ID   CCL13_CANLF             Reviewed;          98 AA.
AC   Q68Y88;
DT   25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   RecName: Full=C-C motif chemokine 13;
DE   AltName: Full=Monocyte chemoattractant protein 4;
DE   AltName: Full=Monocyte chemotactic protein 4;
DE            Short=MCP-4;
DE   AltName: Full=Small-inducible cytokine A13;
DE   Flags: Precursor;
GN   Name=CCL13;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K.,
RA   Tsujimoto H., Iwabuchi S.;
RT   "Expression analysis of monocyte chemotactic protein-4 (MCP-4/CCL13) gene
RT   in canine atopic dermatitis.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chemotactic factor that attracts monocytes, lymphocytes,
CC       basophils and eosinophils, but not neutrophils. Signals through CCR2B
CC       and CCR3 receptors (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   EMBL; AB162849; BAD36827.1; -; mRNA.
DR   RefSeq; NP_001003966.1; NM_001003966.1.
DR   AlphaFoldDB; Q68Y88; -.
DR   SMR; Q68Y88; -.
DR   STRING; 9615.ENSCAFP00000032928; -.
DR   PaxDb; 9612-ENSCAFP00000032928; -.
DR   Ensembl; ENSCAFT00000037424.3; ENSCAFP00000032928.3; ENSCAFG00000024205.3.
DR   Ensembl; ENSCAFT00030031740.1; ENSCAFP00030027680.1; ENSCAFG00030017108.1.
DR   Ensembl; ENSCAFT00805008958; ENSCAFP00805007012; ENSCAFG00805004793.
DR   Ensembl; ENSCAFT00845019830.1; ENSCAFP00845015525.1; ENSCAFG00845011162.1.
DR   GeneID; 445451; -.
DR   KEGG; cfa:445451; -.
DR   CTD; 6357; -.
DR   VEuPathDB; HostDB:ENSCAFG00845011162; -.
DR   eggNOG; ENOG502S776; Eukaryota.
DR   GeneTree; ENSGT01100000263482; -.
DR   InParanoid; Q68Y88; -.
DR   OrthoDB; 4265193at2759; -.
DR   Reactome; R-CFA-380108; Chemokine receptors bind chemokines.
DR   Proteomes; UP000002254; Chromosome 9.
DR   Proteomes; UP000694429; Chromosome 9.
DR   Proteomes; UP000694542; Unplaced.
DR   Proteomes; UP000805418; Chromosome 9.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IEA:Ensembl.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:Ensembl.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR   CDD; cd00272; Chemokine_CC; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015:SF161; C-C MOTIF CHEMOKINE 7; 1.
DR   PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR01721; FRACTALKINE.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..98
FT                   /note="C-C motif chemokine 13"
FT                   /id="PRO_0000005200"
FT   MOD_RES         24
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:Q99616, ECO:0000255"
FT   DISULFID        34..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   98 AA;  10980 MW;  80A81DCD8E76B46F CRC64;
     MKVSAALLCL LLTAAILTTQ VPAQPDALSA LFTCCFTFNN KKIPLQRLES YRITSSHCPR
     KAVIFSTKLA KAICADPKEK WVQDYVKHLD QRTQTPKT
//