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Q69ST6

- PID13_ORYSJ

UniProt

Q69ST6 - PID13_ORYSJ

Protein

Protein disulfide isomerase-like 1-3

Gene

PDIL1-3

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis By similarity.By similarity

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei107 – 1071NucleophileBy similarity
    Sitei108 – 1081Contributes to redox potential valueBy similarity
    Sitei109 – 1091Contributes to redox potential valueBy similarity
    Active sitei110 – 1101NucleophileBy similarity
    Sitei175 – 1751Lowers pKa of C-terminal Cys of first active siteBy similarity
    Active sitei453 – 4531NucleophileBy similarity
    Sitei454 – 4541Contributes to redox potential valueBy similarity
    Sitei455 – 4551Contributes to redox potential valueBy similarity
    Active sitei456 – 4561NucleophileBy similarity
    Sitei515 – 5151Lowers pKa of C-terminal Cys of second active siteBy similarity

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein disulfide isomerase-like 1-3 (EC:5.3.4.1)
    Short name:
    OsPDIL1-3
    Gene namesi
    Name:PDIL1-3
    Ordered Locus Names:Os02g0554900, LOC_Os02g34940
    ORF Names:P0470G10.25
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 2

    Organism-specific databases

    GrameneiQ69ST6.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 545Protein disulfide isomerase-like 1-3PRO_0000400030
    Signal peptidei1 – ?

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi107 ↔ 110Redox-activePROSITE-ProRule annotation
    Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi453 ↔ 456Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi39947.LOC_Os02g34940.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ69ST6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 189135Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini403 – 545143Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi542 – 5454Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 2 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000162459.
    KOiK09580.
    OMAiQYSANNI.

    Family and domain databases

    Gene3Di3.40.30.10. 3 hits.
    InterProiIPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 4 hits.
    TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q69ST6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWPRAPATPP PPPWPSKPSA ASRSALRRLD LDDGRRQGTE GEENHAPLLC    50
    SPAMASSTAF AAAFALLLLA SSAAAEGEAV LTLDAGNFTE VVGAHDFIVV 100
    EFYAPWCGHC NQLAPEYEAA AAALRSHDPP VVLAKVDASA DLNRGLAGEH 150
    GVQGYPTIRI LRDRGARSHN YAGPRDAAGI VAYLKRQAGP ASVEIAASAS 200
    PPAADSIAND GVVVVGVFPE LSGSEFESFM AVAEKMRADY DFRHTTDAGV 250
    LPRGDRTVRG PLVRLFKPFD ELFVDSQDFD RDALEKFIES SGFPTVVTFD 300
    TSPANQKYLL KYFDNAGTKA MLFLSFSDDR AEEFRTQFHE AANQYSANNI 350
    SFLIGDVTAS QGAFQYFGLK ESEVPLVFIL ASKSKYIKPT VEPDQILPYL 400
    KEFTEGTLAP HVKSEPIPEV NDQPVKTVVA DNLREVVFNS GKNVLLEFYA 450
    PWCGHCQKLA PILEEVAVSL KDDEDVVIAK MDGTANDVPS DFAVEGYPSM 500
    YFYSSGGNLL PYDGRTAEEI IDFITKNKGS RPGEATTTES VKDEL 545
    Length:545
    Mass (Da):59,075
    Last modified:October 25, 2004 - v1
    Checksum:i362611FD2AD09ED1
    GO

    Sequence cautioni

    The sequence BAG93318.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004876 Genomic DNA. Translation: BAD33310.1.
    AP008208 Genomic DNA. Translation: BAF09033.1.
    AK073161 mRNA. Translation: BAG93318.1. Different initiation.
    RefSeqiNP_001047119.1. NM_001053654.1.
    UniGeneiOs.53357.

    Genome annotation databases

    EnsemblPlantsiOS02T0554900-01; OS02T0554900-01; OS02G0554900.
    GeneIDi4329652.
    KEGGiosa:4329652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004876 Genomic DNA. Translation: BAD33310.1 .
    AP008208 Genomic DNA. Translation: BAF09033.1 .
    AK073161 mRNA. Translation: BAG93318.1 . Different initiation.
    RefSeqi NP_001047119.1. NM_001053654.1.
    UniGenei Os.53357.

    3D structure databases

    ProteinModelPortali Q69ST6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 39947.LOC_Os02g34940.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS02T0554900-01 ; OS02T0554900-01 ; OS02G0554900 .
    GeneIDi 4329652.
    KEGGi osa:4329652.

    Organism-specific databases

    Gramenei Q69ST6.

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000162459.
    KOi K09580.
    OMAi QYSANNI.

    Family and domain databases

    Gene3Di 3.40.30.10. 3 hits.
    InterProi IPR005792. Prot_disulphide_isomerase.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 4 hits.
    TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 2 hits.
    PS51352. THIOREDOXIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    3. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-545.
      Strain: cv. Nipponbare.
    4. "Phylogenetic analyses identify 10 classes of the protein disulfide isomerase family in plants, including single-domain protein disulfide isomerase-related proteins."
      Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.
      Plant Physiol. 137:762-778(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    5. "The protein disulfide isomerase gene family in bread wheat (T. aestivum L.)."
      d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E., Ciaffi M.
      BMC Plant Biol. 10:101-101(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPID13_ORYSJ
    AccessioniPrimary (citable) accession number: Q69ST6
    Secondary accession number(s): B7ELS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2010
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3