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Protein

Putative pleckstrin homology domain-containing family M member 1P

Gene

PLEKHM1P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri461 – 51555Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pleckstrin homology domain-containing family M member 1P
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:35411. PLEKHM1P.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74748328.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Putative pleckstrin homology domain-containing family M member 1PPRO_0000335679Add
BLAST

Proteomic databases

PaxDbiQ69YJ1.
PeptideAtlasiQ69YJ1.
PRIDEiQ69YJ1.

PTM databases

iPTMnetiQ69YJ1.
PhosphoSiteiQ69YJ1.

Expressioni

Organism-specific databases

HPAiHPA039473.
HPA041005.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000389913.

Structurei

3D structure databases

ProteinModelPortaliQ69YJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 10092PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini158 – 25295PH 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PH domains.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri461 – 51555Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITGM. Eukaryota.
ENOG4111EZ2. LUCA.
HOGENOMiHOG000247013.
InParanoidiQ69YJ1.
PhylomeDBiQ69YJ1.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR025258. Zf-RING_9.
[Graphical view]
PfamiPF13901. zf-RING_9. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM01175. DUF4206. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q69YJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSNPFQGL MKLGTVERQG AMGIWKELFC ELSPLEFRLY LSNEEHTCVE
60 70 80 90 100
NCSLLRCESV GPAHSDGRFE LVFSGKKLAL RASSQDEAED WLDLVREALQ
110 120 130 140 150
KVRPQQEDEW VNVQYSDQPE EPPEAPQGCL SPSDLLSEPA ALQGTQSDWS
160 170 180 190 200
SAQVPELDAI KESLLYLYMD RTWMPYIFSL PLEALKCFRI RNNEKMLSDS
210 220 230 240 250
HGVETIRDIL PDTSLGGPSF FKIITAKAVL KLQAGNAEEA ALWRDLVRKV
260 270 280 290 300
LASYLETAEE AVTLGGSLDE NCQEVLKFAT RENGFLLQYL VAIPMEKGLD
310 320 330 340 350
SQGCFCAGCS RQIGFSFVRP KLCAFSGLYY CDICHQDDAS VIPARIIHNW
360 370 380 390 400
DLTKRPICRQ ALKFLTQIRA QPLINLQMVN ASLYEHVERM HLIGRSREQL
410 420 430 440 450
KLLGDYLGLC RSGALKELSK RLNHRNYLLE SPHRFRVADL RQIADEVYEG
460 470 480 490 500
FLKALIEFAS QHVYHCDLCT QRSFICQICQ HHDIIFPSEF DTTVRCAKCK
510 520
TVFHQSCQAV VKKGCPRCAR
Length:520
Mass (Da):58,973
Last modified:September 13, 2004 - v1
Checksum:iEE271F87C856DDBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833315 mRNA. Translation: CAH10578.1.
UniGeneiHs.646585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833315 mRNA. Translation: CAH10578.1.
UniGeneiHs.646585.

3D structure databases

ProteinModelPortaliQ69YJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000389913.

PTM databases

iPTMnetiQ69YJ1.
PhosphoSiteiQ69YJ1.

Polymorphism and mutation databases

DMDMi74748328.

Proteomic databases

PaxDbiQ69YJ1.
PeptideAtlasiQ69YJ1.
PRIDEiQ69YJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPLEKHM1P.
HGNCiHGNC:35411. PLEKHM1P.
HPAiHPA039473.
HPA041005.
neXtProtiNX_Q69YJ1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITGM. Eukaryota.
ENOG4111EZ2. LUCA.
HOGENOMiHOG000247013.
InParanoidiQ69YJ1.
PhylomeDBiQ69YJ1.

Miscellaneous databases

ChiTaRSiPLEKHM1P. human.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR025258. Zf-RING_9.
[Graphical view]
PfamiPF13901. zf-RING_9. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM01175. DUF4206. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPKHMP_HUMAN
AccessioniPrimary (citable) accession number: Q69YJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 13, 2004
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. Highly similar to PLEKHM1 but is shorter at the N-terminus and lacks the RUN domain. The RUN domain can be found upstream of the CDS but N- and C-terminus are separated by stop codons.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.