Reviewed,
UniProtKB/Swiss-Prot Q69XQ6 (KPRS2_ORYSJ)
Last modified
February 9, 2010.
Version 39.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Ribose-phosphate pyrophosphokinase 2 EC=2.7.6.1 Alternative name(s): Phosphoribosyl pyrophosphate synthetase 2 | ||||
| Gene names |
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| Organism | Oryza sativa subsp. japonica (Rice) | ||||
| Taxonomic identifier | 39947 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza |
Protein attributes
| Sequence length | 399 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. |
| Sequence similarities | Belongs to the ribose-phosphate pyrophosphokinase family. |
| Sequence caution | The sequence BAD35420.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide biosynthesis |
| Coding sequence diversity | Alternative splicing |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Gene Ontology (GO) | |
| Biological process | nucleoside metabolic process Inferred from electronic annotation. Source: InterPro ribonucleoside monophosphate biosynthetic processInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activityInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW ribose phosphate diphosphokinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 2 (identifier: Q69XQ6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: May be due to an intron retention. No experimental confirmation available. | ||||||
| Isoform 1 (identifier: Q69XQ6-2) The sequence of this isoform differs from the canonical sequence as follows: 340-399: SPPAIERLSG...RDGSVSSIFQ → RFGSWFIVTS...DQYKNDRVEQ |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 399 | 399 | Ribose-phosphate pyrophosphokinase 2 | PRO_0000141098 | |||||
Regions | |||||||||
| Region | 299 – 314 | 16 | Binding of phosphoribosylpyrophosphate Potential | ||||||
Sites | |||||||||
| Metal binding | 214 | 1 | Magnesium By similarity | ||||||
| Metal binding | 216 | 1 | Magnesium By similarity | ||||||
| Metal binding | 225 | 1 | Magnesium By similarity | ||||||
| Metal binding | 229 | 1 | Magnesium By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 340 – 399 | 60 | SPPAI…SSIFQ → RFGSWFIVTSMIHVIVLIHW LVAKEPCYGMIRQIGFMFDQ YKNDRVEQ in isoform 1. | VSP_013704 | |||||
Sequences
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References
| [1] | "Oryza sativa nipponbare chromosome 6 genomic DNA sequence." The international rice genome sequencing project (IRGSP) consortium Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare. |
| [2] | "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: cv. Nipponbare. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AP003609 Genomic DNA. Translation: BAD35420.1. Sequence problems. AP003609 Genomic DNA. Translation: BAD35421.1. AK065878 mRNA. No translation available. AK067505 mRNA. No translation available. AK068485 mRNA. No translation available. |
| RefSeq | NP_001058081.1. |
| UniGene | Os.91644 |
3D structure databases | |
| SMR | Q69XQ6. Positions 90-399. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 4341535. |
| KEGG | osa:4341535. |
Organism-specific databases | |
| Gramene | Q69XQ6. |
Family and domain databases | |
| InterPro | IPR000842. PRib-PP_synthetase_CS. IPR000836. PRibTrfase. IPR005946. PRPP_kinase. [Graphical view] |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01251. ribP_PPkin. 1 hit. |
| PROSITE | PS00114. PRPP_SYNTHETASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KPRS2_ORYSJ | ||||||||
| Accession | Primary (citable) accession number: Q69XQ6 Secondary accession number(s): Q69XQ7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Oryza sativa (rice) Index of Oryza sativa entries and their corresponding gene designations |
| SIMILARITY comments Index of protein domains and families |
