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Q69YU3

- AN34A_HUMAN

UniProt

Q69YU3 - AN34A_HUMAN

Protein

Ankyrin repeat domain-containing protein 34A

Gene

ANKRD34A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat domain-containing protein 34A
    Gene namesi
    Name:ANKRD34A
    Synonyms:ANKRD34
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:27639. ANKRD34A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162376563.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Ankyrin repeat domain-containing protein 34APRO_0000319100Add
    BLAST

    Proteomic databases

    PaxDbiQ69YU3.
    PRIDEiQ69YU3.

    PTM databases

    PhosphoSiteiQ69YU3.

    Expressioni

    Gene expression databases

    BgeeiQ69YU3.
    CleanExiHS_ANKRD34A.
    GenevestigatoriQ69YU3.

    Organism-specific databases

    HPAiHPA029642.
    HPA029643.

    Interactioni

    Protein-protein interaction databases

    IntActiQ69YU3. 1 interaction.
    STRINGi9606.ENSP00000314103.

    Structurei

    3D structure databases

    ProteinModelPortaliQ69YU3.
    SMRiQ69YU3. Positions 16-131.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati4 – 3330ANK 1Add
    BLAST
    Repeati37 – 7236ANK 2Add
    BLAST
    Repeati76 – 10631ANK 3Add
    BLAST
    Repeati110 – 13930ANK 4Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi217 – 462246Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ANKRD34 family.Curated
    Contains 4 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG68360.
    HOGENOMiHOG000033934.
    HOVERGENiHBG100441.
    InParanoidiQ69YU3.
    OMAiCKAKGTE.
    OrthoDBiEOG79W955.
    PhylomeDBiQ69YU3.
    TreeFamiTF331155.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q69YU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHTEGHALL RAVGQGKLRL ARLLLEGGAY VNEGDAQGET ALMAACRARY    50
    DDPQNKARMV RYLLEQGADP NIADRLGRTA LMHACAGGGG AAVASLLLAH 100
    GADPSVRDHA GASALVHALD RGDRETLATL LDACKAKGTE VIIITTDTSP 150
    SGTKKTRQYL NSPPSPGVED PAPASPSPGF CTSPSEIQLQ TAGGGGRGML 200
    SPRAQEEEEK RDVFEFPLPK PPDDPSPSEP LPKPPRHPPK PLKRLNSEPW 250
    GLVAPPQPVP PTEGRPGIER LTAEFNGLTL TGRPRLSRRH STEGPEDPPP 300
    WAEKVTSGGP LSRRNTAPEA QESGPPSGLR QKLSRMEPVE LDTPGHLCPD 350
    SPESSRLSLE RRRYSASPLT LPPAGSAPSP RQSQESLPGA VSPLSGRRRS 400
    PGLLERRGSG TLLLDHISQT RPGFLPPLNV SPHPPIPDIR PQPGGRAPSL 450
    PAPPYAGAPG SPRTKRKLVR RHSMQTEQIR LLGGFQSLGG PGEPGR 496
    Length:496
    Mass (Da):52,636
    Last modified:February 26, 2008 - v2
    Checksum:iF13B4F866CD60AC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK094282 mRNA. Translation: BAG52855.1.
    AK128050 mRNA. Translation: BAG54622.1.
    AL160282 Genomic DNA. No translation available.
    AL359622 mRNA. Translation: CAH10676.1.
    CCDSiCCDS30829.1.
    RefSeqiNP_001034977.1. NM_001039888.3.
    XP_005277448.1. XM_005277391.1.
    XP_006711342.1. XM_006711279.1.
    UniGeneiHs.620591.

    Genome annotation databases

    EnsembliENST00000606888; ENSP00000475189; ENSG00000272031.
    GeneIDi284615.
    KEGGihsa:284615.
    UCSCiuc001enq.1. human.

    Polymorphism databases

    DMDMi172045718.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK094282 mRNA. Translation: BAG52855.1 .
    AK128050 mRNA. Translation: BAG54622.1 .
    AL160282 Genomic DNA. No translation available.
    AL359622 mRNA. Translation: CAH10676.1 .
    CCDSi CCDS30829.1.
    RefSeqi NP_001034977.1. NM_001039888.3.
    XP_005277448.1. XM_005277391.1.
    XP_006711342.1. XM_006711279.1.
    UniGenei Hs.620591.

    3D structure databases

    ProteinModelPortali Q69YU3.
    SMRi Q69YU3. Positions 16-131.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q69YU3. 1 interaction.
    STRINGi 9606.ENSP00000314103.

    PTM databases

    PhosphoSitei Q69YU3.

    Polymorphism databases

    DMDMi 172045718.

    Proteomic databases

    PaxDbi Q69YU3.
    PRIDEi Q69YU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000606888 ; ENSP00000475189 ; ENSG00000272031 .
    GeneIDi 284615.
    KEGGi hsa:284615.
    UCSCi uc001enq.1. human.

    Organism-specific databases

    CTDi 284615.
    GeneCardsi GC01P145470.
    H-InvDB HIX0199901.
    HGNCi HGNC:27639. ANKRD34A.
    HPAi HPA029642.
    HPA029643.
    neXtProti NX_Q69YU3.
    PharmGKBi PA162376563.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68360.
    HOGENOMi HOG000033934.
    HOVERGENi HBG100441.
    InParanoidi Q69YU3.
    OMAi CKAKGTE.
    OrthoDBi EOG79W955.
    PhylomeDBi Q69YU3.
    TreeFami TF331155.

    Miscellaneous databases

    GenomeRNAii 284615.
    NextBioi 95007.
    PROi Q69YU3.

    Gene expression databases

    Bgeei Q69YU3.
    CleanExi HS_ANKRD34A.
    Genevestigatori Q69YU3.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum and Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-496.
      Tissue: Amygdala.

    Entry informationi

    Entry nameiAN34A_HUMAN
    AccessioniPrimary (citable) accession number: Q69YU3
    Secondary accession number(s): B3KSU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3