Sequence length	232 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Function	Play a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
Tissue specificity	Higher expression in cerebellum than in whole brain and lower expression in medulloblastoma.
Domain	The BTB domain is required for growth-suppressing properties.
Involvement in disease	Haploinsufficiency of KCTD11 may be a cause of development of medulloblastoma (MDB). MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. An allelic deletion involving genes from chromosome region 17p11.2-pter, sometimes restricted to 17p13.2-13.3, occurs in up to 50% of MDB.
Sequence similarities	Contains 1 BTB (POZ) domain.

Keywords
Biological process	Cell cycle Growth regulation
Coding sequence diversity	Polymorphism
Molecular function	Anti-oncogene Developmental protein
Gene Ontology (GO)
Biological process	negative regulation of cell cycle Inferred from electronic annotation. Source: UniProtKB-KW potassium ion transport Inferred from electronic annotation. Source: InterPro regulation of cell growth Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	voltage-gated potassium channel complex Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro voltage-gated potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma." Di Marcotullio L., Ferretti E., De Smaele E., Argenti B., Mincione C., Zazzeroni F., Gallo R., Masuelli L., Napolitano M., Maroder M., Modesti A., Giangaspero F., Screpanti I., Alesse E., Gulino A. Proc. Natl. Acad. Sci. U.S.A. 101:10833-10838(2004) [PubMed: 15249678] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, CHARACTERIZATION OF BTB DOMAIN, DISEASE.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Sequence databases
	AY646650 mRNA. Translation: AAT75307.1. BC110598 mRNA. Translation: AAI10599.1.
RefSeq	NP_001002914.1.
UniGene	Hs.592112
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q693B1.
Genome annotation databases
Ensembl	ENSG00000213859. Homo sapiens. [Contig view]
GeneID	147040.
KEGG	hsa:147040.
Organism-specific databases
HGNC	HGNC:21302. KCTD11.
MIM	609848. gene.
PharmGKB	PA134890547.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q693B1.
Gene expression databases
ArrayExpress	Q693B1.
CleanEx	HS_KCTD11. HS_REN.
GermOnline	ENSG00000072818. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR003131. K_chnl_volt-dep_Kv_tetra. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
Pfam	PF02214. K_tetra. 1 hit. [Graphical view]
PROSITE	PS50097. BTB. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	85535.
SOURCE	Search...

Names and origin

Protein attributes