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Protein

C5a anaphylatoxin chemotactic receptor 2

Gene

C5ar2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

GO - Molecular functioni

  • complement component C5a receptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 2
Alternative name(s):
Complement component 5a receptor 2
G-protein coupled receptor 77
Gene namesi
Name:C5ar2
Synonyms:C5l2, Gpr77
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1303027. C5ar2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 67Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini68 – 78CytoplasmicSequence analysisAdd BLAST11
Transmembranei79 – 101Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini102 – 120ExtracellularSequence analysisAdd BLAST19
Transmembranei121 – 143Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini144 – 155CytoplasmicSequence analysisAdd BLAST12
Transmembranei156 – 178Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini179 – 208ExtracellularSequence analysisAdd BLAST30
Transmembranei209 – 231Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini232 – 243CytoplasmicSequence analysisAdd BLAST12
Transmembranei244 – 266Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini267 – 280ExtracellularSequence analysisAdd BLAST14
Transmembranei281 – 300Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini301 – 343CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003030841 – 343C5a anaphylatoxin chemotactic receptor 2Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi113 ↔ 192PROSITE-ProRule annotation
Modified residuei326PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ695P6.
PRIDEiQ695P6.

PTM databases

iPTMnetiQ695P6.
PhosphoSitePlusiQ695P6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000049028.

Interactioni

Subunit structurei

Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ695P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHWH. Eukaryota.
ENOG4111DWV. LUCA.
GeneTreeiENSGT00760000118990.
HOVERGENiHBG107547.
InParanoidiQ695P6.
OMAiAACHWAL.
OrthoDBiEOG091G0FUR.
PhylomeDBiQ695P6.

Family and domain databases

InterProiIPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q695P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNDTTSKDY EYEYDQEQYS DLLNVPVDCP AGNCFSNDAY LIVLLGLYSV
60 70 80 90 100
IFLVGVPGNT LLAWVTWKES RHRLGASWFL HLTMADLLCC VSLPFLAVPI
110 120 130 140 150
AQKGHWPYGT AGCWLLSSIT VLSMYASVLL LTGLSGDLFL LAFRPSWKNA
160 170 180 190 200
DQRTCGVRVV QVSSWMLALL LTVPGAVYRK LLQEHYPPRL VCGTNYGGSV
210 220 230 240 250
TAEVTITTVR FLFGFLVPLV FMASCHGILQ RQMARRHWPL GTAVVVGFFI
260 270 280 290 300
CWTPFHLLRV IIAVASSHSP LLAWALEAEP LVTGLALAHS ALNPIMFLYF
310 320 330 340
GRKQLCKSLQ AACHWALRDL QDEEESAVTK VSTSQEMVSE MPV
Length:343
Mass (Da):38,123
Last modified:September 13, 2004 - v1
Checksum:iBB3C9C9E517003C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY600435 mRNA. Translation: AAT12287.1.
RefSeqiXP_006228415.1. XM_006228353.3.
UniGeneiRn.127117.

Genome annotation databases

EnsembliENSRNOT00000071576; ENSRNOP00000067721; ENSRNOG00000049028.
GeneIDi445269.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY600435 mRNA. Translation: AAT12287.1.
RefSeqiXP_006228415.1. XM_006228353.3.
UniGeneiRn.127117.

3D structure databases

ProteinModelPortaliQ695P6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ695P6.
PhosphoSitePlusiQ695P6.

Proteomic databases

PaxDbiQ695P6.
PRIDEiQ695P6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071576; ENSRNOP00000067721; ENSRNOG00000049028.
GeneIDi445269.

Organism-specific databases

CTDi27202.
RGDi1303027. C5ar2.

Phylogenomic databases

eggNOGiENOG410IHWH. Eukaryota.
ENOG4111DWV. LUCA.
GeneTreeiENSGT00760000118990.
HOVERGENiHBG107547.
InParanoidiQ695P6.
OMAiAACHWAL.
OrthoDBiEOG091G0FUR.
PhylomeDBiQ695P6.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-977606. Regulation of Complement cascade.

Miscellaneous databases

PROiQ695P6.

Gene expression databases

BgeeiENSRNOG00000049028.

Family and domain databases

InterProiIPR027809. Anaphtx_C5AR2.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF1. PTHR24225:SF1. 1 hit.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC5AR2_RAT
AccessioniPrimary (citable) accession number: Q695P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.