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Protein

C-C motif chemokine 24

Gene

CCL24

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 24
Alternative name(s):
Eosinophil chemotactic protein 2
Eotaxin-2
Small-inducible cytokine A24
Gene namesi
Name:CCL24
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:38886 CCL24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000523127 – 119C-C motif chemokine 24Add BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 58By similarity
Disulfide bondi34 ↔ 74By similarity
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ68Y86

Expressioni

Gene expression databases

BgeeiENSCAFG00000013396

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000019742

Structurei

3D structure databases

ProteinModelPortaliQ68Y86
SMRiQ68Y86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCGF Eukaryota
ENOG41119KC LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ68Y86
KOiK21097
OMAiSSCCMSF
OrthoDBiEOG091G1251
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68Y86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLATFVVS LLLVTLCAHC IDPAGSVSIP SSCCMFFISK KVPENRVVTY
60 70 80 90 100
QLLNGSVCPK AGVVFTTKKN QKFCGDPQLH WVQKLMKNIE ARRKKVSPGV
110
RAMSTKALVQ RYPANSTSI
Length:119
Mass (Da):12,987
Last modified:October 11, 2004 - v1
Checksum:i4FB8D288F298306C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162851 mRNA Translation: BAD36829.1
AY675235 mRNA Translation: AAU14060.1
RefSeqiNP_001003967.1, NM_001003967.1
UniGeneiCfa.15823

Genome annotation databases

EnsembliENSCAFT00000021262; ENSCAFP00000019742; ENSCAFG00000013396
GeneIDi445452
KEGGicfa:445452

Similar proteinsi

Entry informationi

Entry nameiCCL24_CANLF
AccessioniPrimary (citable) accession number: Q68Y86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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