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Protein

Transmembrane protein 42

Gene

TMEM42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 42
Gene namesi
Name:TMEM42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28444. TMEM42.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914008.

Polymorphism and mutation databases

BioMutaiTMEM42.
DMDMi145572734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Transmembrane protein 42PRO_0000284495Add
BLAST

Proteomic databases

PaxDbiQ69YG0.
PRIDEiQ69YG0.

PTM databases

PhosphoSiteiQ69YG0.

Expressioni

Gene expression databases

BgeeiQ69YG0.
GenevestigatoriQ69YG0.

Organism-specific databases

HPAiHPA052569.

Structurei

3D structure databases

ProteinModelPortaliQ69YG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG16283.
GeneTreeiENSGT00390000012690.
HOGENOMiHOG000154645.
HOVERGENiHBG098258.
InParanoidiQ69YG0.
OMAiFGSEVNM.
OrthoDBiEOG78WKW2.
PhylomeDBiQ69YG0.
TreeFamiTF336306.

Sequencei

Sequence statusi: Complete.

Q69YG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERPGPPGG AVSATAYPDT PAEFPPHLQA GAMRRRFWGV FNCLCAGAFG
60 70 80 90 100
ALAAASAKLA FGSEVSMGLC VLGIIVMAST NSLMWTFFSR GLSFSMSSAI
110 120 130 140 150
ASVTVTFSNI LSSAFLGYVL YGECQEVLWW GGVFLILCGL TLIHRKLPPT

WKPLPHKQQ
Length:159
Mass (Da):16,991
Last modified:April 17, 2007 - v2
Checksum:iA8572BF4BC9CF44E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651V → VV in CAH10689 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834253 mRNA. Translation: CAH10689.1.
BC019851 mRNA. Translation: AAH19851.1.
CCDSiCCDS2722.1.
RefSeqiNP_653239.1. NM_144638.2.
UniGeneiHs.646856.

Genome annotation databases

EnsembliENST00000302392; ENSP00000306564; ENSG00000169964.
ENST00000626748; ENSP00000486141; ENSG00000280516.
GeneIDi131616.
KEGGihsa:131616.
UCSCiuc003cnz.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834253 mRNA. Translation: CAH10689.1.
BC019851 mRNA. Translation: AAH19851.1.
CCDSiCCDS2722.1.
RefSeqiNP_653239.1. NM_144638.2.
UniGeneiHs.646856.

3D structure databases

ProteinModelPortaliQ69YG0.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ69YG0.

Polymorphism and mutation databases

BioMutaiTMEM42.
DMDMi145572734.

Proteomic databases

PaxDbiQ69YG0.
PRIDEiQ69YG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302392; ENSP00000306564; ENSG00000169964.
ENST00000626748; ENSP00000486141; ENSG00000280516.
GeneIDi131616.
KEGGihsa:131616.
UCSCiuc003cnz.3. human.

Organism-specific databases

CTDi131616.
GeneCardsiGC03P044909.
H-InvDBHIX0200526.
HGNCiHGNC:28444. TMEM42.
HPAiHPA052569.
neXtProtiNX_Q69YG0.
PharmGKBiPA134914008.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG16283.
GeneTreeiENSGT00390000012690.
HOGENOMiHOG000154645.
HOVERGENiHBG098258.
InParanoidiQ69YG0.
OMAiFGSEVNM.
OrthoDBiEOG78WKW2.
PhylomeDBiQ69YG0.
TreeFamiTF336306.

Miscellaneous databases

GenomeRNAii131616.
NextBioi82954.
PROiQ69YG0.

Gene expression databases

BgeeiQ69YG0.
GenevestigatoriQ69YG0.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.

Entry informationi

Entry nameiTMM42_HUMAN
AccessioniPrimary (citable) accession number: Q69YG0
Secondary accession number(s): Q8WUQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: May 27, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.