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Protein

Heme oxygenase 1, chloroplastic

Gene

HO1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the opening of the heme ring to form the open-chain tetrapyrrole biliverdin IX with the release of iron and carbon monoxide (CO). Is a key enzyme in the synthesis of the chromophore of the phytochrome family of plant photoreceptors. Essential for photoperiod response and repression of flowering through cytochromes that inhibit flowering by affecting both HD1 and EHD1 flowering pathways.2 Publications

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi96 – 961Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme oxygenase (decyclizing) activity Source: Gramene
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme oxidation Source: Gramene
  2. inflorescence development Source: Gramene
  3. photoperiodism Source: Gramene
  4. photoperiodism, flowering Source: UniProtKB
  5. photosynthesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Photosynthesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase 1, chloroplastic (EC:1.14.99.3)
Alternative name(s):
Protein PHOTOPERIODIC SENSITIVITY 5
Gene namesi
Name:HO1
Synonyms:HY1, SE5
Ordered Locus Names:Os06g0603000, LOC_Os06g40080
ORF Names:OsJ_21897, P0486H12.31
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763 Componenti: Chromosome 6

Organism-specific databases

GrameneiQ69XJ4.

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

Pathology & Biotechi

Disruption phenotypei

Pale green and very early flowering phenotype and complete deficiency in photoperiodic response. Lack of photoreversible phytochromes and responses of coleoptile elongation by light pulses.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6464ChloroplastSequence AnalysisAdd
BLAST
Chaini65 – 289225Heme oxygenase 1, chloroplasticPRO_0000412189Add
BLAST

Proteomic databases

PRIDEiQ69XJ4.

Structurei

3D structure databases

ProteinModelPortaliQ69XJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG308332.
HOGENOMiHOG000265822.
InParanoidiQ69XJ4.
KOiK00510.
OMAiAEEWTRE.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR016951. Haem_Oase_decyc_pln.
[Graphical view]
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF030219. Heme_Oase_decyc_pln. 1 hit.
SUPFAMiSSF48613. SSF48613. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q69XJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAAASLTA PNALAATSLP FLHGRKSGGG GVSVHAGAPS PSRAVAVVAR
60 70 80 90 100
RLWGSASSSR RMVVAAATAA EMAPAASGEE GKPFVEEMRA VAMRLHTKDQ
110 120 130 140 150
AKEGEKEPQA PPVARWEPSV DGYLRFLVDS KLVFETLETI VDRAAVPWYA
160 170 180 190 200
EFRNTGLERS EQLKKDLEWF KEQGHTIPEP SAPGTTYASY LEELAEKDSQ
210 220 230 240 250
AFICHFYNVY FAHTAGGRMI GKKVSENILN KKELEFYKWE GNLSQLLQNV
260 270 280
RNKLNEVASS WTREEKDHCL DETEKSFSYS GDLLRHIFT
Length:289
Mass (Da):31,918
Last modified:September 13, 2004 - v1
Checksum:iC03B0103AD2E6E91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU781632 mRNA. Translation: ACE98543.1.
AP003615 Genomic DNA. Translation: BAD35463.1.
AP008212 Genomic DNA. Translation: BAF19925.1.
CM000143 Genomic DNA. Translation: EEE65978.1.
AK068856 mRNA. Translation: BAG91127.1.
AK104955 mRNA. Translation: BAG97040.1.
RefSeqiNP_001058011.1. NM_001064546.1.
UniGeneiOs.20352.

Genome annotation databases

EnsemblPlantsiOS06T0603000-01; OS06T0603000-01; OS06G0603000.
GeneIDi4341462.
KEGGiosa:4341462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU781632 mRNA. Translation: ACE98543.1.
AP003615 Genomic DNA. Translation: BAD35463.1.
AP008212 Genomic DNA. Translation: BAF19925.1.
CM000143 Genomic DNA. Translation: EEE65978.1.
AK068856 mRNA. Translation: BAG91127.1.
AK104955 mRNA. Translation: BAG97040.1.
RefSeqiNP_001058011.1. NM_001064546.1.
UniGeneiOs.20352.

3D structure databases

ProteinModelPortaliQ69XJ4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ69XJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS06T0603000-01; OS06T0603000-01; OS06G0603000.
GeneIDi4341462.
KEGGiosa:4341462.

Organism-specific databases

GrameneiQ69XJ4.

Phylogenomic databases

eggNOGiNOG308332.
HOGENOMiHOG000265822.
InParanoidiQ69XJ4.
KOiK00510.
OMAiAEEWTRE.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR016951. Haem_Oase_decyc_pln.
[Graphical view]
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF030219. Heme_Oase_decyc_pln. 1 hit.
SUPFAMiSSF48613. SSF48613. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of heme oxygenase-1 from Oryza sativa."
    Xu S., Wu T.T., Lu H., Ling T.F., Xuan W., Sun Y.G., Cao Z., Shen W.B.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.
  6. "Phytochromes confer the photoperiodic control of flowering in rice (a short-day plant)."
    Izawa T., Oikawa T., Tokutomi S., Okuno K., Shimamoto K.
    Plant J. 22:391-399(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "Analysis of PHOTOPERIOD SENSITIVITY5 sheds light on the role of phytochromes in photoperiodic flowering in rice."
    Andres F., Galbraith D.W., Talon M., Domingo C.
    Plant Physiol. 151:681-690(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiHMOX1_ORYSJ
AccessioniPrimary (citable) accession number: Q69XJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 13, 2004
Last modified: January 7, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.