Reviewed, UniProtKB/Swiss-Prot Q69FB6 (CP19A_LAGAC)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 19A1
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthetase
    P-450AROM

Gene names

Name:	CYP19A1
Synonyms:	CYP19

Organism

Lagenorhynchus acutus (Atlantic white-sided dolphin)

Taxonomic identifier

90246 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Cetacea › Odontoceti › Delphinidae › Lagenorhynchus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Cytochrome P450 19A1		PRO_0000051956
Sites
	Metal binding	437	1	Iron (heme axial ligand) By similarity
Amino acid modifications
	Modified residue	162	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q69FB6-1 [UniParc]. Last modified September 13, 2004. Version 1. Checksum: A272FD593B494551	FASTA	503	57,854
	10 20 30 40 50 60 MVLEVLNPRH YNITSMVTEV APVASIAILL LTGFLLLVWN YEDTSSIPGP GYFLGIGPLI 70 80 90 100 110 120 SHCRFLWMGI GSTCNYYNKT YGEFVRVWIC GEETLIISKS SSMFHIMKHS HYTSRFGSKL 130 140 150 160 170 180 GLQCIGMHEK GIIFNNNPAL WKAVRPFFTK ALSGPGLVRM VTVCADSITK HLDRLEEVRN 190 200 210 220 230 240 ELGYVDVLTL MRRIMLDTSN KLFLGIPLDE RAIVVKIQGY FDAWQALLLK PDIFFKISWL 250 260 270 280 290 300 CRKYEKSVKD LKDAMEILIE EKRQRISTAE KLEDCMDFAT ELIFAEKRGD LTKENVDQCI 310 320 330 340 350 360 LEMLIAAPDT MSVSVFFMLF LIAKHPQVEE AIMKEIQTVV GERDIRIDDM QKLKVVENFI 370 380 390 400 410 420 YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAR 430 440 450 460 470 480 NVPYRYFQPF GFGPRACAGK YIAMVMMKVT LVTLLRSFHV QTLQGRCIEK MQKKNDLSLH 490 500 PDETSDLLGM IFIPRNSDKC LDH

References

[1]	"Characterization of a cetacean aromatase (CYP19) and the phylogeny and functional conservation of vertebrate aromatase." Wilson J.Y., McArthur A.G., Stegeman J.J. Gen. Comp. Endocrinol. 140:74-83(2005) [PubMed: 15596073] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY341076 mRNA. Translation: AAR05986.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q69FB6.
Enzyme and pathway databases
BRENDA	1.14.14.1. 297275.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP19A_LAGAC

Accession

Primary (citable) accession number: Q69FB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	September 13, 2004
Last modified:	October 13, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)