Q69YG0 (TMM42_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 42

Gene names

Name:

TMEM42

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	159 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 159	159	Transmembrane protein 42		PRO_0000284495
Regions
	Transmembrane	37 – 57	21	Helical; Potential
	Transmembrane	59 – 79	21	Helical; Potential
	Transmembrane	100 – 120	21	Helical; Potential
	Transmembrane	124 – 144	21	Helical; Potential
Experimental info
	Sequence conflict	65	1	V → VV in CAH10689. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q69YG0 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: A8572BF4BC9CF44E	FASTA	159	16,991
	10 20 30 40 50 60 MAERPGPPGG AVSATAYPDT PAEFPPHLQA GAMRRRFWGV FNCLCAGAFG ALAAASAKLA 70 80 90 100 110 120 FGSEVSMGLC VLGIIVMAST NSLMWTFFSR GLSFSMSSAI ASVTVTFSNI LSSAFLGYVL 130 140 150 YGECQEVLWW GGVFLILCGL TLIHRKLPPT WKPLPHKQQ

References

[1]

"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL834253 mRNA. Translation: CAH10689.1. BC019851 mRNA. Translation: AAH19851.1.
IPI	IPI00102978.
RefSeq	NP_653239.1. NM_144638.1.
UniGene	Hs.646856.
3D structure databases
ProteinModelPortal	Q69YG0.
ModBase	Search...
PTM databases
PhosphoSite	Q69YG0.
Polymorphism databases
DMDM	145572734.
Proteomic databases
PaxDb	Q69YG0.
PRIDE	Q69YG0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302392; ENSP00000306564; ENSG00000169964.
GeneID	131616.
KEGG	hsa:131616.
UCSC	uc003cnz.3. human.
Organism-specific databases
CTD	131616.
GeneCards	GC03P044904.
H-InvDB	HIX0200526.
HGNC	HGNC:28444. TMEM42.
HPA	HPA052569.
neXtProt	NX_Q69YG0.
PharmGKB	PA134914008.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG16283.
HOGENOM	HOG000154645.
HOVERGEN	HBG098258.
OMA	CGLSLIH.
OrthoDB	EOG4868DV.
PhylomeDB	Q69YG0.
Gene expression databases
Bgee	Q69YG0.
Genevestigator	Q69YG0.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	131616.
NextBio	82954.

Entry information

Entry name

TMM42_HUMAN

Accession

Primary (citable) accession number: Q69YG0
Secondary accession number(s): Q8WUQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.