Q69153 (UL70_MUHVS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable primase

Alternative name(s):
DNA replication protein UL70

Gene names

Name:

UL70

Organism

Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) [Reference proteome]

Taxonomic identifier

10367 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Muromegalovirus › Murid herpesvirus 1

Virus host

Mus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length	964 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probable primase that is part of the helicase-primase complex and is required for replication of viral DNA By similarity.
Subunit structure	The helicase-primase complex is composed of the primase, the helicase and the primase-associated factor By similarity.
Sequence similarities	Belongs to the herpesviridae UL52 family.

Ontologies

Keywords
Biological process	DNA replication
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication, synthesis of RNA primer Inferred from electronic annotation. Source: GOC
Molecular_function	DNA primase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 964	964	Probable primase		PRO_0000116116
Regions
	Compositional bias	595 – 598	4	Poly-Gly
	Compositional bias	816 – 824	9	Poly-Gly
	Compositional bias	842 – 845	4	Poly-Asp

Sequences

	Sequence		Length	Mass (Da)
	Q69153 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 70605300E1D85864	FASTA	964	109,704
	10 20 30 40 50 60 MTVVLFATEY DTPNIVVNML SETPTEHHLF PLMIKYKPSN RIEFVLQTQR CPDSTRVRPV 70 80 90 100 110 120 FICDARRLSL SEYVSTNTPL PARVICAGID ADATRELYEH LFDRKKDETG HDEENGSAAR 130 140 150 160 170 180 HLFSNLTSTL KCLVHYNRSA ILRYLNNTFL SPTFPSWFLS TYGTHEGTLI LTMSYYLFER 190 200 210 220 230 240 TYSTIQTTRD YTKCFTADPG RNLFTYINMR DFMATMNGSR FRKQTVLFAV FAKARNARDR 250 260 270 280 290 300 CELEYVDAKI NAFREESRLA ADSCVYYVYL AYRTALCREK FLQYCEHTAY DKNLPDDQQC 310 320 330 340 350 360 AAEENYLGRS LDAELISIMN TYFSVEGYFG SYIHVDRAKL SPPHSYRGYD WNTEADTMVG 370 380 390 400 410 420 YSSTATNLAI SLRKLNSTCE SLFSPLPPTL MGLLKLCASD RYVPRAEKSR KRTSGGREKE 430 440 450 460 470 480 DETRVCRRNY LLNDTSRPIG PMPVFRVEMP EKRHVFCAVS AENWTRRLLP KDLMKNLPSE 490 500 510 520 530 540 YVSDECLTDA VWLREDIAAL CEVGEQLYRT RHEMFNENLP VFNFVGDVDL KLREDLQGLS 550 560 570 580 590 600 RQEVFDLCRA LRRTLIGAWR HLFPEVDPDS HPVFFFKSAC PQNAAGAADE AMLYGGGGYD 610 620 630 640 650 660 EDDDPRPEHA AAMVDYGDAV RRPPFCVCRR KLGLRVIIPF PPRTAAIGAQ TLKRLAGILD 670 680 690 700 710 720 HTLCLDRDLV CKLNAISHPG ECFDTGIYSH GRSIRMPLMY KLDEASGLIL HSRLNPIFIV 730 740 750 760 770 780 PAGYRDRPAE FVLQQLCPQN LTHHGRPPQR DGSADQLTEV VLHITDRACA DSDGNFLQSR 790 800 810 820 830 840 ARRAMSSGRL PLGPLLRAHL SLESGQSAPS LPTLVGRGGG GEGGASSDYE EERAVGSDEE 850 860 870 880 890 900 EDDDDVENLQ AFARRIAWPA LLRHTRNHYR EEVQQQLEAA TVFTAVGRTC VAVKRGLYGR 910 920 930 940 950 960 ARDFSCLARE TYTRQETVQV FLDIRGDQRR NVWATLWSRC FTRRCNSNAK QTHLSLKISL PSQY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a conserved gene block in the murine cytomegalovirus genome." Messerle M., Rapp M., Lucin P., Koszinowski U.H. Virus Genes 10:73-80(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of the complete DNA sequence of murine cytomegalovirus." Rawlinson W.D., Farrell H.E., Barrell B.G. J. Virol. 70:8833-8849(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L07319 Genomic DNA. Translation: AAA96665.1. U68299 Genomic DNA. No translation available.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004340. DNA_primase_UL52/UL70_Herpvir. [Graphical view]
Pfam	PF03121. Herpes_UL52. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UL70_MUHVS

Accession

Primary (citable) accession number: Q69153

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program