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Q69YU3 (AN34A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat domain-containing protein 34A
Gene names
Name:ANKRD34A
Synonyms:ANKRD34
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ANKRD34 family.

Contains 4 ANK repeats.

Ontologies

Keywords
   DomainANK repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Ankyrin repeat domain-containing protein 34A
PRO_0000319100

Regions

Repeat4 – 3330ANK 1
Repeat37 – 7236ANK 2
Repeat76 – 10631ANK 3
Repeat110 – 13930ANK 4
Compositional bias217 – 462246Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q69YU3 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: F13B4F866CD60AC2

FASTA49652,636
        10         20         30         40         50         60 
MLHTEGHALL RAVGQGKLRL ARLLLEGGAY VNEGDAQGET ALMAACRARY DDPQNKARMV 

        70         80         90        100        110        120 
RYLLEQGADP NIADRLGRTA LMHACAGGGG AAVASLLLAH GADPSVRDHA GASALVHALD 

       130        140        150        160        170        180 
RGDRETLATL LDACKAKGTE VIIITTDTSP SGTKKTRQYL NSPPSPGVED PAPASPSPGF 

       190        200        210        220        230        240 
CTSPSEIQLQ TAGGGGRGML SPRAQEEEEK RDVFEFPLPK PPDDPSPSEP LPKPPRHPPK 

       250        260        270        280        290        300 
PLKRLNSEPW GLVAPPQPVP PTEGRPGIER LTAEFNGLTL TGRPRLSRRH STEGPEDPPP 

       310        320        330        340        350        360 
WAEKVTSGGP LSRRNTAPEA QESGPPSGLR QKLSRMEPVE LDTPGHLCPD SPESSRLSLE 

       370        380        390        400        410        420 
RRRYSASPLT LPPAGSAPSP RQSQESLPGA VSPLSGRRRS PGLLERRGSG TLLLDHISQT 

       430        440        450        460        470        480 
RPGFLPPLNV SPHPPIPDIR PQPGGRAPSL PAPPYAGAPG SPRTKRKLVR RHSMQTEQIR 

       490 
LLGGFQSLGG PGEPGR 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum and Testis.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-496.
Tissue: Amygdala.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK094282 mRNA. Translation: BAG52855.1.
AK128050 mRNA. Translation: BAG54622.1.
AL160282 Genomic DNA. No translation available.
AL359622 mRNA. Translation: CAH10676.1.
CCDSCCDS30829.1.
RefSeqNP_001034977.1. NM_001039888.3.
XP_005277448.1. XM_005277391.1.
XP_006711342.1. XM_006711279.1.
UniGeneHs.620591.

3D structure databases

ProteinModelPortalQ69YU3.
SMRQ69YU3. Positions 16-131.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ69YU3. 1 interaction.
STRING9606.ENSP00000314103.

PTM databases

PhosphoSiteQ69YU3.

Polymorphism databases

DMDM172045718.

Proteomic databases

PaxDbQ69YU3.
PRIDEQ69YU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000323397; ENSP00000314103; ENSG00000181039.
GeneID284615.
KEGGhsa:284615.
UCSCuc001enq.1. human.

Organism-specific databases

CTD284615.
GeneCardsGC01P145470.
H-InvDBHIX0199901.
HGNCHGNC:27639. ANKRD34A.
HPAHPA029642.
HPA029643.
neXtProtNX_Q69YU3.
PharmGKBPA162376563.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68360.
HOGENOMHOG000033934.
HOVERGENHBG100441.
InParanoidQ69YU3.
OMACKAKGTE.
OrthoDBEOG79W955.
PhylomeDBQ69YU3.
TreeFamTF331155.

Gene expression databases

BgeeQ69YU3.
CleanExHS_ANKRD34A.
GenevestigatorQ69YU3.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi284615.
NextBio95007.
PROQ69YU3.

Entry information

Entry nameAN34A_HUMAN
AccessionPrimary (citable) accession number: Q69YU3
Secondary accession number(s): B3KSU3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM