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Protein

Protein disulfide isomerase-like 1-3

Gene

PDIL1-3

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds. May play a role in storage protein biogenesis (By similarity).By similarity

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107NucleophileBy similarity1
Sitei108Contributes to redox potential valueBy similarity1
Sitei109Contributes to redox potential valueBy similarity1
Active sitei110NucleophileBy similarity1
Sitei175Lowers pKa of C-terminal Cys of first active siteBy similarity1
Active sitei453NucleophileBy similarity1
Sitei454Contributes to redox potential valueBy similarity1
Sitei455Contributes to redox potential valueBy similarity1
Active sitei456NucleophileBy similarity1
Sitei515Lowers pKa of C-terminal Cys of second active siteBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide isomerase-like 1-3 (EC:5.3.4.1)
Short name:
OsPDIL1-3
Gene namesi
Name:PDIL1-3
Ordered Locus Names:Os02g0554900, LOC_Os02g34940
ORF Names:P0470G10.25
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000400030? – 545Protein disulfide isomerase-like 1-3
Signal peptidei1 – ?

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi107 ↔ 110Redox-activePROSITE-ProRule annotation
Glycosylationi349N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi453 ↔ 456Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ69ST6.

Expressioni

Gene expression databases

ExpressionAtlasiQ69ST6. baseline and differential.
GenevisibleiQ69ST6. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os02g34940.1.

Structurei

3D structure databases

ProteinModelPortaliQ69ST6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 189Thioredoxin 1PROSITE-ProRule annotationAdd BLAST135
Domaini403 – 545Thioredoxin 2PROSITE-ProRule annotationAdd BLAST143

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi542 – 545Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 2 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000162459.
InParanoidiQ69ST6.
KOiK09580.
OMAiFHEAANQ.
OrthoDBiEOG09360AJD.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q69ST6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPRAPATPP PPPWPSKPSA ASRSALRRLD LDDGRRQGTE GEENHAPLLC
60 70 80 90 100
SPAMASSTAF AAAFALLLLA SSAAAEGEAV LTLDAGNFTE VVGAHDFIVV
110 120 130 140 150
EFYAPWCGHC NQLAPEYEAA AAALRSHDPP VVLAKVDASA DLNRGLAGEH
160 170 180 190 200
GVQGYPTIRI LRDRGARSHN YAGPRDAAGI VAYLKRQAGP ASVEIAASAS
210 220 230 240 250
PPAADSIAND GVVVVGVFPE LSGSEFESFM AVAEKMRADY DFRHTTDAGV
260 270 280 290 300
LPRGDRTVRG PLVRLFKPFD ELFVDSQDFD RDALEKFIES SGFPTVVTFD
310 320 330 340 350
TSPANQKYLL KYFDNAGTKA MLFLSFSDDR AEEFRTQFHE AANQYSANNI
360 370 380 390 400
SFLIGDVTAS QGAFQYFGLK ESEVPLVFIL ASKSKYIKPT VEPDQILPYL
410 420 430 440 450
KEFTEGTLAP HVKSEPIPEV NDQPVKTVVA DNLREVVFNS GKNVLLEFYA
460 470 480 490 500
PWCGHCQKLA PILEEVAVSL KDDEDVVIAK MDGTANDVPS DFAVEGYPSM
510 520 530 540
YFYSSGGNLL PYDGRTAEEI IDFITKNKGS RPGEATTTES VKDEL
Length:545
Mass (Da):59,075
Last modified:October 25, 2004 - v1
Checksum:i362611FD2AD09ED1
GO

Sequence cautioni

The sequence BAG93318 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004876 Genomic DNA. Translation: BAD33310.1.
AP008208 Genomic DNA. Translation: BAF09033.1.
AP014958 Genomic DNA. Translation: BAS79202.1.
AK073161 mRNA. Translation: BAG93318.1. Different initiation.
RefSeqiXP_015626051.1. XM_015770565.1.
UniGeneiOs.53357.

Genome annotation databases

EnsemblPlantsiOS02T0554900-01; OS02T0554900-01; OS02G0554900.
GeneIDi4329652.
GrameneiOS02T0554900-01; OS02T0554900-01; OS02G0554900.
KEGGiosa:4329652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004876 Genomic DNA. Translation: BAD33310.1.
AP008208 Genomic DNA. Translation: BAF09033.1.
AP014958 Genomic DNA. Translation: BAS79202.1.
AK073161 mRNA. Translation: BAG93318.1. Different initiation.
RefSeqiXP_015626051.1. XM_015770565.1.
UniGeneiOs.53357.

3D structure databases

ProteinModelPortaliQ69ST6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os02g34940.1.

Proteomic databases

PaxDbiQ69ST6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS02T0554900-01; OS02T0554900-01; OS02G0554900.
GeneIDi4329652.
GrameneiOS02T0554900-01; OS02T0554900-01; OS02G0554900.
KEGGiosa:4329652.

Phylogenomic databases

eggNOGiKOG0190. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000162459.
InParanoidiQ69ST6.
KOiK09580.
OMAiFHEAANQ.
OrthoDBiEOG09360AJD.

Gene expression databases

ExpressionAtlasiQ69ST6. baseline and differential.
GenevisibleiQ69ST6. OS.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPID13_ORYSJ
AccessioniPrimary (citable) accession number: Q69ST6
Secondary accession number(s): A0A0P0VKD4, B7ELS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: October 25, 2004
Last modified: October 5, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.