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Protein

Protein virilizer homolog

Gene

KIAA1429

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and processing (PubMed:24981863). Involved in mRNA splicing regulation, probably via its function in m6A methylation (Probable).Curated1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA methylation Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • RNA splicing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Protein virilizer homolog
Gene namesi
ORF Names:MSTP054
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:24500. KIAA1429.

Subcellular locationi

GO - Cellular componenti

  • nuclear speck Source: UniProtKB
  • nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164944.
PharmGKBiPA142671611.

Polymorphism and mutation databases

BioMutaiKIAA1429.
DMDMi160221326.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00003086052 – 1812Protein virilizer homologAdd BLAST1811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei133PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei184PhosphothreonineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei914PhosphotyrosineCombined sources1
Modified residuei1579PhosphoserineCombined sources1
Modified residuei1708PhosphothreonineCombined sources1
Modified residuei1723Omega-N-methylarginineCombined sources1
Modified residuei1741Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei1741Omega-N-methylarginine; alternateBy similarity1
Modified residuei1773Asymmetric dimethylarginineCombined sources1
Modified residuei1775Asymmetric dimethylarginineCombined sources1
Modified residuei1793Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ69YN4.
MaxQBiQ69YN4.
PaxDbiQ69YN4.
PeptideAtlasiQ69YN4.
PRIDEiQ69YN4.

PTM databases

iPTMnetiQ69YN4.
PhosphoSitePlusiQ69YN4.

Expressioni

Gene expression databases

BgeeiENSG00000164944.
CleanExiHS_KIAA1429.
ExpressionAtlasiQ69YN4. baseline and differential.
GenevisibleiQ69YN4. HS.

Organism-specific databases

HPAiHPA031530.

Interactioni

Subunit structurei

Associated component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14; possibly via its interaction with WTAP (PubMed:24981863). Interacts with WTAP (PubMed:24100041). Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).2 Publications

Protein-protein interaction databases

BioGridi117452. 29 interactors.
IntActiQ69YN4. 14 interactors.
MINTiMINT-3297048.
STRINGi9606.ENSP00000297591.

Structurei

3D structure databases

ProteinModelPortaliQ69YN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 202Pro-richAdd BLAST64
Compositional biasi208 – 314Glu-richAdd BLAST107
Compositional biasi943 – 946Poly-Pro4

Sequence similaritiesi

Belongs to the vir family.Curated

Phylogenomic databases

eggNOGiKOG4822. Eukaryota.
ENOG410XSTI. LUCA.
GeneTreeiENSGT00390000002833.
HOVERGENiHBG094918.
InParanoidiQ69YN4.
OMAiEYIEPAK.
OrthoDBiEOG091G00J3.
PhylomeDBiQ69YN4.
TreeFamiTF323505.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR031801. VIR_N.
IPR026736. Virilizer.
[Graphical view]
PANTHERiPTHR23185. PTHR23185. 1 hit.
PfamiPF15912. VIR_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69YN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVDSAMELL FLDTFKHPSA EQSSHIDVVR FPCVVYINEV RVIPPGVRAH
60 70 80 90 100
SSLPDNRAYG ETSPHTFQLD LFFNNVSKPS APVFDRLGSL EYDENTSIIF
110 120 130 140 150
RPNSKVNTDG LVLRGWYNCL TLAIYGSVDR VISHDRDSPP PPPPPPPPPQ
160 170 180 190 200
PQPSLKRNPK HADGEKEDQF NGSPPRPQPR GPRTPPGPPP PDDDEDDPVP
210 220 230 240 250
LPVSGDKEED APHREDYFEP ISPDRNSVPQ EGQYSDEGEV EEEQQEEGEE
260 270 280 290 300
DEDDVDVEEE EDEDEDDRRT VDSIPEEEEE DEEEEGEEDE EGEGDDGYEQ
310 320 330 340 350
ISSDEDGIAD LERETFKYPN FDVEYTAEDL ASVPPMTYDP YDRELVPLLY
360 370 380 390 400
FSCPYKTTFE IEISRMKDQG PDKENSGAIE ASVKLTELLD LYREDRGAKW
410 420 430 440 450
VTALEEIPSL IIKGLSYLQL KNTKQDSLGQ LVDWTMQALN LQVALRQPIA
460 470 480 490 500
LNVRQLKAGT KLVSSLAECG AQGVTGLLQA GVISGLFELL FADHVSSSLK
510 520 530 540 550
LNAFKALDSV ISMTEGMEAF LRGRQNEKSG YQKLLELILL DQTVRVVTAG
560 570 580 590 600
SAILQKCHFY EVLSEIKRLG DHLAEKTSSL PNHSEPDHDT DAGLERTNPE
610 620 630 640 650
YENEVEASMD MDLLESSNIS EGEIERLINL LEEVFHLMET APHTMIQQPV
660 670 680 690 700
KSFPTMARIT GPPERDDPYP VLFRYLHSHH FLELVTLLLS IPVTSAHPGV
710 720 730 740 750
LQATKDVLKF LAQSQKGLLF FMSEYEATNL LIRALCHFYD QDEEEGLQSD
760 770 780 790 800
GVIDDAFALW LQDSTQTLQC ITELFSHFQR CTASEETDHS DLLGTLHNLY
810 820 830 840 850
LITFNPVGRS AVGHVFSLEK NLQSLITLME YYSKEALGDS KSKKSVAYNY
860 870 880 890 900
ACILILVVVQ SSSDVQMLEQ HAASLLKLCK ADENNAKLQE LGKWLEPLKN
910 920 930 940 950
LRFEINCIPN LIEYVKQNID NLMTPEGVGL TTALRVLCNV ACPPPPVEGQ
960 970 980 990 1000
QKDLKWNLAV IQLFSAEGMD TFIRVLQKLN SILTQPWRLH VNMGTTLHRV
1010 1020 1030 1040 1050
TTISMARCTL TLLKTMLTEL LRGGSFEFKD MRVPSALVTL HMLLCSIPLS
1060 1070 1080 1090 1100
GRLDSDEQKI QNDIIDILLT FTQGVNEKLT ISEETLANNT WSLMLKEVLS
1110 1120 1130 1140 1150
SILKVPEGFF SGLILLSELL PLPLPMQTTQ VIEPHDISVA LNTRKLWSMH
1160 1170 1180 1190 1200
LHVQAKLLQE IVRSFSGTTC QPIQHMLRRI CVQLCDLASP TALLIMRTVL
1210 1220 1230 1240 1250
DLIVEDLQST SEDKEKQYTS QTTRLLALLD ALASHKACKL AILHLINGTI
1260 1270 1280 1290 1300
KGDERYAEIF QDLLALVRSP GDSVIRQQCV EYVTSILQSL CDQDIALILP
1310 1320 1330 1340 1350
SSSEGSISEL EQLSNSLPNK ELMTSICDCL LATLANSESS YNCLLTCVRT
1360 1370 1380 1390 1400
MMFLAEHDYG LFHLKSSLRK NSSALHSLLK RVVSTFSKDT GELASSFLEF
1410 1420 1430 1440 1450
MRQILNSDTI GCCGDDNGLM EVEGAHTSRT MSINAAELKQ LLQSKEESPE
1460 1470 1480 1490 1500
NLFLELEKLV LEHSKDDDNL DSLLDSVVGL KQMLESSGDP LPLSDQDVEP
1510 1520 1530 1540 1550
VLSAPESLQN LFNNRTAYVL ADVMDDQLKS MWFTPFQAEE IDTDLDLVKV
1560 1570 1580 1590 1600
DLIELSEKCC SDFDLHSELE RSFLSEPSSP GRTKTTKGFK LGKHKHETFI
1610 1620 1630 1640 1650
TSSGKSEYIE PAKRAHVVPP PRGRGRGGFG QGIRPHDIFR QRKQNTSRPP
1660 1670 1680 1690 1700
SMHVDDFVAA ESKEVVPQDG IPPPKRPLKV SQKISSRGGF SGNRGGRGAF
1710 1720 1730 1740 1750
HSQNRFFTPP ASKGNYSRRE GTRGSSWSAQ NTPRGNYNES RGGQSNFNRG
1760 1770 1780 1790 1800
PLPPLRPLSS TGYRPSPRDR ASRGRGGLGP SWASANSGSG GSRGKFVSGG
1810
SGRGRHVRSF TR
Length:1,812
Mass (Da):202,025
Last modified:October 23, 2007 - v2
Checksum:iFFF7F006B5EF5B75
GO
Isoform 2 (identifier: Q69YN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1366-1377: SSLRKNSSALHS → RDAVEMIMVSWK
     1378-1812: Missing.

Show »
Length:1,377
Mass (Da):154,472
Checksum:iB32781D9044FD415
GO
Isoform 3 (identifier: Q69YN4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1684-1812: ISSRGGFSGN...RGRHVRSFTR → EQEAPVGVLR...HFTRTIKIRH

Show »
Length:1,797
Mass (Da):201,057
Checksum:i785EC7223BA62A6C
GO
Isoform 4 (identifier: Q69YN4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1132-1147: IEPHDISVALNTRKLW → SLPYNMHLINDCSNTF
     1148-1812: Missing.

Show »
Length:1,147
Mass (Da):128,734
Checksum:iD5CA3651E44FBF31
GO

Sequence cautioni

The sequence BAA91316 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14301 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB55922 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97S → P in CAH10773 (PubMed:17974005).Curated1
Sequence conflicti185Missing in CAH10773 (PubMed:17974005).Curated1
Sequence conflicti524R → G in CAH10773 (PubMed:17974005).Curated1
Sequence conflicti574A → P in CAH10773 (PubMed:17974005).Curated1
Sequence conflicti664Missing in CAH10773 (PubMed:17974005).Curated1
Sequence conflicti1183Q → E in CAB55922 (PubMed:17974005).Curated1
Sequence conflicti1434N → D in BAB14301 (PubMed:14702039).Curated1
Sequence conflicti1563F → I in CAH10773 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036845753I → V.Corresponds to variant rs7814840dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0290171132 – 1147IEPHD…TRKLW → SLPYNMHLINDCSNTF in isoform 4. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_0290181148 – 1812Missing in isoform 4. 2 PublicationsAdd BLAST665
Alternative sequenceiVSP_0290191366 – 1377SSLRK…SALHS → RDAVEMIMVSWK in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0290201378 – 1812Missing in isoform 2. 1 PublicationAdd BLAST435
Alternative sequenceiVSP_0290211684 – 1812ISSRG…RSFTR → EQEAPVGVLRILLEEITMKV VEARAILTEALFHHYDPLVL QVTAQVLGTVLLEVVGDLDL PGLVQIAAVEAQEESLLVEA VVEVVMYAPLHDKNPFGNIL TVYEHFTRTIKIRH in isoform 3. 1 PublicationAdd BLAST129

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117434 mRNA. Translation: CAB55922.1. Different initiation.
AL832487 mRNA. Translation: CAH10773.1.
CR627454 mRNA. Translation: CAH10535.1.
BC003701 mRNA. Translation: AAH03701.2.
BC053875 mRNA. No translation available.
BC069239 mRNA. Translation: AAH69239.1.
BC112288 mRNA. Translation: AAI12289.1.
BC113380 mRNA. Translation: AAI13381.1.
AF116724 mRNA. Translation: AAO15300.1.
AB037850 mRNA. Translation: BAA92667.1.
AK000668 mRNA. Translation: BAA91316.1. Different initiation.
AK022906 mRNA. Translation: BAB14301.1. Different initiation.
CCDSiCCDS34923.1. [Q69YN4-1]
CCDS47894.1. [Q69YN4-4]
PIRiT17232.
RefSeqiNP_056311.2. NM_015496.4. [Q69YN4-1]
NP_892121.1. NM_183009.2. [Q69YN4-4]
UniGeneiHs.202238.

Genome annotation databases

EnsembliENST00000297591; ENSP00000297591; ENSG00000164944. [Q69YN4-1]
ENST00000421249; ENSP00000398390; ENSG00000164944. [Q69YN4-4]
GeneIDi25962.
KEGGihsa:25962.
UCSCiuc003ygo.3. human. [Q69YN4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117434 mRNA. Translation: CAB55922.1. Different initiation.
AL832487 mRNA. Translation: CAH10773.1.
CR627454 mRNA. Translation: CAH10535.1.
BC003701 mRNA. Translation: AAH03701.2.
BC053875 mRNA. No translation available.
BC069239 mRNA. Translation: AAH69239.1.
BC112288 mRNA. Translation: AAI12289.1.
BC113380 mRNA. Translation: AAI13381.1.
AF116724 mRNA. Translation: AAO15300.1.
AB037850 mRNA. Translation: BAA92667.1.
AK000668 mRNA. Translation: BAA91316.1. Different initiation.
AK022906 mRNA. Translation: BAB14301.1. Different initiation.
CCDSiCCDS34923.1. [Q69YN4-1]
CCDS47894.1. [Q69YN4-4]
PIRiT17232.
RefSeqiNP_056311.2. NM_015496.4. [Q69YN4-1]
NP_892121.1. NM_183009.2. [Q69YN4-4]
UniGeneiHs.202238.

3D structure databases

ProteinModelPortaliQ69YN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117452. 29 interactors.
IntActiQ69YN4. 14 interactors.
MINTiMINT-3297048.
STRINGi9606.ENSP00000297591.

PTM databases

iPTMnetiQ69YN4.
PhosphoSitePlusiQ69YN4.

Polymorphism and mutation databases

BioMutaiKIAA1429.
DMDMi160221326.

Proteomic databases

EPDiQ69YN4.
MaxQBiQ69YN4.
PaxDbiQ69YN4.
PeptideAtlasiQ69YN4.
PRIDEiQ69YN4.

Protocols and materials databases

DNASUi25962.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297591; ENSP00000297591; ENSG00000164944. [Q69YN4-1]
ENST00000421249; ENSP00000398390; ENSG00000164944. [Q69YN4-4]
GeneIDi25962.
KEGGihsa:25962.
UCSCiuc003ygo.3. human. [Q69YN4-1]

Organism-specific databases

CTDi25962.
GeneCardsiKIAA1429.
H-InvDBHIX0007653.
HGNCiHGNC:24500. KIAA1429.
HPAiHPA031530.
MIMi616447. gene.
neXtProtiNX_Q69YN4.
OpenTargetsiENSG00000164944.
PharmGKBiPA142671611.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4822. Eukaryota.
ENOG410XSTI. LUCA.
GeneTreeiENSGT00390000002833.
HOVERGENiHBG094918.
InParanoidiQ69YN4.
OMAiEYIEPAK.
OrthoDBiEOG091G00J3.
PhylomeDBiQ69YN4.
TreeFamiTF323505.

Miscellaneous databases

ChiTaRSiKIAA1429. human.
GenomeRNAii25962.
PROiQ69YN4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164944.
CleanExiHS_KIAA1429.
ExpressionAtlasiQ69YN4. baseline and differential.
GenevisibleiQ69YN4. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR031801. VIR_N.
IPR026736. Virilizer.
[Graphical view]
PANTHERiPTHR23185. PTHR23185. 1 hit.
PfamiPF15912. VIR_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 6 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiVIR_HUMAN
AccessioniPrimary (citable) accession number: Q69YN4
Secondary accession number(s): Q2M1N0
, Q6AHX9, Q6NT78, Q7Z6C7, Q8IXH4, Q9BTH4, Q9H9C9, Q9NWR3, Q9P2B8, Q9UFW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.