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Q69BJ7 (UCRI_SAISC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 31, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome b-c1 complex subunit Rieske, mitochondrial
EC=1.10.2.2
Alternative name(s):
Complex III subunit 5
Cytochrome b-c1 complex subunit 5
Rieske iron-sulfur protein
Short name=RISP
Ubiquinol-cytochrome c reductase iron-sulfur subunit

Cleaved into the following chain:

  1. Cytochrome b-c1 complex subunit 11
    Alternative name(s):
    Complex III subunit IX
    Ubiquinol-cytochrome c reductase 8 kDa protein
Gene names
Name:UQCRFS1
OrganismSaimiri sciureus (Common squirrel monkey)
Taxonomic identifier9521 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Saimiriinae › Saimiri

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.

The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex By similarity.

Catalytic activity

QH2 + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H+.

Cofactor

Binds 1 2Fe-2S cluster per subunit By similarity.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity.

Subcellular location

Mitochondrion inner membrane By similarity.

Miscellaneous

The Rieske protein is a high potential 2Fe-2S protein.

Sequence similarities

Contains 1 Rieske domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7878Cytochrome b-c1 complex subunit 11 By similarity
PRO_0000307249
Transit peptide1 – 7878Mitochondrion By similarity
Chain79 – 274196Cytochrome b-c1 complex subunit Rieske, mitochondrial
PRO_0000030672

Regions

Domain187 – 27286Rieske

Sites

Metal binding2171Iron-sulfur (2Fe-2S) By similarity
Metal binding2191Iron-sulfur (2Fe-2S); via pros nitrogen By similarity
Metal binding2361Iron-sulfur (2Fe-2S) By similarity
Metal binding2391Iron-sulfur (2Fe-2S); via pros nitrogen By similarity

Amino acid modifications

Disulfide bond222 ↔ 238 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q69BJ7 [UniParc].

Last modified September 13, 2004. Version 1.
Checksum: 2E7972E5F8EC4FB3

FASTA27430,007
        10         20         30         40         50         60 
MLSVAARSGP FAPVLSAKSR GVXXXXXXXX XXXXXXTPEP PVLDPKRPIL SRESLSGQAA 

        70         80         90        100        110        120 
RRPLVASVGL NVPASVRYSH TDIKVPDFSD YRRSEVLDKT KSSRESSDAR KVFSYMVTAT 

       130        140        150        160        170        180 
TAVGVTYAAK SIVTQFISSM SASADVLAMS KIEIKLSDIP EGKNMAFKWR GKPLFVRHRT 

       190        200        210        220        230        240 
QKEIEQEAAV ELSQLRDPQH DLDRVKKPEW MILIGVCTHL GCVPIANAGD FGGYYCPCHG 

       250        260        270 
SHYDASGRIR KGPAPLNLEV PTYEFLSDDM VVVG

« Hide

References

[1]"Molecular evolution of the iron sulfur protein and subunit 9 of complex III of the electron transport chain in primates."
Doan J.W., Wildman D.E., Schmidt T.R., Weiss M.L., Goodman M., Grossman L.I.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY387514, AY387513 Genomic DNA. Translation: AAR32730.1.

3D structure databases

ProteinModelPortalQ69BJ7.
SMRQ69BJ7. Positions 79-274.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG001040.

Family and domain databases

InterProIPR011070. Globular_prot_asu/bsu.
IPR017941. Rieske_2Fe-2S.
IPR014349. Rieske_Fe-S_prot.
IPR005805. Rieske_Fe-S_prot_C.
IPR015248. Ubiqinol_cyt_c_Rdtase_N.
IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su.
IPR004192. Ubiquinol_cyt_Rdtase_TM.
[Graphical view]
Gene3DG3DSA:2.102.10.10. Rieske_reg. 1 hit.
G3DSA:1.20.5.270. Ubiquinol_cyt_Rdtase_TM. 1 hit.
PANTHERPTHR10134. Rieske. 1 hit.
PfamPF00355. Rieske. 1 hit.
PF09165. Ubiq-Cytc-red_N. 1 hit.
PF02921. UCR_TM. 1 hit.
[Graphical view]
PRINTSPR00162. RIESKE.
SUPFAMSSF56568. AlphaBeta_subunt. 1 hit.
SSF50022. Rieske_dom. 1 hit.
SSF81502. UCR_TM_region. 1 hit.
TIGRFAMsTIGR01416. Rieske_proteo. 1 hit.
PROSITEPS51296. RIESKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUCRI_SAISC
AccessionPrimary (citable) accession number: Q69BJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: September 13, 2004
Last modified: May 31, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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