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Protein
Submitted name:

Interleukin-1 receptor associated kinase-4

Gene

IRAK4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei213 – 2131ATPUniRule annotation
Active sitei311 – 3111Proton acceptorUniRule annotation
Binding sitei313 – 3131ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi313 – 3153ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, ReceptorImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-1 receptor associated kinase-4Imported
Submitted name:
Interleukin-1 receptor-associated kinase 4Imported
Submitted name:
Interleukin-1 receptor-associated kinase 4 isoform 1Imported
Submitted name:
Interleukin-1 receptor-associated kinase 4 variantImported
Gene namesi
Name:IRAK4Imported
ORF Names:hCG_39494Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914577.

Expressioni

Gene expression databases

BgeeiENSG00000198001.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MYD88Q998365EBI-10249217,EBI-447677

Protein-protein interaction databases

STRINGi9606.ENSP00000390651.

Structurei

3D structure databases

SMRiQ69FE3. Positions 4-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 454269Protein kinaseInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG066836.
KOiK04733.
OMAiLAKCQHE.
OrthoDBiEOG091G0YKT.
PhylomeDBiQ69FE3.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR017428. IL-1_rcpt-assoc_kin4.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF038189. IRAK4. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q69FE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPITPSTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ
60 70 80 90 100
FHIRRFEALL QTGKSPTSEL LFDWGTTNCT VGDLVDLLIQ NEFFAPASLL
110 120 130 140 150
LPDAVPKTAN TLPSKEAITV QQKQMPFCDK DRTLMTPVQN LEQSYMPPDS
160 170 180 190 200
SSPENKSLEV SDTRFHSFSF YELKNVTNNF DERPISVGGN KMGEGGFGVV
210 220 230 240 250
YKGYVNNTTV AVKKLAAMVD ITTEELKQQF DQEIKVMAKC QHENLVELLG
260 270 280 290 300
FSSDGDDLCL VYVYMPNGSL LDRLSCLDGT PPLSWHMRCK IAQGAANGIN
310 320 330 340 350
FLHENHHIHR DIKSANILLD EAFTAKISDF GLARASEKFA QTVMTSRIVG
360 370 380 390 400
TTAYMAPEAL RGEITPKSDI YSFGVVLLEI ITGLPAVDEH REPQLLLDIK
410 420 430 440 450
EEIEDEEKTI EDYIDKKMND ADSTSVEAMY SVASQCLHEK KNKRPDIKKV
460
QQLLQEMTAS
Length:460
Mass (Da):51,530
Last modified:May 10, 2005 - v1
Checksum:i6C8156ADF25FF81E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei460 – 4601Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY340962 mRNA. Translation: AAR02358.1.
AY340963 mRNA. Translation: AAR02359.1.
AY730682 mRNA. Translation: AAX22228.1.
KU178631 mRNA. Translation: ALQ34089.1.
CH471111 Genomic DNA. Translation: EAW57867.1.
RefSeqiNP_001107654.1. NM_001114182.2.
NP_057207.2. NM_016123.3.
XP_005269000.1. XM_005268943.3.
XP_005269001.1. XM_005268944.4.
XP_005269002.1. XM_005268945.4.
XP_006719501.1. XM_006719438.3.
XP_011536733.1. XM_011538431.2.
XP_011536734.1. XM_011538432.1.
XP_011536735.1. XM_011538433.2.
UniGeneiHs.138499.

Genome annotation databases

GeneIDi51135.
KEGGihsa:51135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY340962 mRNA. Translation: AAR02358.1.
AY340963 mRNA. Translation: AAR02359.1.
AY730682 mRNA. Translation: AAX22228.1.
KU178631 mRNA. Translation: ALQ34089.1.
CH471111 Genomic DNA. Translation: EAW57867.1.
RefSeqiNP_001107654.1. NM_001114182.2.
NP_057207.2. NM_016123.3.
XP_005269000.1. XM_005268943.3.
XP_005269001.1. XM_005268944.4.
XP_005269002.1. XM_005268945.4.
XP_006719501.1. XM_006719438.3.
XP_011536733.1. XM_011538431.2.
XP_011536734.1. XM_011538432.1.
XP_011536735.1. XM_011538433.2.
UniGeneiHs.138499.

3D structure databases

SMRiQ69FE3. Positions 4-458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000390651.

Protocols and materials databases

DNASUi51135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi51135.
KEGGihsa:51135.

Organism-specific databases

CTDi51135.
PharmGKBiPA134914577.

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG066836.
KOiK04733.
OMAiLAKCQHE.
OrthoDBiEOG091G0YKT.
PhylomeDBiQ69FE3.

Miscellaneous databases

ChiTaRSiIRAK4. human.
GenomeRNAii51135.

Gene expression databases

BgeeiENSG00000198001.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR017428. IL-1_rcpt-assoc_kin4.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF038189. IRAK4. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ69FE3_HUMAN
AccessioniPrimary (citable) accession number: Q69FE3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.