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Q68Y86 (CCL24_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 24
Alternative name(s):
Eosinophil chemotactic protein 2
Eotaxin-2
Small-inducible cytokine A24
Gene names
Name:CCL24
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length119 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 11993C-C motif chemokine 24
PRO_0000005231

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation1151N-linked (GlcNAc...) Potential
Disulfide bond33 ↔ 58 By similarity
Disulfide bond34 ↔ 74 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68Y86 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 4FB8D288F298306C

FASTA11912,987
        10         20         30         40         50         60 
MAGLATFVVS LLLVTLCAHC IDPAGSVSIP SSCCMFFISK KVPENRVVTY QLLNGSVCPK 

        70         80         90        100        110 
AGVVFTTKKN QKFCGDPQLH WVQKLMKNIE ARRKKVSPGV RAMSTKALVQ RYPANSTSI 

« Hide

References

[1]"Expression analysis of eosinophil chemotactic protein-2 (eotaxin-2/CCL24) gene in canine atopic dermatitis."
Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of coding sequences for canine monocyte chemotactic protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine receptor 3 (CCR3)."
Peters I.R., Peeters D., Clercx C., Day M.J.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB162851 mRNA. Translation: BAD36829.1.
AY675235 mRNA. Translation: AAU14060.1.
RefSeqNP_001003967.1. NM_001003967.1.
UniGeneCfa.15823.

3D structure databases

ProteinModelPortalQ68Y86.
SMRQ68Y86. Positions 27-98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000019742.

Proteomic databases

PRIDEQ68Y86.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000021262; ENSCAFP00000019742; ENSCAFG00000013396.
GeneID445452.
KEGGcfa:445452.

Organism-specific databases

CTD6369.

Phylogenomic databases

eggNOGNOG41621.
GeneTreeENSGT00730000110714.
HOGENOMHOG000036685.
HOVERGENHBG017871.
InParanoidQ68Y86.
KOK05514.
OMAQRYPANS.
OrthoDBEOG73BVG4.
TreeFamTF334888.

Family and domain databases

InterProIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
ProtoNetSearch...

Other

NextBio20832133.

Entry information

Entry nameCCL24_CANFA
AccessionPrimary (citable) accession number: Q68Y86
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families