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Q69FB6 (CP19A_LAGAC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene names
Name:CYP19A1
Synonyms:CYP19
OrganismLagenorhynchus acutus (Atlantic white-sided dolphin)
Taxonomic identifier90246 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiDelphinidaeLagenorhynchus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

heme binding

Inferred from sequence or structural similarity. Source: UniProtKB

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Aromatase
PRO_0000051956

Sites

Metal binding4371Iron (heme axial ligand) By similarity
Binding site3091Substrate By similarity
Binding site3741Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q69FB6 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: A272FD593B494551

FASTA50357,854
        10         20         30         40         50         60 
MVLEVLNPRH YNITSMVTEV APVASIAILL LTGFLLLVWN YEDTSSIPGP GYFLGIGPLI 

        70         80         90        100        110        120 
SHCRFLWMGI GSTCNYYNKT YGEFVRVWIC GEETLIISKS SSMFHIMKHS HYTSRFGSKL 

       130        140        150        160        170        180 
GLQCIGMHEK GIIFNNNPAL WKAVRPFFTK ALSGPGLVRM VTVCADSITK HLDRLEEVRN 

       190        200        210        220        230        240 
ELGYVDVLTL MRRIMLDTSN KLFLGIPLDE RAIVVKIQGY FDAWQALLLK PDIFFKISWL 

       250        260        270        280        290        300 
CRKYEKSVKD LKDAMEILIE EKRQRISTAE KLEDCMDFAT ELIFAEKRGD LTKENVDQCI 

       310        320        330        340        350        360 
LEMLIAAPDT MSVSVFFMLF LIAKHPQVEE AIMKEIQTVV GERDIRIDDM QKLKVVENFI 

       370        380        390        400        410        420 
YESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNIGR MHRLEFFPKP NEFTLENFAR 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRACAGK YIAMVMMKVT LVTLLRSFHV QTLQGRCIEK MQKKNDLSLH 

       490        500 
PDETSDLLGM IFIPRNSDKC LDH 

« Hide

References

[1]"Characterization of a cetacean aromatase (CYP19) and the phylogeny and functional conservation of vertebrate aromatase."
Wilson J.Y., McArthur A.G., Stegeman J.J.
Gen. Comp. Endocrinol. 140:74-83(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY341076 mRNA. Translation: AAR05986.1.

3D structure databases

ProteinModelPortalQ69FB6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG050750.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP19A_LAGAC
AccessionPrimary (citable) accession number: Q69FB6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: September 13, 2004
Last modified: December 11, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families