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Protein

Ankyrin repeat domain-containing protein 34A

Gene

ANKRD34A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 34A
Gene namesi
Name:ANKRD34A
Synonyms:ANKRD34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000272031.2.
HGNCiHGNC:27639. ANKRD34A.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000272031.
PharmGKBiPA162376563.

Polymorphism and mutation databases

DMDMi172045718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003191001 – 496Ankyrin repeat domain-containing protein 34AAdd BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei316PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ69YU3.
PeptideAtlasiQ69YU3.
PRIDEiQ69YU3.

PTM databases

iPTMnetiQ69YU3.
PhosphoSitePlusiQ69YU3.

Expressioni

Gene expression databases

BgeeiENSG00000272031.
CleanExiHS_ANKRD34A.
ExpressionAtlasiQ69YU3. baseline and differential.
GenevisibleiQ69YU3. HS.

Organism-specific databases

HPAiHPA029642.
HPA029643.

Interactioni

Protein-protein interaction databases

BioGridi129917. 47 interactors.
IntActiQ69YU3. 1 interactor.
STRINGi9606.ENSP00000314103.

Structurei

3D structure databases

ProteinModelPortaliQ69YU3.
SMRiQ69YU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 33ANK 1Add BLAST30
Repeati37 – 72ANK 2Add BLAST36
Repeati76 – 106ANK 3Add BLAST31
Repeati110 – 139ANK 4Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi217 – 462Pro-richAdd BLAST246

Sequence similaritiesi

Belongs to the ANKRD34 family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJTU. Eukaryota.
ENOG410ZQHG. LUCA.
GeneTreeiENSGT00390000012355.
HOGENOMiHOG000033934.
HOVERGENiHBG100441.
InParanoidiQ69YU3.
OMAiTKKTRQY.
OrthoDBiEOG091G07FJ.
PhylomeDBiQ69YU3.
TreeFamiTF331155.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 4 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.

Sequencei

Sequence statusi: Complete.

Q69YU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHTEGHALL RAVGQGKLRL ARLLLEGGAY VNEGDAQGET ALMAACRARY
60 70 80 90 100
DDPQNKARMV RYLLEQGADP NIADRLGRTA LMHACAGGGG AAVASLLLAH
110 120 130 140 150
GADPSVRDHA GASALVHALD RGDRETLATL LDACKAKGTE VIIITTDTSP
160 170 180 190 200
SGTKKTRQYL NSPPSPGVED PAPASPSPGF CTSPSEIQLQ TAGGGGRGML
210 220 230 240 250
SPRAQEEEEK RDVFEFPLPK PPDDPSPSEP LPKPPRHPPK PLKRLNSEPW
260 270 280 290 300
GLVAPPQPVP PTEGRPGIER LTAEFNGLTL TGRPRLSRRH STEGPEDPPP
310 320 330 340 350
WAEKVTSGGP LSRRNTAPEA QESGPPSGLR QKLSRMEPVE LDTPGHLCPD
360 370 380 390 400
SPESSRLSLE RRRYSASPLT LPPAGSAPSP RQSQESLPGA VSPLSGRRRS
410 420 430 440 450
PGLLERRGSG TLLLDHISQT RPGFLPPLNV SPHPPIPDIR PQPGGRAPSL
460 470 480 490
PAPPYAGAPG SPRTKRKLVR RHSMQTEQIR LLGGFQSLGG PGEPGR
Length:496
Mass (Da):52,636
Last modified:February 26, 2008 - v2
Checksum:iF13B4F866CD60AC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094282 mRNA. Translation: BAG52855.1.
AK128050 mRNA. Translation: BAG54622.1.
AL160282 Genomic DNA. No translation available.
AL359622 mRNA. Translation: CAH10676.1.
CCDSiCCDS72874.1.
RefSeqiNP_001034977.1. NM_001039888.3.
UniGeneiHs.620591.

Genome annotation databases

EnsembliENST00000606888; ENSP00000475189; ENSG00000272031.
GeneIDi284615.
KEGGihsa:284615.
UCSCiuc021ouy.3. human.

Similar proteinsi

Entry informationi

Entry nameiAN34A_HUMAN
AccessioniPrimary (citable) accession number: Q69YU3
Secondary accession number(s): B3KSU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 25, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families