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Q68Y86

- CCL24_CANFA

UniProt

Q68Y86 - CCL24_CANFA

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Protein

C-C motif chemokine 24

Gene
CCL24
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 By similarity.

GO - Biological processi

  1. cytoskeleton organization Source: Ensembl
  2. eosinophil chemotaxis Source: Ensembl
  3. immune response Source: InterPro
  4. inflammatory response Source: UniProtKB-KW
  5. positive regulation of actin filament polymerization Source: Ensembl
  6. positive regulation of angiogenesis Source: Ensembl
  7. positive regulation of endothelial cell proliferation Source: Ensembl
  8. positive regulation of eosinophil migration Source: Ensembl
  9. positive regulation of inflammatory response Source: Ensembl
  10. positive regulation of Rac GTPase activity Source: Ensembl
  11. regulation of cell shape Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 24
Alternative name(s):
Eosinophil chemotactic protein 2
Eotaxin-2
Small-inducible cytokine A24
Gene namesi
Name:CCL24
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 6

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 11993C-C motif chemokine 24PRO_0000005231Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 58 By similarity
Disulfide bondi34 ↔ 74 By similarity
Glycosylationi54 – 541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi115 – 1151N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ68Y86.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000019742.

Structurei

3D structure databases

ProteinModelPortaliQ68Y86.
SMRiQ68Y86. Positions 27-98.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41621.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiQ68Y86.
KOiK05514.
OMAiQRYPANS.
OrthoDBiEOG73BVG4.
TreeFamiTF334888.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68Y86-1 [UniParc]FASTAAdd to Basket

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MAGLATFVVS LLLVTLCAHC IDPAGSVSIP SSCCMFFISK KVPENRVVTY    50
QLLNGSVCPK AGVVFTTKKN QKFCGDPQLH WVQKLMKNIE ARRKKVSPGV 100
RAMSTKALVQ RYPANSTSI 119
Length:119
Mass (Da):12,987
Last modified:October 11, 2004 - v1
Checksum:i4FB8D288F298306C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB162851 mRNA. Translation: BAD36829.1.
AY675235 mRNA. Translation: AAU14060.1.
RefSeqiNP_001003967.1. NM_001003967.1.
UniGeneiCfa.15823.

Genome annotation databases

EnsembliENSCAFT00000021262; ENSCAFP00000019742; ENSCAFG00000013396.
GeneIDi445452.
KEGGicfa:445452.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB162851 mRNA. Translation: BAD36829.1 .
AY675235 mRNA. Translation: AAU14060.1 .
RefSeqi NP_001003967.1. NM_001003967.1.
UniGenei Cfa.15823.

3D structure databases

ProteinModelPortali Q68Y86.
SMRi Q68Y86. Positions 27-98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000019742.

Proteomic databases

PRIDEi Q68Y86.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000021262 ; ENSCAFP00000019742 ; ENSCAFG00000013396 .
GeneIDi 445452.
KEGGi cfa:445452.

Organism-specific databases

CTDi 6369.

Phylogenomic databases

eggNOGi NOG41621.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036685.
HOVERGENi HBG017871.
InParanoidi Q68Y86.
KOi K05514.
OMAi QRYPANS.
OrthoDBi EOG73BVG4.
TreeFami TF334888.

Miscellaneous databases

NextBioi 20832133.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Expression analysis of eosinophil chemotactic protein-2 (eotaxin-2/CCL24) gene in canine atopic dermatitis."
    Tsukui T., Sakaguchi M., Maeda S., Koyanagi M., Masuda K., Ohno K., Tsujimoto H., Iwabuchi S.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of coding sequences for canine monocyte chemotactic protein-2 (CCL8), eotaxin 2 (CCL24), eotaxin 3 (CCL26) and C-C chemokine receptor 3 (CCR3)."
    Peters I.R., Peeters D., Clercx C., Day M.J.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCCL24_CANFA
AccessioniPrimary (citable) accession number: Q68Y86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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