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Protein
Submitted name:

Interleukin-1 receptor-associated kinase 4

Gene

IRAK4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei213ATPUniRule annotation1
Active sitei311Proton acceptorUniRule annotation1
Binding sitei313ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi313 – 315ATPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, ReceptorImported, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-1 receptor-associated kinase 4Imported
Submitted name:
Interleukin-1 receptor-associated kinase 4 isoform 1Imported
Submitted name:
Interleukin-1 receptor-associated kinase 4 variantImported
Gene namesi
Name:IRAK4Imported
ORF Names:hCG_39494Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000198001.13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914577

Expressioni

Gene expression databases

BgeeiENSG00000198001

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MYD88Q998365EBI-10249217,EBI-447677

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 454Protein kinaseInterPro annotationAdd BLAST269

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili396 – 416Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
HOVERGENiHBG066836
KOiK04733
OMAiAQTVMTS
OrthoDBiEOG091G0YKT

Family and domain databases

CDDicd08793 Death_IRAK4, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR017428 IRAK4
IPR037970 IRAK4_Death
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF038189 IRAK4, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q69FE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPITPSTY VRCLNVGLIR KLSDFIDPQE GWKKLAVAIK KPSGDDRYNQ
60 70 80 90 100
FHIRRFEALL QTGKSPTSEL LFDWGTTNCT VGDLVDLLIQ NEFFAPASLL
110 120 130 140 150
LPDAVPKTAN TLPSKEAITV QQKQMPFCDK DRTLMTPVQN LEQSYMPPDS
160 170 180 190 200
SSPENKSLEV SDTRFHSFSF YELKNVTNNF DERPISVGGN KMGEGGFGVV
210 220 230 240 250
YKGYVNNTTV AVKKLAAMVD ITTEELKQQF DQEIKVMAKC QHENLVELLG
260 270 280 290 300
FSSDGDDLCL VYVYMPNGSL LDRLSCLDGT PPLSWHMRCK IAQGAANGIN
310 320 330 340 350
FLHENHHIHR DIKSANILLD EAFTAKISDF GLARASEKFA QTVMTSRIVG
360 370 380 390 400
TTAYMAPEAL RGEITPKSDI YSFGVVLLEI ITGLPAVDEH REPQLLLDIK
410 420 430 440 450
EEIEDEEKTI EDYIDKKMND ADSTSVEAMY SVASQCLHEK KNKRPDIKKV
460
QQLLQEMTAS
Length:460
Mass (Da):51,530
Last modified:May 10, 2005 - v1
Checksum:i6C8156ADF25FF81E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei460Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY340962 mRNA Translation: AAR02358.1
AY340963 mRNA Translation: AAR02359.1
AY730682 mRNA Translation: AAX22228.1
KU178631 mRNA Translation: ALQ34089.1
CH471111 Genomic DNA Translation: EAW57867.1
RefSeqiNP_001107654.1, NM_001114182.2
NP_057207.2, NM_016123.3
XP_005269000.1, XM_005268943.3
XP_005269001.1, XM_005268944.4
XP_005269002.1, XM_005268945.4
XP_006719501.1, XM_006719438.3
XP_011536733.1, XM_011538431.2
XP_011536734.1, XM_011538432.1
XP_011536735.1, XM_011538433.2
XP_016874879.1, XM_017019390.1
UniGeneiHs.138499

Genome annotation databases

GeneIDi51135
KEGGihsa:51135

Similar proteinsi

Entry informationi

Entry nameiQ69FE3_HUMAN
AccessioniPrimary (citable) accession number: Q69FE3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.