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Q69YN2

- C19L1_HUMAN

UniProt

Q69YN2 - C19L1_HUMAN

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Protein
CWF19-like protein 1
Gene
CWF19L1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. catalytic activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CWF19-like protein 1
    Gene namesi
    Name:CWF19L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:25613. CWF19L1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134864340.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538CWF19-like protein 1
    PRO_0000315641Add
    BLAST

    Proteomic databases

    MaxQBiQ69YN2.
    PaxDbiQ69YN2.
    PeptideAtlasiQ69YN2.
    PRIDEiQ69YN2.

    PTM databases

    PhosphoSiteiQ69YN2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ69YN2.
    BgeeiQ69YN2.
    CleanExiHS_CWF19L1.
    GenevestigatoriQ69YN2.

    Organism-specific databases

    HPAiHPA036889.
    HPA036890.

    Interactioni

    Protein-protein interaction databases

    BioGridi120568. 3 interactions.
    IntActiQ69YN2. 1 interaction.
    MINTiMINT-3053442.
    STRINGi9606.ENSP00000326411.

    Structurei

    3D structure databases

    ProteinModelPortaliQ69YN2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CWF19 family.

    Phylogenomic databases

    eggNOGiNOG244783.
    HOVERGENiHBG098124.
    InParanoidiQ69YN2.
    OMAiTLKPRYH.
    OrthoDBiEOG71CFKR.
    PhylomeDBiQ69YN2.
    TreeFamiTF105790.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR006768. Cwf19-like_C_dom-1.
    IPR006767. Cwf19-like_C_dom-2.
    IPR011146. HIT-like.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF04677. CwfJ_C_1. 1 hit.
    PF04676. CwfJ_C_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF54197. SSF54197. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q69YN2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQKPLRLLA CGDVEGKFDI LFNRVQAIQK KSGNFDLLLC VGNFFGSTQD    50
    AEWEEYKTGI KKAPIQTYVL GANNQETVKY FQDADGCELA ENITYLGRKG 100
    IFTGSSGLQI VYLSGTESLN EPVPGYSFSP KDVSSLRMML CTTSQFKGVD 150
    ILLTSPWPKC VGNFGNSSGE VDTKKCGSAL VSSLATGLKP RYHFAALEKT 200
    YYERLPYRNH IILQENAQHA TRFIALANVG NPEKKKYLYA FSIVPMKLMD 250
    AAELVKQPPD VTENPYRKSG QEASIGKQIL APVEESACQF FFDLNEKQGR 300
    KRSSTGRDSK SSPHPKQPRK PPQPPGPCWF CLASPEVEKH LVVNIGTHCY 350
    LALAKGGLSD DHVLILPIGH YQSVVELSAE VVEEVEKYKA TLRRFFKSRG 400
    KWCVVFERNY KSHHLQLQVI PVPISCSTTD DIKDAFITQA QEQQIELLEI 450
    PEHSDIKQIA QPGAAYFYVE LDTGEKLFHR IKKNFPLQFG REVLASEAIL 500
    NVPDKSDWRQ CQISKEDEET LARRFRKDFE PYDFTLDD 538
    Length:538
    Mass (Da):60,619
    Last modified:January 15, 2008 - v2
    Checksum:i63237331F41AD6AE
    GO
    Isoform 2 (identifier: Q69YN2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-296: Missing.
         297-323: KQGRKRSSTGRDSKSSPHPKQPRKPPQ → MKSREGSVHPQVEIANLLLIQSSLANL

    Note: No experimental confirmation available.

    Show »
    Length:242
    Mass (Da):27,694
    Checksum:i4DC2814A6DBF191E
    GO
    Isoform 3 (identifier: Q69YN2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-137: Missing.

    Show »
    Length:401
    Mass (Da):45,537
    Checksum:iC75C41C6FDBD8F44
    GO

    Sequence cautioni

    The sequence CAH72402.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti160 – 1601C → Y.
    Corresponds to variant rs2270962 [ dbSNP | Ensembl ].
    VAR_038264
    Natural varianti259 – 2591P → L.
    Corresponds to variant rs7073610 [ dbSNP | Ensembl ].
    VAR_038265
    Natural varianti523 – 5231R → H.
    Corresponds to variant rs35490714 [ dbSNP | Ensembl ].
    VAR_038266
    Natural varianti526 – 5261R → Q.
    Corresponds to variant rs7922946 [ dbSNP | Ensembl ].
    VAR_038267

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 296296Missing in isoform 2.
    VSP_030586Add
    BLAST
    Alternative sequencei1 – 137137Missing in isoform 3.
    VSP_030587Add
    BLAST
    Alternative sequencei297 – 32327KQGRK…RKPPQ → MKSREGSVHPQVEIANLLLI QSSLANL in isoform 2.
    VSP_030588Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti63 – 631A → V in AAH08746. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001860 mRNA. Translation: BAA91947.1.
    AK023984 mRNA. Translation: BAB14754.1.
    AL832515 mRNA. Translation: CAH10625.1.
    AK295303 mRNA. Translation: BAG58283.1.
    AL138921 Genomic DNA. Translation: CAH72402.1. Sequence problems.
    CH471066 Genomic DNA. Translation: EAW49838.1.
    CH471066 Genomic DNA. Translation: EAW49839.1.
    CH471066 Genomic DNA. Translation: EAW49843.1.
    CH471066 Genomic DNA. Translation: EAW49844.1.
    BC008746 mRNA. Translation: AAH08746.1.
    CCDSiCCDS7489.1. [Q69YN2-1]
    RefSeqiNP_060764.3. NM_018294.4. [Q69YN2-1]
    UniGeneiHs.215502.

    Genome annotation databases

    EnsembliENST00000354105; ENSP00000326411; ENSG00000095485. [Q69YN2-1]
    GeneIDi55280.
    KEGGihsa:55280.
    UCSCiuc001kqq.1. human. [Q69YN2-1]
    uc001kqt.1. human. [Q69YN2-2]

    Polymorphism databases

    DMDMi166225917.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001860 mRNA. Translation: BAA91947.1 .
    AK023984 mRNA. Translation: BAB14754.1 .
    AL832515 mRNA. Translation: CAH10625.1 .
    AK295303 mRNA. Translation: BAG58283.1 .
    AL138921 Genomic DNA. Translation: CAH72402.1 . Sequence problems.
    CH471066 Genomic DNA. Translation: EAW49838.1 .
    CH471066 Genomic DNA. Translation: EAW49839.1 .
    CH471066 Genomic DNA. Translation: EAW49843.1 .
    CH471066 Genomic DNA. Translation: EAW49844.1 .
    BC008746 mRNA. Translation: AAH08746.1 .
    CCDSi CCDS7489.1. [Q69YN2-1 ]
    RefSeqi NP_060764.3. NM_018294.4. [Q69YN2-1 ]
    UniGenei Hs.215502.

    3D structure databases

    ProteinModelPortali Q69YN2.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 120568. 3 interactions.
    IntActi Q69YN2. 1 interaction.
    MINTi MINT-3053442.
    STRINGi 9606.ENSP00000326411.

    PTM databases

    PhosphoSitei Q69YN2.

    Polymorphism databases

    DMDMi 166225917.

    Proteomic databases

    MaxQBi Q69YN2.
    PaxDbi Q69YN2.
    PeptideAtlasi Q69YN2.
    PRIDEi Q69YN2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354105 ; ENSP00000326411 ; ENSG00000095485 . [Q69YN2-1 ]
    GeneIDi 55280.
    KEGGi hsa:55280.
    UCSCi uc001kqq.1. human. [Q69YN2-1 ]
    uc001kqt.1. human. [Q69YN2-2 ]

    Organism-specific databases

    CTDi 55280.
    GeneCardsi GC10M101982.
    HGNCi HGNC:25613. CWF19L1.
    HPAi HPA036889.
    HPA036890.
    neXtProti NX_Q69YN2.
    PharmGKBi PA134864340.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG244783.
    HOVERGENi HBG098124.
    InParanoidi Q69YN2.
    OMAi TLKPRYH.
    OrthoDBi EOG71CFKR.
    PhylomeDBi Q69YN2.
    TreeFami TF105790.

    Miscellaneous databases

    GenomeRNAii 55280.
    NextBioi 59426.
    PROi Q69YN2.

    Gene expression databases

    ArrayExpressi Q69YN2.
    Bgeei Q69YN2.
    CleanExi HS_CWF19L1.
    Genevestigatori Q69YN2.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR006768. Cwf19-like_C_dom-1.
    IPR006767. Cwf19-like_C_dom-2.
    IPR011146. HIT-like.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF04677. CwfJ_C_1. 1 hit.
    PF04676. CwfJ_C_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54197. SSF54197. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Caudate nucleus, Placenta and Retinoblastoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Melanoma.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiC19L1_HUMAN
    AccessioniPrimary (citable) accession number: Q69YN2
    Secondary accession number(s): B4DHX1
    , D3DR66, Q5W0I3, Q96HC3, Q9H865, Q9NV13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: July 9, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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