMNM PEVDKYGTVA PHTLIRQHMD HRHWYDRQKL TLKDVHNCQY
2560 2570 2580 2590 2600
VACMNPTSGS FTIDPRLQRH FCVFAVSFPG QEALTSIYNT ILAQHLSFRS
2610 2620 2630 2640 2650
APLVIQRLSS HLVTAALALH QKVSATFLPT AIKFHYIFNL RDLSNIFQGI
2660 2670 2680 2690 2700
LFSTAEILKT PLDLVRLWLH EAERVYGDKM VDEKDQETLH RVTIASVKKF
2710 2720 2730 2740 2750
FDDLGEENLF AKPNIFCHFT QGIGDPKYFP VTDVAQLNKL LKDVLDSYNE
2760 2770 2780 2790 2800
VNAVMNLVLF EDAVAHICKI NRILESPRGN ALLVGVGGSG KQSLSRLAAY
2810 2820 2830 2840 2850
ISALDVFQIT LKKGYAIPDL KMDLATQYIK SAVKNVPSVF LMTDSQVAEE
2860 2870 2880 2890 2900
QFLVLINDLL ASGEIPGLFG DEDLENIISS MRPQVKSLGI ADTREACWKF
2910 2920 2930 2940 2950
FIEKVRRQLK VILCFSPVGS VLRVRARKFP AVVNCTAINW FHEWPEDALV
2960 2970 2980 2990 3000
SVSARFLEET EGIEPEVKTS ISLFMAYVHT TVNEMSKIYL TIERRYNYTT
3010 3020 3030 3040 3050
PKTFLEQIKL YQNLLAKKRM ELVAKIERLE NGLMKLQSTA SQVDDLKAKL
3060 3070 3080 3090 3100
AVQETELKQK NENADKLIQV VGVETEKVSK EKAIADEEEM KVEVINKNVT
3110 3120 3130 3140 3150
EKQKACETDL AKAEPALLAA QEALDTLNKN NLTELKSFGS PPDAVVNVTA
3160 3170 3180 3190 3200
AVMILTAPGG KIPKDKSWKA AKIMMGKVDT FLDSLKKFDK EHIPEACLKA
3210 3220 3230 3240 3250
FKPYQGNPTF DPEFIRSKST AAAGLCSWCI NIVRFYEVYC DVAPKRQALE
3260 3270 3280 3290 3300
EANAELAEAQ EKLSRIKNKI AELNANLSNL TSAFEKATAE KIKCQQEADA
3310 3320 3330 3340 3350
TNRVISLANR LVGGLASENV RWAESVENFK SQGVTLCGDV LLISAFVSYV
3360 3370 3380 3390 3400
GYFTKKYRNE LMEKFWIPYI NKLKVPIPIT EGLDPLTLLT DDADVATWNN
3410 3420 3430 3440 3450
QGLPSDRMST ENATILCNTE RWPLIVDAQL QGIKWIKNKY GSDLQAIRLG
3460 3470 3480 3490 3500
QKSYLDIIEQ AISAGDTLLI ENIGETVDPV LDPLLGRNTI KKGRFIKIGD
3510 3520 3530 3540 3550
KEVEYHPSFR LILHTKYFNP HYKPEMQAQC TLINFLVTRD GLEDQLLAAV
3560 3570 3580 3590 3600
VAKERPDLEQ LKANLTKSQN EFKIVLKELE DSLLARLSAA SGNFLGDTAL
3610 3620 3630 3640 3650
VENLETTKHT ANEIEEKVQE AKITEVKINE ARENYRPAAE RASLLYFILN
3660 3670 3680 3690 3700
DLNKINPIYQ FSLKAFNVVF EKAIQKTAPA DEVKQRVINL TDEITYSVYM
3710 3720 3730 3740 3750
YTARGLFERD KLIFLAQVTF QVLSMKKELN PVELDFLLRF PFKAGVVSPV
3760 3770 3780 3790 3800
DFLQHQSWGG IKALSEMDEF KNLDSDIEGS AKRWKKLVES EAPEKEIFPK
3810 3820 3830 3840 3850
EWKNKTALQK LCMVRCMRPD RMTYAVKNFV EEKMGSKFVE GRSVEFSKSY
3860 3870 3880 3890 3900
KESSPSTPIF FILSPGVDPL KDVEALGKKL GFTIDNGKLH NVSLGQGQEV
3910 3920 3930 3940 3950
VAENALDVAA EKGHWVILQV RGSLPQNIHL VARWLGILDK KVERYSSGSH
3960 3970 3980 3990 4000
EDYRVFISAE PAPTAETHII PQGILENAIK ITNEPPTGMY ANLHKALDLF
4010 4020 4030 4040 4050
TQDTLEMCTK EIEFKCILFA LCYFHAVVAE RRKFGAQGWN RSYPFNNGDL
4060 4070 4080 4090 4100
TISINVLYNY LEANSKVPWD DLRYLFGEIM YGGHITDDWD RRLCRTYLAE
4110 4120 4130 4140 4150
YIRVEMLEGE VLLAPGFQIP PNLDYKGYHE YIDENLPPES PYLYGLHPNA
4160 4170 4180 4190 4200
EIGFLTVTSE KLFRTVLEMQ PKETDSGAGT GVSREEKVGA VPVPEGSLGS
4210 4220 4230 4240 4250
EGSLGTIGLP GTGFQVKAVL DDILEKIPET FNMAEIMAKA AEKTPYVVVA
4260 4270 4280 4290 4300
FQECERMNIL TNEMRRSLKE LNLGLKGELT ITTDMEDLST ALFYDTVPDT
4310 4320 4330 4340 4350
WVARAYPSMM GLAAWYADLL QRIRELESWT TDFALPTTVW LAGFFNPQSF
4360 4370 4380 4390 4400
LTAIMQSMAR KNEWPLDKMC LSVEVTKKNR EDMTAPPREG SYVYGLFMEG
4410 4420 4430 4440 4450
ARWDTQTGVI AEARLKDLTP VMPVIFIKAI PVDRMETKNI YECPVYKTRI
4460 4470 4480
RGPTYVWTFN LKTKEKAAKW ILAAVALLLQ V
Length:4,481
Mass (Da):511,603
Last modified:March 18, 2008 - v2
Checksum:iA64E53D65671224E
GO
Isoform 2 (identifier: Q69Z23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3828-3852: NFVEEKMGSKFVEGRSVEFSKSYKE → EKTGIYHRQWETPQRVPGARTRGGS
     3853-4481: Missing.

Note: No experimental confirmation available.
Show »
Length:3,852
Mass (Da):440,772
Checksum:i8AA92062B8AC87E1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei3828 – 385225NFVEE…KSYKE → EKTGIYHRQWETPQRVPGAR TRGGS in isoform 2. 1 PublicationVSP_032116Add
BLAST
Alternative sequencei3853 – 4481629Missing in isoform 2. 1 PublicationVSP_032117Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591204 Genomic DNA. No translation available.
AL591433 Genomic DNA. No translation available.
Z83807 mRNA. Translation: CAB06061.1.
AK173343 mRNA. Translation: BAD32621.1.
UniGeneiMm.473893.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591204 Genomic DNA. No translation available.
AL591433 Genomic DNA. No translation available.
Z83807 mRNA. Translation: CAB06061.1.
AK173343 mRNA. Translation: BAD32621.1.
UniGeneiMm.473893.

3D structure databases

ProteinModelPortaliQ69Z23.
SMRiQ69Z23. Positions 1403-1605, 3039-4176, 4278-4364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081864.

PTM databases

iPTMnetiQ69Z23.
PhosphoSiteiQ69Z23.

Proteomic databases

MaxQBiQ69Z23.
PaxDbiQ69Z23.
PRIDEiQ69Z23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1917176. Dnah17.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3595. Eukaryota.
COG5245. LUCA.
HOGENOMiHOG000237309.
HOVERGENiHBG107831.
InParanoidiQ69Z23.
PhylomeDBiQ69Z23.

Miscellaneous databases

PROiQ69Z23.
SOURCEiSearch...

Gene expression databases

CleanExiMM_DNAHC17.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024743. Dynein_HC_stalk.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013594. Dynein_heavy_dom-1.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 3 hits.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08385. DHC_N1. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
PF12777. MT. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDYH17_MOUSE
AccessioniPrimary (citable) accession number: Q69Z23
Secondary accession number(s): O08820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 7, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.