Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Junctophilin-4

Gene

Jph4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Junctophilin-4
Short name:
JP-4
Alternative name(s):
Junctophilin-like 1 protein
Gene namesi
Name:Jph4Imported
Synonyms:Jphl1By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303170. Jph4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 608608CytoplasmicSequence analysisAdd
BLAST
Transmembranei609 – 62921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Junctophilin-4PRO_0000259404Add
BLAST

Proteomic databases

PaxDbiQ69FB3.
PRIDEiQ69FB3.

Interactioni

Protein-protein interaction databases

BioGridi268735. 1 interaction.
STRINGi10116.ENSRNOP00000034702.

Structurei

3D structure databases

ProteinModelPortaliQ69FB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati17 – 3923MORN 1Sequence analysisAdd
BLAST
Repeati41 – 6222MORN 2Sequence analysisAdd
BLAST
Repeati63 – 8422MORN 3Sequence analysisAdd
BLAST
Repeati85 – 10723MORN 4Sequence analysisAdd
BLAST
Repeati108 – 13023MORN 5Sequence analysisAdd
BLAST
Repeati131 – 15323MORN 6Sequence analysisAdd
BLAST
Repeati284 – 30623MORN 7Sequence analysisAdd
BLAST
Repeati307 – 32923MORN 8Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 343330Gly-richSequence analysisAdd
BLAST
Compositional biasi172 – 18211Poly-ProSequence analysisAdd
BLAST
Compositional biasi365 – 41551Ala-richSequence analysisAdd
BLAST

Domaini

The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids.By similarity

Sequence similaritiesi

Belongs to the junctophilin family.Sequence analysis
Contains 8 MORN repeats.Sequence analysis

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
HOGENOMiHOG000264244.
HOVERGENiHBG031648.
InParanoidiQ69FB3.
KOiK19530.
PhylomeDBiQ69FB3.
TreeFamiTF317210.

Family and domain databases

InterProiIPR017191. Junctophilin.
IPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 8 hits.
[Graphical view]
PIRSFiPIRSF037387. Junctophilin. 1 hit.
SMARTiSM00698. MORN. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q69FB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVPLGRKFD FDDGGCYVGG WEAGRAHGYG VCTGPGAQGE YSGCWAHGFE
60 70 80 90 100
SLGVFTGPGG HSYQGHWQQG KREGLGVERK SRWTYRGEWL GGLKGRSGVW
110 120 130 140 150
ESVSGLRYAG LWKDGFQDGY GTETYSDGGT YQGQWQAGKR HGYGVRQSVP
160 170 180 190 200
YHQAALLRSP RRTSLDSGHS DPPTPPPPLP LPGDEGGSPA SGSRGGFVLA
210 220 230 240 250
GPGDADGASS RKRTPAAGGF FRRSLLLSGL RAGGRRSSLG SKRGSLRSEV
260 270 280 290 300
SSEVGSTGPP GSEASGPPIP APPALIEGSA TEVYAGEWRA DRRSGYGVSQ
310 320 330 340 350
RSNGLRYEGE WLGNRRHGYG RTTRPDGSRE EGKYKRNRLV HGGRVRSLLP
360 370 380 390 400
LALRRGKVKE KVDRAVEGAR RAVSAARQRQ EIAAARAADA LLKAVAASSV
410 420 430 440 450
AEKAVEAARM AKLIAQDLQP MLEAPGRRPR QDSGGSDTEP LDEDSPGVYE
460 470 480 490 500
NGLTPSEGSP ELPSSPASSH QPWRAPPCRS PLPPGGNWGP FSSPKAWPEE
510 520 530 540 550
WGGPGEQAEE LAGYEAEDEA GMQGPGPRDG SPLLGGCSDS SGSLREEEGE
560 570 580 590 600
DEESLPQLRA PGGSESEPVT TPVLRGLSSR GPDAGCLTEE FEEPAATERP
610 620 630
AQPGAANPLV VGAVALLDLS LAFLFSQLLT
Length:630
Mass (Da):66,441
Last modified:September 13, 2004 - v1
Checksum:iEE0DB8E0444A41E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341260 mRNA. Translation: AAR08902.1.
RefSeqiNP_001003711.1. NM_001003711.1.
UniGeneiRn.163297.

Genome annotation databases

GeneIDi445271.
KEGGirno:445271.
UCSCiRGD:1303170. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341260 mRNA. Translation: AAR08902.1.
RefSeqiNP_001003711.1. NM_001003711.1.
UniGeneiRn.163297.

3D structure databases

ProteinModelPortaliQ69FB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi268735. 1 interaction.
STRINGi10116.ENSRNOP00000034702.

Proteomic databases

PaxDbiQ69FB3.
PRIDEiQ69FB3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi445271.
KEGGirno:445271.
UCSCiRGD:1303170. rat.

Organism-specific databases

CTDi84502.
RGDi1303170. Jph4.

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
HOGENOMiHOG000264244.
HOVERGENiHBG031648.
InParanoidiQ69FB3.
KOiK19530.
PhylomeDBiQ69FB3.
TreeFamiTF317210.

Miscellaneous databases

PROiQ69FB3.

Family and domain databases

InterProiIPR017191. Junctophilin.
IPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 8 hits.
[Graphical view]
PIRSFiPIRSF037387. Junctophilin. 1 hit.
SMARTiSM00698. MORN. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and functional characterization of a novel subclass of junctophilins in the brain."
    Savaskan N.E., Brauer A.U.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: WistarImported.
    Tissue: BrainImported.

Entry informationi

Entry nameiJPH4_RAT
AccessioniPrimary (citable) accession number: Q69FB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2004
Last modified: July 6, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.