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Q69151 (DUT_MUHVS) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:DUT
Synonyms:UL72
OrganismMurid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) [Reference proteome]
Taxonomic identifier10367 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
Virus hostMus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

dUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182966

Sequences

Sequence LengthMass (Da)Tools
Q69151 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 0280F70C9B46048D

FASTA38242,885
        10         20         30         40         50         60 
MIKPNIPAPV RPNLPLSSPD SVLPQAMKDP FNIFDDDEPS EDTSSSEQSS RPPPREMMIS 

        70         80         90        100        110        120 
SSCALREQTN SSFLNRFFPE DDESSENGAA LAEINQLLRD GPEAPPREPT PKEARRPEKM 

       130        140        150        160        170        180 
QKIFFQTYGN DFKVEAHGDR LLAQNQRVVR LFERGRILGL GVKMNIPMGY CAVTNCFHPP 

       190        200        210        220        230        240 
GCVCVMDMAG YGPSDIRAQI VNISSGPLEL PPNMLQIHIH MLPMLLPEPW QTINLMAPHQ 

       250        260        270        280        290        300 
GDTYFDLRLR RPLSLPPRAS KNLKFEAGHL CEEDARRCLV IPCRHLATKR VLLDPTVWRP 

       310        320        330        340        350        360 
NSLAVLRVLN ASDEHVDLEA GMAMAKIIFT TPGITPFKPS LTSVMMSFDV PRSDLKLVKG 

       370        380 
GRRDYYRAEE RMRSGRDSSN EG 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a conserved gene block in the murine cytomegalovirus genome."
Messerle M., Rapp M., Lucin P., Koszinowski U.H.
Virus Genes 10:73-80(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Analysis of the complete DNA sequence of murine cytomegalovirus."
Rawlinson W.D., Farrell H.E., Barrell B.G.
J. Virol. 70:8833-8849(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L07319 Genomic DNA. Translation: AAA96663.1.
U68299 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalQ69151.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00610; UER00666.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_MUHVS
AccessionPrimary (citable) accession number: Q69151
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways