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Protein

C5a anaphylatoxin chemotactic receptor 2

Gene

C5ar2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

GO - Molecular functioni

  • C5a anaphylatoxin receptor activity Source: InterPro
  • G-protein coupled receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 2
Alternative name(s):
Complement component 5a receptor 2
G-protein coupled receptor 77
Gene namesi
Name:C5ar2
Synonyms:C5l2, Gpr77
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303027. C5ar2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence analysisAdd
BLAST
Transmembranei45 – 6723Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini68 – 7811CytoplasmicSequence analysisAdd
BLAST
Transmembranei79 – 10123Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini102 – 12019ExtracellularSequence analysisAdd
BLAST
Transmembranei121 – 14323Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini144 – 15512CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17823Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 20830ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 23123Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini232 – 24312CytoplasmicSequence analysisAdd
BLAST
Transmembranei244 – 26623Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini267 – 28014ExtracellularSequence analysisAdd
BLAST
Transmembranei281 – 30020Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini301 – 34343CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical part of cell Source: UniProtKB
  • basal plasma membrane Source: UniProtKB
  • integral component of membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343C5a anaphylatoxin chemotactic receptor 2PRO_0000303084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi113 ↔ 192PROSITE-ProRule annotation
Modified residuei326 – 3261PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ695P6.
PRIDEiQ695P6.

PTM databases

PhosphoSiteiQ695P6.

Interactioni

Subunit structurei

Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ695P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHWH. Eukaryota.
ENOG4111DWV. LUCA.
GeneTreeiENSGT00760000118990.
HOVERGENiHBG107547.
InParanoidiQ695P6.
OMAiAACHWAL.
OrthoDBiEOG7G1V6M.
PhylomeDBiQ695P6.

Family and domain databases

InterProiIPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q695P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNDTTSKDY EYEYDQEQYS DLLNVPVDCP AGNCFSNDAY LIVLLGLYSV
60 70 80 90 100
IFLVGVPGNT LLAWVTWKES RHRLGASWFL HLTMADLLCC VSLPFLAVPI
110 120 130 140 150
AQKGHWPYGT AGCWLLSSIT VLSMYASVLL LTGLSGDLFL LAFRPSWKNA
160 170 180 190 200
DQRTCGVRVV QVSSWMLALL LTVPGAVYRK LLQEHYPPRL VCGTNYGGSV
210 220 230 240 250
TAEVTITTVR FLFGFLVPLV FMASCHGILQ RQMARRHWPL GTAVVVGFFI
260 270 280 290 300
CWTPFHLLRV IIAVASSHSP LLAWALEAEP LVTGLALAHS ALNPIMFLYF
310 320 330 340
GRKQLCKSLQ AACHWALRDL QDEEESAVTK VSTSQEMVSE MPV
Length:343
Mass (Da):38,123
Last modified:September 13, 2004 - v1
Checksum:iBB3C9C9E517003C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY600435 mRNA. Translation: AAT12287.1.
RefSeqiXP_006228415.1. XM_006228353.2.
UniGeneiRn.127117.

Genome annotation databases

EnsembliENSRNOT00000071576; ENSRNOP00000067721; ENSRNOG00000049028.
GeneIDi445269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY600435 mRNA. Translation: AAT12287.1.
RefSeqiXP_006228415.1. XM_006228353.2.
UniGeneiRn.127117.

3D structure databases

ProteinModelPortaliQ695P6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ695P6.

Proteomic databases

PaxDbiQ695P6.
PRIDEiQ695P6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071576; ENSRNOP00000067721; ENSRNOG00000049028.
GeneIDi445269.

Organism-specific databases

CTDi27202.
RGDi1303027. C5ar2.

Phylogenomic databases

eggNOGiENOG410IHWH. Eukaryota.
ENOG4111DWV. LUCA.
GeneTreeiENSGT00760000118990.
HOVERGENiHBG107547.
InParanoidiQ695P6.
OMAiAACHWAL.
OrthoDBiEOG7G1V6M.
PhylomeDBiQ695P6.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.

Miscellaneous databases

PROiQ695P6.

Family and domain databases

InterProiIPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of C5L2, a new C5a orphan receptor in sepsis."
    Gao H., Neff T., Younkin E., Hoesel M., Man Y., Sarma V., Guo R.-F., Tomlins S., Riedemann N., Speyer C., Zetoune F., Ward P.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Long Evans.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-326, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiC5AR2_RAT
AccessioniPrimary (citable) accession number: Q695P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 13, 2004
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.