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Q69151

- DUT_MUHVS

UniProt

Q69151 - DUT_MUHVS

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:DUT
    Synonyms:UL72
    OrganismiMurid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
    Taxonomic identifieri10367 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
    Virus hostiMus musculus (Mouse) [TaxID: 10090]
    ProteomesiUP000008774: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182966Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ69151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q69151-1 [UniParc]FASTAAdd to Basket

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    MIKPNIPAPV RPNLPLSSPD SVLPQAMKDP FNIFDDDEPS EDTSSSEQSS    50
    RPPPREMMIS SSCALREQTN SSFLNRFFPE DDESSENGAA LAEINQLLRD 100
    GPEAPPREPT PKEARRPEKM QKIFFQTYGN DFKVEAHGDR LLAQNQRVVR 150
    LFERGRILGL GVKMNIPMGY CAVTNCFHPP GCVCVMDMAG YGPSDIRAQI 200
    VNISSGPLEL PPNMLQIHIH MLPMLLPEPW QTINLMAPHQ GDTYFDLRLR 250
    RPLSLPPRAS KNLKFEAGHL CEEDARRCLV IPCRHLATKR VLLDPTVWRP 300
    NSLAVLRVLN ASDEHVDLEA GMAMAKIIFT TPGITPFKPS LTSVMMSFDV 350
    PRSDLKLVKG GRRDYYRAEE RMRSGRDSSN EG 382
    Length:382
    Mass (Da):42,885
    Last modified:November 1, 1996 - v1
    Checksum:i0280F70C9B46048D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07319 Genomic DNA. Translation: AAA96663.1.
    U68299 Genomic DNA. No translation available.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07319 Genomic DNA. Translation: AAA96663.1 .
    U68299 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali Q69151.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .

    Family and domain databases

    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a conserved gene block in the murine cytomegalovirus genome."
      Messerle M., Rapp M., Lucin P., Koszinowski U.H.
      Virus Genes 10:73-80(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Analysis of the complete DNA sequence of murine cytomegalovirus."
      Rawlinson W.D., Farrell H.E., Barrell B.G.
      J. Virol. 70:8833-8849(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_MUHVS
    AccessioniPrimary (citable) accession number: Q69151
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3