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Q69YU3

- AN34A_HUMAN

UniProt

Q69YU3 - AN34A_HUMAN

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Protein

Ankyrin repeat domain-containing protein 34A

Gene

ANKRD34A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 34A
Gene namesi
Name:ANKRD34A
Synonyms:ANKRD34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:27639. ANKRD34A.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Ankyrin repeat domain-containing protein 34APRO_0000319100Add
BLAST

Proteomic databases

PaxDbiQ69YU3.
PRIDEiQ69YU3.

PTM databases

PhosphoSiteiQ69YU3.

Expressioni

Gene expression databases

BgeeiQ69YU3.
CleanExiHS_ANKRD34A.
GenevestigatoriQ69YU3.

Organism-specific databases

HPAiHPA029642.
HPA029643.

Interactioni

Protein-protein interaction databases

IntActiQ69YU3. 1 interaction.
STRINGi9606.ENSP00000314103.

Structurei

3D structure databases

ProteinModelPortaliQ69YU3.
SMRiQ69YU3. Positions 16-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 3330ANK 1Add
BLAST
Repeati37 – 7236ANK 2Add
BLAST
Repeati76 – 10631ANK 3Add
BLAST
Repeati110 – 13930ANK 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi217 – 462246Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the ANKRD34 family.Curated
Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG68360.
GeneTreeiENSGT00390000012355.
HOGENOMiHOG000033934.
HOVERGENiHBG100441.
InParanoidiQ69YU3.
OMAiCKAKGTE.
OrthoDBiEOG79W955.
PhylomeDBiQ69YU3.
TreeFamiTF331155.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q69YU3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLHTEGHALL RAVGQGKLRL ARLLLEGGAY VNEGDAQGET ALMAACRARY
60 70 80 90 100
DDPQNKARMV RYLLEQGADP NIADRLGRTA LMHACAGGGG AAVASLLLAH
110 120 130 140 150
GADPSVRDHA GASALVHALD RGDRETLATL LDACKAKGTE VIIITTDTSP
160 170 180 190 200
SGTKKTRQYL NSPPSPGVED PAPASPSPGF CTSPSEIQLQ TAGGGGRGML
210 220 230 240 250
SPRAQEEEEK RDVFEFPLPK PPDDPSPSEP LPKPPRHPPK PLKRLNSEPW
260 270 280 290 300
GLVAPPQPVP PTEGRPGIER LTAEFNGLTL TGRPRLSRRH STEGPEDPPP
310 320 330 340 350
WAEKVTSGGP LSRRNTAPEA QESGPPSGLR QKLSRMEPVE LDTPGHLCPD
360 370 380 390 400
SPESSRLSLE RRRYSASPLT LPPAGSAPSP RQSQESLPGA VSPLSGRRRS
410 420 430 440 450
PGLLERRGSG TLLLDHISQT RPGFLPPLNV SPHPPIPDIR PQPGGRAPSL
460 470 480 490
PAPPYAGAPG SPRTKRKLVR RHSMQTEQIR LLGGFQSLGG PGEPGR
Length:496
Mass (Da):52,636
Last modified:February 26, 2008 - v2
Checksum:iF13B4F866CD60AC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094282 mRNA. Translation: BAG52855.1.
AK128050 mRNA. Translation: BAG54622.1.
AL160282 Genomic DNA. No translation available.
AL359622 mRNA. Translation: CAH10676.1.
CCDSiCCDS72874.1.
RefSeqiNP_001034977.1. NM_001039888.3.
XP_005277448.1. XM_005277391.1.
XP_006711342.1. XM_006711279.1.
UniGeneiHs.620591.

Genome annotation databases

EnsembliENST00000606888; ENSP00000475189; ENSG00000272031.
GeneIDi284615.
KEGGihsa:284615.
UCSCiuc001enq.1. human.

Polymorphism databases

DMDMi172045718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094282 mRNA. Translation: BAG52855.1 .
AK128050 mRNA. Translation: BAG54622.1 .
AL160282 Genomic DNA. No translation available.
AL359622 mRNA. Translation: CAH10676.1 .
CCDSi CCDS72874.1.
RefSeqi NP_001034977.1. NM_001039888.3.
XP_005277448.1. XM_005277391.1.
XP_006711342.1. XM_006711279.1.
UniGenei Hs.620591.

3D structure databases

ProteinModelPortali Q69YU3.
SMRi Q69YU3. Positions 16-131.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q69YU3. 1 interaction.
STRINGi 9606.ENSP00000314103.

PTM databases

PhosphoSitei Q69YU3.

Polymorphism databases

DMDMi 172045718.

Proteomic databases

PaxDbi Q69YU3.
PRIDEi Q69YU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000606888 ; ENSP00000475189 ; ENSG00000272031 .
GeneIDi 284615.
KEGGi hsa:284615.
UCSCi uc001enq.1. human.

Organism-specific databases

CTDi 284615.
GeneCardsi GC01P145470.
H-InvDB HIX0199901.
HGNCi HGNC:27639. ANKRD34A.
HPAi HPA029642.
HPA029643.
neXtProti NX_Q69YU3.
PharmGKBi PA162376563.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68360.
GeneTreei ENSGT00390000012355.
HOGENOMi HOG000033934.
HOVERGENi HBG100441.
InParanoidi Q69YU3.
OMAi CKAKGTE.
OrthoDBi EOG79W955.
PhylomeDBi Q69YU3.
TreeFami TF331155.

Miscellaneous databases

GenomeRNAii 284615.
NextBioi 95007.
PROi Q69YU3.

Gene expression databases

Bgeei Q69YU3.
CleanExi HS_ANKRD34A.
Genevestigatori Q69YU3.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 4 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum and Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-496.
    Tissue: Amygdala.

Entry informationi

Entry nameiAN34A_HUMAN
AccessioniPrimary (citable) accession number: Q69YU3
Secondary accession number(s): B3KSU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3