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Q68Y88

- CCL13_CANFA

UniProt

Q68Y88 - CCL13_CANFA

Protein

C-C motif chemokine 13

Gene

CCL13

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors By similarity.By similarity

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. inflammatory response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 13
    Alternative name(s):
    Monocyte chemoattractant protein 4
    Monocyte chemotactic protein 4
    Short name:
    MCP-4
    Small-inducible cytokine A13
    Gene namesi
    Name:CCL13
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 9875C-C motif chemokine 13PRO_0000005200Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidSequence Analysis
    Disulfide bondi34 ↔ 58By similarity
    Disulfide bondi35 ↔ 74By similarity

    Keywords - PTMi

    Disulfide bond, Pyrrolidone carboxylic acid

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000032928.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68Y88.
    SMRiQ68Y88. Positions 24-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG84946.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiQ68Y88.
    KOiK16595.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR008097. Chemokine_CX3CL1.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR01721. FRACTALKINE.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68Y88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSAALLCL LLTAAILTTQ VPAQPDALSA LFTCCFTFNN KKIPLQRLES   50
    YRITSSHCPR KAVIFSTKLA KAICADPKEK WVQDYVKHLD QRTQTPKT 98
    Length:98
    Mass (Da):10,980
    Last modified:October 11, 2004 - v1
    Checksum:i80A81DCD8E76B46F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB162849 mRNA. Translation: BAD36827.1.
    RefSeqiNP_001003966.1. NM_001003966.1.
    UniGeneiCfa.15824.

    Genome annotation databases

    GeneIDi445451.
    KEGGicfa:445451.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB162849 mRNA. Translation: BAD36827.1 .
    RefSeqi NP_001003966.1. NM_001003966.1.
    UniGenei Cfa.15824.

    3D structure databases

    ProteinModelPortali Q68Y88.
    SMRi Q68Y88. Positions 24-97.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000032928.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 445451.
    KEGGi cfa:445451.

    Organism-specific databases

    CTDi 6357.

    Phylogenomic databases

    eggNOGi NOG84946.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi Q68Y88.
    KOi K16595.

    Miscellaneous databases

    NextBioi 20832132.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR008097. Chemokine_CX3CL1.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR01721. FRACTALKINE.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression analysis of monocyte chemotactic protein-4 (MCP-4/CCL13) gene in canine atopic dermatitis."
      Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL13_CANFA
    AccessioniPrimary (citable) accession number: Q68Y88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3