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Q68Y88

- CCL13_CANFA

UniProt

Q68Y88 - CCL13_CANFA

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Protein
C-C motif chemokine 13
Gene
CCL13
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors By similarity.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
  3. inflammatory response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 13
Alternative name(s):
Monocyte chemoattractant protein 4
Monocyte chemotactic protein 4
Short name:
MCP-4
Small-inducible cytokine A13
Gene namesi
Name:CCL13
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 9875C-C motif chemokine 13
PRO_0000005200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acid Reviewed prediction
Disulfide bondi34 ↔ 58 By similarity
Disulfide bondi35 ↔ 74 By similarity

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000032928.

Structurei

3D structure databases

ProteinModelPortaliQ68Y88.
SMRiQ68Y88. Positions 24-97.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG84946.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiQ68Y88.
KOiK16595.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR008097. Chemokine_CX3CL1.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR01721. FRACTALKINE.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68Y88-1 [UniParc]FASTAAdd to Basket

« Hide

MKVSAALLCL LLTAAILTTQ VPAQPDALSA LFTCCFTFNN KKIPLQRLES   50
YRITSSHCPR KAVIFSTKLA KAICADPKEK WVQDYVKHLD QRTQTPKT 98
Length:98
Mass (Da):10,980
Last modified:October 11, 2004 - v1
Checksum:i80A81DCD8E76B46F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB162849 mRNA. Translation: BAD36827.1.
RefSeqiNP_001003966.1. NM_001003966.1.
UniGeneiCfa.15824.

Genome annotation databases

GeneIDi445451.
KEGGicfa:445451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB162849 mRNA. Translation: BAD36827.1 .
RefSeqi NP_001003966.1. NM_001003966.1.
UniGenei Cfa.15824.

3D structure databases

ProteinModelPortali Q68Y88.
SMRi Q68Y88. Positions 24-97.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000032928.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 445451.
KEGGi cfa:445451.

Organism-specific databases

CTDi 6357.

Phylogenomic databases

eggNOGi NOG84946.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi Q68Y88.
KOi K16595.

Miscellaneous databases

NextBioi 20832132.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR008097. Chemokine_CX3CL1.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR01721. FRACTALKINE.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression analysis of monocyte chemotactic protein-4 (MCP-4/CCL13) gene in canine atopic dermatitis."
    Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL13_CANFA
AccessioniPrimary (citable) accession number: Q68Y88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 11, 2004
Last modified: March 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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