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Q68Y86

- CCL24_CANFA

UniProt

Q68Y86 - CCL24_CANFA

Protein

C-C motif chemokine 24

Gene

CCL24

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 By similarity.By similarity

    GO - Biological processi

    1. cytoskeleton organization Source: Ensembl
    2. eosinophil chemotaxis Source: Ensembl
    3. immune response Source: InterPro
    4. inflammatory response Source: UniProtKB-KW
    5. positive regulation of actin filament polymerization Source: Ensembl
    6. positive regulation of angiogenesis Source: Ensembl
    7. positive regulation of endothelial cell proliferation Source: Ensembl
    8. positive regulation of eosinophil migration Source: Ensembl
    9. positive regulation of inflammatory response Source: Ensembl
    10. positive regulation of Rac GTPase activity Source: Ensembl
    11. regulation of cell shape Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 24
    Alternative name(s):
    Eosinophil chemotactic protein 2
    Eotaxin-2
    Small-inducible cytokine A24
    Gene namesi
    Name:CCL24
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 6

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 11993C-C motif chemokine 24PRO_0000005231Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 58By similarity
    Disulfide bondi34 ↔ 74By similarity
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ68Y86.

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000019742.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68Y86.
    SMRiQ68Y86. Positions 27-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41621.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    InParanoidiQ68Y86.
    KOiK05514.
    OMAiQRYPANS.
    OrthoDBiEOG73BVG4.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68Y86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLATFVVS LLLVTLCAHC IDPAGSVSIP SSCCMFFISK KVPENRVVTY    50
    QLLNGSVCPK AGVVFTTKKN QKFCGDPQLH WVQKLMKNIE ARRKKVSPGV 100
    RAMSTKALVQ RYPANSTSI 119
    Length:119
    Mass (Da):12,987
    Last modified:October 11, 2004 - v1
    Checksum:i4FB8D288F298306C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB162851 mRNA. Translation: BAD36829.1.
    AY675235 mRNA. Translation: AAU14060.1.
    RefSeqiNP_001003967.1. NM_001003967.1.
    UniGeneiCfa.15823.

    Genome annotation databases

    EnsembliENSCAFT00000021262; ENSCAFP00000019742; ENSCAFG00000013396.
    GeneIDi445452.
    KEGGicfa:445452.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB162851 mRNA. Translation: BAD36829.1 .
    AY675235 mRNA. Translation: AAU14060.1 .
    RefSeqi NP_001003967.1. NM_001003967.1.
    UniGenei Cfa.15823.

    3D structure databases

    ProteinModelPortali Q68Y86.
    SMRi Q68Y86. Positions 27-98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000019742.

    Proteomic databases

    PRIDEi Q68Y86.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000021262 ; ENSCAFP00000019742 ; ENSCAFG00000013396 .
    GeneIDi 445452.
    KEGGi cfa:445452.

    Organism-specific databases

    CTDi 6369.

    Phylogenomic databases

    eggNOGi NOG41621.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    InParanoidi Q68Y86.
    KOi K05514.
    OMAi QRYPANS.
    OrthoDBi EOG73BVG4.
    TreeFami TF334888.

    Miscellaneous databases

    NextBioi 20832133.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Expression analysis of eosinophil chemotactic protein-2 (eotaxin-2/CCL24) gene in canine atopic dermatitis."
      Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of coding sequences for canine monocyte chemotactic protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine receptor 3 (CCR3)."
      Peters I.R., Peeters D., Clercx C., Day M.J.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCCL24_CANFA
    AccessioniPrimary (citable) accession number: Q68Y86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3