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Protein

Cytospin-A

Gene

SPECC1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.1 Publication

GO - Biological processi

  • cell adhesion Source: MGI
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cytospin-A
Alternative name(s):
Renal carcinoma antigen NY-REN-22
Sperm antigen with calponin homology and coiled-coil domains 1-like
Short name:
SPECC1-like protein
Gene namesi
Name:SPECC1L
Synonyms:CYTSA, KIAA0376
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:29022. SPECC1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Gap junction

Pathology & Biotechi

Involvement in diseasei

Facial clefting, oblique, 1 (OBLFC1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare form of facial clefting. A facial cleft is any of the fissures between the embryonic prominences that normally unite to form the face.
See also OMIM:600251
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti415 – 4151Q → P in OBLFC1; severely impairs the stabilization of microtubules. 1 Publication
VAR_066873
Opitz GBBB syndrome 2 (GBBB2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Opitz GBBB syndrome, a congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, cleft lip/palate, laryngotracheoesophageal abnormalities, imperforate anus, developmental delay and congenital heart defects.
See also OMIM:145410
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti397 – 3971T → P in GBBB2; has an abnormal punctate expression pattern; has a drastically reduced ability to stabilize microtubules. 1 Publication
VAR_073384
Natural varianti1083 – 10831G → S in GBBB2; has an abnormal punctate expression pattern; has a drastically reduced ability to stabilize microtubules. 1 Publication
VAR_073385

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiSPECC1L.
MIMi145410. phenotype.
600251. phenotype.
Orphaneti141276. Commissural facial cleft.
141258. Tessier number 4 facial cleft.
PharmGKBiPA164718673.

Polymorphism and mutation databases

DMDMi300669640.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11171117Cytospin-APRO_0000231018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei384 – 3841PhosphoserineBy similarity
Modified residuei385 – 3851PhosphoserineBy similarity
Modified residuei389 – 3891PhosphoserineBy similarity
Modified residuei868 – 8681PhosphoserineCombined sources
Modified residuei881 – 8811PhosphoserineCombined sources
Modified residuei887 – 8871PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ69YQ0.
MaxQBiQ69YQ0.
PaxDbiQ69YQ0.
PeptideAtlasiQ69YQ0.
PRIDEiQ69YQ0.

PTM databases

iPTMnetiQ69YQ0.
PhosphoSiteiQ69YQ0.

Expressioni

Gene expression databases

BgeeiQ69YQ0.
ExpressionAtlasiQ69YQ0. baseline and differential.
GenevisibleiQ69YQ0. HS.

Interactioni

Subunit structurei

May interact with both microtubules and actin cytoskeleton.

Protein-protein interaction databases

BioGridi116960. 56 interactions.
DIPiDIP-33173N.
IntActiQ69YQ0. 30 interactions.
MINTiMINT-1134595.
STRINGi9606.ENSP00000325785.

Structurei

3D structure databases

ProteinModelPortaliQ69YQ0.
SMRiQ69YQ0. Positions 1014-1113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1011 – 1113103CHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili168 – 280113Sequence analysisAdd
BLAST
Coiled coili394 – 44956Sequence analysisAdd
BLAST
Coiled coili487 – 807321Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi858 – 8614Poly-Ala

Sequence similaritiesi

Belongs to the cytospin-A family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4678. Eukaryota.
COG5069. LUCA.
HOGENOMiHOG000015307.
HOVERGENiHBG056096.
InParanoidiQ69YQ0.
PhylomeDBiQ69YQ0.
TreeFamiTF316716.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
[Graphical view]
PfamiPF00307. CH. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69YQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKASRSVGS VPKVSAISKT QTAEKIKPEN SSSASTGGKL VKPGTAASLS
60 70 80 90 100
KTKSSDDLLA GMAGGVTVTN GVKGKKSTCP SAAPSASAPA MTTVENKSKI
110 120 130 140 150
STGTASSTKR STSTGNKESS STRERLRERT RLNQSKKLPS AGQGANDMAL
160 170 180 190 200
AKRSRSRTAT ECDVRMSKSK SDNQISDRAA LEAKVKDLLT LAKTKDVEIL
210 220 230 240 250
HLRNELRDMR AQLGINEDHS EGDEKSEKET IMAHQPTDVE STLLQLQEQN
260 270 280 290 300
TAIREELNQL KNENRMLKDR LNALGFSLEQ RLDNSEKLFG YQSLSPEITP
310 320 330 340 350
DNQSDGGGTL TSSVEGSAPG SVEDLLSQDE NTLMDHQHSN SMDNLDSECS
360 370 380 390 400
EVYQPLTSSD DALDAPSSSE SEGIPSIERS RKGSSGNASE VSVACLTERI
410 420 430 440 450
HQMEENQHST SEELQATLQE LADLQQITQE LNSENERLGE EKVILMESLC
460 470 480 490 500
QQSDKLEHFS RQIEYFRSLL DEHHISYVID EDVKSGRYME LEQRYMDLAE
510 520 530 540 550
NARFEREQLL GVQQHLSNTL KMAEQDNKEA QEMIGALKER SHHMERIIES
560 570 580 590 600
EQKGKAALAA TLEEYKATVA SDQIEMNRLK AQLENEKQKV AELYSIHNSG
610 620 630 640 650
DKSDIQDLLE SVRLDKEKAE TLASSLQEDL AHTRNDANRL QDAIAKVEDE
660 670 680 690 700
YRAFQEEAKK QIEDLNMTLE KLRSDLDEKE TERSDMKETI FELEDEVEQH
710 720 730 740 750
RAVKLHDNLI ISDLENTVKK LQDQKHDMER EIKTLHRRLR EESAEWRQFQ
760 770 780 790 800
ADLQTAVVIA NDIKSEAQEE IGDLKRRLHE AQEKNEKLTK ELEEIKSRKQ
810 820 830 840 850
EEERGRVYNY MNAVERDLAA LRQGMGLSRR SSTSSEPTPT VKTLIKSFDS
860 870 880 890 900
ASQVPNPAAA AIPRTPLSPS PMKTPPAAAV SPMQRHSISG PISTSKPLTA
910 920 930 940 950
LSDKRPNYGE IPVQEHLLRT SSASRPASLP RVPAMESAKT LSVSRRSSEE
960 970 980 990 1000
VKRDISAQEG ASPASLMAMG TTSPQLSLSS SPTASVTPTT RSRIREERKD
1010 1020 1030 1040 1050
PLSALAREYG GSKRNALLKW CQKKTEGYQN IDITNFSSSW NDGLAFCALL
1060 1070 1080 1090 1100
HTYLPAHIPY QELNSQDKRR NFMLAFQAAE SVGIKSTLDI NEMVRTERPD
1110
WQNVMLYVTA IYKYFET
Length:1,117
Mass (Da):124,602
Last modified:July 13, 2010 - v2
Checksum:i607845611F5301C3
GO
Isoform 2 (identifier: Q69YQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1068: Missing.

Show »
Length:1,078
Mass (Da):120,182
Checksum:i69B7490E00156AF2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti375 – 3751P → L in AAX84184 (Ref. 1) Curated
Sequence conflicti375 – 3751P → L in CAH10609 (PubMed:14702039).Curated
Sequence conflicti1041 – 10411N → K in BAA21574 (PubMed:10591208).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti190 – 1901T → M No effect on the stabilization of microtubules. 1 Publication
Corresponds to variant rs142144652 [ dbSNP | Ensembl ].
VAR_066872
Natural varianti301 – 3011D → G.4 Publications
Corresponds to variant rs204710 [ dbSNP | Ensembl ].
VAR_060448
Natural varianti397 – 3971T → P in GBBB2; has an abnormal punctate expression pattern; has a drastically reduced ability to stabilize microtubules. 1 Publication
VAR_073384
Natural varianti415 – 4151Q → P in OBLFC1; severely impairs the stabilization of microtubules. 1 Publication
VAR_066873
Natural varianti712 – 7121S → F.
Corresponds to variant rs5760340 [ dbSNP | Ensembl ].
VAR_060449
Natural varianti717 – 7171T → A.
Corresponds to variant rs6004132 [ dbSNP | Ensembl ].
VAR_060450
Natural varianti943 – 9431V → A.
Corresponds to variant rs11704759 [ dbSNP | Ensembl ].
VAR_060451
Natural varianti951 – 9511V → M.4 Publications
Corresponds to variant rs204718 [ dbSNP | Ensembl ].
VAR_060452
Natural varianti1083 – 10831G → S in GBBB2; has an abnormal punctate expression pattern; has a drastically reduced ability to stabilize microtubules. 1 Publication
VAR_073385

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1030 – 106839Missing in isoform 2. 1 PublicationVSP_047359Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY884293 mRNA. Translation: AAX84184.1.
AK301482 mRNA. Translation: BAH13494.1.
AL832425 mRNA. Translation: CAH10609.1.
AP000354 Genomic DNA. No translation available.
AP000355 Genomic DNA. No translation available.
AB002374 mRNA. Translation: BAA21574.1.
CCDSiCCDS33619.1. [Q69YQ0-1]
CCDS58797.1. [Q69YQ0-2]
RefSeqiNP_001241661.2. NM_001254732.2.
NP_056145.4. NM_015330.4.
UniGeneiHs.474384.

Genome annotation databases

EnsembliENST00000314328; ENSP00000325785; ENSG00000100014.
ENST00000437398; ENSP00000393363; ENSG00000100014.
ENST00000541492; ENSP00000439633; ENSG00000100014.
GeneIDi23384.
KEGGihsa:23384.
UCSCiuc002zzv.6. human. [Q69YQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY884293 mRNA. Translation: AAX84184.1.
AK301482 mRNA. Translation: BAH13494.1.
AL832425 mRNA. Translation: CAH10609.1.
AP000354 Genomic DNA. No translation available.
AP000355 Genomic DNA. No translation available.
AB002374 mRNA. Translation: BAA21574.1.
CCDSiCCDS33619.1. [Q69YQ0-1]
CCDS58797.1. [Q69YQ0-2]
RefSeqiNP_001241661.2. NM_001254732.2.
NP_056145.4. NM_015330.4.
UniGeneiHs.474384.

3D structure databases

ProteinModelPortaliQ69YQ0.
SMRiQ69YQ0. Positions 1014-1113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116960. 56 interactions.
DIPiDIP-33173N.
IntActiQ69YQ0. 30 interactions.
MINTiMINT-1134595.
STRINGi9606.ENSP00000325785.

PTM databases

iPTMnetiQ69YQ0.
PhosphoSiteiQ69YQ0.

Polymorphism and mutation databases

DMDMi300669640.

Proteomic databases

EPDiQ69YQ0.
MaxQBiQ69YQ0.
PaxDbiQ69YQ0.
PeptideAtlasiQ69YQ0.
PRIDEiQ69YQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314328; ENSP00000325785; ENSG00000100014.
ENST00000437398; ENSP00000393363; ENSG00000100014.
ENST00000541492; ENSP00000439633; ENSG00000100014.
GeneIDi23384.
KEGGihsa:23384.
UCSCiuc002zzv.6. human. [Q69YQ0-1]

Organism-specific databases

CTDi23384.
GeneCardsiSPECC1L.
H-InvDBHIX0016229.
HIX0213259.
HGNCiHGNC:29022. SPECC1L.
MalaCardsiSPECC1L.
MIMi145410. phenotype.
600251. phenotype.
614140. gene.
neXtProtiNX_Q69YQ0.
Orphaneti141276. Commissural facial cleft.
141258. Tessier number 4 facial cleft.
PharmGKBiPA164718673.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4678. Eukaryota.
COG5069. LUCA.
HOGENOMiHOG000015307.
HOVERGENiHBG056096.
InParanoidiQ69YQ0.
PhylomeDBiQ69YQ0.
TreeFamiTF316716.

Miscellaneous databases

ChiTaRSiSPECC1L. human.
GenomeRNAii23384.
PROiQ69YQ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ69YQ0.
ExpressionAtlasiQ69YQ0. baseline and differential.
GenevisibleiQ69YQ0. HS.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
[Graphical view]
PfamiPF00307. CH. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of cytospin A as a multiple coiled coil protein involved in cytokinesis and spindle organization."
    Huang C.-H., Ye T., Chen Y.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLY-301 AND MET-951.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLY-301 AND MET-951.
    Tissue: Synovium.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-301 AND MET-951.
    Tissue: Melanoma.
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 157-1041 (ISOFORM 1), VARIANTS GLY-301 AND MET-951.
    Tissue: Brain.
  6. Cited for: IDENTIFICATION AS A RENAL CANCER ANTIGEN.
    Tissue: Renal cell carcinoma.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-868 AND SER-881, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: FUNCTION, INTERACTION WITH MICROTUBULES AND ACTIN CYTOSKELETON, SUBCELLULAR LOCATION, VARIANT OBLFC1 PRO-415, VARIANT MET-190.
  11. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-881 AND SER-887, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-887, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  13. "Mutations in SPECC1L, encoding sperm antigen with calponin homology and coiled-coil domains 1-like, are found in some cases of autosomal dominant Opitz G/BBB syndrome."
    Kruszka P., Li D., Harr M.H., Wilson N.R., Swarr D., McCormick E.M., Chiavacci R.M., Li M., Martinez A.F., Hart R.A., McDonald-McGinn D.M., Deardorff M.A., Falk M.J., Allanson J.E., Hudson C., Johnson J.P., Saadi I., Hakonarson H., Muenke M., Zackai E.H.
    J. Med. Genet. 52:104-110(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN GBBB2, VARIANTS GBBB2 PRO-397 AND SER-1083, CHARACTERIZATION OF VARIANTS GBBB2 PRO-397 AND SER-1083.

Entry informationi

Entry nameiCYTSA_HUMAN
AccessioniPrimary (citable) accession number: Q69YQ0
Secondary accession number(s): B7Z758, F5H1H6, O15081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 13, 2010
Last modified: July 6, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.