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Protein

Aromatase

Gene

CYP19A1

Organism
Lagenorhynchus acutus (Atlantic white-sided dolphin)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091SubstrateBy similarity
Binding sitei374 – 3741Substrate; via amide nitrogenBy similarity
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiLagenorhynchus acutus (Atlantic white-sided dolphin)
Taxonomic identifieri90246 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiDelphinidaeLagenorhynchus

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503AromatasePRO_0000051956Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ69FB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q69FB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLEVLNPRH YNITSMVTEV APVASIAILL LTGFLLLVWN YEDTSSIPGP
60 70 80 90 100
GYFLGIGPLI SHCRFLWMGI GSTCNYYNKT YGEFVRVWIC GEETLIISKS
110 120 130 140 150
SSMFHIMKHS HYTSRFGSKL GLQCIGMHEK GIIFNNNPAL WKAVRPFFTK
160 170 180 190 200
ALSGPGLVRM VTVCADSITK HLDRLEEVRN ELGYVDVLTL MRRIMLDTSN
210 220 230 240 250
KLFLGIPLDE RAIVVKIQGY FDAWQALLLK PDIFFKISWL CRKYEKSVKD
260 270 280 290 300
LKDAMEILIE EKRQRISTAE KLEDCMDFAT ELIFAEKRGD LTKENVDQCI
310 320 330 340 350
LEMLIAAPDT MSVSVFFMLF LIAKHPQVEE AIMKEIQTVV GERDIRIDDM
360 370 380 390 400
QKLKVVENFI YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEFFPKP NEFTLENFAR NVPYRYFQPF GFGPRACAGK YIAMVMMKVT
460 470 480 490 500
LVTLLRSFHV QTLQGRCIEK MQKKNDLSLH PDETSDLLGM IFIPRNSDKC

LDH
Length:503
Mass (Da):57,854
Last modified:September 13, 2004 - v1
Checksum:iA272FD593B494551
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341076 mRNA. Translation: AAR05986.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341076 mRNA. Translation: AAR05986.1.

3D structure databases

ProteinModelPortaliQ69FB6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of a cetacean aromatase (CYP19) and the phylogeny and functional conservation of vertebrate aromatase."
    Wilson J.Y., McArthur A.G., Stegeman J.J.
    Gen. Comp. Endocrinol. 140:74-83(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCP19A_LAGAC
AccessioniPrimary (citable) accession number: Q69FB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: September 13, 2004
Last modified: January 7, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.