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Q68Y88 (CCL13_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 13
Alternative name(s):
Monocyte chemoattractant protein 4
Monocyte chemotactic protein 4
Short name=MCP-4
Small-inducible cytokine A13
Gene names
Name:CCL13
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 9875C-C motif chemokine 13
PRO_0000005200

Amino acid modifications

Modified residue241Pyrrolidone carboxylic acid Potential
Disulfide bond34 ↔ 58 By similarity
Disulfide bond35 ↔ 74 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68Y88 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 80A81DCD8E76B46F

FASTA9810,980
        10         20         30         40         50         60 
MKVSAALLCL LLTAAILTTQ VPAQPDALSA LFTCCFTFNN KKIPLQRLES YRITSSHCPR 

        70         80         90 
KAVIFSTKLA KAICADPKEK WVQDYVKHLD QRTQTPKT 

« Hide

References

[1]"Expression analysis of monocyte chemotactic protein-4 (MCP-4/CCL13) gene in canine atopic dermatitis."
Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB162849 mRNA. Translation: BAD36827.1.
RefSeqNP_001003966.1. NM_001003966.1.
UniGeneCfa.15824.

3D structure databases

ProteinModelPortalQ68Y88.
SMRQ68Y88. Positions 24-97.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000032928.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID445451.
KEGGcfa:445451.

Organism-specific databases

CTD6357.

Phylogenomic databases

eggNOGNOG84946.
HOGENOMHOG000036686.
HOVERGENHBG017871.
InParanoidQ68Y88.
KOK16595.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR008097. Chemokine_CX3CL1.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR01721. FRACTALKINE.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20832132.

Entry information

Entry nameCCL13_CANFA
AccessionPrimary (citable) accession number: Q68Y88
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 11, 2004
Last modified: March 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families