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Protein

C-type lectin domain family 4 member D

Gene

Clec4d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity, Innate immunity
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member D
Alternative name(s):
C-type lectin superfamily member 8
Gene namesi
Name:Clec4d
Synonyms:Clecsf8, Mcl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303339 Clec4d

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 47Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini48 – 218ExtracellularSequence analysisAdd BLAST171

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466181 – 218C-type lectin domain family 4 member DAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi82 ↔ 93PROSITE-ProRule annotation
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 205PROSITE-ProRule annotation
Disulfide bondi180 ↔ 197PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ69FH1
PRIDEiQ69FH1

Expressioni

Tissue specificityi

Expressed in myeloid cells (dendritic cells, macrophages and neutrophils) and B-cells.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ69FH1
SMRiQ69FH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 206C-type lectinPROSITE-ProRule annotationAdd BLAST118

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
HOGENOMiHOG000059556
HOVERGENiHBG050992
InParanoidiQ69FH1
KOiK10058
PhylomeDBiQ69FH1

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q69FH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLEESQMKS KGALHPRRIP WVCAVVSISF LSACFISTCV VTHYFLLWKR
60 70 80 90 100
GSALKFSDYH TRLTCILEEP QPGATGGTWT CCPVSWRAFQ SNCYFALNDN
110 120 130 140 150
QTWHESERNC SGMSSHLVTI NTEAEQDFVT QLLDEQFSYF LGLSYEKVEG
160 170 180 190 200
QWQWVDKTPF NPNVVFWKVG EPKDSMEEDC VVLVYDQDKW VWNDFPCHFE
210
MGRICKLPGA TFDWNPSK
Length:218
Mass (Da):25,312
Last modified:September 13, 2004 - v1
Checksum:i357E411CB748B9B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY339882 mRNA Translation: AAR02097.1
AY494065 mRNA Translation: AAS76661.1
RefSeqiNP_001003707.1, NM_001003707.1
UniGeneiRn.144379

Genome annotation databases

GeneIDi362432
KEGGirno:362432
UCSCiRGD:1303339 rat

Similar proteinsi

Entry informationi

Entry nameiCLC4D_RAT
AccessioniPrimary (citable) accession number: Q69FH1
Secondary accession number(s): Q2TUL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: September 13, 2004
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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