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Q69151

- DUT_MUHVS

UniProt

Q69151 - DUT_MUHVS

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene
DUT, UL72
Organism
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:DUT
Synonyms:UL72
OrganismiMurid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Taxonomic identifieri10367 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]
ProteomesiUP000008774: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182966Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ69151.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Q69151-1 [UniParc]FASTAAdd to Basket

« Hide

MIKPNIPAPV RPNLPLSSPD SVLPQAMKDP FNIFDDDEPS EDTSSSEQSS    50
RPPPREMMIS SSCALREQTN SSFLNRFFPE DDESSENGAA LAEINQLLRD 100
GPEAPPREPT PKEARRPEKM QKIFFQTYGN DFKVEAHGDR LLAQNQRVVR 150
LFERGRILGL GVKMNIPMGY CAVTNCFHPP GCVCVMDMAG YGPSDIRAQI 200
VNISSGPLEL PPNMLQIHIH MLPMLLPEPW QTINLMAPHQ GDTYFDLRLR 250
RPLSLPPRAS KNLKFEAGHL CEEDARRCLV IPCRHLATKR VLLDPTVWRP 300
NSLAVLRVLN ASDEHVDLEA GMAMAKIIFT TPGITPFKPS LTSVMMSFDV 350
PRSDLKLVKG GRRDYYRAEE RMRSGRDSSN EG 382
Length:382
Mass (Da):42,885
Last modified:November 1, 1996 - v1
Checksum:i0280F70C9B46048D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07319 Genomic DNA. Translation: AAA96663.1.
U68299 Genomic DNA. No translation available.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L07319 Genomic DNA. Translation: AAA96663.1 .
U68299 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali Q69151.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .

Family and domain databases

InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a conserved gene block in the murine cytomegalovirus genome."
    Messerle M., Rapp M., Lucin P., Koszinowski U.H.
    Virus Genes 10:73-80(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the complete DNA sequence of murine cytomegalovirus."
    Rawlinson W.D., Farrell H.E., Barrell B.G.
    J. Virol. 70:8833-8849(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_MUHVS
AccessioniPrimary (citable) accession number: Q69151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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