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Protein

Envelope glycoprotein D

Gene

gD

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, NECTIN1 and 3-O-sulfated heparan sulfate (By similarity). May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Zinc; shared with dimeric partnerBy similarity1
Metal bindingi240Zinc; shared with dimeric partnerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral attachment to host cell, Viral attachment to host entry receptor, Virus entry into host cell
LigandMetal-binding, Zinc

Protein family/group databases

TCDBi1.G.10.1.1. the herpes simplex virus membrane fusion complex (hsv-mfc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein D
Short name:
gD
Gene namesi
Name:gD
ORF Names:US6
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 340Virion surfaceSequence analysisAdd BLAST315
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 394IntravirionSequence analysisAdd BLAST33

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • viral envelope Source: CAFA
  • virion membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2364696.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003821326 – 394Envelope glycoprotein DAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi91 ↔ 2141 Publication
Glycosylationi119N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Disulfide bondi131 ↔ 2271 Publication
Disulfide bondi143 ↔ 1521 Publication
Glycosylationi146N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ69091.

Interactioni

Subunit structurei

Homodimer (Probable). Interacts with host receptor TNFRSF14. Interacts with host receptor NECTIN1 (By similarity). Interacts (via profusion domain) with gB; this interaction occurs in the absence of gH/gL. Interacts (via profusion domain) with gH/gL heterodimer; this interaction occurs in the absence of gB. Associates with the gB-gH/gL-gD complex (Probable). Interacts (via C-terminus) with UL11 tegument protein. Interacts (via C-terminus) with VP22 tegument protein (By similarity); this interaction has been demonstrated in other strains, but might be very weak since PubMed:19279114 has failed to see it.By similarityCurated1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NECTIN1Q9GL764EBI-11691180,EBI-11691211From Sus scrofa.

Protein-protein interaction databases

IntActiQ69091. 2 interactors.

Structurei

Secondary structure

1394
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi60 – 63Combined sources4
Beta strandi65 – 68Combined sources4
Beta strandi82 – 87Combined sources6
Beta strandi92 – 96Combined sources5
Helixi102 – 107Combined sources6
Helixi111 – 114Combined sources4
Beta strandi118 – 128Combined sources11
Beta strandi131 – 143Combined sources13
Beta strandi153 – 156Combined sources4
Beta strandi159 – 162Combined sources4
Turni164 – 166Combined sources3
Beta strandi167 – 169Combined sources3
Beta strandi176 – 180Combined sources5
Helixi183 – 185Combined sources3
Beta strandi187 – 195Combined sources9
Beta strandi198 – 212Combined sources15
Helixi224 – 226Combined sources3
Helixi230 – 235Combined sources6
Turni239 – 243Combined sources5
Helixi250 – 264Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U82X-ray3.16A26-310[»]
ProteinModelPortaliQ69091.
SMRiQ69091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 57Interaction with TNFRSF14By similarityAdd BLAST32
Regioni261 – 305ProfusionAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi269 – 337Pro-richAdd BLAST69
Compositional biasi365 – 381Arg/Lys-rich (highly basic; probably serves to anchor the glycoprotein in the membrane)Add BLAST17

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK19264.
OrthoDBiVOG090000AQ.

Family and domain databases

InterProiView protein in InterPro
IPR002896. Herpes_glycop_dom.
IPR007110. Ig-like_dom.
PfamiView protein in Pfam
PF01537. Herpes_glycop_D. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q69091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGAAARLGA VILFVVIVGL HGVRSKYALV DASLKMADPN RFRGKDLPVL
60 70 80 90 100
DQLTDPPGVR RVYHIQAGLP DPFQPPSLPI TVYYAVLERA CRSVLLNAPS
110 120 130 140 150
EAPQIVRGAS EDVRKQPYNL TIAWFRMGGN CAIPITVMEY TECSYNKSLG
160 170 180 190 200
ACPIRTQPRW NYYDSFSAVS EDNLGFLMHA PAFETAGTYL RLVKINDWTE
210 220 230 240 250
ITQFILEHRA KGSCKYALPL RIPPSACLSP QAYQQGVTVD SIGMLPRFIP
260 270 280 290 300
ENQRTVAVYS LKIAGWHGPK APYTSTLLPP ELSETPNATQ PELAPEDPED
310 320 330 340 350
SALLEDPVGT VAPQIPPNWH IPSIQDAATP YHPPATPNNM GLIAGAVGGS
360 370 380 390
LLAALVICGI VYWMRRHTQK APKRIRLPHI REDDQPSSHQ PLFY
Length:394
Mass (Da):43,347
Last modified:November 1, 1996 - v1
Checksum:i94B52171F355F6FC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti25S → G. 1
Natural varianti30V → A in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti218L → I in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti353A → V in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti367H → R in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA. Translation: CAA32283.1.
L00036 Genomic DNA. Translation: AAA96682.1.
DQ889502 Genomic DNA. Translation: ABI63524.1.
FJ593289 Genomic DNA. Translation: ACM62295.1.
PIRiA03730. VGBE17.
RefSeqiYP_009137141.1. NC_001806.2.

Genome annotation databases

GeneIDi2703444.
KEGGivg:2703444.

Similar proteinsi

Entry informationi

Entry nameiGD_HHV11
AccessioniPrimary (citable) accession number: Q69091
Secondary accession number(s): B9VQK0
, O12544, O12833, P03171, Q09I71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families