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Protein

Nuclear apoptosis-inducing factor 1

Gene

NAIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces apoptosis.1 Publication

GO - Biological processi

  • negative regulation of cell growth Source: UniProtKB
  • regulation of mitochondrial membrane permeability involved in apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear apoptosis-inducing factor 1
Gene namesi
Name:NAIF1
Synonyms:C9orf90
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25446. NAIF1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: GOC
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396796.

Polymorphism and mutation databases

BioMutaiNAIF1.
DMDMi68565165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Nuclear apoptosis-inducing factor 1PRO_0000089724Add
BLAST

Proteomic databases

EPDiQ69YI7.
MaxQBiQ69YI7.
PaxDbiQ69YI7.
PeptideAtlasiQ69YI7.
PRIDEiQ69YI7.

PTM databases

iPTMnetiQ69YI7.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ69YI7.
CleanExiHS_NAIF1.
ExpressionAtlasiQ69YI7. baseline and differential.
GenevisibleiQ69YI7. HS.

Interactioni

Subunit structurei

Interacts with HARBI1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10249231,EBI-748961
SOX14O954163EBI-10249231,EBI-9087806
TERF2Q155542EBI-10249231,EBI-706637

Protein-protein interaction databases

BioGridi128460. 8 interactions.
IntActiQ69YI7. 4 interactions.
STRINGi9606.ENSP00000362170.

Structurei

3D structure databases

ProteinModelPortaliQ69YI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7070Required for nuclear localization and apoptosis-inducing activityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi92 – 11726Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the NAIF1 family.Curated

Phylogenomic databases

eggNOGiENOG410IDY8. Eukaryota.
ENOG4110DBH. LUCA.
GeneTreeiENSGT00450000040324.
HOGENOMiHOG000065749.
HOVERGENiHBG080480.
InParanoidiQ69YI7.
OMAiAMQQRIC.
OrthoDBiEOG7B05DR.
PhylomeDBiQ69YI7.
TreeFamiTF332812.

Family and domain databases

InterProiIPR028002. Myb_DNA-bind_5.
IPR026753. NAIF1.
[Graphical view]
PANTHERiPTHR23098. PTHR23098. 1 hit.
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q69YI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVPAKKRKM NFSEREVEII VEELELKKHL LVNHFNAGVP LAAKSAAWHG
60 70 80 90 100
ILRRVNAVAT CRRELPEVKK KWSDLKTEVR RKVAQVRAAV EGGEAPGPTE
110 120 130 140 150
EDGAGGPGTG GGSGGGGPAV APVLLTPMQQ RICNLLGEAT IISLPSTTEI
160 170 180 190 200
HPVALGPSAT AAAATVTLTQ IPTETTYHTL EEGVVEYCTA EAPPPLPPET
210 220 230 240 250
PVDMMAQHAD TSVKPQALKS RIALNSAKLI QEQRVTNLHV KEIAQHLEQQ
260 270 280 290 300
NDLLQMIRRS QEVQACAQER QAQAMEGTQA ALSVLIQVLR PMIKDFRRYL
310 320
QSNTANPAPA SDPGQVAQNG QPDSIIQ
Length:327
Mass (Da):35,164
Last modified:September 13, 2004 - v1
Checksum:i52FC0BAB88BC0EAA
GO
Isoform 2 (identifier: Q69YI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-172: IP → SE
     173-327: Missing.

Note: No experimental confirmation available.
Show »
Length:172
Mass (Da):17,997
Checksum:i52A688B3775B8316
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei171 – 1722IP → SE in isoform 2. 1 PublicationVSP_014447
Alternative sequencei173 – 327155Missing in isoform 2. 1 PublicationVSP_014448Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122729 mRNA. Translation: BAG53693.1.
AL833392 mRNA. Translation: CAH10588.1.
AL360268 Genomic DNA. Translation: CAH73132.1.
CH471090 Genomic DNA. Translation: EAW87735.1.
BC021580 mRNA. Translation: AAH21580.1.
CCDSiCCDS6889.1. [Q69YI7-1]
RefSeqiNP_931045.1. NM_197956.3. [Q69YI7-1]
UniGeneiHs.373606.
Hs.740682.

Genome annotation databases

EnsembliENST00000373078; ENSP00000362170; ENSG00000171169. [Q69YI7-1]
GeneIDi203245.
KEGGihsa:203245.
UCSCiuc004bta.4. human. [Q69YI7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122729 mRNA. Translation: BAG53693.1.
AL833392 mRNA. Translation: CAH10588.1.
AL360268 Genomic DNA. Translation: CAH73132.1.
CH471090 Genomic DNA. Translation: EAW87735.1.
BC021580 mRNA. Translation: AAH21580.1.
CCDSiCCDS6889.1. [Q69YI7-1]
RefSeqiNP_931045.1. NM_197956.3. [Q69YI7-1]
UniGeneiHs.373606.
Hs.740682.

3D structure databases

ProteinModelPortaliQ69YI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128460. 8 interactions.
IntActiQ69YI7. 4 interactions.
STRINGi9606.ENSP00000362170.

PTM databases

iPTMnetiQ69YI7.

Polymorphism and mutation databases

BioMutaiNAIF1.
DMDMi68565165.

Proteomic databases

EPDiQ69YI7.
MaxQBiQ69YI7.
PaxDbiQ69YI7.
PeptideAtlasiQ69YI7.
PRIDEiQ69YI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373078; ENSP00000362170; ENSG00000171169. [Q69YI7-1]
GeneIDi203245.
KEGGihsa:203245.
UCSCiuc004bta.4. human. [Q69YI7-1]

Organism-specific databases

CTDi203245.
GeneCardsiNAIF1.
HGNCiHGNC:25446. NAIF1.
MIMi610673. gene.
neXtProtiNX_Q69YI7.
PharmGKBiPA162396796.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDY8. Eukaryota.
ENOG4110DBH. LUCA.
GeneTreeiENSGT00450000040324.
HOGENOMiHOG000065749.
HOVERGENiHBG080480.
InParanoidiQ69YI7.
OMAiAMQQRIC.
OrthoDBiEOG7B05DR.
PhylomeDBiQ69YI7.
TreeFamiTF332812.

Miscellaneous databases

GenomeRNAii203245.
PROiQ69YI7.
SOURCEiSearch...

Gene expression databases

BgeeiQ69YI7.
CleanExiHS_NAIF1.
ExpressionAtlasiQ69YI7. baseline and differential.
GenevisibleiQ69YI7. HS.

Family and domain databases

InterProiIPR028002. Myb_DNA-bind_5.
IPR026753. NAIF1.
[Graphical view]
PANTHERiPTHR23098. PTHR23098. 1 hit.
PfamiPF13873. Myb_DNA-bind_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Melanoma.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  6. "Overexpression of the novel human gene, nuclear apoptosis-inducing factor 1, induces apoptosis."
    Lv B., Shi T., Wang X., Song Q., Zhang Y., Shen Y., Ma D., Lou Y.
    Int. J. Biochem. Cell Biol. 38:671-683(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes."
    Sinzelle L., Kapitonov V.V., Grzela D.P., Jursch T., Jurka J., Izsvak Z., Ivics Z.
    Proc. Natl. Acad. Sci. U.S.A. 105:4715-4720(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HARBI1, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNAIF1_HUMAN
AccessioniPrimary (citable) accession number: Q69YI7
Secondary accession number(s): B3KV81, Q8WU12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: September 13, 2004
Last modified: July 6, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.