Probable cellulose synthase A catalytic subunit 3 [UDP-forming]

Names and origin

Protein names

Recommended name:
    Probable cellulose synthase A catalytic subunit 3 [UDP-forming]
    EC=2.4.1.12
Alternative name(s):
    OsCesA3

Gene names

Name:	CESA3
Ordered Locus Names:	Os07g0424400, LOC_Os07g24190
ORF Names:	P0409D09.11

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

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Protein attributes

Sequence length	1093 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Probable catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation By similarity.
Catalytic activity	UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Glycan metabolism; plant cellulose biosynthesis.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily. Contains 1 RING-type zinc finger.
Sequence caution	The sequence AK073561 differs from that shown. Reason: Frameshift at position 499.

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Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation Cellulose biosynthesis
Cellular component	Cell membrane Membrane
Domain	Coiled coil Transmembrane Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW cellulose biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cellulose synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1093

1093

Probable cellulose synthase A catalytic subunit 3 [UDP-forming]

PRO_0000319361

Regions

Topological domain

1 – 280

280

Cytoplasmic Potential

Transmembrane

281 – 301

21

Potential

Topological domain

302 – 303

2

Extracellular Potential

Transmembrane

304 – 324

21

Potential

Topological domain

325 – 869

545

Cytoplasmic Potential

Transmembrane

870 – 890

21

Potential

Topological domain

891 – 902

12

Extracellular Potential

Transmembrane

903 – 923

21

Potential

Topological domain

924 – 939

16

Cytoplasmic Potential

Transmembrane

940 – 960

21

Potential

Topological domain

961 – 988

28

Extracellular Potential

Transmembrane

989 – 1009

21

Potential

Topological domain

1010 – 1020

11

Cytoplasmic Potential

Transmembrane

1021 – 1041

21

Potential

Topological domain

1042 – 1050

9

Extracellular Potential

Transmembrane

1051 – 1071

21

Potential

Topological domain

1072 – 1093

22

Cytoplasmic Potential

Zinc finger

39 – 85

47

RING-type; degenerate

Coiled coil

453 – 480

28

Potential

Sites

Active site

399

1

Potential

Active site

793

1

Potential

Metal binding

39

1

Zinc 1 By similarity

Metal binding

42

1

Zinc 1 By similarity

Metal binding

58

1

Zinc 2 By similarity

Metal binding

61

1

Zinc 2 By similarity

Metal binding

66

1

Zinc 1 By similarity

Metal binding

69

1

Zinc 1 By similarity

Metal binding

81

1

Zinc 2 By similarity

Metal binding

84

1

Zinc 2 By similarity

Binding site

565

1

Substrate Potential

Binding site

567

1

Substrate Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

Q69V23-1 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 33075A79C634AD31
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FASTA

1,093

123,503

        10         20         30         40         50         60 
MEASAGLVAG SHNRNELVVI RRDGDPGPKP LRQQNGQVCQ ICGDDVGLNP DGEPFVACNE 

        70         80         90        100        110        120 
CAFPVCRDCY EYERREGTQN CPQCKTRFKR LRGCARVPGD EEEDGVDDLE NEFNWRDRND 

       130        140        150        160        170        180 
SQYVAESMLH AHMSYGRGGV DVNGVPQPFQ PNPNVPLLTD GQMVDDIPPE QHALVPSFMG 

       190        200        210        220        230        240 
GGGKRIHPLP YADPNLPVQP RSMDPSKDLA AYGYGSVAWK ERMESWKQKQ ERLHQMRNDG 

       250        260        270        280        290        300 
GGKDWDGDGD DGDLPLMDEA RQPLSRKVPI PSSQINPYRM VIIIRLVVLG FFFHYRVMHP 

       310        320        330        340        350        360 
VPDAFALWLI SVICEIWFAM SWILDQFPKW FPIERETYLD RLTLRFDKEG QTSQLAPIDF 

       370        380        390        400        410        420 
FVSTVDPLKE PPLVTANTVL SILAVDYPVD KVSCYVSDDG AAMLTFEALS ETSEFAKKWV 

       430        440        450        460        470        480 
PFCKKYSIEP RAPEWYFQQK IDYLKDKVAP YFVRERRAMK REYEEFKVRI NALVAKAQKV 

       490        500        510        520        530        540 
PEEGWTMQDG TPWPGNNVRD HPGMIQVFLG QSGGHDIEGN ELPRLVYVSR EKRPGYNHHK 

       550        560        570        580        590        600 
KAGAMNALVR VSAVLTNAPY MLNLDCDHYI NNSKAIKEAM CFMMDPLVGK KVCYVQFPQR 

       610        620        630        640        650        660 
FDGIDRHDRY ANRNVVFFDI NMKGLDGIQG PIYVGTGCVF RRQALYGYDA PKTKKPPSRT 

       670        680        690        700        710        720 
CNCWPKWCIC CCCFGDRKSK KKTTKPKTEK KKRSFFKRAE NQSPAYALGE IEEGAPGAEN 

       730        740        750        760        770        780 
EKAGIVNQQK LEKKFGQSSV FVASTLLENG GTLKSASPAS LLKEAIHVIS CGYEDKTDWG 

       790        800        810        820        830        840 
KEIGWIYGSV TEDILTGFKM HCHGWRSIYC IPKLPAFKGS APLNLSDRLH QVLRWALGSV 

       850        860        870        880        890        900 
EIFFSNHCPL WYGYGGGLKC LERFSYINSI VYPFTSIPLL AYCTLPAICL LTGKFITPEL 

       910        920        930        940        950        960 
TNVASLWFMS LFICIFATGI LEMRWSGVGI DDWWRNEQFW VIGGVSSHLF ALFQGLLKVI 

       970        980        990       1000       1010       1020 
AGIDTSFTVT SKGGDDEEFS ELYTFKWTTL LIPPTTLLLL NFIGVVAGVS NAINNGYESW 

      1030       1040       1050       1060       1070       1080 
GPLFGKLFFA FWVIVHLYPF LKGLVGRQNR TPTIVIVWSI LLASIFSLLW VRIDPFLAKN 

      1090 
DGPLLEECGL DCN

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed: 16100779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana." The rice annotation project (RAP) Genome Res. 17:175-183(2007) [PubMed: 17210932] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[3]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

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Cross-references

Sequence databases
	AP004298 Genomic DNA. Translation: BAD30574.1. AP008213 Genomic DNA. Translation: BAF21401.1. AK073561 mRNA. No translation available.
RefSeq	NP_001059487.1.
UniGene	Os.10178
3D structure databases
SMR	Q69V23. Positions 24-97.
ModBase	Search...
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
Genome annotation databases
GeneID	4343049.
KEGG	osa:4343049.
Organism-specific databases
Gramene	Q69V23.
Family and domain databases
InterPro	IPR005150. Cellulose_synth. IPR001841. Znf_RING. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF03552. Cellulose_synt. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

CESA3_ORYSJ

Accession

Primary (citable) accession number: Q69V23

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	September 13, 2004
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)

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Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Family and domain databases

Entry information

Relevant documents