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Protein

C-type lectin domain family 4 member D

Gene

Clec4d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity, Innate immunity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member D
Alternative name(s):
C-type lectin superfamily member 8
Gene namesi
Name:Clec4d
Synonyms:Clecsf8, Mcl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303339. Clec4d.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 47Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini48 – 218ExtracellularSequence analysisAdd BLAST171

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466181 – 218C-type lectin domain family 4 member DAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 93PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 205PROSITE-ProRule annotation
Disulfide bondi180 ↔ 197PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ69FH1.
PRIDEiQ69FH1.

Expressioni

Tissue specificityi

Expressed in myeloid cells (dendritic cells, macrophages and neutrophils) and B-cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013536.

Structurei

3D structure databases

ProteinModelPortaliQ69FH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 206C-type lectinPROSITE-ProRule annotationAdd BLAST118

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000059556.
HOVERGENiHBG050992.
InParanoidiQ69FH1.
KOiK10058.
PhylomeDBiQ69FH1.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q69FH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLEESQMKS KGALHPRRIP WVCAVVSISF LSACFISTCV VTHYFLLWKR
60 70 80 90 100
GSALKFSDYH TRLTCILEEP QPGATGGTWT CCPVSWRAFQ SNCYFALNDN
110 120 130 140 150
QTWHESERNC SGMSSHLVTI NTEAEQDFVT QLLDEQFSYF LGLSYEKVEG
160 170 180 190 200
QWQWVDKTPF NPNVVFWKVG EPKDSMEEDC VVLVYDQDKW VWNDFPCHFE
210
MGRICKLPGA TFDWNPSK
Length:218
Mass (Da):25,312
Last modified:September 13, 2004 - v1
Checksum:i357E411CB748B9B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339882 mRNA. Translation: AAR02097.1.
AY494065 mRNA. Translation: AAS76661.1.
RefSeqiNP_001003707.1. NM_001003707.1.
UniGeneiRn.144379.

Genome annotation databases

GeneIDi362432.
KEGGirno:362432.
UCSCiRGD:1303339. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339882 mRNA. Translation: AAR02097.1.
AY494065 mRNA. Translation: AAS76661.1.
RefSeqiNP_001003707.1. NM_001003707.1.
UniGeneiRn.144379.

3D structure databases

ProteinModelPortaliQ69FH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013536.

Proteomic databases

PaxDbiQ69FH1.
PRIDEiQ69FH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362432.
KEGGirno:362432.
UCSCiRGD:1303339. rat.

Organism-specific databases

CTDi338339.
RGDi1303339. Clec4d.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOGENOMiHOG000059556.
HOVERGENiHBG050992.
InParanoidiQ69FH1.
KOiK10058.
PhylomeDBiQ69FH1.

Miscellaneous databases

PROiQ69FH1.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC4D_RAT
AccessioniPrimary (citable) accession number: Q69FH1
Secondary accession number(s): Q2TUL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.