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Protein

Heme oxygenase 1, chloroplastic

Gene

HO1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the opening of the heme ring to form the open-chain tetrapyrrole biliverdin IX with the release of iron and carbon monoxide (CO). Is a key enzyme in the synthesis of the chromophore of the phytochrome family of plant photoreceptors. Essential for photoperiod response and repression of flowering through cytochromes that inhibit flowering by affecting both HD1 and EHD1 flowering pathways.2 Publications

Catalytic activityi

Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi96Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • heme oxygenase (decyclizing) activity Source: Gramene
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • heme oxidation Source: Gramene
  • inflorescence development Source: Gramene
  • photoperiodism Source: Gramene
  • photoperiodism, flowering Source: UniProtKB
  • photosynthesis Source: UniProtKB-KW

Keywordsi

Molecular functionOxidoreductase
Biological processPhotosynthesis
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase 1, chloroplastic (EC:1.14.14.18By similarity)
Alternative name(s):
Protein PHOTOPERIODIC SENSITIVITY 5
Gene namesi
Name:HO1
Synonyms:HY1, SE5
Ordered Locus Names:Os06g0603000, LOC_Os06g40080
ORF Names:OsJ_21897, P0486H12.31
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

Pathology & Biotechi

Disruption phenotypei

Pale green and very early flowering phenotype and complete deficiency in photoperiodic response. Lack of photoreversible phytochromes and responses of coleoptile elongation by light pulses.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 64ChloroplastSequence analysisAdd BLAST64
ChainiPRO_000041218965 – 289Heme oxygenase 1, chloroplasticAdd BLAST225

Proteomic databases

PaxDbiQ69XJ4
PRIDEiQ69XJ4

Expressioni

Gene expression databases

ExpressionAtlasiQ69XJ4 baseline and differential
GenevisibleiQ69XJ4 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os06g40080.1

Structurei

3D structure databases

ProteinModelPortaliQ69XJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4480 Eukaryota
COG5398 LUCA
HOGENOMiHOG000265822
InParanoidiQ69XJ4
KOiK21480
OMAiPPEFICH
OrthoDBiEOG09360KFI

Family and domain databases

CDDicd00232 HemeO, 1 hit
Gene3Di1.20.910.101 hit
InterProiView protein in InterPro
IPR016053 Haem_Oase-like
IPR016084 Haem_Oase-like_multi-hlx
IPR016951 Haem_Oase_decyc_pln
PfamiView protein in Pfam
PF01126 Heme_oxygenase, 1 hit
PIRSFiPIRSF030219 Heme_Oase_decyc_pln, 1 hit
SUPFAMiSSF48613 SSF48613, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q69XJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAAASLTA PNALAATSLP FLHGRKSGGG GVSVHAGAPS PSRAVAVVAR
60 70 80 90 100
RLWGSASSSR RMVVAAATAA EMAPAASGEE GKPFVEEMRA VAMRLHTKDQ
110 120 130 140 150
AKEGEKEPQA PPVARWEPSV DGYLRFLVDS KLVFETLETI VDRAAVPWYA
160 170 180 190 200
EFRNTGLERS EQLKKDLEWF KEQGHTIPEP SAPGTTYASY LEELAEKDSQ
210 220 230 240 250
AFICHFYNVY FAHTAGGRMI GKKVSENILN KKELEFYKWE GNLSQLLQNV
260 270 280
RNKLNEVASS WTREEKDHCL DETEKSFSYS GDLLRHIFT
Length:289
Mass (Da):31,918
Last modified:September 13, 2004 - v1
Checksum:iC03B0103AD2E6E91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU781632 mRNA Translation: ACE98543.1
AP003615 Genomic DNA Translation: BAD35463.1
AP008212 Genomic DNA Translation: BAF19925.1
AP014962 Genomic DNA Translation: BAS98507.1
CM000143 Genomic DNA Translation: EEE65978.1
AK068856 mRNA Translation: BAG91127.1
AK104955 mRNA Translation: BAG97040.1
RefSeqiXP_015643881.1, XM_015788395.1
UniGeneiOs.20352

Genome annotation databases

EnsemblPlantsiOs06t0603000-01; Os06t0603000-01; Os06g0603000
GeneIDi4341462
GrameneiOs06t0603000-01; Os06t0603000-01; Os06g0603000
KEGGiosa:4341462

Similar proteinsi

Entry informationi

Entry nameiHMOX1_ORYSJ
AccessioniPrimary (citable) accession number: Q69XJ4
Secondary accession number(s): A0A0P0WYR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: September 13, 2004
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome